TDR Targets

Basic information

Technical information

TDR Targets ID: 1732167
Name: 2-chloro-6-[[4-(4-fluorophenyl)-1-methylpiper idin-4-yl]methoxymethyl]-4-(trifluoromethyl)p yridine
MW: 416.84 | Formula: C20H21ClF4N2O
H donors: 0 H acceptors: 1 LogP: 4.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)(COCc1nc(Cl)cc(c1)C(F)(F)F)c1ccc(cc1)F
InChi: 1S/C20H21ClF4N2O/c1-27-8-6-19(7-9-27,14-2-4-16(22)5-3-14)13-28-12-17-10-15(20(23,24)25)11-18(21)26-17/h2-5,10-11H,6-9,12-13H2,1H3
InChiKey: IWZSETOJTMHNIP-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-chloro-6-[[4-(4-fluorophenyl)-1-methyl-4-piperidyl]methoxymethyl]-4-(trifluoromethyl)pyridine
2-chloro-6-[[4-(4-fluorophenyl)-1-methyl-4-piperidinyl]methoxymethyl]-4-(trifluoromethyl)pyridine
2-chloro-6-[[4-(4-fluorophenyl)-1-methyl-piperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0159	0.0033
Echinococcus multilocularis	signal transduction protein lnk realted	0.0015	0.0124	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Brugia malayi	hypothetical protein	0.003	0.0455	0.0993
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0192	0.3866	0.8443
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Leishmania major	carbonic anhydrase-like protein	0.0225	0.4579	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0034	0.0537	0.0537
Echinococcus multilocularis	serotonin transporter	0.0073	0.1357	0.1357
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0022	0.027	0.059
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	SH2A	0.0015	0.0124	0.0124
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0034	0.0537	0.0537
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0015	0.0124	0.0271
Onchocerca volvulus		0.003	0.0455	0.2958
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0012	0.0076	0.0076
Echinococcus multilocularis	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0016	0.0144	0.2082
Entamoeba histolytica	receptor protein kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0016	0.0144	0.0617
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0012	0.0076	0.0165
Schistosoma mansoni	tensin	0.0015	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1357	0.2963
Giardia lamblia	Kinase, NEK	0.0016	0.0144	0.5
Schistosoma mansoni	tyrosine kinase	0.0034	0.0537	0.0537
Trichomonas vaginalis	TK family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Tensin	0.0015	0.0124	0.0271
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Onchocerca volvulus		0.0016	0.0144	0.0537
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0015	0.0124	0.0124
Brugia malayi	ephrin receptor 1 precursor	0.0016	0.0144	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Echinococcus multilocularis	SH2 motif	0.0015	0.0124	0.0124
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0016	0.0144	0.0144
Schistosoma mansoni	signal transduction protein lnk-related	0.0015	0.0124	0.0124
Loa Loa (eye worm)	TK/Met protein kinase	0.0016	0.0144	0.0315
Onchocerca volvulus		0.0015	0.0124	0.0377
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	c src tyrosine kinase	0.0034	0.0537	0.0537
Brugia malayi	map kinase activated protein kinase protein 2	0.0192	0.3866	0.8443
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Echinococcus granulosus	hypothetical protein	0.0015	0.0124	0.0124
Schistosoma mansoni	protein kinase	0.0016	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0993	0.2169
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/EPH protein kinase	0.0016	0.0144	0.0315
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0016	0.0144	0.0144
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0034	0.0537	0.0537
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0016	0.0159	0.0159
Onchocerca volvulus		0.0015	0.0124	0.0377
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0016	0.0144	0.0144
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0016	0.0144	0.0144
Onchocerca volvulus		0.003	0.0455	0.2958
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1179	0.2576
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Echinococcus multilocularis	carbonic anhydrase II	0.0225	0.4579	0.4579
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0086	0.0189
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	RhoGAP domain containing protein	0.0022	0.027	0.059
Echinococcus multilocularis	tensin	0.0015	0.0124	0.0124
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0012	0.0076	0.0165
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0124	0.0124
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0016	0.0144	0.0617
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0016	0.0144	0.0144
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0015	0.0124	0.0271
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0016	0.0144	0.0144
Echinococcus granulosus	SH2 domain containing protein 7	0.0015	0.0124	0.0124
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0124	0.0124
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0034	0.0537	0.0537
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0012	0.0076	0.0076
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0016	0.0144	1
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Plasmodium falciparum	tyrosine kinase-like protein	0.0016	0.0144	0.0153
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0015	0.0124	0.0124
Onchocerca volvulus		0.003	0.0455	0.2958
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0016	0.0144	0.0315
