Detailed information for compound 174636

Basic information

Technical information
  • TDR Targets ID: 174636
  • Name: 3-[(2R)-3-[4-(2-hydroxyethyl)piperazin-1-yl]- 2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl] benzenecarboximidamide
  • MW: 509.62 | Formula: C26H31N5O4S
  • H donors: 3 H acceptors: 4 LogP: 1.75 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCN1CCN(CC1)C(=O)[C@H](NS(=O)(=O)c1ccc2c(c1)cccc2)Cc1cccc(c1)C(=N)N
  • InChi: 1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1
  • InChiKey: SVQXGJDWUSQUPO-XMMPIXPASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2R)-3-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(2-naphthylsulfonylamino)-3-oxo-propyl]benzamidine
  • 3-[(2R)-3-[4-(2-hydroxyethyl)-1-piperazinyl]-2-(2-naphthalenylsulfonylamino)-3-oxopropyl]benzamidine
  • 3-[(2R)-3-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxo-propyl]benzenecarboximidamide
  • 3-[(2R)-3-[4-(2-hydroxyethyl)piperazino]-3-keto-2-(2-naphthylsulfonylamino)propyl]benzamidine
  • 3-[(2R)-3-[4-(2-hydroxyethyl)-1-piperazinyl]-2-(2-naphthylsulfonylamino)-3-oxopropyl]benzamidine
  • 3-[(2R)-3-[4-(2-hydroxyethyl)piperazin-1-yl]-3-keto-2-(2-naphthylsulfonylamino)propyl]benzamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Thrombin Starlite/ChEMBL References
Bos taurus Trypsin II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster Jonah 65Aiii Trypsin II   247 aa 238 aa 32.8 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Trypsin II   247 aa 251 aa 27.1 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Trypsin II   247 aa 262 aa 31.3 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Trypsin II   247 aa 223 aa 33.2 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Trypsin II   247 aa 287 aa 27.2 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Trypsin II   247 aa 240 aa 32.9 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Trypsin II   247 aa 254 aa 33.1 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 217 aa 23.0 %
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Trypsin II   247 aa 224 aa 34.4 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Trypsin II   247 aa 263 aa 32.7 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Trypsin II   247 aa 205 aa 30.2 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Trypsin II   247 aa 224 aa 29.5 %
Echinococcus granulosus glycoprotein Antigen 5 Trypsin II   247 aa 301 aa 22.3 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Trypsin II   247 aa 242 aa 29.8 %
Echinococcus multilocularis glycoprotein Antigen 5 Trypsin II   247 aa 302 aa 23.2 %
Echinococcus granulosus enteropeptidase Trypsin II   247 aa 227 aa 26.4 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 239 aa 22.2 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Trypsin II   247 aa 233 aa 28.3 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Trypsin II   247 aa 234 aa 31.2 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Trypsin II   247 aa 213 aa 24.9 %
Schistosoma japonicum Enteropeptidase, putative Trypsin II   247 aa 267 aa 26.2 %
Onchocerca volvulus Trypsin II   247 aa 257 aa 26.5 %
Echinococcus multilocularis Mastin Trypsin II   247 aa 306 aa 25.5 %
Echinococcus multilocularis transmembrane protease serine 3 Trypsin II   247 aa 233 aa 34.8 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Trypsin II   247 aa 238 aa 30.2 %
Echinococcus granulosus Mastin Trypsin II   247 aa 306 aa 25.2 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 302 aa 25.5 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Trypsin II   247 aa 212 aa 23.6 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Trypsin II   247 aa 236 aa 30.1 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 247 aa 34.0 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Trypsin II   247 aa 258 aa 26.4 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Trypsin II   247 aa 208 aa 27.4 %
Echinococcus multilocularis enteropeptidase Trypsin II   247 aa 227 aa 26.0 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Trypsin II   247 aa 257 aa 28.8 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Trypsin II   247 aa 244 aa 37.3 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 217 aa 23.0 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Trypsin II   247 aa 248 aa 28.6 %
Drosophila melanogaster Jonah 65Aii Trypsin II   247 aa 237 aa 35.4 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Trypsin II   247 aa 255 aa 29.4 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Trypsin II   247 aa 257 aa 33.5 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Trypsin II   247 aa 246 aa 24.8 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Trypsin II   247 aa 298 aa 24.5 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Trypsin II   247 aa 250 aa 31.6 %
Echinococcus granulosus transmembrane protease serine 3 Trypsin II   247 aa 233 aa 34.3 %
Drosophila melanogaster Jonah 99Ci Trypsin II   247 aa 268 aa 32.5 %
Onchocerca volvulus Trypsin II   247 aa 258 aa 22.9 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Trypsin II   247 aa 303 aa 24.8 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Trypsin II   247 aa 249 aa 23.7 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 287 aa 27.2 %
Drosophila melanogaster Jonah 66Ci Trypsin II   247 aa 237 aa 30.4 %
Drosophila melanogaster Spatzle-Processing Enzyme Trypsin II   247 aa 269 aa 27.5 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Trypsin II   247 aa 203 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RGC/RGC protein kinase 0.0198 0.1824 0.1824
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0052 0.0262 0.0444
