Detailed information for compound 1705369

Basic information

Technical information
  • TDR Targets ID: 1705369
  • Name: N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-4 -butyl-N-(3-methylbutyl)cyclohexane-1-carboxa mide
  • MW: 434.615 | Formula: C24H42N4O3
  • H donors: 2 H acceptors: 3 LogP: 5.2 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1CCC(CC1)C(=O)N(c1c(=O)[nH]c(=O)n(c1N)CCCC)CCC(C)C
  • InChi: 1S/C24H42N4O3/c1-5-7-9-18-10-12-19(13-11-18)23(30)27(16-14-17(3)4)20-21(25)28(15-8-6-2)24(31)26-22(20)29/h17-19H,5-16,25H2,1-4H3,(H,26,29,31)
  • InChiKey: CGNNRAHOKKUVOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(6-amino-1-butyl-2,4-dioxo-pyrimidin-5-yl)-4-butyl-N-isopentyl-cyclohexane-1-carboxamide
  • N-(6-amino-1-butyl-2,4-dioxo-5-pyrimidinyl)-4-butyl-N-isopentyl-1-cyclohexanecarboxamide
  • N-(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-4-butyl-N-isoamyl-cyclohexane-1-carboxamide
  • N-(6-amino-1-butyl-2,4-dioxo-pyrimidin-5-yl)-4-butyl-N-(3-methylbutyl)cyclohexane-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0043 0.0021 0.0015
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Trypanosoma brucei polo-like protein kinase 0.0115 0.0095 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0061 0.0559
Trypanosoma brucei glucosidase, putative 0.0041 0.0018 0.1948
Echinococcus multilocularis geminin 0.0337 0.0323 0.1046
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0021 0.1851
Mycobacterium ulcerans dehydrogenase 0.0083 0.0061 0.0519
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.0444 0.1445
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Brugia malayi chromobox protein homolog 3 0.0038 0.0016 0.001
Schistosoma mansoni amine oxidase 0.0083 0.0061 0.0068
Echinococcus multilocularis peregrin 0.0029 0.0006 0.0001
Schistosoma mansoni kinase 0.0069 0.0048 0.0051
Mycobacterium leprae Probable lipase LipE 0.0043 0.0021 0.3419
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Echinococcus multilocularis 0.0083 0.0061 0.0185
Schistosoma mansoni chromobox protein 0.0069 0.0047 0.005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0035 0.0013 0.0008
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0013 0.0832
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Schistosoma mansoni chromobox protein 0.0069 0.0047 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0021 0.2223
Echinococcus granulosus expressed protein 0.0367 0.0354 0.1148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0061 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1177 0.1185 1
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0013 0.2083
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0095 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0095 0.0292
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Schistosoma mansoni alpha glucosidase 0.0041 0.0018 0.0015
Onchocerca volvulus 0.0082 0.006 0.018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0095 0.0108
Brugia malayi heat shock protein 90 0.0035 0.0013 0.0007
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0083 0.0061 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0073 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.1278
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0083 0.0061 1
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Plasmodium falciparum plasmepsin I 0.0055 0.0033 0.5369
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0262 0.2379
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0017 0.004
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0005 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0047 0.4709
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0013 0.0832
Loa Loa (eye worm) hypothetical protein 0.2982 0.304 0.3698
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0021 0.0191
Echinococcus granulosus jumonji domain containing protein 0.004 0.0017 0.004
Plasmodium falciparum plasmepsin VI 0.0055 0.0033 0.5369
Brugia malayi jmjC domain containing protein 0.0094 0.0073 0.0067
Mycobacterium ulcerans hypothetical protein 0.0043 0.0021 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Schistosoma mansoni endoplasmin 0.0035 0.0013 0.0008
Giardia lamblia PHD finger protein 15 0.0029 0.0006 0.0051
Loa Loa (eye worm) endoplasmin 0.0035 0.0013 0.0008
Echinococcus granulosus GPCR family 2 0.0031 0.0009 0.0011
Brugia malayi hypothetical protein 0.0083 0.0061 0.0056
Schistosoma mansoni deleted in oral cancer 1/cdk2-associated protein-like 0.2982 0.304 0.3698
Plasmodium vivax plasmepsin IV, putative 0.0055 0.0033 0.5369
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0019 0.0013
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1177 0.1185 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0021 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0021 0.1754
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0013 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0021 0.0019
Plasmodium falciparum phd finger protein, putative 0.0029 0.0006 0.0949
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0013 0.1354
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0078 0.0088
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0018 0.1563
Echinococcus multilocularis expressed protein 0.0367 0.0354 0.1148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0021 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Plasmodium falciparum plasmepsin II 0.0055 0.0033 0.5369
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.1278
Onchocerca volvulus 0.0083 0.0061 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0012 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0021 0.0177
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.1948
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0006 0.0001
Plasmodium falciparum protoporphyrinogen oxidase 0.0083 0.0061 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0026
Echinococcus multilocularis Cyclin dependent kinase 2 associated protein 0.2982 0.304 1
