Detailed information for compound 1727710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.409 | Formula: C19H17NO2S
  • H donors: 0 H acceptors: 1 LogP: 4.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1ccc(s1)C(=O)N(c1ccccc1)C
  • InChi: 1S/C19H17NO2S/c1-20(15-8-4-3-5-9-15)19(21)18-12-11-17(23-18)14-7-6-10-16(13-14)22-2/h3-13H,1-2H3
  • InChiKey: LSAGCFTYAUSIQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MBCTL1 0.0053 0.0468 0.1959
Loa Loa (eye worm) animal heme peroxidase 0.008 0.081 0.3393
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1146 0.3304
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0154 0.0645
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0157 1
Onchocerca volvulus 0.0047 0.0385 0.1403
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0157 0.1366
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.2135 0.6371
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Loa Loa (eye worm) hypothetical protein 0.0047 0.0385 0.1614
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1146 0.4803
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1146 0.4176
Schistosoma mansoni rab6-interacting 0.0019 0.0036 0.0092
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.1612 0.1609
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0077 0.0779 0.0775
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1146 0.4176
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0354 0.1288
Onchocerca volvulus 0.008 0.081 0.2949
Loa Loa (eye worm) animal heme peroxidase 0.008 0.081 0.3393
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0036 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0239 0.0679
Loa Loa (eye worm) hypothetical protein 0.0077 0.0769 0.3222
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0005 0.0019
Brugia malayi Matrixin family protein 0.0077 0.0769 0.3222
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0468 0.0463
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0468 0.1959
Brugia malayi Matrixin family protein 0.0077 0.0769 0.3222
Schistosoma mansoni atypical protein kinase C 0.0029 0.0156 0.0438
Plasmodium falciparum phd finger protein, putative 0.0028 0.0154 0.978
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Echinococcus multilocularis peroxidasin 0.008 0.081 0.0806
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0231 0.0965
Schistosoma mansoni glucose-6-phosphatase 0.0287 0.346 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0077 0.0769 0.2212
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0354 0.1288
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1146 1
Echinococcus granulosus RNA directed DNA polymerase 0.0077 0.0779 0.2315
Onchocerca volvulus 0.0109 0.1178 0.4291
Plasmodium vivax SET domain protein, putative 0.0029 0.0163 1
Schistosoma mansoni hypothetical protein 0.0019 0.0036 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0036 0.0032
Brugia malayi Doublecortin family protein 0.0019 0.0036 0.0151
Entamoeba histolytica protein kinase, putative 0.0017 0.0005 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Brugia malayi Animal haem peroxidase family protein 0.008 0.081 0.3393
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0385 0.1614
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0036 0.0095
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1146 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0163 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0354 0.3084
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0188 0.053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0354 0.1288
Brugia malayi Blistered cuticle protein 3 0.008 0.081 0.3393
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1146 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0354 0.0349
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1146 0.3304
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0154 0.0432
Loa Loa (eye worm) matrixin family protein 0.0185 0.2157 0.9036
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0354 0.1044
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0555 0.055
Brugia malayi Matrixin family protein 0.0077 0.0769 0.3222
Brugia malayi Protein kinase domain containing protein 0.0017 0.0005 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0231 0.0654
Echinococcus multilocularis conserved hypothetical protein 0.0286 0.3437 0.3434
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2387 1
Mycobacterium ulcerans hydrolase 0.0093 0.0982 0.7439
Onchocerca volvulus 0.0029 0.0163 0.0592
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0005 0.0019
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0093 0.0982 0.4115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0354 0.1288
Schistosoma mansoni lipoxygenase 0.0054 0.0479 0.1373
Entamoeba histolytica protein kinase, putative 0.0017 0.0005 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0157 0.4356
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1146 1
Echinococcus multilocularis protein kinase c epsilon type 0.0031 0.0188 0.0183
Schistosoma mansoni hypothetical protein 0.0028 0.0154 0.0432
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0354 0.1481
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Echinococcus multilocularis protein kinase c iota type 0.0029 0.0156 0.0152
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1146 0.1142
Entamoeba histolytica hypothetical protein 0.0035 0.0239 0.2085
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0005 0.0019
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0354 0.1481
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1176 0.339
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0737 0.2119
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0385 0.0381
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.1288
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1146 0.4176
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1146 0.4803
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0354 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.017 0.1961 0.7143
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.0645
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0468 0.1385
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.1288