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0134 0.0134
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Echinococcus granulosus retinal guanylyl cyclase 2 0.0198 0.1824 0.3094
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Trypanosoma brucei Pseudokinase, putative 0.0198 0.1824 0.8491
Entamoeba histolytica cell division protein kinase 2, putative 0.022 0.2055 0.32
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.0262 0.0262
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Schistosoma mansoni serine/threonine protein kinase 0.022 0.2055 0.3503
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0174 0.0296
Onchocerca volvulus 0.0577 0.5867 0.6203
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0198 0.1824 0.3109
Brugia malayi hypothetical protein 0.0198 0.1824 0.1824
Echinococcus multilocularis insulin receptor 0.0198 0.1824 0.3109
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Brugia malayi Variant SH3 domain containing protein 0.0379 0.3749 0.3749
Schistosoma mansoni serine/threonine RGC 0.0198 0.1824 0.3109
Onchocerca volvulus 0.0577 0.5867 0.6203
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0106 0.0035
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus granulosus protein kinase 0.0198 0.1824 0.3094
Plasmodium falciparum protein kinase, putative 0.0198 0.1824 0.8709
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0577 0.5867 1
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus multilocularis SH2 motif 0.0379 0.3749 0.639
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Trichomonas vaginalis cyclin B, putative 0.0052 0.0262 0.0831
Echinococcus multilocularis cyclin dependent kinase 1 0.022 0.2055 0.3503
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0379 0.3749 0.639
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus granulosus cyclin b3 0.0052 0.0262 0.0444
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus activin receptor type 0.0201 0.1852 0.3142
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0198 0.1824 0.8817
Echinococcus multilocularis SH2 motif 0.0379 0.3749 0.639
Echinococcus multilocularis Immunoglobulin 0.0047 0.0212 0.0361
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0379 0.3749 0.6359
Plasmodium falciparum tyrosine kinase-like protein 0.0198 0.1824 0.8709
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) cyclin domain-containing protein 0.0243 0.2305 0.2305
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0577 0.5867 1
Echinococcus granulosus cyclins 0.0052 0.0262 0.0444
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis transfer RNA-Thr 0.0198 0.1824 0.3109
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus carbonic anhydrase II 0.0119 0.0979 0.166
Entamoeba histolytica SH2 domain containing protein 0.0379 0.3749 0.6221
Giardia lamblia Kinase, CMGC CDK 0.022 0.2055 1
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0198 0.1824 0.3094
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0198 0.1824 0.1824
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0201 0.1852 0.3142
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0198 0.1824 0.1824
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0198 0.1824 0.3094
Echinococcus granulosus retinal guanylyl cyclase 2 0.0198 0.1824 0.3094
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Echinococcus multilocularis tyrosine protein kinase 0.0198 0.1824 0.3109
Brugia malayi cytokine inducible SH2-containing protein 5 0.0379 0.3749 0.3749
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica hypothetical protein 0.0207 0.1921 0.296
Echinococcus multilocularis protein KINase family member (kin 25) 0.0198 0.1824 0.3109
Brugia malayi Furin-like cysteine rich region family protein 0.0198 0.1824 0.1824
Schistosoma mansoni tensin 0.0379 0.3749 0.639
Echinococcus multilocularis FL cytokine receptor 0.0198 0.1824 0.3109
Trypanosoma cruzi cdc2-related kinase 1 0.022 0.2055 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0212
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus cyclins 0.0052 0.0262 0.0444
Echinococcus granulosus integrin linked protein kinase 0.0198 0.1824 0.3094
Schistosoma mansoni growth factor receptor-bound protein 0.0379 0.3749 0.639
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.0262 0.0262
Loa Loa (eye worm) SH2 domain-containing protein 0.0379 0.3749 0.3749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0198 0.1824 0.3109
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0964 1 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0379 0.3749 0.639
Echinococcus multilocularis tyrosine protein kinase shark 0.0577 0.5867 1
Schistosoma mansoni vesicular amine transporter 0.005 0.024 0.0409
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Echinococcus granulosus epidermal growth factor receptor 0.0198 0.1824 0.3094
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0577 0.5867 0.9952
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0134 0.0229
Trichomonas vaginalis TK family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Echinococcus granulosus tyrosine protein kinase csk 0.0198 0.1824 0.3094
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni cyclin B 0.0076 0.0521 0.0888
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Echinococcus granulosus p2X purinoceptor 4 0.0378 0.3745 0.6353
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Raf kinase 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0577 0.5867 0.9952
Onchocerca volvulus 0.0106 0.0842 0.089
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0577 0.5867 0.9952
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0198 0.1824 0.3094
Loa Loa (eye worm) SRC-1 0.0577 0.5867 0.5867
