TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.451 | Formula: C19H28N4O2
H donors: 1 H acceptors: 3 LogP: 3.43 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCn1cc(C(=O)NC2CCCCC2)c(=O)c2c1n(C)nc2
InChi: 1S/C19H28N4O2/c1-3-4-8-11-23-13-16(17(24)15-12-20-22(2)19(15)23)18(25)21-14-9-6-5-7-10-14/h12-14H,3-11H2,1-2H3,(H,21,25)
InChiKey: JLRWXZDRAZQWDA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB2 receptor	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Cannabinoid CB2 receptor	360 aa	360 aa	23.1 %
Schistosoma mansoni	opsin-like receptor	Cannabinoid CB2 receptor	360 aa	314 aa	22.0 %
Onchocerca volvulus		Cannabinoid CB2 receptor	360 aa	330 aa	20.9 %
Echinococcus multilocularis	neuropeptide receptor	Cannabinoid CB2 receptor	360 aa	299 aa	24.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Cannabinoid CB2 receptor	360 aa	311 aa	20.6 %
Onchocerca volvulus		Cannabinoid CB2 receptor	360 aa	389 aa	21.1 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Cannabinoid CB2 receptor	360 aa	370 aa	23.5 %
Echinococcus granulosus	neuropeptide receptor	Cannabinoid CB2 receptor	360 aa	337 aa	24.0 %
Onchocerca volvulus		Cannabinoid CB2 receptor	360 aa	297 aa	21.9 %
Echinococcus multilocularis	allatostatin A receptor	Cannabinoid CB2 receptor	360 aa	342 aa	22.8 %
Onchocerca volvulus	Phospholipase d-related homolog	Cannabinoid CB2 receptor	360 aa	309 aa	23.3 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Cannabinoid CB2 receptor	360 aa	323 aa	22.6 %
Echinococcus granulosus	allatostatin A receptor	Cannabinoid CB2 receptor	360 aa	363 aa	22.9 %
Onchocerca volvulus		Cannabinoid CB2 receptor	360 aa	327 aa	19.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Cannabinoid CB2 receptor	360 aa	370 aa	23.8 %
Loa Loa (eye worm)	neuropeptide F receptor	Cannabinoid CB2 receptor	360 aa	348 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.003	0.003
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	histamine h1 receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Brugia malayi	SRC-1	0.004	0.1705	0.1705
Brugia malayi	GnHR receptor homolog	0.0011	0.0236	0.0236
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.003	0.003
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0583	0.4987
Echinococcus multilocularis	serotonin receptor	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	0.1705	0.9866
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0011	0.0191	0.1118
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0934	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0236	0.1363
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0583	0.442
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0236	0.1363
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0236	0.1363
Brugia malayi	Dopamine receptor protein 1	0.0011	0.0236	0.0236
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0583	0.3373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0583	0.5386
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0236	0.1363
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0236	0.1382
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0007	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0934	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0036	0.1515	0.8882
Loa Loa (eye worm)	TK protein kinase	0.0032	0.1319	0.1319
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	hypothetical protein	0.0011	0.0236	0.1363
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.0236	0.0236
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0236	0.0236
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0236	0.1363
Onchocerca volvulus		0.0011	0.0236	1
Brugia malayi	Sex muscle abnormal protein 5	0.0007	0.003	0.003
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0236	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0236	0.1363
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Serotonin receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	fkbp-rapamycin associated protein	0.001	0.0173	0.0173
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0236	0.1382
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0236	0.0236
Brugia malayi	follicle stimulating hormone receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0583	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.004	0.1705	1
Loa Loa (eye worm)	NEK/NEK6 protein kinase	0.0201	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0007	0.003	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.004	0.1705	1
Brugia malayi	FAT domain containing protein	0.0008	0.0053	0.0053
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.0236	0.0236
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.003	0.003
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0234	0.2052
Schistosoma mansoni	tyrosine kinase	0.004	0.1705	0.1705
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0236	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0008	0.0053	0.0053
Schistosoma mansoni	hypothetical protein	0.0011	0.0236	0.0236
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0583	0.442
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0583	0.5386
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0934	0.5403
Schistosoma mansoni	amine GPCR	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0236	0.1363
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0236	0.1363
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0033	0.1354	0.7939
Brugia malayi	neuropeptide F receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.0201	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0011	0.0236	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0236	0.1382
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0036	0.1515	0.8763
Echinococcus granulosus	sex peptide receptor	0.0011	0.0236	0.1363
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0583	0.0583
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.004	0.1705	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0036	0.1515	0.8882
Schistosoma mansoni	adapter molecule crk	0.0007	0.003	0.003
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0036	0.1515	0.8882