Echinococcus granulosus peregrin 0.0028 0.0154 0.0447
Onchocerca volvulus Peroxidase homolog 0.008 0.081 0.2949
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1146 1
Onchocerca volvulus 0.008 0.081 0.2949
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0093 0.0982 0.7439
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0149 0.0432
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0154 0.9312
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0541 0.2268
Entamoeba histolytica hypothetical protein 0.0035 0.0239 0.2085
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0005 0.0019
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0458 0.1918
Brugia malayi mbt repeat family protein 0.0047 0.0385 0.1614
Echinococcus multilocularis RNA directed DNA polymerase 0.0077 0.0779 0.0775
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1146 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0385 0.1403
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.008 0.0815 0.3414
Brugia malayi Matrixin family protein 0.0185 0.2157 0.9036
Onchocerca volvulus 0.0115 0.1259 0.4585
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0297 0.0292
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.0005 0.0039
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0385 0.1139
Echinococcus granulosus jumonji domain containing protein 0.004 0.0297 0.0873
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0157 0.4356
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0354 0.3084
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0468 0.134
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Onchocerca volvulus 0.0231 0.2746 1
Onchocerca volvulus Peroxidasin homolog 0.008 0.081 0.2949
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.2135 0.2132
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0354 0.3084
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0231 0.0226
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0239 0.0701
Schistosoma mansoni rab6-interacting 0.0019 0.0036 0.0092
Echinococcus multilocularis conserved hypothetical protein 0.0286 0.3437 0.3434
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.1288
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1146 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0005 0.0019
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0385 0.1102
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0163 0.0158
Brugia malayi hypothetical protein 0.0035 0.0239 0.1001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.1612 0.6755
Trypanosoma brucei glucosidase, putative 0.0044 0.0354 0.3084
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.1612 0.6755
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0385 0.1102
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0005 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0154 0.428
Onchocerca volvulus Alhambra homolog 0.0028 0.0154 0.0561
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.1288
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Loa Loa (eye worm) hypothetical protein 0.0093 0.0982 0.4115
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0157 0.4356
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0468 0.0463
Schistosoma mansoni alpha glucosidase 0.0044 0.0354 0.101
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0385 0.1102
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0555 0.202
Brugia malayi protein kinase C II. 0.0031 0.0188 0.0785
Onchocerca volvulus Dual oxidase homolog 0.008 0.081 0.2949
Echinococcus granulosus Protein kinase C brain isozyme 0.0109 0.1176 0.3503
Onchocerca volvulus Chorion peroxidase homolog 0.008 0.081 0.2949
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Brugia malayi 6-phosphofructokinase 0.0106 0.1146 0.4803
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Schistosoma mansoni peroxidasin 0.008 0.081 0.233
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0231 0.0676
Loa Loa (eye worm) animal heme peroxidase 0.008 0.081 0.3393
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0354 0.3084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0231 0.0654
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0154 0.428
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0279 0.3349 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0157 0.9521
Brugia malayi hypothetical protein 0.0019 0.0036 0.0151
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0036 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Brugia malayi jmjC domain containing protein 0.0034 0.0231 0.0965
Schistosoma mansoni hypothetical protein 0.0035 0.0239 0.0679
Loa Loa (eye worm) hypothetical protein 0.0049 0.0414 0.1734
Onchocerca volvulus Matrilysin homolog 0.0077 0.0769 0.2801
Echinococcus granulosus RUN 0.0019 0.0036 0.0095
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1146 0.4803
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0163 0.453
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0151
Onchocerca volvulus Peroxidasin homolog 0.008 0.081 0.2949
Brugia malayi Peroxidasin 0.008 0.081 0.3393
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.1612 0.1609
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0555 0.1644
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0005 0.0019
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0468 0.1385
Echinococcus multilocularis RUN 0.0019 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0077 0.0769 0.3222
Entamoeba histolytica protein kinase, putative 0.0017 0.0005 0.0039
Brugia malayi hypothetical protein 0.0019 0.0036 0.0151
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0154 0.015
Schistosoma mansoni hypothetical protein 0.0109 0.1178 0.3396
Brugia malayi Animal haem peroxidase family protein 0.008 0.081 0.3393
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0982 0.2921
Entamoeba histolytica hypothetical protein 0.0035 0.0239 0.2085
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0157 0.9521
Onchocerca volvulus Matrilysin homolog 0.017 0.1961 0.7143
Schistosoma mansoni hypothetical protein 0.0283 0.3408 0.9849
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1146 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0157 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0982 0.0977
