Detailed information for compound 1695187

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.478 | Formula: C27H23F3N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1CN(C1)CCCc1ccc2c(c1)nc(o2)c1ccc(c(c1)C(F)(F)F)c1ccccc1
  • InChi: 1S/C27H23F3N2O3/c28-27(29,30)22-14-19(9-10-21(22)18-6-2-1-3-7-18)25-31-23-13-17(8-11-24(23)35-25)5-4-12-32-15-20(16-32)26(33)34/h1-3,6-11,13-14,20H,4-5,12,15-16H2,(H,33,34)
  • InChiKey: HCARWJSMYJDNRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 3 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0455 0.2547
Trypanosoma cruzi target of rapamycin kinase 3 0.0028 0.0461 0.4207
Plasmodium falciparum hexose transporter 0.0091 0.1788 0.2094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0712 0.0712
Giardia lamblia Prolyl-tRNA synthetase 0.0027 0.0436 0.6304
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0017 0.0222 0.0096
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0128 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0388 0.1407
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0027 0.0439 0.0439
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0712 0.0712
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0028 0.0448 0.0404
Mycobacterium tuberculosis Probable hydrolase 0.0058 0.1097 0.0982
Onchocerca volvulus 0.0058 0.1097 0.4283
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0616 0.3447
Trypanosoma cruzi sugar transporter, putative 0.0013 0.0128 0.1166
Echinococcus granulosus lysyl tRNA synthetase 0.002 0.0287 0.0383
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.0152 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0616 0.2579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0306 0.1711
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0184 0.1675
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0439 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Leishmania major glucose transporter/membrane transporter D2, putative 0.0028 0.0455 0.3492
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0439 0.0584
Loa Loa (eye worm) hypothetical protein 0.0027 0.0439 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0128 0.0715
Entamoeba histolytica protein kinase, putative 0.0028 0.0448 0.7266
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.004
Mycobacterium tuberculosis Conserved protein 0.0058 0.1097 0.0982
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0388 0.0516
Toxoplasma gondii lysine-tRNA ligase 0.002 0.0287 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0111 0.0622
Plasmodium falciparum calcium-dependent protein kinase 3 0.0028 0.0448 0.0404
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0013 0.0128 0.0067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0388 0.0516
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0013 0.0128 0.0128
Entamoeba histolytica protein kinase, putative 0.0028 0.0448 0.7266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0388 0.1621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0616 0.3447
Schistosoma mansoni cpg binding protein 0.0027 0.0424 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Toxoplasma gondii ABC1 family protein 0.0058 0.1097 0.2064
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0028 0.0448 0.1874
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0027 0.0436 0.0436
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0465 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0616 0.3447
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0439 0.2453
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.015 0.015
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Echinococcus granulosus solute carrier family 22 0.0013 0.0128 0.017
Leishmania major glucose transporter, lmgt3 0.0028 0.0455 0.3492
Loa Loa (eye worm) hypothetical protein 0.0119 0.239 0.8677
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.0152 0.2473
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0058 0.1097 0.0982
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0712 0.0948
Entamoeba histolytica hypothetical protein 0.002 0.0287 0.4664
Mycobacterium tuberculosis Conserved protein 0.0058 0.1097 0.0982
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0455 0.2547
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0032 0.0532 0.4849
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0874 0.1645
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0012 0.0111 0.0148
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0012 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Schistosoma mansoni sugar transporter 0.0013 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0028 0.0461 0.3554
Brugia malayi hypothetical protein 0.0013 0.0128 0.0535
Schistosoma mansoni jumonji domain containing protein 0.0052 0.0957 0.0957
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.035 0.1956
Leishmania major hypothetical protein, conserved 0.0013 0.0128 0.017
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0017 0.0222 0.0096
Schistosoma mansoni sugar transporter 0.0013 0.0128 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.0616 0.5125
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.0616 0.5125
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0152 0.0638
Echinococcus granulosus synaptic vesicle 2 protein 0.0013 0.0128 0.017
Echinococcus multilocularis lysyl tRNA synthetase 0.002 0.0287 0.0383
Loa Loa (eye worm) hypothetical protein 0.002 0.0287 0.1044
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.0616 0.5619
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0455 0.4152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0987 0.0987
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0439 0.0584
Entamoeba histolytica hypothetical protein 0.0029 0.0465 0.754
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0015 0.0172 0.1568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0267 0.1491