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.1705	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0753	0.7623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0583	0.4987
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0236	0.1382
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	opsin-like receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus granulosus	serotonin receptor	0.0011	0.0236	0.1363
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.0236	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	0.1705	0.9866
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0753	0.0753
Brugia malayi	putative neuropeptide receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Tyrosine-protein kinase abl-1	0.0011	0.0191	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0236	0.1382
Schistosoma mansoni	tyrosine kinase	0.004	0.1705	0.1705
Brugia malayi	AKH receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Chlamydia trachomatis	serine/threonine protein kinase	0.0201	1	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0583	0.4987
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.001	0.0173	0.1017
Echinococcus granulosus	growth factor receptor bound protein 2	0.0007	0.003	0.0173
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0236	0.0236
Entamoeba histolytica	protein kinase rad3, putative	0.001	0.0173	0.1315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0934	1
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0236	0.1363
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0583	0.4987
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0236	0.1363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.001	0.0173	0.1315
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0033	0.1354	0.7832
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Brugia malayi	protein-tyrosine kinase	0.0036	0.1515	0.1515
Schistosoma mansoni	nck2/grb4	0.0007	0.003	0.003
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0008	0.0053	0.0308
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0236	0.1363
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0236	0.1363
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Serotonin receptor	0.0011	0.0236	0.0236
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0585	1
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Schistosoma mansoni	amine GPCR	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase HCK	0.0032	0.1319	0.7632
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0236	0.1382
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	serotonin receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	0.1705	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.1705	0.9866
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0236	0.1382
Brugia malayi	larval opioid receptor	0.0011	0.0236	0.0236
Brugia malayi	RE15519p	0.0011	0.0236	0.0236
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0236	0.1363
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0236	0.0236
Brugia malayi	G-protein coupled receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	amine GPCR	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0011	0.0191	0.1118
Brugia malayi	Dopamine receptor protein 2	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0236	0.1363
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Schistosoma mansoni	tyrosine kinase	0.0011	0.0191	0.0191
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.0236	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0236	0.1363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Onchocerca volvulus		0.0011	0.0236	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.004	0.1705	1
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0236	0.1363
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	tyrosine kinase	0.0011	0.0191	0.0191
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0236	0.1382
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0583	0.4987
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	somatostatin receptor	0.0011	0.0236	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0236	0.1363
Brugia malayi	neuropeptide F receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0583	0.0583
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0234	0.0234
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.001	0.0173	0.1003
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.0236	0.0236
Schistosoma mansoni	myosin xvIII	0.0011	0.0236	0.0236
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0236	0.1363
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase Lyn	0.004	0.1728	1
Schistosoma mansoni	amine GPCR	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine protein kinase Blk	0.0036	0.1515	0.8763
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.0236	0.0236
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0236	0.1363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0236	0.0236
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0236	0.1363
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0236	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Schistosoma mansoni	adenoreceptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0934	0.0934
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0236	0.1382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Entamoeba histolytica	protein kinase, putative	0.0032	0.1319	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0934	0.0934
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0008	0.0053	0.0312
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus granulosus	c src tyrosine kinase	0.0011	0.0191	0.1103
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0236	0.0236
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.0236	0.0236
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0236	0.1382
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0236	0.1382
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus granulosus	tyrosine protein kinase Src64B	0.004	0.1705	0.9866
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.0236	0.0236
