Detailed information for compound 1727711

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.43 | Formula: C20H16N4O4S
  • H donors: 1 H acceptors: 7 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc(nc2c1cnn2Cc1ccncc1)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C20H16N4O4S/c1-29(27,28)15-4-2-14(3-5-15)18-10-16(20(25)26)17-11-22-24(19(17)23-18)12-13-6-8-21-9-7-13/h2-11H,12H2,1H3,(H,25,26)
  • InChiKey: XMDHRSATZNNZCZ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi protein kinase C II. 0.0048 0.0279 0.0381
Brugia malayi 6-phosphofructokinase 0.0111 0.1058 0.1472
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1058 0.3958
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.0852 0.3188
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0133 0.0126
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0056 0.0149
Onchocerca volvulus 0.0114 0.109 0.4021
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Onchocerca volvulus 0.0077 0.0635 0.2304
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1542 0.1536
Onchocerca volvulus 0.0094 0.0852 0.3123
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0058 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.0852 0.3188
Echinococcus granulosus neutral alpha glucosidase AB 0.0046 0.0261 0.0777
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1058 0.1891
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1058 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0048 0.0279 0.0489
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0058 0.0608
Entamoeba histolytica alcohol dehydrogenase, putative 0.0027 0.0025 0.0177
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Plasmodium vivax SET domain protein, putative 0.003 0.0064 1
Loa Loa (eye worm) oxidoreductase 0.0094 0.0852 0.1521
Brugia malayi Pre-SET motif family protein 0.003 0.0064 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Loa Loa (eye worm) hypothetical protein 0.0055 0.0373 0.0658
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0027 0.0025 0.0057
Brugia malayi 6-phosphofructokinase 0.0111 0.1058 0.1472
Trypanosoma brucei glucosidase, putative 0.0046 0.0261 0.0298
Plasmodium vivax hypothetical protein, conserved 0.003 0.0056 0.7746
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.1748 0.2035
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0025 0.0095
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0289 0.033
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.0852 0.3188
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0058 0.5
Loa Loa (eye worm) matrixin family protein 0.0178 0.1881 0.3372
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Trypanosoma brucei aldo-keto reductase, putative 0.0094 0.0852 0.0988
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0056 0.0088
Plasmodium falciparum phd finger protein, putative 0.003 0.0056 0.9188
Entamoeba histolytica hypothetical protein 0.0037 0.0142 0.1282
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0058 0.0034
Loa Loa (eye worm) oxidoreductase 0.0094 0.0852 0.1521
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0411 0.0405
Trypanosoma brucei aldo/keto reductase, putative 0.0027 0.0025 0.0022
Onchocerca volvulus Matrilysin homolog 0.0178 0.1881 0.7008
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0373 0.0366
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0261 0.0978
Toxoplasma gondii aldo-keto reductase 0.0027 0.0025 0.022
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0289 0.0997
Schistosoma mansoni aldo-keto reductase 0.0094 0.0852 0.0988
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0058 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0098 0.0892 0.8395
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0373 0.0366
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1058 0.1228
Echinococcus multilocularis protein kinase c epsilon type 0.0048 0.0279 0.0272
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1058 0.3958
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0291 0.3282 0.3278
Trypanosoma brucei prostaglandin f synthase 0.0094 0.0852 0.0988
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0058 0.8431
Echinococcus multilocularis conserved hypothetical protein 0.0298 0.3371 0.3366
Loa Loa (eye worm) oxidoreductase 0.0094 0.0852 0.1521
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Echinococcus granulosus peroxidasin 0.0077 0.0635 0.1919
Trichomonas vaginalis sucrase-isomaltase, putative 0.0046 0.0261 0.0978
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0058 0.5
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0133 0.0385
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.0852 0.1184
Entamoeba histolytica alcohol dehydrogenase, putative 0.0027 0.0025 0.0177
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0384 0.0377
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0261 0.0978
Loa Loa (eye worm) oxidoreductase 0.0094 0.0852 0.1521
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0373 0.1116
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.02 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0142 0.0135
Onchocerca volvulus 0.0094 0.0852 0.3123
Echinococcus granulosus aldehyde reductase 0.0067 0.0515 0.1552
Loa Loa (eye worm) hypothetical protein 0.0098 0.0892 0.1593
Echinococcus multilocularis peroxidasin 0.0077 0.0635 0.0629
Echinococcus multilocularis RNA directed DNA polymerase 0.0119 0.1158 0.1152
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0064 0.0681