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0212
Onchocerca volvulus 0.0379 0.3749 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) protein kinase domain-containing protein 0.0198 0.1824 0.1824
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0379 0.3749 0.639
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0198 0.1824 0.1824
Echinococcus granulosus tyrosine protein kinase Srms 0.0577 0.5867 0.9952
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Onchocerca volvulus 0.0198 0.1824 0.1928
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Trichomonas vaginalis cyclin B, putative 0.0076 0.0521 0.2156
Echinococcus multilocularis epidermal growth factor receptor 0.0198 0.1824 0.3109
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0521 0.0521
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0198 0.1824 0.3109
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0577 0.5867 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0577 0.5867 1
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni tensin-related 0.0379 0.3749 0.639
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0198 0.1824 0.3094
Echinococcus multilocularis p2X purinoceptor 4 0.0378 0.3745 0.6384
Loa Loa (eye worm) TK/EPH protein kinase 0.0198 0.1824 0.1824
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0198 0.1824 0.8817
Schistosoma mansoni hypothetical protein 0.0379 0.3749 0.639
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Schistosoma mansoni nck2/grb4 0.0379 0.3749 0.639
Loa Loa (eye worm) TK protein kinase 0.021 0.1953 0.1953
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Onchocerca volvulus 0.0379 0.3749 0.3963
Echinococcus multilocularis tyrosine protein kinase csk 0.0198 0.1824 0.3109
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0379 0.3749 0.3749
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0979 0.1668
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0047 0.0212 0.0361
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Onchocerca volvulus 0.0198 0.1824 0.1928
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis cyclin b3 0.0052 0.0262 0.0446
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0063 0.0377 0.0377
Echinococcus multilocularis integrin linked protein kinase 0.0198 0.1824 0.3109
Leishmania major hypothetical protein, conserved 0.0198 0.1824 0.8491
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus activated cdc42 kinase 1 0.0198 0.1824 0.3094
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0521 0.0521
Echinococcus granulosus natriuretic peptide receptor 1 0.0198 0.1824 0.3094
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni protein kinase 0.0201 0.1852 0.3157
Schistosoma mansoni P2X receptor subunit 0.0378 0.3745 0.6384
Echinococcus granulosus cyclin B3 1 0.0052 0.0262 0.0444
Schistosoma mansoni nephrin 0.0059 0.0341 0.0581
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0198 0.1824 0.1824
Echinococcus granulosus tyrosine protein kinase HCK 0.0198 0.1824 0.3094
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Echinococcus multilocularis protein kinase 0.0198 0.1824 0.3109
Echinococcus granulosus SH2 domain containing adapter protein F 0.0379 0.3749 0.6359
Loa Loa (eye worm) TK/CSK protein kinase 0.0198 0.1824 0.1824
Trypanosoma brucei protein kinase, putative 0.0201 0.1852 0.8676
Schistosoma mansoni signal transduction protein lnk-related 0.0379 0.3749 0.639
Schistosoma mansoni protein kinase 0.0201 0.1852 0.3157
Echinococcus granulosus tyrosine protein kinase Fyn 0.0577 0.5867 0.9952
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Trichomonas vaginalis CMGC family protein kinase 0.022 0.2055 1
Trypanosoma cruzi cdc2-related kinase 1 0.022 0.2055 1
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0198 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0056 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0262 0.0831
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0198 0.1824 0.1928
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) TK/ROR protein kinase 0.0232 0.218 0.218
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Echinococcus multilocularis p2X purinoceptor 4 0.0378 0.3745 0.6384
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) TK/INSR protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0577 0.5867 0.9952
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus granulosus tyrosine protein kinase pr2 0.0198 0.1824 0.3094
Echinococcus multilocularis cyclin dependent kinase 0.022 0.2055 0.3503
Loa Loa (eye worm) TK/ABL protein kinase 0.0577 0.5867 0.5867
Trypanosoma brucei carbonic anhydrase-like protein 0.0119 0.0979 0.2982
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0379 0.3749 0.639
Echinococcus multilocularis tensin 0.0379 0.3749 0.639
Entamoeba histolytica cell division protein kinase 2, putative 0.022 0.2055 0.32
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0106 0.0035
Echinococcus multilocularis tyrosine protein kinase csk 0.0198 0.1824 0.3109
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Onchocerca volvulus 0.0198 0.1824 0.1928
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni protein kinase 0.0201 0.1852 0.3157
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0379 0.3749 0.639
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Trichomonas vaginalis CMGC family protein kinase 0.022 0.2055 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0198 0.1824 0.3109
Entamoeba histolytica tyrosin kinase, putative 0.0198 0.1824 0.2787
Echinococcus granulosus tyrosine protein kinase Lyn 0.058 0.5895 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0379 0.3749 0.6359