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1146 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0157 0.5
Echinococcus granulosus protein kinase C gamma type 0.0097 0.1025 0.305
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0157 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0157 0.0571
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0479 0.0475
Brugia malayi hypothetical protein 0.008 0.081 0.3393
Echinococcus multilocularis serine threonine protein kinase 0.0097 0.1025 0.102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0354 0.3084
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0157 0.0571
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1176 0.339
Brugia malayi Bromodomain containing protein 0.0028 0.0154 0.0645
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1146 0.4176
Trypanosoma brucei RNA helicase, putative 0.0101 0.1082 0.9436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0163 0.0458
Brugia malayi Pre-SET motif family protein 0.0029 0.0163 0.0681
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0151
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0279 0.3349 0.3346
Loa Loa (eye worm) matrixin family protein 0.017 0.1961 0.8216
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0681
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0479 0.1419
Brugia malayi Hemopexin family protein 0.0109 0.1178 0.4936
Onchocerca volvulus 0.0077 0.0769 0.2801
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1146 0.3414
Schistosoma mansoni hypothetical protein 0.006 0.0555 0.1591
Brugia malayi 6-phosphofructokinase 0.0106 0.1146 0.4803
Echinococcus granulosus peroxidasin 0.008 0.081 0.2408
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0036 0.0032
Brugia malayi Protein kinase c protein 2 0.0092 0.0966 0.4048
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0506 0.212
Onchocerca volvulus 0.008 0.081 0.2949
Echinococcus granulosus protein kinase c iota type 0.0029 0.0156 0.0453
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Entamoeba histolytica hypothetical protein 0.0035 0.0239 0.2085
Onchocerca volvulus 0.0019 0.0036 0.0132
Brugia malayi Hr1 repeat family protein 0.0017 0.0005 0.0019
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1146 1
Schistosoma mansoni peroxidasin 0.008 0.081 0.233
Loa Loa (eye worm) hypothetical protein 0.0089 0.093 0.3897
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0555 0.2323
Brugia malayi mbt repeat family protein 0.0047 0.0385 0.1614
Schistosoma mansoni alpha-glucosidase 0.0115 0.1259 0.3629
Onchocerca volvulus Peroxidase homolog 0.008 0.081 0.2949
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0154 0.0447
Schistosoma mansoni polycystin 1-related 0.0019 0.0036 0.0092
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0823 0.237
Schistosoma mansoni alpha-glucosidase 0.0115 0.1259 0.3629
Echinococcus granulosus lysosomal alpha glucosidase 0.0143 0.1612 0.4807
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0163 0.0473
Echinococcus multilocularis peregrin 0.0028 0.0154 0.015
Brugia malayi Matrixin family protein 0.0077 0.0769 0.3222
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0019
Brugia malayi DnaJ domain containing protein 0.006 0.0555 0.2323
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2746 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0506 0.4413
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0506 0.0502
Schistosoma mansoni hypothetical protein 0.0101 0.1082 0.3117
Onchocerca volvulus 0.0019 0.0036 0.0132
Loa Loa (eye worm) blistered cuticle protein 3 0.008 0.081 0.3393
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0385 0.1139
Brugia malayi Pre-SET motif family protein 0.0203 0.2387 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0157 1
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Brugia malayi PHD-finger family protein 0.0028 0.0154 0.0645
Schistosoma mansoni loxhd1 0.0019 0.0036 0.0092
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1959
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0005 0.0017
Entamoeba histolytica protein kinase, putative 0.0017 0.0005 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0163 0.0458
Brugia malayi Protein kinase domain containing protein 0.0017 0.0005 0.0019
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0385 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0163 0.0458
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0506 0.1451
Echinococcus granulosus protein kinase c epsilon type 0.0031 0.0188 0.0547
Brugia malayi Protein kinase domain containing protein 0.0017 0.0005 0.0019
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0005 0.0019
Loa Loa (eye worm) matrix metalloproteinase 0.0077 0.0769 0.3222
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0109 0.1176 0.1172
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0506 0.1499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0239 0.0235
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0036 0.0151
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.1288
Brugia malayi jmjC domain containing protein 0.0093 0.0982 0.4112
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393
Loa Loa (eye worm) hypothetical protein 0.0077 0.0779 0.3262
Brugia malayi Animal haem peroxidase family protein 0.008 0.081 0.3393
Loa Loa (eye worm) animal heme peroxidase 0.008 0.081 0.3393
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0031 0.0188 0.0785
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0163 0.0458
Loa Loa (eye worm) hypothetical protein 0.0077 0.0769 0.3222
Brugia malayi phosphofructokinase 0.0106 0.1146 0.4803
Brugia malayi Animal haem peroxidase family protein 0.008 0.081 0.3393
Schistosoma mansoni lipoxygenase 0.0019 0.0036 0.0092
Brugia malayi Animal haem peroxidase family protein 0.008 0.081 0.3393
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0036 0.0095
Loa Loa (eye worm) hypothetical protein 0.008 0.081 0.3393

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 10 % Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate after 10 mins at 1 uM by HPLC analysis ChEMBL. 23145773
Inhibition (binding) = 67 % Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate at 1 uM after 20 mins by HPLC analysis ChEMBL. 23145773

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.