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Onchocerca volvulus 0.0094 0.0852 0.3123
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1058 0.3209
Echinococcus multilocularis aldo keto reductase 0.0094 0.0852 0.0846
Echinococcus granulosus lysosomal alpha glucosidase 0.015 0.1542 0.4687
Echinococcus multilocularis aldo keto reductase 0.0094 0.0852 0.0846
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0261 0.2286
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0088
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Brugia malayi NADH-dependent xylose reductase 0.0027 0.0025 0.0026
Schistosoma mansoni potassium channel beta 0.0027 0.0025 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0046 0.0261 0.0978
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0261 0.0978
Echinococcus granulosus aldo keto reductase 0.0094 0.0852 0.2581
Loa Loa (eye worm) matrix metalloproteinase 0.008 0.0677 0.1205
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Loa Loa (eye worm) oxidoreductase 0.0094 0.0852 0.1521
Trypanosoma cruzi aldo-keto reductase 0.0094 0.0852 0.8008
Schistosoma mansoni hypothetical protein 0.0063 0.046 0.053
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.0852 0.3188
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1058 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Onchocerca volvulus 0.0077 0.0635 0.2304
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0373 0.0512
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0635 0.1131
Loa Loa (eye worm) hypothetical protein 0.0137 0.1383 0.2476
Entamoeba histolytica hypothetical protein 0.0037 0.0142 0.1282
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0447 0.0792
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Giardia lamblia Aldose reductase 0.0094 0.0852 1
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.0635 0.2304
Brugia malayi Glycosyl hydrolases family 31 protein 0.015 0.1542 0.2151
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0058 0.8431
Onchocerca volvulus 0.003 0.0064 0.0147
Schistosoma mansoni peroxidasin 0.0077 0.0635 0.0734
Schistosoma mansoni glucose-6-phosphatase 0.03 0.3395 0.3959
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0027 0.0025 0.0033
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0289 0.0508
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0635 0.1131
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0644 0.0745
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Schistosoma mansoni alpha glucosidase 0.0046 0.0261 0.0298
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.2057 0.6258
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.0852 0.3188
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.0852 0.1184
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0027 0.0025 0.022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0133 0.0147
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0142 0.0411
Echinococcus multilocularis serine threonine protein kinase 0.0149 0.1523 0.1517
Schistosoma mansoni pol-related 0.0094 0.0852 0.0988
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0046 0.0261 0.0458
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.046 0.1721
Echinococcus granulosus protein kinase c epsilon type 0.0048 0.0279 0.0831
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0133 0.0227
Trichomonas vaginalis maltase-glucoamylase, putative 0.0046 0.0261 0.0978
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0635 0.0881
Brugia malayi phosphofructokinase 0.0111 0.1058 0.1472
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1542 0.1536
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0142 0.0157
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0058 0.0489
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0289 0.0862
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0289 0.033
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0261 0.2286
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0635 0.2304
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0362 0.064
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.0852 0.1184
Schistosoma mansoni lipoxygenase 0.0056 0.0384 0.0441
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0104
Echinococcus multilocularis voltage gated potassium channel subunit 0.0027 0.0025 0.0019
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1058 0.1891
Loa Loa (eye worm) hypothetical protein 0.0476 0.5564 1
Brugia malayi Pre-SET motif family protein 0.0212 0.2311 0.3227
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1058 1
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1058 0.1052
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0384 0.1151
Brugia malayi Hemopexin family protein 0.0114 0.109 0.1517
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0411 0.1234
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0056 0.0057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0411 0.3736
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1058 0.1228
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.046 0.1384
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0027 0.0025 0.0095
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0058 0.0218
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1058 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0411 0.3736
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.1748 0.2035
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0635 0.0881
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0289 0.033