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Brugia malayi protein-tyrosine kinase 0.0577 0.5867 0.5867
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis peroxidasin 0.0037 0.0097 0.0166
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Schistosoma mansoni cell adhesion molecule 0.0063 0.0377 0.0642
Echinococcus multilocularis kinase suppressor of Ras 1 0.0198 0.1824 0.3109
Echinococcus multilocularis 0.0379 0.3749 0.639
Echinococcus granulosus tyrosine protein kinase Src42A 0.0577 0.5867 0.9952
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Echinococcus granulosus suppressor of cytokine signaling 7 0.0379 0.3749 0.6359
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Brugia malayi Protein kinase domain containing protein 0.0388 0.3846 0.3846
Trichomonas vaginalis AGC family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0577 0.5867 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis c src tyrosine kinase 0.0577 0.5867 1
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0379 0.3749 0.639
Schistosoma mansoni growth factor receptor-bound protein 0.0379 0.3749 0.639
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0198 0.1824 0.2787
Echinococcus granulosus cyclin B 0.0076 0.0521 0.0884
Echinococcus granulosus hypothetical protein 0.0379 0.3749 0.6359
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis roundabout 2 0.0075 0.0506 0.0862
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Schistosoma mansoni SH2A 0.0379 0.3749 0.639
Trypanosoma brucei cdc2-related kinase 3 0.022 0.2055 1
Brugia malayi SH2 domain containing protein 0.0577 0.5867 0.5867
Echinococcus granulosus activated cdc42 kinase 1 0.0198 0.1824 0.3094
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0134 0.0228
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Echinococcus granulosus tyrosine protein kinase csk 0.0198 0.1824 0.3094
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.022 0.2055 0.3487
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0577 0.5867 1
Echinococcus multilocularis cyclin dependent kinase 1 0.022 0.2055 0.3503
Echinococcus granulosus roundabout 2 0.0075 0.0506 0.0858
Echinococcus multilocularis tyrosine kinase 0.0577 0.5867 1
Echinococcus granulosus neuroglian 0.0059 0.0341 0.0578
Trichomonas vaginalis protein tyrosine kinase, putative 0.0198 0.1824 0.8817
Echinococcus granulosus SH2 motif 0.0379 0.3749 0.6359
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Echinococcus granulosus tyrosine protein kinase Blk 0.0577 0.5867 0.9952
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni hypothetical protein 0.0379 0.3749 0.639
Brugia malayi bone morphogenetic protein type 1 receptor 0.0198 0.1824 0.1824
Trypanosoma cruzi protein kinase, putative 0.0198 0.1824 0.8491
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0379 0.3749 0.639
Loa Loa (eye worm) SH2 domain-containing protein 0.0379 0.3749 0.3749
Loa Loa (eye worm) TK protein kinase 0.0577 0.5867 0.5867
Brugia malayi Tyrosine-protein kinase PR2 0.0198 0.1824 0.1824
Echinococcus multilocularis cyclin B 0.0076 0.0521 0.0888
Onchocerca volvulus 0.0379 0.3749 0.3963
Brugia malayi Protein kinase domain containing protein 0.0577 0.5867 0.5867
Brugia malayi C-terminal src kinase protein 1 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.021 0.1953 0.3329
Trichomonas vaginalis cyclins, putative 0.0076 0.0521 0.2156
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Onchocerca volvulus 0.0198 0.1824 0.1928
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Onchocerca volvulus 0.0379 0.3749 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) hypothetical protein 0.0075 0.0506 0.0506
Echinococcus granulosus cyclin dependent kinase 0.022 0.2055 0.3487
Onchocerca volvulus 0.0198 0.1824 0.1928
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0198 0.1824 0.3109
Schistosoma mansoni adapter molecule crk 0.0379 0.3749 0.639
Echinococcus multilocularis protein kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis raf serine:threonine protein kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Brugia malayi Protein kinase domain containing protein 0.0577 0.5867 0.5867
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0379 0.3749 0.639
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Echinococcus granulosus Immunoglobulin 0.0047 0.0212 0.0359
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0198 0.1824 0.3109
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Echinococcus multilocularis SH2 domain containing protein 7 0.0379 0.3749 0.639
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0198 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0379 0.3749 0.3749
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1824 0.3109
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0198 0.1824 0.3109
Echinococcus granulosus retinal guanylyl cyclase 2 0.0198 0.1824 0.3094
Giardia lamblia Kinase, NEK 0.0198 0.1824 0.8709
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0198 0.1824 0.1824
Schistosoma mansoni shc transforming protein 0.0379 0.3749 0.639
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.022 0.2055 0.2055
Brugia malayi Protein kinase domain containing protein 0.022 0.2055 0.2055
Brugia malayi RhoGAP domain containing protein 0.0379 0.3749 0.3749
Brugia malayi SH2 domain containing protein 0.0577 0.5867 0.5867
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) serine/threonine protein kinase 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein kinase Srms 0.0577 0.5867 1
Trichomonas vaginalis cyclin D, putative 0.0052 0.0262 0.0831
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0198 0.1824 0.3109
Loa Loa (eye worm) SH2 domain-containing protein 0.0379 0.3749 0.3749
