Detailed information for compound 170860

Basic information

Technical information
  • TDR Targets ID: 170860
  • Name: N-[6-(furan-2-yl)-1H-indazol-3-yl]cyclopropan ecarboxamide
  • MW: 267.283 | Formula: C15H13N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC1)Nc1n[nH]c2c1ccc(c2)c1ccco1
  • InChi: 1S/C15H13N3O2/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)
  • InChiKey: IJMSMJUUYYSKBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[6-(2-furyl)-1H-indazol-3-yl]cyclopropanecarboxamide
  • N-(6-furan-2-yl-1H-indazol-3-yl)cyclopropanecarboxamide
  • indazole analogue 27

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 alpha Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proteasome (prosome, macropain) 0.0085 1 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.6557 0.5801
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.5796 0.4872
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.1801 0.1005
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.5796 0.5594
Giardia lamblia Kinase, CMGC GSK 0.0059 0.6557 0.1811
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.5796 0.5594
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.5796 0.5594
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.1801 0.1408
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.6557 0.6557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Loa Loa (eye worm) hypothetical protein 0.0052 0.5653 0.5231
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.1801 0.1801
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.1801 0.1408
Trypanosoma brucei protein kinase, putative 0.0059 0.6557 0.6392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0085 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus multilocularis cysteine protease 0.0022 0.1801 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1801 0.1408
Onchocerca volvulus 0.0022 0.1801 0.1615
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Onchocerca volvulus 0.0022 0.1801 0.1615
Loa Loa (eye worm) ctsf protein 0.0022 0.1801 0.1005
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0085 1 0.5
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.5796 0.5594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.6557 0.6392
Echinococcus granulosus cathepsin l1 0.0014 0.0885 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.1801 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Onchocerca volvulus 0.0022 0.1801 0.1615
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.5796 0.5388
Onchocerca volvulus Cathepsin F homolog 0.0022 0.1801 0.1615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Echinococcus granulosus cyclin dependent kinase 0.0053 0.5796 0.5594
Brugia malayi cell division control protein 2 homolog 0.0053 0.5796 0.5594
Loa Loa (eye worm) cysteine protease 0.0022 0.1801 0.1005
Plasmodium vivax vivapain-2 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Plasmodium vivax protein kinase Crk2 0.0053 0.5796 0.5594
Brugia malayi intracellular kinase 0.0059 0.6557 0.6392
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.1801 0.1408
Echinococcus granulosus proteasome prosome macropain 0.0085 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus granulosus cathepsin l1 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine proteinase 1, putative 0.0011 0.0458 0.0458
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.5796 0.5594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0085 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.1801 0.1408
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.6557 0.6392
Entamoeba histolytica cysteine protease, putative 0.0022 0.1801 0.1801
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.5796 0.5594
Echinococcus multilocularis cysteine protease 0.0022 0.1801 0.1408
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.6557 0.6392
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.6557 0.6392
Brugia malayi Cathepsin L-like precursor 0.0014 0.0885 0.0448
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0458 0.0458
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.5796 0.5594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.5796 0.4872
Brugia malayi Protein kinase domain containing protein 0.0053 0.5796 0.5594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.5796 0.5594
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.6557 0.6557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.1801 0.1801
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Brugia malayi Cathepsin L-like precursor 0.0014 0.0885 0.0448
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.5796 0.5594
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Onchocerca volvulus 0.0022 0.1801 0.1615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Plasmodium vivax proteasome subunit beta type-5, putative 0.0085 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.5796 0.5594
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.6557 0.6223
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.5796 0.5594
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.5796 0.5594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0885 0.0448
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.5796 0.5388
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Leishmania major proteasome beta 5 subunit, putative 0.0085 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.5796 0.5594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.6557 0.6392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.6557 0.6392
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.5796 0.5796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.1801 0.1408
Echinococcus granulosus protein kinase shaggy 0.0059 0.6557 0.6392
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Brugia malayi cathepsin L-like precursor 0.0014 0.0885 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine proteinase 2 0.0011 0.0458 0.0458
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0885 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Plasmodium falciparum proteasome subunit beta type-5 0.0085 1 1
Loa Loa (eye worm) fibroinase 0.0022 0.1801 0.1005
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.5796 0.5594
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.5796 0.5388
Onchocerca volvulus Cathepsin L homolog 0.0022 0.1801 0.1615
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0458 0.0458
Entamoeba histolytica protein kinase, putative 0.0059 0.6557 0.6557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0885 0.0448
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0085 1 1
Onchocerca volvulus 0.0059 0.6557 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.6557 0.6392
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.6557 0.6223
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.5796 0.5594
Onchocerca volvulus 0.0022 0.1801 0.1615
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0458 0.0458
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0085 1 0.5
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.5796 0.5796
Loa Loa (eye worm) hypothetical protein 0.0022 0.1801 0.1005
Echinococcus multilocularis protein kinase shaggy 0.0059 0.6557 0.6392
Giardia lamblia Kinase, CMGC GSK 0.0059 0.6557 0.1811
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0885 0.0448
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.1801 0.1408
Mycobacterium ulcerans proteasome PrcB 0.0085 1 0.5
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.6557 0.6392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.1801 0.1408
Onchocerca volvulus 0.0022 0.1801 0.1615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine protease, putative 0.0011 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Plasmodium vivax vivapain-2 0.0022 0.1801 0.1408
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0458 0.0458
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.1801 0.1005
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.6557 0.5801
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.5796 0.5594
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0085 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.5796 0.5594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.1801 0.1408
Toxoplasma gondii proteasome subunit beta type, putative 0.0085 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0014 0.0885 0.0448
Brugia malayi Cathepsin L-like precursor 0.0022 0.1801 0.1408
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.5796 0.5594
Onchocerca volvulus Cathepsin L homolog 0.0022 0.1801 0.1615
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0085 1 1
Plasmodium falciparum protein kinase 5 0.0053 0.5796 0.5594
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0085 1 1
Onchocerca volvulus 0.0022 0.1801 0.1615
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0885 0.0885
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.5796 0.4872
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.1801 0.1408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.1801 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.1801 0.1408
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0085 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.1801 0.1408

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50 nM Inhibitory concentration against glycogen synthase kinase-3 alpha ChEMBL. 12941333
IC50 (binding) = 50 nM Inhibitory concentration against glycogen synthase kinase-3 alpha ChEMBL. 12941333
IC50 (binding) = 631 nM Inhibitory concentration against cyclin-dependent kinase 2 ChEMBL. 12941333
IC50 (binding) = 631 nM Inhibitory concentration against cyclin-dependent kinase 2 ChEMBL. 12941333
IC50 (binding) = 631 nM Inhibition of CDK2 ChEMBL. 17707953

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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