Entamoeba histolytica aldose reductase, putative 0.0094 0.0852 0.8043
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1058 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0056 0.0577
Loa Loa (eye worm) matrixin family protein 0.0194 0.2078 0.3728
Echinococcus multilocularis conserved hypothetical protein 0.0298 0.3371 0.3366
Echinococcus granulosus voltage gated potassium channel subunit 0.0027 0.0025 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Brugia malayi Glycosyl hydrolases family 31 protein 0.0046 0.0261 0.0357
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0057
Echinococcus multilocularis aldehyde reductase 0.0067 0.0515 0.0509
Schistosoma mansoni hypothetical protein 0.0114 0.109 0.1265
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0261 0.0978
Schistosoma mansoni hypothetical protein 0.0037 0.0142 0.0157
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0094 0.0852 0.8008
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.015 0.1542 0.2762
Loa Loa (eye worm) hypothetical protein 0.008 0.0677 0.1205
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0056 0.0577
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Onchocerca volvulus Dual oxidase homolog 0.0077 0.0635 0.2304
Entamoeba histolytica hypothetical protein 0.0037 0.0142 0.1282
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Brugia malayi Protein kinase c protein 2 0.0142 0.1437 0.2003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0051 0.0133
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Onchocerca volvulus 0.0094 0.0852 0.3123
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Onchocerca volvulus 0.0077 0.0635 0.2304
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0373 0.0427
Onchocerca volvulus 0.0094 0.0852 0.3123
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0051 0.0318 0.056
Brugia malayi mbt repeat family protein 0.0049 0.0289 0.0396
Onchocerca volvulus Matrilysin homolog 0.008 0.0677 0.246
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0027 0.0025 0.022
Onchocerca volvulus 0.008 0.0677 0.246
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2311 0.4145
Schistosoma mansoni alpha-glucosidase 0.0121 0.1182 0.1373
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.008 0.0677 0.0783
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1058 0.3958
Echinococcus multilocularis peregrin 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.008 0.0677 0.1205
Brugia malayi mbt repeat family protein 0.0049 0.0289 0.0396
Onchocerca volvulus Peroxidase homolog 0.0077 0.0635 0.2304
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1058 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Onchocerca volvulus 0.0121 0.1182 0.437
Echinococcus granulosus aldo keto reductase 0.0094 0.0852 0.2581
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0167 0.1748 0.1743
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2673 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0058 0.0608
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0891 0.2701
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Onchocerca volvulus 0.0094 0.0852 0.3123
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.0852 0.1184
Loa Loa (eye worm) hypothetical protein 0.0119 0.1158 0.2071
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0289 0.0283
Loa Loa (eye worm) hypothetical protein 0.0094 0.0852 0.1521
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0025 0.0095
Leishmania major prostaglandin f synthase, putative 0.0094 0.0852 0.8008
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0094 0.0852 0.8008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0046 0.0261 0.0978
Schistosoma mansoni hypothetical protein 0.0296 0.3342 0.3897
Brugia malayi jmjC domain containing protein 0.0097 0.0891 0.1239
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Toxoplasma gondii aldose reductase, putative 0.0094 0.0852 1
Brugia malayi jmjC domain containing protein 0.0036 0.0133 0.0177
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.046 0.0454
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0027 0.0025 0.0026
Echinococcus granulosus protein kinase c iota type 0.0044 0.0232 0.0688
Schistosoma mansoni aldo-keto reductase 0.0094 0.0852 0.0988
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1058 0.1891
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Loa Loa (eye worm) hypothetical protein 0.0077 0.0635 0.1131
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0891 0.0885
Mycobacterium leprae Conserved hypothetical protein 0.0067 0.0515 0.4743
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Echinococcus multilocularis neutral alpha glucosidase AB 0.0046 0.0261 0.0255
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0635 0.1131
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0604 0.7145 1
Brugia malayi Blistered cuticle protein 3 0.0077 0.0635 0.0881
Brugia malayi Peroxidasin 0.0077 0.0635 0.0881
Onchocerca volvulus 0.0242 0.2673 1
Onchocerca volvulus Alhambra homolog 0.003 0.0056 0.0114
Echinococcus granulosus aldo keto reductase 0.0094 0.0852 0.2581
Brugia malayi Matrixin family protein 0.008 0.0677 0.0939
Loa Loa (eye worm) MBCTL1 0.0055 0.0373 0.0658
Schistosoma mansoni atypical protein kinase C 0.0044 0.0232 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Onchocerca volvulus Matrix metalloproteinase homolog 0.0178 0.1881 0.7008
Brugia malayi hypothetical protein 0.0077 0.0635 0.0881
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0635 0.1131
Brugia malayi Matrixin family protein 0.0194 0.2078 0.2902