Trypanosoma brucei Flagellum attachment zone protein 20 0.0198 0.1824 0.8491
Echinococcus multilocularis tyrosine protein kinase Abl 0.0577 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Trypanosoma cruzi protein kinase, putative 0.0198 0.1824 0.8491
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Onchocerca volvulus 0.0379 0.3749 0.3963
Toxoplasma gondii STE kinase 0.0198 0.1824 0.8799
Echinococcus granulosus kinase suppressor of Ras 1 0.0198 0.1824 0.3094
Echinococcus multilocularis NCK adaptor protein 0.0379 0.3749 0.639
Echinococcus granulosus cyclins 0.0052 0.0262 0.0444
Echinococcus multilocularis carbonic anhydrase II 0.0119 0.0979 0.1668
Loa Loa (eye worm) hypothetical protein 0.0075 0.0506 0.0506
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis tyrosine protein kinase pr2 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus granulosus tyrosine protein kinase Src64B 0.0577 0.5867 0.9952
Entamoeba histolytica ankyrin repeat protein 0.0198 0.1824 0.2787
Echinococcus multilocularis protein tyrosine kinase 0.0386 0.3822 0.6515
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0379 0.3749 0.639
Echinococcus multilocularis tyrosine protein kinase HCK 0.0198 0.1824 0.3109
Onchocerca volvulus 0.0577 0.5867 0.6203
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Trichomonas vaginalis cyclin B, putative 0.0076 0.0521 0.2156
Plasmodium falciparum protein kinase, putative 0.0198 0.1824 0.8709
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Giardia lamblia Protein 21.1 0.0198 0.1824 0.8709
Echinococcus granulosus peroxidasin 0.0037 0.0097 0.0165
Brugia malayi Variant SH3 domain containing protein 0.0379 0.3749 0.3749
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0379 0.3749 0.6359
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.0207 0.1921 0.296
Brugia malayi Cyclin, N-terminal domain containing protein 0.0243 0.2305 0.2305
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0201 0.1852 0.3157
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0379 0.3749 0.3963
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Brugia malayi Receptor family ligand binding region containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0379 0.3749 0.639
Loa Loa (eye worm) TK/FER protein kinase 0.0198 0.1824 0.1824
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Schistosoma mansoni vav2 0.0379 0.3749 0.639
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0379 0.3749 0.3749
Echinococcus granulosus tyrosine protein kinase ABL1 0.0577 0.5867 0.9952
Trypanosoma cruzi cdc2-related kinase 3 0.022 0.2055 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0198 0.1824 0.1824
Schistosoma mansoni ephrin receptor 0.0198 0.1824 0.3109
Brugia malayi Variant SH3 domain containing protein 0.0379 0.3749 0.3749
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0198 0.1824 0.3109
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0201 0.1852 0.8676
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0198 0.1824 0.1824
Brugia malayi Peroxidasin 0.0037 0.0097 0.0097
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica serine/threonine kinase, putative 0.0198 0.1824 0.2787
Trichomonas vaginalis cyclin B3, putative 0.0052 0.0262 0.0831
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0379 0.3749 0.639
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0198 0.1824 0.8799
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0134 0.0134
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Brugia malayi cell division control protein 2 homolog 0.022 0.2055 0.2055
Loa Loa (eye worm) hypothetical protein 0.0198 0.1824 0.1824
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Brugia malayi Protein kinase domain containing protein 0.0577 0.5867 0.5867
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0377 0.0639
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Plasmodium vivax protein kinase Crk2 0.022 0.2055 1
Trypanosoma cruzi cdc2-related kinase 3 0.022 0.2055 1
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0198 0.1824 0.8817
Echinococcus granulosus cyclins 0.0052 0.0262 0.0444
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Plasmodium falciparum tyrosine kinase-like protein 0.0198 0.1824 0.8709
Echinococcus granulosus c src tyrosine kinase 0.0577 0.5867 0.9952
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Brugia malayi SRC-1 0.0577 0.5867 0.5867
Entamoeba histolytica hypothetical protein 0.0207 0.1921 0.296
Schistosoma mansoni suppressor of cytokine signaling 0.0379 0.3749 0.639
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0577 0.5867 0.5867
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0212
Entamoeba histolytica receptor protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi hypothetical protein 0.0379 0.3749 0.3749
Trichomonas vaginalis cyclin B, putative 0.0076 0.0521 0.2156
Echinococcus multilocularis signal transduction protein lnk realted 0.0379 0.3749 0.639
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0174 0.0296
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0577 0.5867 1
Echinococcus granulosus p2X purinoceptor 4 0.0378 0.3745 0.6353
Echinococcus granulosus receptor type guanylyl cyclase 0.0198 0.1824 0.3094
Onchocerca volvulus 0.0577 0.5867 0.6203
Schistosoma mansoni hypothetical protein 0.0198 0.1824 0.3109
Echinococcus granulosus epidermal growth factor receptor 0.0198 0.1824 0.3094
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni P2X receptor subunit 0.0378 0.3745 0.6384
Echinococcus multilocularis epidermal growth factor receptor 0.0198 0.1824 0.3109
Onchocerca volvulus 0.0379 0.3749 0.3963
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Echinococcus granulosus tyrosine protein kinase csk 0.0198 0.1824 0.3094