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Echinococcus granulosus	integrin linked protein kinase	0.0016	0.0144	0.0144
Echinococcus multilocularis	protein kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0993	0.2169
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0034	0.0537	0.0537
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0015	0.0124	0.0124
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0034	0.0537	0.0537
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus granulosus	growth factor receptor bound protein 2	0.0019	0.0206	0.0206
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0016	0.0159	0.0186
Brugia malayi	C1-like domain containing protein	0.0063	0.1155	0.2522
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.003	0.0455	0.0455
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0023	0.0291	0.0291
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0016	0.0144	0.0144
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0016	0.0144	0.0144
Echinococcus granulosus	expressed conserved protein	0.0015	0.0124	0.0124
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	heat shock protein 70	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0016	0.0144	0.0144
Schistosoma mansoni	adapter molecule crk	0.0019	0.0206	0.0206
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0012	0.0076	0.0076
Onchocerca volvulus		0.0016	0.0144	0.0537
Echinococcus multilocularis	SH2 motif	0.0015	0.0124	0.0124
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Entamoeba histolytica	ankyrin repeat protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	growth factor receptor-bound protein	0.0019	0.0206	0.0206
Schistosoma mansoni	carbonic anhydrase-related	0.0225	0.4579	0.4579
Echinococcus multilocularis	tyrosine protein kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	growth factor receptor-bound protein	0.0019	0.0206	0.0206
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	SH2 domain-containing protein	0.0015	0.0124	0.0271
Schistosoma mansoni	serine/threonine RGC	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	carbonic anhydrase 3	0.0225	0.4579	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0016	0.0144	0.0537
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0225	0.4579	0.4579
Loa Loa (eye worm)	SH2 domain-containing protein	0.0015	0.0124	0.0271
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	SH2 domain-containing protein	0.0015	0.0124	0.0271
Echinococcus multilocularis	tyrosine protein kinase Blk	0.003	0.0455	0.0455
Echinococcus granulosus	N chimaerin	0.0022	0.027	0.027
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0016	0.0144	0.0315
Brugia malayi	SH2 domain containing protein	0.003	0.0455	0.0993
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0019	0.0206	0.0206
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0016	0.0144	0.0144
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	carbonic anhydrase	0.0225	0.4579	0.4579
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	FL cytokine receptor	0.0016	0.0144	0.0144
Schistosoma mansoni	protein tyrosine kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	tyrosine kinase	0.0034	0.0537	0.0537
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0034	0.0537	0.0537
Loa Loa (eye worm)	SRC-1	0.0034	0.0537	0.1173
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0124	0.0124
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	STAT protein	0.0015	0.0124	0.0271
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	tyrosin kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Brugia malayi	Protein kinase domain containing protein	0.003	0.0455	0.0993
Echinococcus multilocularis		0.0015	0.0124	0.0124
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0225	0.4579	1
Brugia malayi	integrin-linked kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Echinococcus granulosus	SH2 motif	0.0015	0.0124	0.0124
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0086	0.0086
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0073	0.1357	0.1357
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0016	0.0144	0.2082
Schistosoma mansoni	tensin-related	0.0015	0.0124	0.0124
Echinococcus granulosus	natriuretic peptide receptor 1	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase ABL1	0.003	0.0455	0.0455
Echinococcus granulosus	tyrosine protein kinase Blk	0.003	0.0455	0.0455
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	carbonic anhydrase	0.0225	0.4579	0.4579
Echinococcus multilocularis	tensin	0.0015	0.0124	0.0124
Entamoeba histolytica	ankyrin repeat protein	0.0016	0.0144	0.0617
Schistosoma mansoni	sodium/chloride dependent transporter	0.0013	0.009	0.009
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0057	0.1008	0.2202
Brugia malayi	Receptor family ligand binding region containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK protein kinase	0.003	0.0455	0.0993
Loa Loa (eye worm)	TK/ABL protein kinase	0.003	0.0455	0.0993
Echinococcus granulosus	serotonin transporter	0.0073	0.1357	0.1357
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0016	0.0144	0.0144
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0159	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1357	0.2963
Brugia malayi	Raf kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Brugia malayi	Variant SH3 domain containing protein	0.0019	0.0206	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4579	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0016	0.0144	0.0153
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus		0.0063	0.114	0.8307
