TDR Targets

Basic information

Technical information

TDR Targets ID: 173040
Name: 2-(2-benzo[b][1]benzazepin-11-ylethyl)guanidi ne
MW: 278.352 | Formula: C17H18N4
H donors: 2 H acceptors: 0 LogP: 2.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)NCCN1c2ccccc2C=Cc2c1cccc2
InChi: 1S/C17H18N4/c18-17(19)20-11-12-21-15-7-3-1-5-13(15)9-10-14-6-2-4-8-16(14)21/h1-10H,11-12H2,(H4,18,19,20)
InChiKey: JEEPEWZQEZVNNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(11-benzo[b][1]benzazepinyl)ethyl]guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5608	0.8495	0.8495
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0436	0.0495	0.0486
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0457	0.0529	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0457	0.0529	0.0519
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.6581	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0457	0.0529	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2249	0.33	0.33
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0457	0.0529	0.0529
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0644	0.0818	0.0818
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0436	0.0495	0.0486
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0568	0.0701	0.0691
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.3105	0.4623	0.4618
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0457	0.0529	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5244	0.7932	0.7932
Loa Loa (eye worm)	phosphatidylinositol 3	0.0436	0.0495	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0829	0.1104	0.1104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3575	0.535	0.535
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0457	0.0529	0.0519
Loa Loa (eye worm)	phosphatidylinositol 3	0.0436	0.0495	0.0486
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0501	0.0596	0.0596
Loa Loa (eye worm)	phosphatidylinositol 3	0.6581	1	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0436	0.0495	0.9355
Echinococcus granulosus	serine protein kinase ATM	0.1265	0.1778	0.1769
Loa Loa (eye worm)	phosphatidylinositol 3	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1265	0.1778	0.1778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5244	0.7932	0.7932
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0973	0.1326	0.1318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3575	0.535	0.535
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0501	0.0596	0.0587
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0457	0.0529	0.0519
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0436	0.0495	0.9355
Loa Loa (eye worm)	phosphatidylinositol 3	0.2249	0.33	0.3294
Echinococcus multilocularis	serine protein kinase ATM	0.1265	0.1778	0.1769
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1767	0.2555	0.2555
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0457	0.0529	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3912	0.5872	0.5872
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0436	0.0495	0.0495
Schistosoma mansoni	voltage-gated potassium channel	0.0135	0.003	0.002
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2238	0.3282	0.3276
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0577	0.0714	0.0714
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0124	0.0013	0.0003
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0436	0.0495	0.0495
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0457	0.0529	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4271	0.6427	0.6427
Loa Loa (eye worm)	phosphatidylinositol 3	0.079	0.1043	0.1034
Loa Loa (eye worm)	hypothetical protein	0.1332	0.1881	0.1873
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0833	0.111	0.1102
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.6581	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.1265	0.1778	0.1769
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2249	0.33	0.3294
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0501	0.0596	0.0587
Giardia lamblia	GTOR	0.6581	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.048	0.0563	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.1409	0.2	0.2
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.6581	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0209	0.0144	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0568	0.0701	0.0691
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0525	0.0633	0.0623
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0124	0.0013	0.0003
Echinococcus multilocularis		0.0436	0.0495	0.0486
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0501	0.0596	0.0596
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1265	0.1778	0.1769
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0501	0.0596	0.0596
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.6581	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0124	0.0013	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2293	0.3368	0.3361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3934	0.5905	0.5905
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2238	0.3282	0.3282
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2293	0.3368	0.3361
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2293	0.3368	0.3361
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.0486
Toxoplasma gondii	FATC domain-containing protein	0.1265	0.1778	0.1854
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.6581	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2238	0.3282	0.3282
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0436	0.0495	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5244	0.7932	0.7932
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1265	0.1778	0.1769
Brugia malayi	FAT domain containing protein	0.0973	0.1326	0.1318
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2293	0.3368	0.3361
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0457	0.0529	0.0519
Plasmodium vivax	hypothetical protein	0.0436	0.0495	0.9355
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2293	0.3368	0.3361
Leishmania major	hypothetical protein, conserved	0.0535	0.0649	0.064
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0501	0.0596	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1265	0.1778	0.1778
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0644	0.0818	0.0809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5244	0.7932	0.7932
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0436	0.0495	0.0486
Onchocerca volvulus		0.0436	0.0495	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1265	0.1778	0.1769
Schistosoma mansoni	hypothetical protein	0.0436	0.0495	0.0486
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0436	0.0495	0.0486
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0457	0.0529	0.0519
Entamoeba histolytica	hypothetical protein	0.06	0.075	0.0741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6581	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1265	0.1778	0.1769
Giardia lamblia	Hypothetical protein	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3575	0.535	0.535
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0717	0.093	0.0921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3569	0.5342	0.5342
Schistosoma mansoni	voltage-gated potassium channel	0.0135	0.003	0.002
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.06	0.075	0.0741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0829	0.1104	0.1104