Loa Loa (eye worm) carbonic anhydrase 3 0.0119 0.0979 0.0979
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0198 0.1824 0.3094
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Echinococcus multilocularis growth factor receptor bound protein 2 0.0379 0.3749 0.639
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0052 0.0262 0.0446
Onchocerca volvulus 0.0703 0.7211 0.7624
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0198 0.1824 0.1928
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TK/FAK protein kinase 0.0388 0.3846 0.3846
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.0979 0.0979
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0201 0.1852 0.8676
Echinococcus multilocularis activin receptor type 0.0201 0.1852 0.3157
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Schistosoma mansoni protein tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Loa Loa (eye worm) RGC/RGC protein kinase 0.0198 0.1824 0.1824
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0979 0.0979
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Echinococcus granulosus tyrosine protein kinase Src42A 0.0379 0.3749 0.6359
Schistosoma mansoni tyrosine kinase 0.0226 0.2118 0.361
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0381 0.3777 0.6272
Leishmania major protein kinase, putative 0.0201 0.1852 0.8676
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0198 0.1824 0.3094
Brugia malayi Protein kinase domain containing protein 0.0577 0.5867 0.5867
Trichomonas vaginalis cyclin D, putative 0.0052 0.0262 0.0831
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0379 0.3749 0.3749
Brugia malayi Tensin 0.0379 0.3749 0.3749
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis tyrosine protein kinase csk 0.0198 0.1824 0.3109
Echinococcus multilocularis tensin 0.0379 0.3749 0.639
Echinococcus granulosus raf serine:threonine protein kinase 0.0198 0.1824 0.3094
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0198 0.1824 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Echinococcus granulosus NCK adaptor protein 0.0379 0.3749 0.6359
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus granulosus tyrosine kinase 0.0577 0.5867 0.9952
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Brugia malayi tRNA modification GTPase TrmE family protein 0.0379 0.3749 0.3749
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Trichomonas vaginalis protein kinase atn1, putative 0.0198 0.1824 0.8817
Toxoplasma gondii protein kinase domain-containing protein 0.0198 0.1824 0.8799
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0198 0.1824 0.3094
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Trichomonas vaginalis cyclins, putative 0.0076 0.0521 0.2156
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0198 0.1824 0.8817
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Trichomonas vaginalis CMGC family protein kinase 0.022 0.2055 1
Giardia lamblia Kinase, NEK 0.0198 0.1824 0.8709
Schistosoma mansoni cyclins 0.0052 0.0262 0.0446
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0201 0.1852 0.8946
Echinococcus granulosus tyrosine kinase 0.0198 0.1824 0.3094
Schistosoma mansoni ephrin receptor 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni tyrosine kinase 0.0386 0.3822 0.6515
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Brugia malayi Variant SH3 domain containing protein 0.0379 0.3749 0.3749
Echinococcus granulosus p2X purinoceptor 4 0.0378 0.3745 0.6353
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Giardia lamblia Kinase 0.0198 0.1824 0.8709
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Schistosoma mansoni P2X receptor subunit 0.0378 0.3745 0.6384
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) STAT protein 0.0379 0.3749 0.3749
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus granulosus twitchin 0.0062 0.0369 0.0626
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0201 0.1852 0.8676
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis tyrosine protein kinase Blk 0.0577 0.5867 1
Schistosoma mansoni tyrosine kinase 0.0577 0.5867 1
Trichomonas vaginalis STE family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.022 0.2055 0.2055
Brugia malayi Sex muscle abnormal protein 5 0.0379 0.3749 0.3749
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0379 0.3749 0.6359
Schistosoma mansoni P2X receptor subunit 0.0378 0.3745 0.6384
Echinococcus multilocularis N chimaerin 0.0379 0.3749 0.639
Brugia malayi hypothetical protein 0.0047 0.0212 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.022 0.2055 0.3503
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0379 0.3749 0.6359
Entamoeba histolytica tyrosin kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0212
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.022 0.2055 0.2055
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0198 0.1824 0.1824
Echinococcus multilocularis tyrosine protein kinase csk 0.0198 0.1824 0.3109
Echinococcus granulosus fibroblast growth factor receptor 4 0.0198 0.1824 0.3094
Brugia malayi Immunoglobulin I-set domain containing protein 0.021 0.1953 0.1953
Onchocerca volvulus 0.0198 0.1824 0.1928
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0379 0.3749 0.639
Echinococcus multilocularis SH2 motif 0.0379 0.3749 0.639
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni tensin 0.0379 0.3749 0.639
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0198 0.1824 0.3109
Echinococcus multilocularis SHC transforming protein 3 0.0379 0.3749 0.639
Onchocerca volvulus Tyrosine kinase homolog 0.0913 0.9458 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0979 0.1668