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Brugia malayi beta-lactamase family protein 0.0058 0.1097 0.4589
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0027 0.0439 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0461 0.2577
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0079 0.1535 0.5574
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0027 0.0436 0.058
Echinococcus multilocularis solute carrier family 22 0.0013 0.0128 0.017
Plasmodium vivax calcium-dependent protein kinase, putative 0.0028 0.0448 0.0404
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0012 0.0111 0.1013
Leishmania major protein kinase, putative 0.0028 0.0448 0.3416
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0012 0.0111 0.1013
Echinococcus multilocularis ubiquitin specific protease 41 0.0027 0.0439 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0987 0.3584
Toxoplasma gondii sugar transporter ST1 0.0013 0.0128 0.0241
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0012 0.0111 0.1013
Chlamydia trachomatis lysine--tRNA ligase 0.002 0.0287 0.0228
Brugia malayi jmjC domain containing protein 0.0053 0.0987 0.413
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0012 0.0111 0.1013
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0028 0.0448 0.0404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0027 0.0436 0.0436
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0465 0.0619
Entamoeba histolytica hypothetical protein 0.0029 0.0465 0.754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0461 0.2577
Brugia malayi hypothetical protein 0.0013 0.0128 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.1097 0.6134
Loa Loa (eye worm) beta-lactamase 0.0058 0.1097 0.3982
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0147 0.2978 0.5603
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0455 0.4152
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0022 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0439 0.1835
Brugia malayi lysyl-tRNA synthetase 0.002 0.0287 0.1203
Brugia malayi hypothetical protein 0.0013 0.0128 0.0535
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0027 0.0436 0.2437
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Leishmania major myo-inositol/proton symporter (MIT) 0.0013 0.0128 0.017
Echinococcus multilocularis lysine specific demethylase 5A 0.0052 0.0957 0.1274
Toxoplasma gondii protein kinase, putative 0.0256 0.5315 1
Mycobacterium leprae conserved hypothetical protein 0.0058 0.1097 0.0894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.0152 0.139
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0266 0.1488
Echinococcus granulosus ubiquitin specific protease 41 0.0027 0.0439 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0111 0.0622
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Loa Loa (eye worm) hypothetical protein 0.0025 0.0388 0.1407
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0439 0.2453
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Echinococcus granulosus phd:f box containing protein 0.0014 0.015 0.0199
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0532 0.4849
Schistosoma mansoni jumonji domain containing protein 0.0014 0.015 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.015 0.0543
Trypanosoma cruzi hexose transporter 0.0028 0.0455 0.4152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Echinococcus granulosus cpg binding protein 0.0027 0.0424 0.0565
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0287 0.1608
Schistosoma mansoni sugar transporter 0.0013 0.0128 0.0128
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0372 0.7782 0.7754
Echinococcus granulosus geminin 0.0125 0.2525 0.3363
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0287 0.0228
Mycobacterium tuberculosis Probable esterase LipL 0.0058 0.1097 0.0982
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0028 0.0448 0.0843
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0014 0.015 0.1364
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0028 0.0448 0.0404
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Brugia malayi Calcitonin receptor-like protein seb-1 0.0079 0.1535 0.6424
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.018 0.024
Trichomonas vaginalis myo-inositol transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.1097 0.1097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0079 0.1535 0.6424
Echinococcus granulosus solute carrier family 22 0.0013 0.0128 0.017
Plasmodium vivax CDK-related protein kinase 6, putative 0.0385 0.8056 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0476 1 1
Plasmodium falciparum protein kinase 7 0.0256 0.5315 0.6542
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0058 0.1097 0.1097
Brugia malayi beta-lactamase 0.0058 0.1097 0.4589
Echinococcus multilocularis synaptic vesicle 2 protein 0.0013 0.0128 0.017
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0017 0.0216 0.1967
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Toxoplasma gondii sugar transporter ST2 0.0013 0.0128 0.0241
Schistosoma mansoni hypothetical protein 0.0029 0.0465 0.0465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.002 0.0085
Mycobacterium ulcerans esterase/lipase LipP 0.0058 0.1097 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0366 0.2047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0712 0.0948
Schistosoma mansoni cpg binding protein 0.0027 0.0424 0.0424
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0027 0.0439 0.6362
Entamoeba histolytica hypothetical protein 0.0029 0.0465 0.754
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0128 0.0464
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0532 0.4268
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0008 0.0016 0.0031
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0147 0.2978 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0455 0.2547
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.1097 0.6134
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0439 0.3999
