Detailed information for compound 1739737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.379 | Formula: C18H12N4OS
  • H donors: 1 H acceptors: 3 LogP: 4.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)sc1c2ncnc1Nc1ccc(cc1)C#N
  • InChi: 1S/C18H12N4OS/c1-23-13-6-7-14-15(8-13)24-17-16(14)20-10-21-18(17)22-12-4-2-11(9-19)3-5-12/h2-8,10H,1H3,(H,20,21,22)
  • InChiKey: RSGHKFIXZUHUCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0156 0.1667 0.1629
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.1667 0.1629
Echinococcus multilocularis integrin linked protein kinase 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase Fyn 0.0401 0.9943 0.9943
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis protein kinase 0.0156 0.1667 0.1629
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0401 0.9943 0.9943
Giardia lamblia Kinase, NEK 0.0156 0.1667 0.5
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Echinococcus granulosus growth factor receptor bound protein 2 0.0244 0.4646 0.4615
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis NCK adaptor protein 0.0244 0.4646 0.4641
Echinococcus multilocularis 0.0244 0.4646 0.4641
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Brugia malayi Receptor family ligand binding region containing protein 0.0156 0.1667 0.1629
Giardia lamblia Protein 21.1 0.0156 0.1667 0.5
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis protein KINase family member (kin 25) 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus SH2 domain containing adapter protein F 0.0244 0.4646 0.4615
Entamoeba histolytica receptor protein kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis kinase suppressor of Ras 1 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Trypanosoma cruzi protein kinase, putative 0.0156 0.1667 0.9661
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0244 0.4646 0.4615
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Brugia malayi Sex muscle abnormal protein 5 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus SH2 motif 0.0244 0.4646 0.4615
Echinococcus multilocularis SHC transforming protein 3 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK protein kinase 0.0401 0.9943 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase pr2 0.0156 0.1667 0.162
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Schistosoma mansoni protein kinase 0.0158 0.1724 0.1686
Onchocerca volvulus 0.0401 0.9943 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Schistosoma mansoni tensin-related 0.0244 0.4646 0.4641
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0401 0.9943 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Echinococcus multilocularis tyrosine protein kinase pr2 0.0156 0.1667 0.1629
Echinococcus granulosus natriuretic peptide receptor 1 0.0156 0.1667 0.162
Echinococcus granulosus activin receptor type 0.0158 0.1724 0.1676
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis AGC family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/ROR protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus protein kinase 0.0156 0.1667 0.162
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.6835 0.6817
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis heat shock protein 70 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein kinase shark 0.0401 0.9943 1
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Brugia malayi hypothetical protein 0.0156 0.1667 0.1629
Brugia malayi tRNA modification GTPase TrmE family protein 0.0244 0.4646 0.4641
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0401 0.9943 1
Onchocerca volvulus 0.0244 0.4646 0.3599
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Loa Loa (eye worm) STAT protein 0.0244 0.4646 0.4672
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0156 0.1667 0.162
Schistosoma mansoni shc transforming protein 0.0244 0.4646 0.4641
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0244 0.4646 0.3599
Echinococcus multilocularis SH2 motif 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0156 0.1667 0.1629
Trypanosoma brucei Pseudokinase, putative 0.0156 0.1667 0.9661
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus retinal guanylyl cyclase 2 0.0156 0.1667 0.162
Trypanosoma brucei protein kinase, putative 0.0158 0.1724 1
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Plasmodium falciparum protein kinase, putative 0.0158 0.1724 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0156 0.1667 0.162
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0401 0.9943 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0156 0.1667 0.162
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0156 0.1667 0.162
Echinococcus multilocularis transfer RNA-Thr 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0244 0.4646 0.4672
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0158 0.1724 0.1676
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Echinococcus multilocularis signal transduction protein lnk realted 0.0244 0.4646 0.4641
Brugia malayi Variant SH3 domain containing protein 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0246 0.4702 0.4699
Onchocerca volvulus 0.0401 0.9943 1
Brugia malayi integrin-linked kinase 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine protein kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0401 0.9943 0.9943
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica ankyrin repeat protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis insulin receptor 0.0156 0.1667 0.1629
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0401 0.9943 1
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus integrin linked protein kinase 0.0156 0.1667 0.162
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Plasmodium vivax tyrosine kinase-like protein, putative 0.0156 0.1667 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus tyrosine protein kinase shark 0.0401 0.9943 0.9943
Trichomonas vaginalis protein tyrosine kinase, putative 0.0156 0.1667 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0148 0.1379 0.1387
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0401 0.9943 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus tyrosine protein kinase csk 0.0156 0.1667 0.162