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) TK/EGFR protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.0198 0.1824 0.2787
Trichomonas vaginalis cyclins, putative 0.0076 0.0521 0.2156
Echinococcus granulosus SH2 motif 0.0379 0.3749 0.6359
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase, putative 0.0207 0.1921 0.296
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0198 0.1824 0.3094
Loa Loa (eye worm) TK/Met protein kinase 0.0198 0.1824 0.1824
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Brugia malayi STAT protein, DNA binding domain containing protein 0.0379 0.3749 0.3749
Entamoeba histolytica protein kinase domain containing protein 0.0201 0.1852 0.2837
Echinococcus multilocularis p2X purinoceptor 4 0.0378 0.3745 0.6384
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Trichomonas vaginalis cyclins, putative 0.0076 0.0521 0.2156
Echinococcus multilocularis activated cdc42 kinase 1 0.0198 0.1824 0.3109
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0212 0.0212
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Onchocerca volvulus 0.0198 0.1824 0.1928
Schistosoma mansoni suppressor of cytokine signaling 0.0379 0.3749 0.639
Schistosoma mansoni tensin-related 0.0379 0.3749 0.639
Brugia malayi hypothetical protein 0.0577 0.5867 0.5867
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Entamoeba histolytica ankyrin repeat protein 0.0198 0.1824 0.2787
Echinococcus granulosus cyclin dependent kinase 5 0.022 0.2055 0.3487
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0198 0.1824 0.3094
Loa Loa (eye worm) hypothetical protein 0.0217 0.2027 0.2027
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0198 0.1824 0.3094
Loa Loa (eye worm) TK/ACK protein kinase 0.0198 0.1824 0.1824
Plasmodium falciparum protein kinase 5 0.022 0.2055 1
Entamoeba histolytica tyrosin kinase, putative 0.0198 0.1824 0.2787
Entamoeba histolytica protein kinase, putative 0.0381 0.3777 0.6272
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus cyclin dependent kinase 1 0.022 0.2055 0.3487
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0379 0.3749 0.3749
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) TK/FER protein kinase 0.0577 0.5867 0.5867
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0577 0.5867 1
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0198 0.1824 0.3109
Echinococcus multilocularis ephrin type A receptor 4 A 0.0198 0.1824 0.3109
Echinococcus granulosus tyrosine protein kinase shark 0.0577 0.5867 0.9952
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0379 0.3749 0.3963
Onchocerca volvulus 0.0198 0.1824 0.1928
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0198 0.1824 0.3094
Schistosoma mansoni cyclin B3 0.0052 0.0262 0.0446
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0207 0.1921 0.296
Trichomonas vaginalis cyclins, putative 0.0052 0.0262 0.0831
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0198 0.1824 0.1824
Schistosoma mansoni GTPase activating protein 0.0379 0.3749 0.639
Loa Loa (eye worm) hypothetical protein 0.0577 0.5867 0.5867
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) RGC/RGC protein kinase 0.0198 0.1824 0.1824
Echinococcus multilocularis cyclins 0.0052 0.0262 0.0446
Onchocerca volvulus 0.0577 0.5867 0.6203
Echinococcus granulosus suppressor of cytokine signaling 6 0.0379 0.3749 0.6359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0078 0.0078
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0577 0.5867 0.9952
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.022 0.2055 1
Echinococcus multilocularis tyrosine kinase 0.0198 0.1824 0.3109
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0379 0.3749 0.3749
Trichomonas vaginalis cyclin A, putative 0.0076 0.0521 0.2156
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus multilocularis natriuretic peptide receptor 1 0.0198 0.1824 0.3109
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.021 0.1953 0.3313
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus defective proboscis extension response 0.0047 0.0212 0.0359
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus expressed conserved protein 0.0379 0.3749 0.6359
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0577 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0953 0.0953
Brugia malayi Protein kinase domain containing protein 0.0577 0.5867 0.5867
Leishmania major protein kinase, putative 0.0198 0.1824 0.8491
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0198 0.1824 0.8491
Echinococcus granulosus growth factor receptor bound protein 2 0.0379 0.3749 0.6359
Brugia malayi integrin-linked kinase 0.0198 0.1824 0.1824
Loa Loa (eye worm) TK protein kinase 0.0198 0.1824 0.1824
Echinococcus multilocularis heat shock protein 70 0.0198 0.1824 0.3109
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0198 0.1824 0.3109
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0379 0.3749 0.3749
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0577 0.5867 1
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0076 0.0521 0.0521
Brugia malayi Protein kinase domain containing protein 0.022 0.2051 0.2051
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0198 0.1824 0.8799
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.022 0.2055 1
Echinococcus granulosus signal transduction protein lnk realted 0.0379 0.3749 0.6359
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.022 0.2055 1
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0577 0.5867 1
Echinococcus granulosus protein tyrosine kinase 0.0386 0.3822 0.6484
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus granulosus SH2 domain containing protein 7 0.0379 0.3749 0.6359
