TDR Targets

Basic information

Technical information

TDR Targets ID: 173153
Name: 4-fluoro-N-[2-(4-phenylpiperazin-1-yl)ethyl]b enzamide
MW: 327.396 | Formula: C19H22FN3O
H donors: 1 H acceptors: 1 LogP: 2.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1ccccc1
InChi: 1S/C19H22FN3O/c20-17-8-6-16(7-9-17)19(24)21-10-11-22-12-14-23(15-13-22)18-4-2-1-3-5-18/h1-9H,10-15H2,(H,21,24)
InChiKey: FWFUQMYEGCASTF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-fluoro-N-[2-(4-phenyl-1-piperazinyl)ethyl]benzamide
4-fluoro-N-[2-(4-phenylpiperazino)ethyl]benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine D2 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	Octopamine receptor 1, putative	Serotonin 1a (5-HT1a) receptor	422 aa	424 aa	24.3 %
Echinococcus granulosus	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.0 %
Schistosoma mansoni	biogenic amine receptor	Dopamine D2 receptor	444 aa	452 aa	30.1 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Serotonin 1a (5-HT1a) receptor	422 aa	452 aa	21.0 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Serotonin 1a (5-HT1a) receptor	422 aa	444 aa	29.3 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Dopamine D2 receptor	444 aa	474 aa	23.4 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	407 aa	23.3 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Serotonin 1a (5-HT1a) receptor	422 aa	448 aa	29.7 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Dopamine D2 receptor	444 aa	494 aa	26.3 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	426 aa	29.6 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Dopamine D2 receptor	444 aa	487 aa	23.8 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Serotonin 1a (5-HT1a) receptor	422 aa	339 aa	23.0 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	436 aa	23.9 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Serotonin 1a (5-HT1a) receptor	422 aa	383 aa	30.5 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Serotonin 1a (5-HT1a) receptor	422 aa	410 aa	27.8 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	24.3 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	417 aa	21.1 %
Loa Loa (eye worm)	hypothetical protein	Serotonin 1a (5-HT1a) receptor	422 aa	388 aa	26.5 %
Echinococcus granulosus	biogenic amine 5HT receptor	Dopamine D2 receptor	444 aa	429 aa	31.7 %
Schistosoma japonicum	Octopamine receptor, putative	Dopamine D2 receptor	444 aa	456 aa	29.4 %
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Serotonin 1a (5-HT1a) receptor	422 aa	350 aa	20.6 %
Loa Loa (eye worm)	TYRA-2 protein	Serotonin 1a (5-HT1a) receptor	422 aa	491 aa	27.3 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.6 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	433 aa	22.4 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.4 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	390 aa	33.6 %
Echinococcus multilocularis	neuropeptides capa receptor	Serotonin 1a (5-HT1a) receptor	422 aa	430 aa	20.0 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Serotonin 1a (5-HT1a) receptor	422 aa	477 aa	24.3 %
Echinococcus multilocularis	serotonin receptor	Dopamine D2 receptor	444 aa	428 aa	31.3 %
Schistosoma mansoni	amine GPCR	Serotonin 1a (5-HT1a) receptor	422 aa	440 aa	31.6 %
Echinococcus multilocularis	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.2 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	392 aa	20.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0417	1	1
Echinococcus granulosus	hypothetical protein	0.0245	0.2981	0.2981
Brugia malayi	RhoGAP domain containing protein	0.0245	0.2981	0.2981
Trypanosoma brucei	protein kinase, putative	0.0172	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tensin	0.0245	0.2981	0.2981
Trypanosoma brucei	Pseudokinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0245	0.2981	0.2981
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0245	0.2981	0.2981
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0417	1	1
Plasmodium falciparum	protein kinase, putative	0.0172	0	0.5
Echinococcus multilocularis	SH2 motif	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0245	0.2981	0.2981
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0417	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0245	0.2981	0.2981
Echinococcus granulosus	SHC transforming protein 3	0.0245	0.2981	0.2981
Trypanosoma cruzi	protein kinase, putative	0.0172	0	0.5
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0417	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Toxoplasma gondii	STE kinase	0.0172	0	0.5
Schistosoma mansoni	hypothetical protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK protein kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tensin	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0417	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0417	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0417	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0417	1	1
Schistosoma mansoni	vav2	0.0245	0.2981	0.2981
Brugia malayi	SRC-1	0.0417	1	1
Schistosoma mansoni	tensin	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0172	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0245	0.2981	0.2981
Onchocerca volvulus		0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	hypothetical protein	0.0245	0.2981	0.2981
Brugia malayi	SH2 domain containing protein	0.0417	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0245	0.2981	0.2981
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	AGC family protein kinase	0.0172	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0245	0.2981	0.2981
Loa Loa (eye worm)	SRC-1	0.0417	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0245	0.2981	0.2981
Brugia malayi	Variant SH3 domain containing protein	0.0245	0.2981	0.2981
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Entamoeba histolytica	protein kinase, putative	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0245	0.2981	0.2981
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Giardia lamblia	Kinase, NEK	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0417	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0245	0.2981	0.2981
Toxoplasma gondii	protein kinase	0.0172	0	0.5
Onchocerca volvulus		0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0417	1	1
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0417	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Trichomonas vaginalis	STE family protein kinase	0.0172	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0172	0	0.5
Onchocerca volvulus		0.0417	1	1
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Plasmodium falciparum	protein kinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0172	0	0.5
Onchocerca volvulus		0.0417	1	1
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0245	0.2981	0.2981
Echinococcus granulosus	growth factor receptor bound protein 2	0.0245	0.2981	0.2981
Echinococcus multilocularis	N chimaerin	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Giardia lamblia	Kinase	0.0172	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0245	0.2981	0.2981
