Detailed information for compound 1679532

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.327 | Formula: C19H16O5
  • H donors: 2 H acceptors: 4 LogP: 2.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)C[C@H](c1c(O)oc2c(c1=O)cc(cc2)O)c1ccccc1
  • InChi: 1S/C19H16O5/c1-11(20)9-14(12-5-3-2-4-6-12)17-18(22)15-10-13(21)7-8-16(15)24-19(17)23/h2-8,10,14,21,23H,9H2,1H3/t14-/m0/s1
  • InChiKey: JFCOGWFGPAUYNK-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0068 0.0704 0.1328
Loa Loa (eye worm) hypothetical protein 0.0227 0.3897 0.7357
Brugia malayi Thioredoxin reductase 0.0069 0.0721 0.0721
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0239 0.045
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0098 0.1312 0.2476
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0197 0.3292 0.6215
Trypanosoma brucei membrane transporter protein, putative 0.0074 0.0834 0.0419
Trypanosoma brucei RNA helicase, putative 0.0142 0.2198 0.5487
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0721 0.1361
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0039 0.0133 0.0251
Echinococcus granulosus serotonin transporter 0.0197 0.3292 0.6215
Plasmodium falciparum amino acid transporter, putative 0.0033 0.002 0.0046
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.0037
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0683 0.0683
Schistosoma mansoni copper/topaquinone oxidase 0.0093 0.1206 0.2277
Echinococcus granulosus glutamate NMDA receptor subunit 0.0127 0.1883 0.3554
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.1084 0.2046
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0297 0.5297 1
Mycobacterium ulcerans hypothetical protein 0.0044 0.0224 0.0379
Onchocerca volvulus 0.0044 0.0224 0.0575
Echinococcus granulosus DNA topoisomerase 1 0.0203 0.3414 0.6444
Echinococcus granulosus Mastin 0.0044 0.0224 0.0423
Entamoeba histolytica DNA topoisomerase II, putative 0.0152 0.2389 0.5
Toxoplasma gondii hypothetical protein 0.0047 0.0288 0.0833
Echinococcus granulosus glycoprotein Antigen 5 0.0044 0.0224 0.0423
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.1084 0.2046
Plasmodium falciparum thioredoxin reductase 0.0069 0.0721 0.2103
Echinococcus multilocularis sodium and chloride dependent glycine 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.0423
Schistosoma mansoni sodium/chloride dependent transporter 0.0197 0.3292 0.6215
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0226 0.0427
Plasmodium vivax DNA topoisomerase II, putative 0.0152 0.2389 0.6994
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0131 0.1974 0.1974
Echinococcus granulosus nmda type glutamate receptor 0.0106 0.1466 0.2767
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0093 0.1206 0.2277
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0834 0.1659
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.1084 0.2046
Echinococcus granulosus sodium and chloride dependent glycine 0.0033 0.002 0.0037
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.0721 0.1361
Schistosoma mansoni ATP-binding cassette transporter 0.0067 0.0683 0.1289
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0131 0.1974 0.5065
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0203 0.3414 1
Loa Loa (eye worm) trypsin family protein 0.0044 0.0224 0.0423
Plasmodium falciparum DNA topoisomerase 2 0.0152 0.2389 0.6994
Echinococcus multilocularis nmda type glutamate receptor 0.0106 0.1466 0.2767
Onchocerca volvulus 0.0044 0.0224 0.0575
Leishmania major trypanothione reductase 0.0069 0.0721 0.1294
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Onchocerca volvulus 0.0033 0.002 0.005
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.0224 0.0423
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0033 0.002 0.014
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0131 0.1974 0.3727
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0683 0.1289
Brugia malayi hypothetical protein 0.0044 0.0224 0.0224
Trypanosoma brucei membrane transporter protein, putative 0.0074 0.0834 0.0419
Schistosoma mansoni hypothetical protein 0.0093 0.1206 0.2277
Loa Loa (eye worm) hypothetical protein 0.0103 0.1407 0.2655
Echinococcus multilocularis NMDA receptor 0.0039 0.0133 0.0251
Schistosoma mansoni glutamate receptor NMDA 0.0127 0.1883 0.3554
Plasmodium vivax amine transporter, putative 0.0033 0.002 0.0046
Brugia malayi Probable DNA topoisomerase II 0.0152 0.2389 0.2389
Echinococcus granulosus biogenic amine 5HT receptor 0.0297 0.5297 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0323 0.5805 1
Echinococcus multilocularis serotonin receptor 0.0297 0.5297 1
Schistosoma mansoni hypothetical protein 0.0039 0.0133 0.0251
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.002 0.0037
Echinococcus multilocularis transmembrane protease serine 3 0.0044 0.0224 0.0423