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Onchocerca volvulus 0.003 0.0007 0.0005
Mycobacterium ulcerans oxidoreductase 0.0083 0.0061 0.0519
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.006 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0078 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0006 0.0949
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0012 0.0022
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0083 0.0061 0.0068
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0013 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0019 0.0044
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0012 0.0008
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Onchocerca volvulus 0.0043 0.0021 0.005
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0046 0.4655
Loa Loa (eye worm) hypothetical protein 0.0068 0.0046 0.0049
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0018 0.0043
Brugia malayi SWIRM domain containing protein 0.0083 0.0061 0.0056
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0016 0.0033
Mycobacterium ulcerans monoamine oxidase 0.0083 0.0061 0.0519
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0061 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0095 0.0294
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0013 0.0008
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0083 0.0061 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Loa Loa (eye worm) hypothetical protein 0.0082 0.006 0.0067
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0083 0.0061 0.0519
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0083 0.0061 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0018 0.0015
Giardia lamblia Kinase, PLK 0.0115 0.0095 1
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0095 0.0108
Toxoplasma gondii ABC1 family protein 0.0043 0.0021 0.3419
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0013 0.0024
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0018 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0061 0.6291
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0021 0.0191
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0083 0.0061 0.0068
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.006 0.0055
Onchocerca volvulus 0.0107 0.0086 0.0264
Schistosoma mansoni alpha-glucosidase 0.0159 0.014 0.0163
Echinococcus granulosus neuropeptide s receptor 0.0455 0.0444 0.1445
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0021 0.0191
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0033 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Echinococcus granulosus heat shock protein 90 0.0035 0.0013 0.0024
Brugia malayi Heterochromatin protein 1 0.0069 0.0047 0.0041
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0095 1
Leishmania major hypothetical protein, conserved 0.0043 0.0021 0.2223
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0021 0.0019
Plasmodium falciparum heat shock protein 90 0.0035 0.0013 0.2083
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0005 1
Brugia malayi Protein kinase domain containing protein 0.8015 0.8211 0.821
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Leishmania major UDP-galactopyranose mutase 0.0083 0.0061 0.6502
Schistosoma mansoni serine/threonine protein kinase 0.8015 0.8211 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Treponema pallidum heat shock protein 90 0.0028 0.0005 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0012 0.0008
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0055 0.0033 0.318
Toxoplasma gondii aspartyl protease ASP1 0.0055 0.0033 0.5369
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0055 0.0033 0.0091
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0091
Schistosoma mansoni hypothetical protein 0.0337 0.0323 0.0386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0033 0.0027
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0055 0.0033 0.5369
Onchocerca volvulus 0.0043 0.0021 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0018 0.1462
Chlamydia trachomatis protoporphyrinogen oxidase 0.0083 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0078 0.0088
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0018 0.1948
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Echinococcus granulosus chromobox protein 1 0.0069 0.0047 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0021 0.1851
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0021 0.0177
Echinococcus granulosus heat shock protein 0.0035 0.0013 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0009 0.0011
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0012 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0021 0.3419
Brugia malayi beta-lactamase family protein 0.0043 0.0021 0.0015
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0021 0.0191
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0003
Echinococcus multilocularis protoporphyrinogen oxidase 0.0083 0.0061 0.0185
Echinococcus granulosus chromobox protein 1 0.0069 0.0047 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0091
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0018 0.1563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.0444 0.1445
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0095 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0047 0.0137
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1094 0.11 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0055 0.0033 0.0091
Plasmodium vivax endoplasmin, putative 0.0035 0.0013 0.2083
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.0221 0.0262
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Loa Loa (eye worm) beta-lactamase 0.0043 0.0021 0.0019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.1948
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.0221 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0002
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Plasmodium vivax aspartyl proteinase, putative 0.0055 0.0033 0.5369