Giardia lamblia	Protein 21.1	0.0172	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0245	0.2981	0.2981
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0417	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0172	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0417	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	SH2 domain-containing protein	0.0245	0.2981	0.2981
Brugia malayi	Variant SH3 domain containing protein	0.0245	0.2981	0.2981
Brugia malayi	Protein kinase domain containing protein	0.0417	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0172	0	0.5
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Echinococcus granulosus	N chimaerin	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0417	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Echinococcus multilocularis	tyrosine kinase	0.0417	1	1
Onchocerca volvulus		0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0417	1	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0245	0.2981	0.2981
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0417	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0417	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0245	0.2981	0.2981
Schistosoma mansoni	signal transduction protein lnk-related	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0417	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0245	0.2981	0.2981
Toxoplasma gondii	protein kinase domain-containing protein	0.0172	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine kinase	0.0417	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0172	0	0.5
Brugia malayi	SH2 domain containing protein	0.0417	1	1
Schistosoma mansoni	tensin	0.0245	0.2981	0.2981
Schistosoma mansoni	SH2A	0.0245	0.2981	0.2981
Onchocerca volvulus		0.0245	0.2981	0.2981
Brugia malayi	hypothetical protein	0.0417	1	1
Brugia malayi	Tensin	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0417	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0417	1	1
Echinococcus multilocularis	SH2 motif	0.0245	0.2981	0.2981
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0245	0.2981	0.2981
Schistosoma mansoni	tensin	0.0245	0.2981	0.2981
Schistosoma mansoni	nck2/grb4	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0245	0.2981	0.2981
Onchocerca volvulus		0.0245	0.2981	0.2981
Loa Loa (eye worm)	STAT protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	signal transduction protein lnk realted	0.0245	0.2981	0.2981
Onchocerca volvulus		0.0417	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0417	1	1
Echinococcus granulosus	expressed conserved protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0245	0.2981	0.2981
Schistosoma mansoni	adapter molecule crk	0.0245	0.2981	0.2981
Trichomonas vaginalis	TK family protein kinase	0.0172	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0417	1	1
Brugia malayi	Protein kinase domain containing protein	0.0417	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0172	0	0.5
Echinococcus multilocularis	tensin	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis		0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0417	1	1
Echinococcus multilocularis	SH2 motif	0.0245	0.2981	0.2981
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0172	0	0.5
Echinococcus granulosus	SH2 motif	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Onchocerca volvulus		0.0245	0.2981	0.2981
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0172	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0172	0	0.5
Schistosoma mansoni	tensin-related	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0417	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0417	1	1
Leishmania major	protein kinase, putative	0.0172	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0245	0.2981	0.2981
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0245	0.2981	0.2981
Schistosoma mansoni	shc transforming protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0245	0.2981	0.2981
Echinococcus granulosus	tyrosine protein kinase shark	0.0417	1	1
Echinococcus granulosus	SH2 motif	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Schistosoma mansoni	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0245	0.2981	0.2981
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0417	1	1
Onchocerca volvulus		0.0245	0.2981	0.2981
Schistosoma mansoni	growth factor receptor-bound protein	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0417	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0417	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0245	0.2981	0.2981
Leishmania major	hypothetical protein, conserved	0.0172	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0245	0.2981	0.2981
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0417	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0245	0.2981	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus granulosus	c src tyrosine kinase	0.0417	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0417	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Leishmania major	protein kinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0417	1	1
Giardia lamblia	Kinase, NEK	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0417	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0245	0.2981	0.2981
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0172	0	0.5
Plasmodium vivax	protein kinase, putative	0.0172	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0417	1	1
Onchocerca volvulus		0.0245	0.2981	0.2981
Echinococcus multilocularis	tyrosine protein kinase shark	0.0417	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0245	0.2981	0.2981
Plasmodium falciparum	tyrosine kinase-like protein	0.0172	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0245	0.2981	0.2981
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0417	1	1
Schistosoma mansoni	tensin-related	0.0245	0.2981	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0172	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0245	0.2981	0.2981
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0	0.5
Brugia malayi	SH2 domain containing protein	0.0245	0.2981	0.2981
Onchocerca volvulus		0.0417	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0172	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2981	0.2981
Trypanosoma cruzi	protein kinase, putative	0.0172	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4.9 nM	Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition site in rat frontal cortex homogenate.	ChEMBL.	9022796
Ki (binding)	= 4.9 nM	Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition site in rat frontal cortex homogenate.	ChEMBL.	9022796
Ki (binding)	= 92 nM	In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.	ChEMBL.	9022796
Ki (binding)	= 92 nM	In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.	ChEMBL.	9022796

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL104578
PubChem: 42266164

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 173153