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0098 0.0892 0.124
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.0852 0.2581
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0411 0.3736
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0095
Echinococcus multilocularis aldo keto reductase 0.0094 0.0852 0.0846
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0094 0.0852 0.8008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0289 0.0508
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0123 0.1211 0.2167
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1058 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0085 0.0732 0.0847
Echinococcus granulosus RNA directed DNA polymerase 0.0119 0.1158 0.3514
Echinococcus granulosus protein kinase C gamma type 0.0149 0.1523 0.4629
Echinococcus granulosus peregrin 0.003 0.0056 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.022 0.2407 0.2805
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0025 0.0095
Brugia malayi DnaJ domain containing protein 0.0063 0.046 0.0635
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0411 0.3736
Giardia lamblia Aldose reductase 0.0094 0.0852 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0677 0.1205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0064 0.0058
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0119 0.1158 0.1152
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0058 0.0608
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.2057 0.2051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0046 0.0261 0.2423
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0289 0.0283
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0635 0.0881
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Schistosoma mansoni hypothetical protein 0.0719 0.8566 1
Entamoeba histolytica aldose reductase, putative 0.0094 0.0852 0.8043
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Leishmania major aldo-keto reductase-like protein 0.0094 0.0852 0.8008
Echinococcus granulosus hypothetical protein 0.0094 0.0852 0.2581
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.0852 0.3188
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0411 0.0472
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0056 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0852 0.8008
Echinococcus granulosus jumonji domain containing protein 0.0041 0.02 0.0588
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0279 0.0318
Mycobacterium ulcerans hydrolase 0.0098 0.0892 0.8395
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.0635 0.1131
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0046 0.0261 0.3012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0046 0.0261 0.2423
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0635 0.2304
Brugia malayi Bromodomain containing protein 0.003 0.0056 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1058 0.3958
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.0852 0.0846
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0067
Echinococcus granulosus Protein kinase C brain isozyme 0.0167 0.1748 0.5317
Schistosoma mansoni peroxidasin 0.0077 0.0635 0.0734
Entamoeba histolytica hypothetical protein 0.0037 0.0142 0.1282
Trypanosoma cruzi aldo/keto reductase, putative 0.0094 0.0852 0.8008
Leishmania major alpha glucosidase II subunit, putative 0.0046 0.0261 0.2286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0064 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0058 0.0218
Echinococcus multilocularis aldo keto reductase 0.0094 0.0852 0.0846
Brugia malayi hypothetical protein 0.0037 0.0142 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0261 0.0978
Mycobacterium leprae PROBABLE HYDROLASE 0.0098 0.0892 0.8395
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0007 0.0026
Onchocerca volvulus 0.0049 0.0289 0.0997
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0635 0.0881
Loa Loa (eye worm) hypothetical protein 0.0256 0.2845 0.5107
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0411 0.0566
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0289 0.0862
Loa Loa (eye worm) hypothetical protein 0.0128 0.1265 0.2263
Entamoeba histolytica aldose reductase, putative 0.0094 0.0852 0.8043
Brugia malayi Matrixin family protein 0.008 0.0677 0.0939
Schistosoma mansoni alpha-glucosidase 0.0121 0.1182 0.1373
Brugia malayi Matrixin family protein 0.008 0.0677 0.0939
Brugia malayi PHD-finger family protein 0.003 0.0056 0.0068
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1058 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0064 0.0176
Onchocerca volvulus Peroxidase homolog 0.0077 0.0635 0.2304
Brugia malayi Matrixin family protein 0.008 0.0677 0.0939
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.046 0.0816
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1058 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0373 0.1116
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0232 0.0225
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0291 0.3282 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0133 0.0147
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0635 0.0881
Trypanosoma brucei RNA helicase, putative 0.0719 0.8566 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1058 0.1228
Mycobacterium ulcerans oxidoreductase 0.0094 0.0852 0.8008
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.0852 0.3188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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