Brugia malayi	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.004	0.1705	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	amine GPCR	0.0011	0.0236	0.0236
Loa Loa (eye worm)	SRC-1	0.004	0.1705	0.1705
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.004	0.1705	0.9866
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.0236	0.0236
Entamoeba histolytica	hypothetical protein	0.0025	0.0934	0.708
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0583	0.3373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.001	0.0173	0.0173
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	opsin-like receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0011	0.0191	0.0191
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	0.1705	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0011	0.0236	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0583	0.0583
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	ORL1-like opioid receptor	0.0011	0.0236	0.0236
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0583	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus granulosus	NCK adaptor protein	0.0007	0.003	0.0173
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0583	0.0583
Brugia malayi	G-protein coupled receptor	0.0011	0.0236	0.0236
Giardia lamblia	GTOR	0.0018	0.0583	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0583	0.5386
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0007	0.003	0.003
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	0.1705	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0236	0.1363
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0236	0.1363
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0236	0.1382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0236	0.1363
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Onchocerca volvulus		0.0011	0.0236	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0236	0.1382
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0934	0.5477
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0236	0.0236
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0583	0.3419
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	0.1705	0.9866
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.0236	0.0236
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.0236	0.0236
Echinococcus granulosus	tyrosine kinase	0.0036	0.1515	0.8763
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0934	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0236	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.004	0.1705	0.9866
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Onchocerca volvulus		0.0011	0.0236	1
Brugia malayi	Dopamine receptor	0.0011	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Echinococcus multilocularis	c src tyrosine kinase	0.0011	0.0191	0.1118
Onchocerca volvulus		0.0011	0.0236	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0011	0.0191	0.1103
Brugia malayi	G protein-coupled receptor	0.0011	0.0236	0.0236
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0236	0.1382
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0236	0.1363
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0032	0.1319	0.7735
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0583	0.6016
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0236	0.1382
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0236	0.1382
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0236	0.1382
Brugia malayi	Melatonin receptor type 1A	0.0011	0.0236	0.0236
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0583	0.3419
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0236	0.1382
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0007	0.003	0.0175
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.0236	0.0236
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0585	0.541
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0236	0.1382
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0236	0.1363
Onchocerca volvulus		0.0011	0.0236	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0236	0.0236
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0236	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0234	0.2052
Brugia malayi	sulfakinin receptor protein	0.0011	0.0236	0.0236
Onchocerca volvulus		0.0011	0.0236	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0173	0.1365
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0583	0.5386
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0236	0.1363
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0236	0.0236
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0236	0.1363
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0236	0.1382
Loa Loa (eye worm)	TK protein kinase	0.0036	0.1515	0.1515
Loa Loa (eye worm)	hypothetical protein	0.001	0.0173	0.0173
Schistosoma mansoni	opsin-like receptor	0.0011	0.0236	0.0236
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0236	0.1382

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 872 nM	Agonist activity at human CB2 receptor expressed in CHO cells assessed as forskolin-stimulated [3H]cyclic-AMP accumulation by scintillation counting analysis	ChEMBL.	23350768
Emax (functional)	= 48 %	Agonist activity at human CB2 receptor expressed in CHO cells assessed as forskolin-stimulated [3H]cyclic-AMP accumulation by scintillation counting analysis relative to WIN 55,212-2	ChEMBL.	23350768
Ki (binding)	= 237 nM	Displacement of [3H]CP-55,940 from human recombinant CB2 receptor expressed in CHO cell membranes after 60 mins by scintillation counting analysis	ChEMBL.	23350768
Ki (binding)	= 250 nM	Displacement of [3H]CP-55,940 from Sprague-Dawley rat spleen CB2 receptor by scintillation counting analysis	ChEMBL.	23350768
Ki (binding)	= 5150 nM	Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in CHO cell membranes after 90 mins by scintillation counting analysis	ChEMBL.	23350768
Ki (binding)	= 5650 nM	Displacement of [3H]CP-55,940 from Sprague-Dawley rat brain CB1 receptor by scintillation counting analysis	ChEMBL.	23350768

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2316272

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1737313