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0016	0.0144	0.2082
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	SH2 domain containing protein 7	0.0015	0.0124	0.0124
Onchocerca volvulus		0.0065	0.1179	0.8618
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0012	0.0076	0.0076
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	tyrosine kinase	0.0467	0.969	0.969
Loa Loa (eye worm)	TK/CSK protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Giardia lamblia	Protein 21.1	0.0016	0.0144	0.5
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0016	0.0144	0.0144
Treponema pallidum	sodium- and chloride- dependent transporter	0.0073	0.1357	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0022	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0631	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Brugia malayi	protein-tyrosine kinase	0.003	0.0455	0.0993
Echinococcus multilocularis	tyrosine protein kinase Srms	0.003	0.0455	0.0455
Echinococcus granulosus	NCK adaptor protein	0.0019	0.0206	0.0206
Loa Loa (eye worm)	TK/FAK protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0012	0.0076	0.0076
Schistosoma mansoni	tyrosine kinase	0.0034	0.0537	0.0537
Entamoeba histolytica	receptor protein kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0073	0.1357	0.2963
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0034	0.0537	0.0537
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Echinococcus multilocularis	tyrosine kinase	0.003	0.0455	0.0455
Schistosoma mansoni	tensin	0.0015	0.0124	0.0124
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0015	0.0124	0.0124
Echinococcus multilocularis	activin receptor type	0.0016	0.0159	0.0159
Onchocerca volvulus		0.0016	0.0144	0.0537
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0016	0.0144	0.0537
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0159	0.0033
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0086	0.0086
Schistosoma mansoni	ephrin receptor	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0206	0.0451
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0016	0.0144	0.0144
Toxoplasma gondii	hypothetical protein	0.0225	0.4579	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Echinococcus granulosus	epidermal growth factor receptor	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	c src tyrosine kinase	0.0034	0.0537	0.0537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	protein tyrosine kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Schistosoma mansoni	suppressor of cytokine signaling	0.0015	0.0124	0.0124
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0086	0.0086
Echinococcus multilocularis	NCK adaptor protein	0.0019	0.0206	0.0206
Onchocerca volvulus		0.0015	0.0124	0.0377
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0016	0.0144	0.0315
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus granulosus	insulin receptor	0.0016	0.0144	0.0144
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0144	0.0617
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0015	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0225	0.4579	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0016	0.0144	0.0315
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0016	0.0144	0.0315
Onchocerca volvulus		0.003	0.0455	0.2958
Echinococcus granulosus	raf serine:threonine protein kinase	0.0023	0.0291	0.0291
Brugia malayi	C-terminal src kinase protein 1	0.0016	0.0144	0.0315
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0022	0.027	0.027
Echinococcus granulosus	carbonic anhydrase	0.0225	0.4579	0.4579
Echinococcus granulosus	epidermal growth factor receptor	0.0016	0.0144	0.0144
Echinococcus granulosus	kinase suppressor of Ras 1	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus		0.0016	0.0144	0.0537
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Plasmodium falciparum	protein kinase, putative	0.0016	0.0144	0.0153
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	hypothetical protein	0.0015	0.0124	0.0124
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0012	0.0076	0.0076
Echinococcus granulosus	SHC transforming protein 3	0.0015	0.0124	0.0124
Echinococcus multilocularis	insulin receptor	0.0016	0.0144	0.0144
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0016	0.0144	1
Onchocerca volvulus		0.0056	0.0993	0.7164
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.0144	0.0144
Schistosoma mansoni	tyrosine kinase	0.0034	0.0537	0.0537
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0842	0.0842
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0016	0.0144	0.0144
Entamoeba histolytica	tyrosin kinase, putative	0.0016	0.0144	0.0617
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0755	0.0755
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0015	0.0124	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0015	0.0124	0.0377
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	hypothetical protein	0.0016	0.0144	0.0144
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0225	0.4579	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0086	0.0086
Echinococcus granulosus	activin receptor type	0.0016	0.0159	0.0159
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0225	0.4579	1
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4579	1
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	tyrosine protein kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0017	0.0164	0.0358