Brugia malayi hypothetical protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0401 0.9943 0.9943
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Schistosoma mansoni adapter molecule crk 0.0244 0.4646 0.4641
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Onchocerca volvulus 0.0244 0.4646 0.3599
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis natriuretic peptide receptor 1 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0156 0.1667 0.9661
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0244 0.4646 0.4672
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0244 0.4646 0.3599
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0156 0.1667 0.1629
Trypanosoma brucei Flagellum attachment zone protein 20 0.0156 0.1667 0.9661
Echinococcus granulosus NCK adaptor protein 0.0244 0.4646 0.4615
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0244 0.4646 0.4641
Leishmania major protein kinase, putative 0.0158 0.1724 1
Entamoeba histolytica tyrosin kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus ephrin type A receptor 4 A 0.0156 0.1667 0.162
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Echinococcus multilocularis protein tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TK family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni SH2A 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0156 0.1667 0.5
Brugia malayi Protein kinase domain containing protein 0.0401 0.9943 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0401 0.9943 0.9943
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0401 0.9943 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0246 0.4702 0.4699
Schistosoma mansoni serine/threonine RGC 0.0156 0.1667 0.1629
Brugia malayi RhoGAP domain containing protein 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine kinase 0.0401 0.9943 1
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase 0.0156 0.1667 0.162
Onchocerca volvulus 0.0244 0.4646 0.3599
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Brugia malayi cytokine inducible SH2-containing protein 5 0.0244 0.4646 0.4641
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0244 0.4646 0.4641
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0401 0.9943 0.9943
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Schistosoma mansoni ephrin receptor 0.0156 0.1667 0.1629
Entamoeba histolytica hypothetical protein, conserved 0.0156 0.1667 0.1629
Echinococcus multilocularis protein kinase 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase Src42A 0.0244 0.4646 0.4615
Echinococcus multilocularis tensin 0.0244 0.4646 0.4641
Entamoeba histolytica tyrosin kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/ALK protein kinase 0.0156 0.1667 0.1676
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Onchocerca volvulus 0.0244 0.4646 0.3599
Loa Loa (eye worm) TK/EPH protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis activin receptor type 0.0158 0.1724 0.1686
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0401 0.9943 0.9943
Schistosoma mansoni vav2 0.0244 0.4646 0.4641
Echinococcus granulosus activated cdc42 kinase 1 0.0156 0.1667 0.162
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Echinococcus granulosus hypothetical protein 0.0244 0.4646 0.4615
Echinococcus granulosus SH2 domain containing protein 7 0.0244 0.4646 0.4615
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni signal transduction protein lnk-related 0.0244 0.4646 0.4641
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0156 0.1667 0.1629
Schistosoma mansoni hypothetical protein 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0156 0.1667 0.162
Brugia malayi Variant SH3 domain containing protein 0.0244 0.4646 0.4641
Echinococcus multilocularis tyrosine protein kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus tyrosine kinase 0.0401 0.9943 0.9943
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus tensin 0.0244 0.4646 0.4615
Brugia malayi SH2 domain containing protein 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0156 0.1667 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0401 0.9943 1
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Brugia malayi ephrin receptor 1 precursor 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus SH2 motif 0.0244 0.4646 0.4615
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0401 0.9943 1
Brugia malayi Protein kinase domain containing protein 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus c src tyrosine kinase 0.0401 0.9943 0.9943
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.1667 0.1629
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0244 0.4646 0.4615
Loa Loa (eye worm) TK/CSK protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0156 0.1667 0.162
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein kinase Abl 0.0401 0.9943 1
Echinococcus granulosus tyrosine protein kinase csk 0.0156 0.1667 0.162
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis STE family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis SH2 motif 0.0244 0.4646 0.4641
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0401 0.9943 1
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Brugia malayi Variant SH3 domain containing protein 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Giardia lamblia Kinase 0.0156 0.1667 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0244 0.4646 0.4641
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0244 0.4646 0.4615
Echinococcus granulosus tyrosine protein kinase csk 0.0156 0.1667 0.162
Echinococcus multilocularis FL cytokine receptor 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Brugia malayi Protein kinase domain containing protein 0.0401 0.9943 1
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0401 0.9943 0.9943
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.1667 0.162
Schistosoma mansoni suppressor of cytokine signaling 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0401 0.9943 0.9943
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0244 0.4646 0.4641