Schistosoma mansoni biogenic amine (5HT) receptor 0.0297 0.5297 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0039 0.0133 0.0251
Plasmodium falciparum DNA gyrase subunit B 0.0089 0.1122 0.3279
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0152 0.0287
Plasmodium vivax glutathione reductase, putative 0.0069 0.0721 0.2103
Echinococcus granulosus sodium and chloride dependent glycine 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0059 0.0529 0.4697
Schistosoma mansoni amine GPCR 0.0212 0.36 0.6796
Loa Loa (eye worm) hypothetical protein 0.0103 0.1407 0.2655
Echinococcus multilocularis nmda type glutamate receptor 0.0184 0.3026 0.5713
Loa Loa (eye worm) hypothetical protein 0.0197 0.3292 0.6215
Loa Loa (eye worm) hypothetical protein 0.0297 0.5297 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Loa Loa (eye worm) hypothetical protein 0.0197 0.3292 0.6215
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1107
Echinococcus granulosus nmda type glutamate receptor 0.0184 0.3026 0.5713
Brugia malayi DNA topoisomerase I 0.0203 0.3414 0.3414
Onchocerca volvulus 0.0197 0.3292 0.8447
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.03 0.535 1
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0683 0.1289
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0103 0.1404 0.3602
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0127 0.1883 0.3554
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.0031 0.0059
Leishmania major DNA topoisomerase IB, large subunit 0.0203 0.3414 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0033 0.002 0.0037
Onchocerca volvulus 0.0044 0.0239 0.0612
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.039 0.0735
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0224 0.0423
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0044 0.0224 0.0224
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0152 0.0287
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0033 0.002 0.0037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.002 0.0037
Plasmodium falciparum transporter, putative 0.0033 0.002 0.0046
Schistosoma mansoni sodium-dependent amino acid transporter 0.0033 0.002 0.0037
Onchocerca volvulus 0.0044 0.0239 0.0612
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.0037
Trypanosoma brucei MATE efflux family protein, putative 0.0074 0.0834 0.0419
Schistosoma mansoni hypothetical protein 0.0049 0.0321 0.0605
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0074 0.0834 0.1574
Echinococcus multilocularis serotonin receptor 0.0297 0.5297 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0224 0.0423
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.002 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0069 0.0721 0.1341
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0152 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0834 0.1659
Schistosoma mansoni DNA topoisomerase II 0.0152 0.2389 0.4509
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0144 0.2225 0.5585
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0152 0.2389 0.2389
Trypanosoma cruzi DNA topoisomerase II, putative 0.0144 0.2225 0.6156
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0683 0.1289
Toxoplasma gondii DNA topoisomerase I, putative 0.0203 0.3414 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0044 0.0224 0.0423
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.002 0.0037
Schistosoma mansoni glutamate receptor NMDA 0.0172 0.2798 0.5283
Plasmodium falciparum cysteine repeat modular protein 1 0.0049 0.0321 0.0928
Brugia malayi hypothetical protein 0.0033 0.002 0.002
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0152 0.2389 0.2389
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0197 0.3292 0.3292
Loa Loa (eye worm) glutathione reductase 0.0069 0.0721 0.1361
Plasmodium falciparum topoisomerase I 0.0203 0.3414 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0044 0.0224 0.0423
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0033 0.002 0.0037
Leishmania major DNA topoisomerase ii 0.0144 0.2225 0.6156
Loa Loa (eye worm) solute carrier family 6 member 4 0.0197 0.3292 0.6215
Brugia malayi Trypsin family protein 0.0044 0.0224 0.0224
Toxoplasma gondii kringle domain-containing protein 0.0049 0.0321 0.0928
Loa Loa (eye worm) hypothetical protein 0.0197 0.3292 0.6215
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Plasmodium vivax DNA gyrase subunit B, putative 0.0089 0.1122 0.3279
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0044 0.0224 0.0423
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0039 0.0133 0.0251
Toxoplasma gondii hypothetical protein 0.0033 0.002 0.0046
Chlamydia trachomatis DNA gyrase subunit B 0.0089 0.1122 1
Onchocerca volvulus 0.0033 0.002 0.005
Loa Loa (eye worm) norepinephrine transporter 0.0197 0.3292 0.6215