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0016	0.0144	0.0144
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0015	0.0124	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0225	0.4579	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0016	0.0144	0.0144
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0019	0.0206	0.0451
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0192	0.3866	0.3866
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0012	0.0076	0.0165
Onchocerca volvulus		0.003	0.0455	0.2958
Brugia malayi	Guanylyl cyclase protein 23	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Brugia malayi	SRC-1	0.0034	0.0537	0.1173
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.3866	0.3866
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK/DDR protein kinase	0.0016	0.0144	0.0315
Brugia malayi	Protein kinase domain containing protein	0.003	0.0455	0.0993
Trichomonas vaginalis	STE family protein kinase	0.0016	0.0144	0.2082
Echinococcus multilocularis	N chimaerin	0.0022	0.027	0.027
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0015	0.0124	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	suppressor of cytokine signaling	0.0015	0.0124	0.0124
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0842	0.0842
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0124	0.0271
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0016	0.0144	0.0315
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0016	0.0144	0.0537
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0063	0.1155	0.2522
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0012	0.0076	0.0165
Schistosoma mansoni	ephrin receptor	0.0016	0.0144	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0035	0.0552	0.0552
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/INSR protein kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0225	0.4579	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0034	0.0537	0.0537
Loa Loa (eye worm)	norepinephrine transporter	0.0073	0.1357	0.2963
Echinococcus multilocularis	transfer RNA-Thr	0.0016	0.0144	0.0144
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0019	0.0206	0.0451
Loa Loa (eye worm)	serine/threonine protein kinase	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0016	0.0144	0.0144
Toxoplasma gondii	protein kinase	0.0016	0.0144	0.0153
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0755	0.0755
Brugia malayi	Tyrosine-protein kinase abl-1	0.0034	0.0537	0.1173
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.003	0.0455	0.0455
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	tensin-related	0.0015	0.0124	0.0124
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0016	0.0144	0.0144
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0016	0.0144	0.0144
Echinococcus multilocularis	SHC transforming protein 3	0.0015	0.0124	0.0124
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0693	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0016	0.0144	0.0315
Plasmodium vivax	protein kinase, putative	0.0016	0.0144	1
Plasmodium falciparum	protein kinase, putative	0.0016	0.0159	0.0186
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine kinase	0.003	0.0455	0.0455
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Brugia malayi	Protein kinase domain containing protein	0.003	0.0455	0.0993
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0016	0.0144	0.0153
Echinococcus multilocularis	carbonic anhydrase	0.0225	0.4579	0.4579
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0022	0.027	0.027
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Onchocerca volvulus		0.0015	0.0124	0.0377
Schistosoma mansoni	nck2/grb4	0.0019	0.0206	0.0206
Onchocerca volvulus		0.0016	0.0144	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.003	0.0455	0.0455
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0755	0.1649
Echinococcus granulosus	signal transduction protein lnk realted	0.0015	0.0124	0.0124
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0015	0.0124	0.0124
Trypanosoma brucei	carbonic anhydrase-like protein	0.0225	0.4579	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0034	0.0537	0.0537
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0192	0.3866	0.3866
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4579	1
Schistosoma mansoni	vav2	0.0023	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/RYK protein kinase	0.0016	0.0144	0.0315
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus		0.0016	0.0144	0.0537
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0016	0.0159	0.0159
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0012	0.0076	0.0165
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0086	0.0086
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0012	0.0076	0.0076
Echinococcus multilocularis	protein kinase	0.0016	0.0144	0.0144
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0086	0.0086
Entamoeba histolytica	tyrosin kinase, putative	0.0016	0.0144	0.0617
Toxoplasma gondii	STE kinase	0.0016	0.0144	0.0153
Onchocerca volvulus		0.0015	0.0124	0.0377
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0016	0.0144	0.0144
Brugia malayi	Sex muscle abnormal protein 5	0.0019	0.0206	0.0451
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0225	0.4579	1
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus multilocularis	epidermal growth factor receptor	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0016	0.0144	0.0144
Onchocerca volvulus		0.0073	0.1357	1