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0501	0.0596	0.0587
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0122	0.001	0.001
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3912	0.5872	0.5872
Plasmodium vivax	hypothetical protein, conserved	0.0436	0.0495	0.9355
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0644	0.0818	0.0809
Trypanosoma cruzi	target of rapamycin kinase 3	0.5249	0.794	0.7938
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0457	0.0529	0.0529
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3934	0.5905	0.5905
Loa Loa (eye worm)	hypothetical protein	0.0973	0.1326	0.1318
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0833	0.111	0.1102
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0457	0.0529	0.0519
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0436	0.0495	0.9355
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0644	0.0818	0.0809
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.1796	0.1796
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0122	0.001	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1409	0.2	0.2176
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.6581	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.1326	0.1326
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.6581	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.6581	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.9355
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0501	0.0596	0.0587
Onchocerca volvulus		0.0436	0.0495	0.5
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0568	0.0701	0.0691
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0436	0.0495	0.0486
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4415	0.665	0.665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0436	0.0495	0.0486
Trichomonas vaginalis	immunophilin, putative	0.0122	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1265	0.1778	0.1769
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.5249	0.794	0.7938
Schistosoma mansoni	hypothetical protein	0.0973	0.1326	0.1318
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.0486
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0436	0.0495	0.0486
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4907	0.741	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3934	0.5905	0.5905
Entamoeba histolytica	hypothetical protein	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3569	0.5342	0.5342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6581	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0457	0.0529	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0436	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1265	0.1778	0.1769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0436	0.0495	0.0495
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2293	0.3368	0.3361
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0457	0.0529	0.0519
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0457	0.0529	0.0048
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0457	0.0529	0.0519
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0436	0.0495	0.0486
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0644	0.0818	0.0809
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0189	0.0114	0.0104
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0436	0.0495	0.9355
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0833	0.111	0.1102
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0436	0.0495	0.0486
Entamoeba histolytica	hypothetical protein	0.1265	0.1778	0.1769
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0644	0.0818	0.0818
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.6581	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.5249	0.794	0.7938
Loa Loa (eye worm)	hypothetical protein	0.1409	0.2	0.1992
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1277	0.1796	0.1788
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2238	0.3282	0.3282
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0973	0.1326	0.1318
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0457	0.0529	0.0529
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0436	0.0495	0.0486
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2746	0.4068	0.4062
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0577	0.0714	0.0714
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.6581	1	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0457	0.0529	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0436	0.0495	0.0486
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0501	0.0596	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2238	0.3282	0.3282
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.6581	1	1
Loa Loa (eye worm)	hypothetical protein	0.0436	0.0495	0.0486
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0457	0.0529	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0829	0.1104	0.1095
Mycobacterium leprae	conserved hypothetical protein	0.0436	0.0495	0.5
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0568	0.0701	0.0691
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0122	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0436	0.0495	0.0486
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0533	0.0646	0.0636
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0124	0.0013	0.0003
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0644	0.0818	0.0818
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1265	0.1778	0.1769
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0717	0.093	0.0921
Echinococcus multilocularis	Zinc finger, PHD finger	0.0457	0.0529	0.0519
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0457	0.0529	0.0519
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0122	0.001	0.5
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1265	0.1778	0.1769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4907	0.741	0.741
Entamoeba histolytica	hypothetical protein	0.0436	0.0495	0.0486
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1265	0.1778	0.1769
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0436	0.0495	0.0486
Loa Loa (eye worm)	hypothetical protein	0.1265	0.1778	0.1769
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2249	0.33	0.3294
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0436	0.0495	0.0486
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2238	0.3282	0.3276
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0829	0.1104	0.1095
Leishmania major	hypothetical protein, unknown function	0.0436	0.0495	0.0486
Trichomonas vaginalis	fk506-binding protein, putative	0.0122	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5244	0.7932	0.7932
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3575	0.535	0.535
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6581	1	1
Leishmania major	phosphatidylinositol kinase, putative	0.0436	0.0495	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3569	0.5342	0.5342
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0436	0.0495	0.0486

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.03 uM	Inhibition of [3H]-NE uptake into human SK-N-SH-SY5Y Neuroblastoma cells	ChEMBL.	10447954
IC50 (functional)	= 0.03 uM	Inhibition of [3H]-NE uptake into human SK-N-SH-SY5Y Neuroblastoma cells	ChEMBL.	10447954

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	10447954

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10492870

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 173040