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0152 0.2389 0.4509
Brugia malayi Protein kinase domain containing protein 0.0131 0.1974 0.1974
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0049 0.0321 0.0928
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0039 0.0133 0.0251
Echinococcus granulosus glutamate receptor 2 0.0087 0.1084 0.2046
Leishmania major mitochondrial DNA topoisomerase II 0.0171 0.2761 0.7889
Schistosoma mansoni DNA topoisomerase type I 0.0203 0.3414 0.6444
Brugia malayi Protein kinase domain containing protein 0.0049 0.0321 0.0321
Brugia malayi Muscle positioning protein 4 0.0044 0.0239 0.0239
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.1084 0.2046
Plasmodium vivax hypothetical protein, conserved 0.0033 0.002 0.0046
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0059 0.0529 0.1597
Onchocerca volvulus 0.0049 0.0321 0.0822
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0721 0.1294
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.1084 0.2046
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0131 0.1974 0.3727
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0039 0.014 0.5
Echinococcus granulosus transmembrane protease serine 3 0.0044 0.0224 0.0423
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0224 0.0423
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0131 0.1974 0.3727
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0721 0.1361
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0059 0.0529 0.1597
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0033 0.002 0.0037
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0089 0.1122 0.34
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0089 0.1122 0.2091
Schistosoma mansoni hypothetical protein 0.0044 0.0224 0.0423
Plasmodium falciparum glutathione reductase 0.0069 0.0721 0.2103
Mycobacterium ulcerans acetyltransferase 0.0113 0.161 0.2769
Echinococcus multilocularis enteropeptidase 0.0044 0.0224 0.0423
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0683 0.1289
Brugia malayi Trypsin-like protease protein 5 0.0044 0.0224 0.0224
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0171 0.2761 0.7889
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.002
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0087 0.1084 0.2046
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0033 0.002 0.0037
Brugia malayi Kringle domain containing protein 0.0049 0.0321 0.0321
Onchocerca volvulus 0.0227 0.3897 1
Trypanosoma cruzi membrane transporter protein, putative 0.0074 0.0834 0.1659
Schistosoma mansoni hypothetical protein 0.0044 0.0239 0.045
Treponema pallidum sodium- and chloride- dependent transporter 0.0197 0.3292 1
Echinococcus multilocularis tissue type plasminogen activator 0.0049 0.0321 0.0605
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Echinococcus multilocularis glutamate receptor NMDA 0.0086 0.1065 0.201
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0683 0.1289
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0152 0.0152
Echinococcus multilocularis sodium and chloride dependent glycine 0.0033 0.002 0.0037
Brugia malayi Trypsin family protein 0.0227 0.3897 0.3897
Chlamydia trachomatis DNA gyrase subunit B 0.007 0.075 0.6674
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.1084 0.2046
Loa Loa (eye worm) serotonin transporter b 0.0197 0.3292 0.6215
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0834 0.1659
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0683 0.1289
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0059 0.0529 0.0905
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0224 0.0423
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0087 0.1084 0.2046
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0039 0.0133 0.0251
Loa Loa (eye worm) TOPoisomerase family member 0.0152 0.2389 0.4509
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0301 0.0569
Loa Loa (eye worm) DOMON domain-containing protein 0.0044 0.0239 0.045
Brugia malayi SEA domain containing protein 0.0044 0.0239 0.0239
Echinococcus multilocularis glutamate receptor 2 0.0087 0.1084 0.2046
Echinococcus multilocularis serotonin transporter 0.0197 0.3292 0.6215
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0089 0.1122 1
Schistosoma mansoni DNA topoisomerase type I 0.0203 0.3414 0.6444
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0227 0.3897 0.7357
Mycobacterium ulcerans DNA gyrase subunit B 0.0089 0.1122 0.1928
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0227 0.3897 0.7357
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.0423
Echinococcus granulosus tissue type plasminogen activator 0.0049 0.0321 0.0605
Onchocerca volvulus 0.0033 0.002 0.005
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0152 0.2389 0.4509