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	ephrin type A receptor 4 A	0.0016	0.0144	0.0144
Schistosoma mansoni	hypothetical protein	0.0015	0.0124	0.0124
Brugia malayi	Protein kinase domain containing protein	0.003	0.0455	0.0993
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Schistosoma mansoni	shc transforming protein	0.0015	0.0124	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0034	0.0537	0.0537
Onchocerca volvulus		0.003	0.0455	0.2958
Schistosoma mansoni	protein kinase C mu	0.0063	0.1155	0.1155
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	carbonic anhydrase-related	0.0225	0.4579	0.4579
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0016	0.0144	0.0315
Leishmania major	protein kinase, putative	0.0016	0.0159	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Schistosoma mansoni	protein kinase	0.0016	0.0159	0.0159
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	serotonin transporter b	0.0073	0.1357	0.2963
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0015	0.0124	0.0124
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0225	0.4579	1
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	epidermal growth factor receptor	0.0016	0.0144	0.0144
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0124	0.0271
Brugia malayi	Protein kinase domain containing protein	0.003	0.0455	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1357	0.2963
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0015	0.0124	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0034	0.0537	0.0537
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0693	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0016	0.0144	0.0144
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Onchocerca volvulus		0.0016	0.0144	0.0537
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Brugia malayi	hypothetical protein	0.0012	0.0076	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Plasmodium falciparum	protein kinase, putative	0.0016	0.0144	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0016	0.0144	0.0144
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Giardia lamblia	Kinase	0.0016	0.0144	0.5
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0225	0.4579	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0016	0.0144	0.0315
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Schistosoma mansoni	hypothetical protein	0.0225	0.4579	0.4579
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0015	0.0139	0.0449
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Brugia malayi	Variant SH3 domain containing protein	0.0017	0.0164	0.0358
Echinococcus multilocularis	carbonic anhydrase	0.0225	0.4579	0.4579
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0164	0.0358
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0455	0.0993
Echinococcus granulosus	receptor type guanylyl cyclase	0.0016	0.0144	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Brugia malayi	hypothetical protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0144	0.2082
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Echinococcus granulosus	sodium and chloride dependent glycine	0.0012	0.0076	0.0076
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0016	0.0144	0.0315
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0015	0.0124	0.0271
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0015	0.0124	0.0124
Schistosoma mansoni	tyrosine kinase	0.003	0.0455	0.0455
Echinococcus granulosus	activated cdc42 kinase 1	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0015	0.0124	0.0124
Echinococcus multilocularis	tyrosine protein kinase shark	0.0482	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0225	0.4579	1
Echinococcus granulosus	tensin	0.0015	0.0124	0.0124
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0124	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Schistosoma mansoni	carbonic anhydrase-related	0.0225	0.4579	0.4579
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0022	0.027	0.027
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0015	0.0124	0.0124
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0012	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0076	0.0165
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0015	0.0124	0.0271
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0144	0.0315
Echinococcus granulosus	tyrosine kinase	0.003	0.0455	0.0455
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	protein kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0291	0.0291
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0016	0.0144	0.2082
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Echinococcus multilocularis	integrin linked protein kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	sodium and chloride dependent glycine	0.0012	0.0076	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Echinococcus granulosus	protein tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase Srms	0.003	0.0455	0.0455
Echinococcus granulosus	SH2 motif	0.0015	0.0124	0.0124
Echinococcus granulosus	carbonic anhydrase	0.0225	0.4579	0.4579
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Plasmodium falciparum	tyrosine kinase-like protein	0.0016	0.0144	0.0153
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0012	0.0076	0.0076
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus		0.0015	0.0124	0.0377
Trypanosoma brucei	protein kinase, putative	0.0016	0.0159	0.0033
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Plasmodium falciparum	carbonic anhydrase	0.0225	0.4579	1