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.0616 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0012 0.0111 0.0111
Brugia malayi major facilitator superfamily protein 0.0013 0.0128 0.0535
Echinococcus granulosus solute carrier family 22 0.0013 0.0128 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.0996 0.0996
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0152 0.139
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0058 0.1097 0.4589
Schistosoma mansoni protein kinase 0.0028 0.0448 0.0448
Echinococcus multilocularis solute carrier family 22 0.0013 0.0128 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0128 0.0535
Brugia malayi CXXC zinc finger family protein 0.0025 0.0394 0.1646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.031 0.1736
Schistosoma mansoni hypothetical protein 0.0125 0.2525 0.2525
Plasmodium vivax lysine--tRNA ligase, putative 0.002 0.0287 0.0201
Schistosoma mansoni hypothetical protein 0.0125 0.2525 0.2525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0267 0.1491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0712 0.2585
Echinococcus multilocularis General substrate transporter 0.0078 0.1517 0.202
Schistosoma mansoni protein kinase 0.0028 0.0448 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0266 0.1488
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.0616 0.5619
Brugia malayi jmjC domain containing protein 0.0052 0.0957 0.4002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0436 0.1582
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Brugia malayi jmjC domain containing protein 0.0014 0.015 0.0626
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.0152 0.0419
Toxoplasma gondii exonuclease III APE 0.0014 0.0152 0.0287
Echinococcus granulosus calcium dependent protein kinase 0.0026 0.0411 0.0548
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0455 0.4152
Echinococcus multilocularis cpg binding protein 0.0027 0.0424 0.0565
Echinococcus multilocularis solute carrier family 22 0.0013 0.0128 0.017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0388 0.0516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0111 0.0622
Schistosoma mansoni ap endonuclease 0.0014 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0079 0.1535 0.5574
Plasmodium falciparum protein kinase 6 0.0385 0.8056 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.006 0.0337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0436 0.1582
Brugia malayi jmjC domain containing protein 0.0014 0.015 0.0626
Loa Loa (eye worm) hypothetical protein 0.0054 0.1004 0.3645
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0052 0.0957 0.1274
Schistosoma mansoni hypothetical protein 0.0054 0.1004 0.1004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Brugia malayi beta-lactamase family protein 0.0058 0.1097 0.4589
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.1004 0.4201
Echinococcus granulosus Sugar transporter ERD6 protein 0.0013 0.0128 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0712 0.0712
Plasmodium falciparum lysine--tRNA ligase 0.002 0.0287 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0128 0.0715
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0543
Plasmodium vivax hexose transporter 0.0091 0.1788 0.2094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Schistosoma mansoni cpg binding protein 0.0025 0.0394 0.0394
Trypanosoma brucei glucose transporter 2A 0.0028 0.0455 0.4152
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0439 0.3999
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0543
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0532 0.4268
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0013 0.0128 0.1166
Brugia malayi hypothetical protein 0.0119 0.239 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.015 0.1364
Mycobacterium tuberculosis Conserved protein 0.0058 0.1097 0.0982
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0018 0.0234 0.131
Plasmodium vivax JmjC domain containing protein 0.0014 0.015 0.0027
Onchocerca volvulus 0.0058 0.1097 0.4283
Brugia malayi Sugar transporter family protein 0.0013 0.0128 0.0535
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.1097 0.6134
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0152 0.0031
Onchocerca volvulus 0.0119 0.239 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0058 0.1097 0.1461
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0013 0.0128 0.017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.0476 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Toxoplasma gondii facilitative glucose transporter GT1 0.0091 0.1788 0.3365
Plasmodium falciparum calcium-dependent protein kinase 1 0.0028 0.0448 0.0404
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0128 0.0535
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0439 0.3999
Schistosoma mansoni hypothetical protein 0.0359 0.7509 0.7509
Toxoplasma gondii target of rapamycin (TOR), putative 0.0027 0.0422 0.0793
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0013 0.0128 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0388 0.1621
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0128 0.0715
Trypanosoma brucei sugar transporter, putative 0.0013 0.0128 0.1166
Trypanosoma cruzi hexose transporter, putative 0.0013 0.0128 0.1166
Echinococcus granulosus lysine specific demethylase 5A 0.0053 0.0987 0.1315
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0616 0.2238
Trypanosoma cruzi glucose transporter, putative 0.0013 0.0128 0.1166
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Brugia malayi Cam kinase protein 1 0.0028 0.0448 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0027 0.0436 0.1824
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0439 0.2453
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.0152 0.139
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0027 0.0439 0.7117
Echinococcus granulosus dnaJ subfamily B 0.0359 0.7509 1