Onchocerca volvulus 0.0044 0.0239 0.0612
Loa Loa (eye worm) TK/ROR protein kinase 0.0049 0.0321 0.0605
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Schistosoma mansoni multidrug resistance protein 0.0074 0.0834 0.1574
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0683 0.1289
Leishmania major hypothetical protein, conserved 0.0074 0.0834 0.1659
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0037
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0033 0.002 0.002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0226 0.0427
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0144 0.2225 0.5585
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0089 0.1122 0.3279
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0044 0.0224 0.0423
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0103 0.1404 0.3602
Loa Loa (eye worm) hypothetical protein 0.0049 0.0321 0.0605
Trichomonas vaginalis DNA topoisomerase II, putative 0.0152 0.2389 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0039 0.0133 0.0251
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0103 0.1404 0.3602
Loa Loa (eye worm) DNA topoisomerase I 0.0203 0.3414 0.6444
Schistosoma mansoni sodium/chloride dependent transporter 0.0033 0.002 0.0037
Toxoplasma gondii thioredoxin reductase 0.0069 0.0721 0.2103
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0171 0.2761 0.7889
Onchocerca volvulus 0.0044 0.0239 0.0612
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0244 0.4225 0.7975
Brugia malayi Trypsin family protein 0.0044 0.0224 0.0224
Plasmodium vivax thioredoxin reductase, putative 0.0069 0.0721 0.2103
Plasmodium vivax topoisomerase I, putative 0.0203 0.3414 1
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0203 0.3414 1
Onchocerca volvulus 0.0044 0.0224 0.0575
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0059 0.0529 0.0982
Chlamydia trachomatis glutamine binding protein 0.0059 0.0529 0.4697
Toxoplasma gondii DNA topoisomerase 2, putative 0.0152 0.2389 0.6994
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.0423
Echinococcus granulosus amiloride sensitive amine oxidase 0.0093 0.1206 0.2277
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.0046
Onchocerca volvulus 0.0044 0.0224 0.0575
Brugia malayi Trypsin family protein 0.0044 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0044 0.0224 0.0423
Trypanosoma brucei membrane transporter protein, putative 0.0074 0.0834 0.0419
Brugia malayi glutathione reductase 0.0069 0.0721 0.0721
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.002 0.0037
Echinococcus granulosus glutamate receptor 2 0.0048 0.0301 0.0569
Toxoplasma gondii hypothetical protein 0.0033 0.002 0.0046
Loa Loa (eye worm) glutamate receptor 2 0.0067 0.0683 0.1289
Giardia lamblia DNA topoisomerase II 0.0144 0.2231 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.0423
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.002
Onchocerca volvulus 0.0044 0.0239 0.0612
Echinococcus multilocularis DNA topoisomerase 1 0.0203 0.3414 0.6444
Trypanosoma cruzi DNA topoisomerase II, putative 0.0144 0.2225 0.6156
Trypanosoma brucei DNA topoisomerase ii 0.0171 0.2761 0.7575
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0323 0.5805 1
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0683 0.0683
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0039 0.0133 0.0251
Schistosoma mansoni DNA topoisomerase type I 0.0203 0.3414 0.6444
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.002 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0224 0.0423
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.0423
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0074 0.0834 0.1574
Leishmania major acetyltransferase-like protein 0.0113 0.161 0.417
Echinococcus granulosus glutamate receptor NMDA 0.0086 0.1065 0.201
Onchocerca volvulus 0.0184 0.3024 0.7759
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0033 0.002 0.0037
Echinococcus multilocularis Mastin 0.0044 0.0224 0.0423
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0131 0.1974 0.3727
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1107
Leishmania major hypothetical protein, conserved 0.0074 0.0834 0.1659
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0224 0.0423
Loa Loa (eye worm) hypothetical protein 0.0044 0.0239 0.045
Schistosoma mansoni hypothetical protein 0.0142 0.2198 0.415
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.1974 0.3727
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0834 0.1659
Echinococcus granulosus enteropeptidase 0.0044 0.0224 0.0423
Onchocerca volvulus 0.0044 0.0224 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0834 0.1659
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.002 0.0046

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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