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Brugia malayi	Furin-like cysteine rich region family protein	0.0016	0.0144	0.0315
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.003	0.0455	0.0455
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.003	0.0455	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0016	0.0144	0.0144
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0019	0.0206	0.0206
Echinococcus granulosus	carbonic anhydrase	0.0225	0.4579	0.4579
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Onchocerca volvulus		0.0016	0.0144	0.0537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0063	0.1155	0.2522
Brugia malayi	SH2 domain containing protein	0.003	0.0455	0.0993
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	protein kinase	0.0016	0.0144	0.0144
Loa Loa (eye worm)	TK/ALK protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	sodium/chloride dependent transporter	0.0012	0.0076	0.0076
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0225	0.4579	1
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0012	0.0076	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0034	0.0537	0.0537
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0016	0.0144	0.0617
Onchocerca volvulus		0.0016	0.0144	0.0537
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0034	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0063	0.114	0.2489
Schistosoma mansoni	sodium/chloride dependent transporter	0.0073	0.1357	0.1357
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0073	0.1357	0.2963
Echinococcus multilocularis	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Brugia malayi	hypothetical protein	0.0015	0.0124	0.0271
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0755	0.1649
Echinococcus granulosus	tyrosine protein kinase	0.0016	0.0144	0.0144
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0144	0.0144
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0086	0.0189
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.027	0.059
Schistosoma mansoni	tensin	0.0015	0.0124	0.0124
Entamoeba histolytica	hypothetical protein	0.0016	0.0144	0.0617
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Echinococcus multilocularis	activated cdc42 kinase 1	0.0016	0.0144	0.0144
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	tyrosine kinase, putative	0.0016	0.0144	0.0617
Schistosoma mansoni	tyrosine kinase	0.0016	0.0144	0.0144
Echinococcus multilocularis	tyrosine protein kinase csk	0.0016	0.0144	0.0144
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0225	0.4579	0.4579
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0012	0.0076	0.0165
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0016	0.0144	0.0315
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0159	0.0033
Trichomonas vaginalis	protein kinase atn1, putative	0.0016	0.0144	0.2082
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0016	0.0144	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0144	0.0315
Entamoeba histolytica	tyrosin kinase, putative	0.0016	0.0144	0.0617
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0016	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.003	0.0455	0.0993
Giardia lamblia	Kinase, NEK	0.0016	0.0144	0.5
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.003	0.0455	0.0455
Entamoeba histolytica	protein kinase, putative	0.0015	0.0139	0.0449
Echinococcus multilocularis	SH2 motif	0.0015	0.0124	0.0124
Echinococcus granulosus	carbonic anhydrase II	0.0225	0.4579	0.4579
Schistosoma mansoni	GTPase activating protein	0.0015	0.0124	0.0124
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0016	0.0144	0.0315
Schistosoma mansoni	protein kinase	0.0016	0.0159	0.0159
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0015	0.0124	0.0377
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0012	0.0076	0.0076
Brugia malayi	Variant SH3 domain containing protein	0.0019	0.0206	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0271
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0012	0.0076	0.0076
Entamoeba histolytica	serine/threonine kinase, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0144	0.0315
Entamoeba histolytica	protein kinase, putative	0.0016	0.0144	0.0617
Trichomonas vaginalis	CAMK family protein kinase	0.0016	0.0144	0.2082
Entamoeba histolytica	cysteine surface protein, putative	0.0016	0.0144	0.0617
Loa Loa (eye worm)	TK/ROR protein kinase	0.0016	0.0144	0.0315
Toxoplasma gondii	protein kinase domain-containing protein	0.0016	0.0144	0.0153
Brugia malayi	hypothetical protein	0.0016	0.0144	0.0315
Trichomonas vaginalis	TKL family protein kinase	0.0016	0.0144	0.2082
Brugia malayi	Tyrosine-protein kinase PR2	0.0016	0.0144	0.0315
Loa Loa (eye worm)	TK/ACK protein kinase	0.0016	0.0144	0.0315
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0034	0.0537	0.0537
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0144	0.0617
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0016	0.0144	0.0315
Brugia malayi	SH2 domain containing protein	0.0015	0.0124	0.0271

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.3 nM	Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cell membranes after 1 hr by scintillation counting analysis	ChEMBL.	23253443
IC50 (binding)	= 45 nM	Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis	ChEMBL.	23253443
IC50 (binding)	= 6 uM	Inhibition of human ERG	ChEMBL.	23253443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333643

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1732167