Schistosoma mansoni phd/f-box containing protein 0.0014 0.015 0.015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.0152 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0128 0.0715
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0032 0.0532 0.4849
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0128 0.0464
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0476 1 1
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.015 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0028 0.0448 0.0843
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0287 0.0228
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.015 0.0543
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.015 0.1364
Schistosoma mansoni protein kinase 0.0028 0.0448 0.0448
Plasmodium falciparum JmjC domain-containing protein, putative 0.0014 0.015 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0128 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0027 0.0436 0.1824
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0011 0.0094 0.0342
Giardia lamblia Lysyl-tRNA synthetase 0.002 0.0287 0.3267
Plasmodium falciparum mitogen-activated protein kinase 2 0.0147 0.2978 0.3595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0266 0.1488
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0028 0.0448 0.0596
Brugia malayi major facilitator superfamily protein 0.0013 0.0128 0.0535
Plasmodium vivax hypothetical protein, conserved 0.0058 0.1097 0.1222
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0027 0.0436 0.7071
Echinococcus multilocularis phd:f box containing protein 0.0014 0.015 0.0199
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.0152 0.0025
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Mycobacterium ulcerans beta-lactamase 0.0058 0.1097 0.1042
Echinococcus granulosus GPCR family 2 0.0025 0.0388 0.0516
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.002 0.0287 0.0066
Trichomonas vaginalis esterase, putative 0.0058 0.1097 0.6134
Leishmania major lysyl-tRNA synthetase, putative 0.002 0.0287 0.1789
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0455 0.2547
Toxoplasma gondii transporter, major facilitator family protein 0.0013 0.0128 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0306 0.1711
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0448 0.2504
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1097 1
Trichomonas vaginalis D-aminoacylase, putative 0.0058 0.1097 0.6134
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0052 0.0957 0.1274
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0058 0.1097 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0111 0.0622
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.0616 0.0616
Brugia malayi Sugar transporter family protein 0.0091 0.1788 0.7482
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis sugar transport protein, putative 0.0013 0.0128 0.0715
Toxoplasma gondii sugar transporter ST3 0.0013 0.0128 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0058 0.1097 0.1461
Plasmodium falciparum calcium-dependent protein kinase 4 0.0028 0.0448 0.0404
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.015 0.0199
Schistosoma mansoni hypothetical protein 0.0025 0.0388 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0448 0.0448
Loa Loa (eye worm) sugar transporter 0.0091 0.1788 0.6492
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0027 0.0439 0.3322
Onchocerca volvulus 0.0025 0.0394 0.1174
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Leishmania major glucose transporter, lmgt1 0.0028 0.0455 0.3492
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.0152 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0152 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Brugia malayi Sugar transporter family protein 0.0013 0.0128 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0032 0.0532 0.1001
Schistosoma mansoni ap endonuclease 0.0014 0.0152 0.0152
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0027 0.0436 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0712 0.0948
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0028 0.0448 0.0843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0267 0.1491
Schistosoma mansoni hypothetical protein 0.0025 0.0388 0.0388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0028 0.0461 0.4207
Mycobacterium tuberculosis Probable lipase LipE 0.0058 0.1097 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0461 0.2577
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0505 0.2825
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0014 0.015 0.0282
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0058 0.1097 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.031 0.1736
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0455 0.2547
Echinococcus granulosus General substrate transporter 0.0078 0.1517 0.202
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0455 0.4152
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0455 0.4152
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0028 0.0448 0.1626
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Mycobacterium leprae Probable lipase LipE 0.0058 0.1097 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.0616 0.5619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0712 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1097 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.031 0.1736
Echinococcus multilocularis solute carrier family 22 0.0013 0.0128 0.017
Echinococcus multilocularis geminin 0.0125 0.2525 0.3363
Plasmodium falciparum calcium-dependent protein kinase 2 0.0028 0.0448 0.0404
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0152 0.0203
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.0152 0.0025
Plasmodium vivax proline--tRNA ligase, putative 0.0032 0.0532 0.051
Brugia malayi jmjC domain containing protein 0.0014 0.015 0.0626
Mycobacterium ulcerans integral membrane transport protein 0.0013 0.0128 0.0067
