TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.488 | Formula: C25H17F3N4O2S
H donors: 2 H acceptors: 3 LogP: 5.4 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)nc([nH]2)c1ccc(cc1)Oc1ccccc1C(F)(F)F)NCc1nccs1
InChi: 1S/C25H17F3N4O2S/c26-25(27,28)18-3-1-2-4-21(18)34-17-8-5-15(6-9-17)23-31-19-10-7-16(13-20(19)32-23)24(33)30-14-22-29-11-12-35-22/h1-13H,14H2,(H,30,33)(H,31,32)
InChiKey: JGJAWQWWGRTAPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	FAT-3 protein	0.0018	0.0297	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0236	0.027
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0858	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1741	0.1994
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	0.8903	1
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0018	0.0297	0.0081
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1741	0.1994
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0297	0.0341
Onchocerca volvulus		0.0223	0.8903	0.8903
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0858	1
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0018	0.0297	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma cruzi	fatty acid desaturase, putative	0.0018	0.0297	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0227	0.0227
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Onchocerca volvulus		0.0223	0.8903	0.8903
Brugia malayi	Pre-SET motif family protein	0.0219	0.873	1
Leishmania major	fatty-acid desaturase, putative	0.0223	0.8903	1
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0018	0.0297	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2161	0.2228
Onchocerca volvulus		0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0236	0.0136
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.873	1
Schistosoma mansoni	fatty acid desaturase	0.0018	0.0297	0.2847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0227	0.0227
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0858	0.8213
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0227	0.0227
Onchocerca volvulus		0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Leishmania major	delta-5 fatty acid desaturase	0.0018	0.0297	0.0081
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0858	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2161	0.2228
Trypanosoma cruzi	sphingolipid delta 4 desaturase, putative	0.0018	0.0297	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.2161	0.2228
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0227	0.2178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Loa Loa (eye worm)	acyl-CoA desaturase	0.0205	0.8145	0.933
Onchocerca volvulus		0.0031	0.0858	0.0858
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0018	0.0297	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2161	0.2228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Brugia malayi	Pre-SET motif family protein	0.0031	0.0858	0.0982
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0297	0.5
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0297	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.16	0.1582
Leishmania major	cathepsin L-like protease	0.0062	0.2161	0.2228
Schistosoma mansoni	hypothetical protein	0.0036	0.1044	1
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0227	0.0261
Leishmania major	cathepsin L-like protease	0.0062	0.2161	0.2228
Echinococcus granulosus	Sphingolipid delta4 desaturase DES1	0.0018	0.0297	0.3467
Trichomonas vaginalis	set domain proteins, putative	0.0249	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0227	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0227	0.0261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Leishmania major	stearic acid desaturase, putative	0.0223	0.8903	1
Mycobacterium ulcerans	electron transfer protein FdxB	0.0018	0.0297	0.5
Echinococcus multilocularis	Fatty acid desaturase, type 1	0.0018	0.0297	0.111
Echinococcus granulosus	Fatty acid desaturase type 1	0.0018	0.0297	0.3467
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0227	0.0227
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0297	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma cruzi	cytochrome b5-dependent oleate desaturase	0.0018	0.0297	0.0081
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0297	0.0341
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0227	0.2178
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.1933	0.1966
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0236	0.2752
Onchocerca volvulus		0.0016	0.0227	0.0227
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0297	0.0081
Loa Loa (eye worm)	ctsf protein	0.0016	0.0227	0.0261
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0236	0.027
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0297	0.5
Plasmodium vivax	SET domain protein, putative	0.0031	0.0858	0.0796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1741	0.1994
Brugia malayi	Delta5 fatty acid desaturase	0.0018	0.0297	0.0341
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0227	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.226
Leishmania major	delta-4 fatty acid desaturase	0.0018	0.0297	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0297	0.0341
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0297	0.111
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0809	0.9435
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.226
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Plasmodium falciparum	stearoyl-CoA desaturase	0.0205	0.8145	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0858	0.8213
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0858	0.8213
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0236	0.0136
Leishmania major	cathepsin L-like protease	0.0062	0.2161	0.2228
Trypanosoma brucei	fatty acid desaturase, putative	0.0223	0.8903	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0236	0.027
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0858	0.0982
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0297	0.0341
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0858	0.8213
Leishmania major	fatty acid desaturase, putative	0.0018	0.0297	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0227	0.0261
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0227	1
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0297	0.111
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1044	0.1196
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0018	0.0297	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0236	0.2752
Loa Loa (eye worm)	cysteine protease	0.0016	0.0227	0.0261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0227	0.0227
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0297	0.0081
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0236	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.8145	0.9126
Onchocerca volvulus		0.0016	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Loa Loa (eye worm)	fibroinase	0.0016	0.0227	0.0261
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0858	1
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0297	0.0081
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0297	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0227	0.0227
Echinococcus granulosus	cathepsin l1	0.0016	0.0227	0.2652
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0227	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1741	0.1994
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.226
Onchocerca volvulus		0.0016	0.0227	0.0227
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0227	0.0261
Leishmania major	delta-12 fatty acid desaturase	0.0018	0.0297	0.0081
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.1044	0.1196
Trypanosoma cruzi	fatty acid desaturase, putative	0.0018	0.0297	0.0081
Brugia malayi	acyl-CoA desaturase	0.0205	0.8145	0.933
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0227	0.0261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0018	0.0297	0.0081
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.8145	0.9126
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0236	0.027
Onchocerca volvulus		0.0016	0.0227	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2161	0.2165
Onchocerca volvulus		0.0016	0.0227	0.0227
Toxoplasma gondii	sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein	0.0018	0.0297	0.111
Leishmania major	delta-6 fatty acid desaturase	0.0018	0.0297	0.0081
Leishmania major	fatty acid desaturase, putative	0.0018	0.0297	0.0081
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0205	0.8145	1
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0297	0.0341
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0227	0.2652
Echinococcus granulosus	GPCR family 2	0.0017	0.0236	0.2752
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0227	0.0227
Onchocerca volvulus		0.0018	0.0297	0.0297
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0018	0.0297	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.212 uM	Inhibition of SCD1 in Wistar rat liver microsomes using [14C] stearic acid as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by chromatographic analysis	ChEMBL.	23395660
IC50 (binding)	= 0.313 uM	Inhibition of SCD1 in human HepG2 cells	ChEMBL.	23395660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2334635

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1731266