Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Loa Loa (eye worm) | tubulin beta chain | 0.0102 | 0.3953 | 0.3953 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0012 | 0.0012 |
Brugia malayi | Cell division protein ftsZ | 0.0102 | 0.3953 | 0.3953 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.3907 | 0.3907 |
Onchocerca volvulus | 0.0132 | 0.5359 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3907 | 0.3907 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.5359 | 0.5359 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Brugia malayi | Tubulin alpha chain | 0.0102 | 0.3953 | 0.3953 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0132 | 0.5359 | 0.5359 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4611 | 0.4611 |
Trichomonas vaginalis | tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Trichomonas vaginalis | tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Trypanosoma brucei | alpha tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1525 | 0.1525 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Treponema pallidum | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4611 | 0.4611 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3953 | 0.3953 |
Schistosoma mansoni | tubulin subunit delta | 0.0102 | 0.3953 | 0.3953 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.5359 | 0.5359 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.3907 | 0.3907 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0012 | 0.0012 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0102 | 0.3953 | 0.3953 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0132 | 0.5359 | 0.2326 |
Mycobacterium leprae | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0012 | 0.0012 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0132 | 0.5359 | 0.2326 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0012 | 0.0012 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0132 | 0.5359 | 0.2326 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3589 | 0.3589 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0824 | 0.0824 |
Schistosoma mansoni | tubulin subunit beta | 0.0102 | 0.3953 | 0.3953 |
Echinococcus multilocularis | tubulin delta chain | 0.0102 | 0.3953 | 0.3953 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0012 | 0.0012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1525 | 0.1525 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Brugia malayi | Tubulin beta chain | 0.0132 | 0.5359 | 0.5359 |
Brugia malayi | Tubulin beta chain | 0.0102 | 0.3953 | 0.3953 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4611 | 0.4611 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1525 | 0.1525 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Echinococcus granulosus | tubulin delta chain | 0.0102 | 0.3953 | 0.3953 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0012 | 0.0012 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5359 | 0.5359 |
Schistosoma mansoni | tubulin subunit alpha | 0.0102 | 0.3953 | 0.3953 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0824 | 0.0824 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.3907 | 0.3907 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3907 | 0.3907 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.04 | Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR | ChEMBL. | 23083093 |
Emax (functional) | > 90 % | Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR relative to nicotine | ChEMBL. | 23083093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.