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0083 0.0061 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0019 0.161
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0005 0.0569
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0013 0.1354
Schistosoma mansoni alpha-glucosidase 0.0159 0.014 0.0163
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0009 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Onchocerca volvulus Diphthamide biosynthesis protein 7 homolog 0.2982 0.304 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0005 0.0049
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.006 0.0181
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0006 0.0949
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0006 0.0001
Plasmodium falciparum plasmepsin IV 0.0055 0.0033 0.5369
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0095 0.0294
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0019 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0047 0.4709
Toxoplasma gondii histone lysine-specific demethylase 0.0083 0.0061 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0053 0.0058
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0013 0.1354
Schistosoma mansoni endoplasmin 0.0035 0.0013 0.0008
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0019 0.0016
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Schistosoma mansoni heat shock protein 0.0035 0.0013 0.0008
Brugia malayi Endoplasmin precursor 0.0035 0.0013 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0009 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0021 0.0052
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.2996
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0037 0.0038
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0166 0.016
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0018 0.1563
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0013 0.1354
Echinococcus multilocularis heat shock protein 90 0.0035 0.0013 0.0024
Schistosoma mansoni cathepsin D (A01 family) 0.0163 0.0143 0.0168
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0005 0.0875
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Mycobacterium ulcerans beta-lactamase 0.0043 0.0021 0.0177
Mycobacterium tuberculosis Possible oxidoreductase 0.0083 0.0061 0.0559
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0019 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0009 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0018 0.1462
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0046 0.4655
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Echinococcus granulosus geminin 0.0337 0.0323 0.1046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0021 0.0191
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Onchocerca volvulus 0.0043 0.0021 0.005
Echinococcus multilocularis heat shock protein 0.0035 0.0013 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0021 0.0019
Schistosoma mansoni cathepsin D (A01 family) 0.0163 0.0143 0.0168
Schistosoma mansoni amine oxidase 0.0083 0.0061 0.0068
Echinococcus granulosus peregrin 0.0029 0.0006 0.0001
Brugia malayi hypothetical protein 0.0035 0.0013 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0016 0.0012
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0013 0.0832
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0078 0.0073
Schistosoma mansoni hypothetical protein 0.0068 0.0046 0.0049
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0019 0.0044
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.0444 0.1445
Brugia malayi MH2 domain containing protein 0.0238 0.0221 0.0215
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0019 0.161
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0018 0.1563
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0021 0.3419
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0013 0.2083
Loa Loa (eye worm) hypothetical protein 0.0055 0.0033 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0009 0.0011
Echinococcus granulosus Cyclin dependent kinase 2 associated protein 0.2982 0.304 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0055 0.0033 0.0033
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.8015 0.8211 1
Schistosoma mansoni hypothetical protein 0.0337 0.0323 0.0386
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.006 0.0181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0009 0.0011
Schistosoma mansoni heat shock protein 0.0035 0.0013 0.0008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0166 0.0195
Brugia malayi amine oxidase, flavin-containing family protein 0.0083 0.0061 0.0056
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0095 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0095 0.0089
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0047 0.005
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0073 0.0223
Brugia malayi beta-lactamase 0.0043 0.0021 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0021 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0006 0.0949
Brugia malayi jmjC domain containing protein 0.0035 0.0012 0.0006
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0061 0.6291
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0046 0.004
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Echinococcus multilocularis GPCR, family 2 0.0031 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0013 0.0941
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0013 0.2083
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Echinococcus multilocularis chromobox protein 1 0.0069 0.0047 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0013 0.1354
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0021 0.0177
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0009 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0021 0.1754
Trichomonas vaginalis esterase, putative 0.0043 0.0021 0.1851

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.