Detailed information for compound 174380

Basic information

Technical information
  • TDR Targets ID: 174380
  • Name: 4-hydroxy-3-methoxy-N-[(E)-[3-[3-(trifluorome thyl)phenoxy]phenyl]methylideneamino]benzamid e
  • MW: 430.377 | Formula: C22H17F3N2O4
  • H donors: 2 H acceptors: 2 LogP: 4.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)C(=O)N/N=C/c1cccc(c1)Oc1cccc(c1)C(F)(F)F
  • InChi: 1S/C22H17F3N2O4/c1-30-20-11-15(8-9-19(20)28)21(29)27-26-13-14-4-2-6-17(10-14)31-18-7-3-5-16(12-18)22(23,24)25/h2-13,28H,1H3,(H,27,29)/b26-13+
  • InChiKey: IEQSQFNTSXRZPH-LGJNPRDNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-hydroxy-3-methoxy-N-[(E)-[3-[3-(trifluoromethyl)phenoxy]phenyl]methyleneamino]benzamide
  • 4-hydroxy-3-methoxy-N-[(E)-[3-[3-(trifluoromethyl)phenoxy]benzylidene]amino]benzamide
  • 4-hydroxy-3-methoxy-N-[[3-[3-(trifluoromethyl)phenoxy]phenyl]methylideneamino]benzamide
  • 4-hydroxy-3-methoxy-N-[[3-[3-(trifluoromethyl)phenoxy]phenyl]methyleneamino]benzamide
  • 4-hydroxy-3-methoxy-N-[[3-[3-(trifluoromethyl)phenoxy]benzylidene]amino]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon receptor 477 aa 457 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0279 0.0245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0221 0.0188
Echinococcus multilocularis hyperpolarization activated cyclic 0.0038 0.0255 0.0222
Brugia malayi ion channel NompC 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.004 0.0279 0.0245
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0221 0.0188
Brugia malayi Cyclic-nucleotide gated cation channel 0.0038 0.0255 0.0222
Echinococcus multilocularis sodium channel protein 0.0035 0.0221 0.0188
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0221 1
Plasmodium vivax plasmepsin IV, putative 0.003 0.0165 0.5
Plasmodium falciparum plasmepsin X 0.003 0.0165 0.5
Onchocerca volvulus 0.0035 0.0221 0.3362
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0221 0.0188
Plasmodium vivax aspartyl protease, putative 0.003 0.0165 0.5
Plasmodium falciparum plasmepsin I 0.003 0.0165 0.5
Plasmodium falciparum plasmepsin V 0.003 0.0165 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0221 0.0188
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0121 0.1206 1
Schistosoma mansoni transient receptor potential channel 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0221 0.0188
Echinococcus multilocularis two pore calcium channel protein 1 0.0035 0.0221 0.0188
Trichomonas vaginalis beta-hexosaminidase, putative 0.0045 0.0332 0.2405
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Schistosoma mansoni transient receptor potential channel 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis serotonin receptor 0.0168 0.175 0.1721
Plasmodium falciparum plasmepsin IV 0.003 0.0165 0.5
Loa Loa (eye worm) voltage-gated calcium channel 0.0035 0.0221 0.0188
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0045 0.0332 0.0298
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0193 0.2042 0.2015
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0168 0.175 0.1721
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Schistosoma mansoni calcium-activated potassium channel 0.0035 0.0221 0.0188
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0038 0.0255 0.0222
Onchocerca volvulus Hexosaminidase D homolog 0.0045 0.0332 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.175 0.1721
Echinococcus granulosus bifunctional protein NCOAT 0.0883 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0035 0.0221 0.0188
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0221 0.0188
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.175 0.1721
Loa Loa (eye worm) aspartic protease BmAsp-2 0.003 0.0165 0.0132
Schistosoma mansoni vesicular amine transporter 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Plasmodium vivax aspartyl protease, putative 0.003 0.0165 0.5
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0035 0.0221 0.4853
Schistosoma mansoni cathepsin D (A01 family) 0.003 0.0165 0.0132
Echinococcus multilocularis ryanodine receptor 44f 0.0035 0.0221 0.0188
Echinococcus granulosus voltage gated potassium channel 0.004 0.0279 0.0245
Schistosoma mansoni voltage-gated ion channel 0.0035 0.0221 0.0188
Echinococcus multilocularis conserved hypothetical protein 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0035 0.0221 0.0188
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0255 0.1741
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0038 0.0255 0.0222
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0035 0.0221 0.0188
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0035 0.0221 0.0188
Schistosoma mansoni transient receptor potential channel 4 0.0035 0.0221 0.0188
Brugia malayi cation channel family protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0038 0.0255 0.0222
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0051 0.0401 0.0368
Brugia malayi aspartic protease BmAsp-2, identical 0.003 0.0165 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Plasmodium falciparum plasmepsin VIII, putative 0.003 0.0165 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0255 0.1741
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0221 0.0188
Brugia malayi hypothetical protein 0.003 0.0165 0.0132
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Toxoplasma gondii hypothetical protein 0.0035 0.0221 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0038 0.0255 0.0222
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0221 0.0188
Giardia lamblia Kinase, AGC AKT 0.0044 0.0318 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0038 0.0255 0.0222
Loa Loa (eye worm) ion channel NompC 0.0035 0.0221 0.0188