Entamoeba histolytica tyrosin kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0244 0.4646 0.4641
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Echinococcus granulosus tyrosine protein kinase Src42A 0.0401 0.9943 0.9943
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica SH2 domain containing protein 0.0244 0.4646 0.4641
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0401 0.9943 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0156 0.1667 0.162
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus expressed conserved protein 0.0244 0.4646 0.4615
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine kinase 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni hypothetical protein 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0156 0.1667 0.1676
Schistosoma mansoni tensin-related 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0156 0.1667 0.1629
Loa Loa (eye worm) SRC-1 0.0401 0.9943 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0156 0.1667 0.162
Echinococcus granulosus suppressor of cytokine signaling 7 0.0244 0.4646 0.4615
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis SH2 motif 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/DDR protein kinase 0.0156 0.1667 0.1676
Brugia malayi Tyrosine-protein kinase PR2 0.0156 0.1667 0.1629
Brugia malayi Variant SH3 domain containing protein 0.0244 0.4646 0.4641
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0244 0.4646 0.4641
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0156 0.1667 0.162
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0156 0.1667 0.162
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0156 0.1667 0.162
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Onchocerca volvulus 0.0244 0.4646 0.3599
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0401 0.9943 1
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0156 0.1667 0.1629
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Brugia malayi SH2 domain containing protein 0.0401 0.9943 1
Echinococcus granulosus tyrosine kinase 0.0156 0.1667 0.162
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0401 0.9943 0.9943
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0244 0.4646 0.4641
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0156 0.1667 0.1676
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0158 0.1724 0.1686
Brugia malayi Raf kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis c src tyrosine kinase 0.0401 0.9943 1
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) RGC/RGC protein kinase 0.0156 0.1667 0.1676
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0158 0.1724 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0244 0.4646 0.4615
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Schistosoma mansoni GTPase activating protein 0.0244 0.4646 0.4641
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/FAK protein kinase 0.0156 0.1667 0.1676
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosin kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus protein tyrosine kinase 0.0156 0.1667 0.162
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0156 0.1667 0.1629
Schistosoma mansoni tensin 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Brugia malayi hypothetical protein 0.0148 0.1379 0.1338
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/Met protein kinase 0.0156 0.1667 0.1676
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni protein kinase 0.0158 0.1724 0.1686
Entamoeba histolytica receptor protein kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0156 0.1667 0.162
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0401 0.9943 1
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis receptor type guanylyl cyclase 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0156 0.1667 0.1629
Leishmania major protein kinase, putative 0.0156 0.1667 0.9661
Loa Loa (eye worm) TK/INSR protein kinase 0.0156 0.1667 0.1676
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.1667 0.162
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0156 0.1667 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0156 0.1667 0.162
Onchocerca volvulus 0.0401 0.9943 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0156 0.1667 0.162
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0156 0.1667 0.1629
Onchocerca volvulus 0.0244 0.4646 0.3599
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0244 0.4646 0.4672
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0158 0.1724 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Echinococcus multilocularis tyrosine protein kinase csk 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0401 0.9943 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0401 0.9943 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0401 0.9943 1
Brugia malayi protein-tyrosine kinase 0.0401 0.9943 1
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Plasmodium vivax protein kinase, putative 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus tyrosine kinase 0.0401 0.9943 0.9943
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0401 0.9943 1
Echinococcus granulosus activated cdc42 kinase 1 0.0156 0.1667 0.162
Echinococcus granulosus SHC transforming protein 3 0.0244 0.4646 0.4615
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus suppressor of cytokine signaling 6 0.0244 0.4646 0.4615
Trichomonas vaginalis protein kinase atn1, putative 0.0156 0.1667 0.5
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0158 0.1724 1
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Schistosoma mansoni tensin 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TK/ABL protein kinase 0.0401 0.9943 1
Schistosoma mansoni nck2/grb4 0.0244 0.4646 0.4641
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0244 0.4646 0.4672
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi hypothetical protein 0.0244 0.4646 0.4641
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0244 0.4646 0.4641
Echinococcus multilocularis tyrosine protein kinase Blk 0.0401 0.9943 1
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0156 0.1667 0.1629
