Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Steroid 5-alpha-reductase | Starlite/ChEMBL | References |
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Synaptic glycoprotein SC2 | 0.008 | 0.3061 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0242 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0242 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 1 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0242 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0242 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.008 | 0.3061 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.4741 | 0.4741 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.008 | 0.3061 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0242 | 1 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.008 | 0.3061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3061 | 0.3061 |
Onchocerca volvulus | 0.008 | 0.3061 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3061 | 0.3061 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0242 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.008 | 0.3061 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.008 | 0.3061 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.008 | 0.3061 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0242 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.4741 | 0.4741 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.008 | 0.3061 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0242 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.4741 | 0.4741 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.008 | 0.3061 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0242 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.008 | 0.3061 | 0.3061 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.008 | 0.3061 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.008 | 0.3061 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 35 nM | Inhibition of rat 5alpha reductase isozyme. | ChEMBL. | 9135028 |
Ki (binding) | = 26 nM | In vitro inhibition of Steroid 5-alpha-reductase in human prostatic tissue. | ChEMBL. | 2308145 |
Ki (binding) | = 35 nM | In vitro inhibition of Steroid 5-alpha-reductase in rat ventral prostates. | ChEMBL. | 2308145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.