Echinococcus granulosus transient receptor potential gamma protein 0.0035 0.0221 0.0188
Brugia malayi olfactory channel protein osm-9 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0298
Loa Loa (eye worm) aspartyl protease 6 0.003 0.0165 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0121 0.1206 0.1176
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0221 0.0188
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0038 0.0255 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0221 0.0188
Echinococcus granulosus ryanodine receptor 44f 0.0035 0.0221 0.0188
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0221 0.0188
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0045 0.0332 0.0298
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0038 0.0255 0.0222
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0221 0.0188
Echinococcus multilocularis transfer RNA-Gly 0.0035 0.0221 0.0188
Echinococcus multilocularis calcium activated potassium channel 0.0035 0.0223 0.019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus multilocularis two pore calcium channel protein 2 0.0035 0.0221 0.0188
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) voltage-dependent calcium channel 0.0035 0.0221 0.0188
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0193 0.2042 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.0461 0.0429
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0221 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Brugia malayi hypothetical protein 0.003 0.0165 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0193 0.2042 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0035 0.0221 0.0188
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0056 0.0461 0.0429
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0035 0.0221 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0509 0.0476
Brugia malayi voltage-dependent calcium channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0121 0.1206 0.1176
Plasmodium falciparum plasmepsin IX 0.003 0.0165 0.5
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0193 0.2042 0.5
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0035 0.0221 0.0188
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0193 0.2042 0.2015
Schistosoma mansoni two-pore calcium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0035 0.0221 0.0188
Echinococcus granulosus two pore calcium channel protein 1 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage gated potassium channel 0.004 0.0279 0.0245
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0035 0.0221 0.0188
Plasmodium vivax aspartyl protease, putative 0.003 0.0165 0.5
Echinococcus granulosus voltage gated hydrogen channel 1 0.0035 0.0221 0.0188
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0289 0.0256
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Plasmodium falciparum plasmepsin VI 0.003 0.0165 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188
Echinococcus multilocularis shaker cognate 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0221 0.0188
Echinococcus granulosus hyperpolarization activated cyclic 0.0038 0.0255 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0401 0.0368
Schistosoma mansoni Hyaluronidase 0.0883 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0056 0.0461 0.0429
Schistosoma mansoni transient receptor potential channel 0.0035 0.0221 0.0188
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0509 0.0476
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0051 0.0401 0.0368
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0485 0.0452
Trichomonas vaginalis beta-hexosaminidase, putative 0.0121 0.1206 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0883 1 1
Echinococcus multilocularis bifunctional protein NCOAT 0.0883 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0279 0.0245
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Loa Loa (eye worm) hyaluronidase 0.0883 1 1
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0221 0.0188
Schistosoma mansoni beta-hexosaminidase B 0.0193 0.2042 0.2015
Brugia malayi Eukaryotic aspartyl protease family protein 0.003 0.0165 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0221 0.0188
Echinococcus granulosus beta hexosaminidase subunit beta 0.0193 0.2042 0.2015
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0132
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.003 0.0165 0.0132
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0193 0.2042 0.2015
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0035 0.0221 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0221 0.0188
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Toxoplasma gondii hypothetical protein 0.0035 0.0221 1
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0221 0.0188
Brugia malayi Pepsin A precursor 0.003 0.0165 0.0132
Plasmodium vivax plasmepsin V, putative 0.003 0.0165 0.5
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.003 0.0165 0.096
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0221 0.0188
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0165 0.5
Brugia malayi aspartic protease BmAsp-1, identical 0.003 0.0165 0.0132
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0221 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0221 0.0188
Schistosoma mansoni 60S ribosomal protein L21 0.0037 0.0245 0.0211
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0221 0.0188
Echinococcus granulosus hyperpolarization activated cyclic 0.0038 0.0255 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0035 0.0221 0.0188
Trichomonas vaginalis beta-hexosaminidase, putative 0.0121 0.1206 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0279 0.0245