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) SH2 domain-containing protein 0.0244 0.4646 0.4672
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Onchocerca volvulus 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni ephrin receptor 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus insulin receptor 0.0156 0.1667 0.162
Brugia malayi Guanylyl cyclase protein 23 0.0156 0.1667 0.1629
Loa Loa (eye worm) RGC/RGC protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0244 0.4646 0.4641
Loa Loa (eye worm) SH2 domain-containing protein 0.0244 0.4646 0.4672
Loa Loa (eye worm) RGC/RGC protein kinase 0.0156 0.1667 0.1676
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0244 0.4646 0.4672
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0401 0.9943 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Brugia malayi bone morphogenetic protein type 1 receptor 0.0156 0.1667 0.1629
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0244 0.4646 0.4672
Echinococcus granulosus N chimaerin 0.0244 0.4646 0.4615
Echinococcus multilocularis tyrosine protein kinase csk 0.0156 0.1667 0.1629
Brugia malayi SRC-1 0.0401 0.9943 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0156 0.1667 0.1629
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.6835 0.6856
Schistosoma mansoni growth factor receptor-bound protein 0.0244 0.4646 0.4641
Echinococcus granulosus tyrosine protein kinase HCK 0.0156 0.1667 0.162
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Leishmania major hypothetical protein, conserved 0.0156 0.1667 0.9661
Loa Loa (eye worm) hypothetical protein 0.0148 0.1379 0.1387
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tensin 0.0244 0.4646 0.4641
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0109 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0309 0.6835 0.6874
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0156 0.1667 0.5
Brugia malayi Tensin 0.0244 0.4646 0.4641
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0244 0.4646 0.4641
Brugia malayi SH2 domain containing protein 0.0244 0.4646 0.4641
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Schistosoma mansoni protein tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.6835 0.6856
Echinococcus granulosus signal transduction protein lnk realted 0.0244 0.4646 0.4615
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0244 0.4646 0.4672
Trypanosoma cruzi protein kinase, putative 0.0156 0.1667 0.9661
Onchocerca volvulus 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0156 0.1667 0.162
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Brugia malayi C-terminal src kinase protein 1 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0156 0.1667 0.1629
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0156 0.1667 0.1676
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0156 0.1667 0.1629
Brugia malayi hypothetical protein 0.0401 0.9943 1
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Loa Loa (eye worm) protein kinase domain-containing protein 0.0156 0.1667 0.1676
Echinococcus multilocularis growth factor receptor bound protein 2 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK protein kinase 0.0156 0.1667 0.1676
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Onchocerca volvulus 0.0401 0.9943 1
Schistosoma mansoni protein kinase 0.0156 0.1667 0.1629
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0156 0.1667 0.162
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0401 0.9943 1
Entamoeba histolytica protein kinase domain containing protein 0.0158 0.1724 0.1686
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.1676
Giardia lamblia Kinase, NEK 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0244 0.4646 0.4641
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Entamoeba histolytica ankyrin repeat protein 0.0156 0.1667 0.1629
Schistosoma mansoni tyrosine kinase 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase Srms 0.0401 0.9943 0.9943
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0244 0.4646 0.4615
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0244 0.4646 0.4641
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.9943 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.4646 0.4672
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica tyrosine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus tyrosine protein kinase Src64B 0.0401 0.9943 0.9943
Schistosoma mansoni tensin 0.0244 0.4646 0.4641
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0158 0.1724 1
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1667 0.5
Schistosoma mansoni hypothetical protein 0.0156 0.1667 0.1629
Echinococcus multilocularis N chimaerin 0.0244 0.4646 0.4641
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Entamoeba histolytica protein kinase, putative 0.0156 0.1667 0.1629
Brugia malayi Immunoglobulin I-set domain containing protein 0.0156 0.1667 0.1629
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.1667 0.162
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0156 0.1667 0.1629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0156 0.1667 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0156 0.1667 0.5
Schistosoma mansoni protein kinase 0.0158 0.1724 0.1686
Entamoeba histolytica serine/threonine kinase, putative 0.0156 0.1667 0.1629
Echinococcus granulosus raf serine:threonine protein kinase 0.0156 0.1667 0.162
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0156 0.1667 0.1629
Brugia malayi Protein kinase domain containing protein 0.0156 0.1667 0.1629
Entamoeba histolytica hypothetical protein 0.0156 0.1667 0.1629
Loa Loa (eye worm) hypothetical protein 0.0401 0.9943 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.6 uM Inhibition of rat recombinant DYRK1A-GST expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate ChEMBL. 23237976
IC50 (binding) = 6.8 uM Inhibition of human recombinant CLK1-GST expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23237976
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting ChEMBL. 23237976

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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