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0028 0.0448 0.1626
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0014 0.015 0.0282
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0287 0.0287
Brugia malayi hypothetical protein 0.0029 0.0465 0.1945
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.0616 1
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Mycobacterium ulcerans sugar transporter 0.0013 0.0128 0.0067
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.0616 0.0821
Plasmodium falciparum calcium-dependent protein kinase 5 0.0028 0.0448 0.0404
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0091 0.1788 0.1788
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0465 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0448 0.1626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0267 0.1491
Echinococcus multilocularis dnaJ subfamily B 0.0359 0.7509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0461 0.2577
Mycobacterium ulcerans lipase LipD 0.0058 0.1097 0.1042
Mycobacterium tuberculosis Probable lipase LipD 0.0058 0.1097 0.0982
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1788 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.002 0.0287 0.2621
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0476 1 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0455 0.2547
Echinococcus multilocularis calcium dependent protein kinase 0.0026 0.0411 0.0548
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0152 0.0553
Loa Loa (eye worm) hypothetical protein 0.0058 0.1097 0.3982
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.015 0.0543
Treponema pallidum replicative DNA helicase (dnaB) 0.0476 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0091 0.1788 0.2382
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.003
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0455 0.4152
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni sugar transporter 0.0013 0.0128 0.0128
Plasmodium falciparum proline--tRNA ligase 0.0032 0.0532 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0422 0.2358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0461 0.2577
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0388 0.0516
Leishmania major hypothetical protein, conserved 0.0014 0.015 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni protein phosphatase 2C 0.0014 0.015 0.015
Trichomonas vaginalis penicillin-binding protein, putative 0.0058 0.1097 0.6134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0111 0.0465
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.002 0.0287 0.2621
Brugia malayi jmjC domain containing protein 0.0014 0.015 0.0626
Schistosoma mansoni Replicative DNA helicase 0.0476 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0152 0.0203
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0448 0.0596
Leishmania major hypothetical protein, conserved 0.0058 0.1097 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0091 0.1788 0.2382
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0058 0.1097 0.0982
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0439 0.0584
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.0616 0.0821
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0455 0.2547
Loa Loa (eye worm) phosphatidylinositol 3 0.0012 0.0111 0.0404
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.1097 1
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.015 0.0199
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0394 0.1429
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0152 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni hypothetical protein 0.0025 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0464
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0058 0.1097 0.3982
Schistosoma mansoni glucose transporter 0.0013 0.0128 0.0128
Leishmania major glucose transporter, lmgt2 0.0028 0.0455 0.3492
Loa Loa (eye worm) twinkle helicase 0.0136 0.2754 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.015 0.0199
Echinococcus multilocularis GPCR, family 2 0.0025 0.0388 0.0516
Entamoeba histolytica hypothetical protein 0.0029 0.0465 0.754
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.015 0.015
Onchocerca volvulus 0.0058 0.1097 0.4283
Schistosoma mansoni glucose transport protein 0.0091 0.1788 0.1788
Trichomonas vaginalis sugar transporter, putative 0.0013 0.0128 0.0715
Schistosoma mansoni glucose transport protein 0.0091 0.1788 0.1788
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0616 0.5619
Loa Loa (eye worm) hypothetical protein 0.0022 0.0327 0.1188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0712 0.2979
Giardia lamblia GTOR 0.0036 0.0616 1
Trichomonas vaginalis glucose transporter, putative 0.0013 0.0128 0.0715
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.015 0.0199
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.018 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0111 0.0622
Loa Loa (eye worm) sugar transporter 0.0013 0.0128 0.0464
Mycobacterium ulcerans hypothetical protein 0.0058 0.1097 0.1042
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.015 0.0199
Schistosoma mansoni hypothetical protein 0.0025 0.0388 0.0388
Schistosoma mansoni glucose transport protein 0.0091 0.1788 0.1788
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0027 0.0436 0.058
Echinococcus granulosus solute carrier family 22 0.0013 0.0128 0.017
Trypanosoma brucei glucose transporter, putative 0.0028 0.0455 0.4152
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0152 0.0031
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0028 0.0448 0.4083
Trypanosoma brucei glucose transporter 1E 0.0028 0.0455 0.4152

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.9 Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assay ChEMBL. 22583616
EC50 (functional) = 10 Agonist activity at SIP1 receptor by tango assay ChEMBL. 22583616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.