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0221 0.3362
Loa Loa (eye worm) hypothetical protein 0.0168 0.175 0.1721
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0051 0.0401 0.0368
Plasmodium falciparum plasmepsin VII 0.003 0.0165 0.5
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0035 0.0221 0.5
Plasmodium falciparum plasmepsin II 0.003 0.0165 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0289 0.0256
Echinococcus multilocularis serotonin receptor 0.0168 0.175 0.1721
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0053 0.0427 0.0395
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0221 0.0188
Schistosoma mansoni cathepsin D (A01 family) 0.003 0.0165 0.0132
Echinococcus multilocularis hyperpolarization activated cyclic 0.0038 0.0255 0.0222
Trypanosoma brucei RNA helicase, putative 0.0056 0.0456 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0507 0.5663 0.5648
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0221 0.3362
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0221 0.0188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0221 1
Schistosoma mansoni hypothetical protein 0.0041 0.0289 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0279 0.0245
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0245
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0221 0.0188
Echinococcus granulosus sodium channel protein 0.0035 0.0221 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0165 0.0132
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0035 0.0221 0.0188
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0485 0.0452
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0035 0.0221 0.0188
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0509 0.0476
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0221 0.0188
Brugia malayi hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0245 0.0211
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.0461 0.0429
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0035 0.0221 0.0188
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0038 0.0255 0.0222
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0221 0.0188
Echinococcus granulosus two pore calcium channel protein 2 0.0035 0.0221 0.0188
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0221 0.0188
Loa Loa (eye worm) calcium channel 0.0035 0.0221 0.0188
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0193 0.2042 0.5
Plasmodium falciparum plasmepsin III 0.003 0.0165 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0375 0.4142 0.4121
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0221 0.0188
Echinococcus granulosus shaker cognate 0.0035 0.0221 0.0188
Schistosoma mansoni beta-hexosaminidase B 0.0193 0.2042 0.2015
Schistosoma mansoni ryanodine receptor related 0.0035 0.0221 0.0188
Echinococcus multilocularis potassium large conductance calcium activated 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0298
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0221 0.0188
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0035 0.0221 0.0188
Echinococcus granulosus sodium leak channel non selective protein 0.0035 0.0221 0.0188
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0509 0.0476
Echinococcus granulosus hypothetical protein 0.0035 0.0221 0.0188
Echinococcus granulosus potassium large conductance calcium activated 0.0035 0.0221 0.0188
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0255 0.0222
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0044 0.0318 0.0285
Schistosoma mansoni hypothetical protein 0.0056 0.0456 0.0423
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0035 0.0221 0.0188
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0165 0.5
Brugia malayi cation channel family protein 0.0035 0.0221 0.0188
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0038 0.0255 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.003 0.0165 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0038 0.0255 0.0222
Trichomonas vaginalis beta-hexosaminidase, putative 0.0121 0.1206 1
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0044 0.0318 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0255 0.0222
Schistosoma mansoni voltage-dependent calcium channel 0.0035 0.0221 0.0188
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0038 0.0255 0.0222
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0221 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0188
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0221 0.0188
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0221 0.0188
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0035 0.0221 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0221 0.0188
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0038 0.0255 0.0222
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0038 0.0255 0.0222
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0221 0.0188
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0221 0.0188
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0035 0.0221 0.4853
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0035 0.0221 0.0188
Echinococcus granulosus calcium activated potassium channel 0.0035 0.0223 0.019
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0038 0.0255 0.0222
Loa Loa (eye worm) aspartic protease BmAsp-1 0.003 0.0165 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0221 0.0188

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.9 uM Binding affinity for human Glucagon Receptor ChEMBL. 11543683
IC50 (binding) = 4.9 uM Binding affinity for human Glucagon Receptor ChEMBL. 11543683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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