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0047 0.0212 0.0361
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0577 0.5867 1
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0198 0.1824 0.3109
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0212
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0198 0.1824 0.3109
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Loa Loa (eye worm) TK/DDR protein kinase 0.0198 0.1824 0.1824
Entamoeba histolytica cyclin, putative 0.0076 0.0521 0.0463
Echinococcus granulosus ephrin type A receptor 4 A 0.0198 0.1824 0.3094
Echinococcus multilocularis Immunoglobulin 0.0047 0.0212 0.0361
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.0212 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis cyclin B, putative 0.0076 0.0521 0.2156
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica receptor protein kinase, putative 0.0198 0.1824 0.2787
Plasmodium falciparum protein kinase, putative 0.0201 0.1852 0.8867
Entamoeba histolytica tyrosin kinase, putative 0.0198 0.1824 0.2787
Echinococcus multilocularis cyclin dependent kinase 5 0.022 0.2055 0.3503
Echinococcus granulosus cyclins 0.0052 0.0262 0.0444
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0119 0.0979 0.0979
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Schistosoma mansoni tensin 0.0379 0.3749 0.639
Entamoeba histolytica tyrosine kinase, putative 0.0198 0.1824 0.2787
Loa Loa (eye worm) hypothetical protein 0.0037 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0117 0.0953 0.0953
Toxoplasma gondii protein kinase 0.0198 0.1824 0.8799
Entamoeba histolytica hypothetical protein, conserved 0.0198 0.1824 0.2787
Onchocerca volvulus 0.0577 0.5867 0.6203
Brugia malayi hypothetical protein 0.0198 0.1824 0.1824
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus granulosus SHC transforming protein 3 0.0379 0.3749 0.6359
Schistosoma mansoni tyrosine protein kinase 0.0198 0.1824 0.3109
Giardia lamblia Kinase, CMGC CDK 0.022 0.2055 1
Brugia malayi Trypsin family protein 0.0117 0.0953 0.0953
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Onchocerca volvulus 0.0117 0.0953 0.1007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0577 0.5867 0.9952
Entamoeba histolytica cysteine surface protein, putative 0.0198 0.1824 0.2787
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0379 0.3749 0.639
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0047 0.0212 0.0361
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0577 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0521 0.0521
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0198 0.1824 0.2787
Trypanosoma brucei cdc2-related kinase 1 0.022 0.2055 1
Echinococcus granulosus tensin 0.0379 0.3749 0.6359
Brugia malayi Guanylyl cyclase protein 23 0.0198 0.1824 0.1824
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Echinococcus granulosus tyrosine kinase 0.0577 0.5867 0.9952
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0379 0.3749 0.639
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Entamoeba histolytica protein kinase, putative 0.0198 0.1824 0.2787
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.0953 0.1624
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.1824 0.8817
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Echinococcus multilocularis neuroglian 0.0059 0.0341 0.0581
Giardia lamblia G2/mitotic-specific cyclin B 0.0076 0.0521 0.1446
Brugia malayi SH2 domain containing protein 0.0379 0.3749 0.3749
Schistosoma mansoni protein kinase 0.0198 0.1824 0.3109
Onchocerca volvulus 0.0198 0.1824 0.1928
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787
Echinococcus multilocularis cyclin B3 1 0.0052 0.0262 0.0446
Loa Loa (eye worm) hypothetical protein 0.0379 0.3749 0.3749
Echinococcus granulosus insulin receptor 0.0198 0.1824 0.3094
Brugia malayi Protein kinase domain containing protein 0.0198 0.1824 0.1824
Echinococcus multilocularis receptor type guanylyl cyclase 0.0198 0.1824 0.3109
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0577 0.5867 1
Onchocerca volvulus 0.0076 0.0521 0.0551
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0577 0.5867 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0979 0.2982
Echinococcus granulosus tyrosine protein kinase 0.0198 0.1824 0.3094
Trichomonas vaginalis TKL family protein kinase 0.0198 0.1824 0.8817
Schistosoma mansoni tyrosine kinase 0.0198 0.1824 0.3109
Echinococcus granulosus tyrosine protein kinase Fyn 0.0577 0.5867 0.9952
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.0953 0.1624
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0979 0.2982
Echinococcus granulosus N chimaerin 0.0379 0.3749 0.6359
Brugia malayi ephrin receptor 1 precursor 0.0198 0.1824 0.1824
Leishmania major carbonic anhydrase-like protein 0.0119 0.0979 0.2982
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1824 0.2787

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.14 uM Concentration for doubling of thrombin time ChEMBL. 9301673
IC50 (functional) = 0.56 uM Concentration for doubling of partial thromboplastin time ChEMBL. 9301673
IC50 (functional) = 1.1 uM Concentration for doubling of prothrombin time ChEMBL. 9301673
Ki (binding) = 0.037 uM Inhibitory activity against thrombin ChEMBL. 9301673
Ki (binding) = 0.037 uM Inhibitory activity against thrombin ChEMBL. 9301673
Ki (binding) = 0.6 uM Inhibitory activity against trypsin ChEMBL. 9301673
Ki (binding) = 0.6 uM Inhibitory activity against trypsin ChEMBL. 9301673
Ki (binding) = 21 uM Inhibitory activity against Plasmin. ChEMBL. 9301673
Ki (binding) = 21 uM Inhibitory activity against Plasmin. ChEMBL. 9301673
Ki (binding) = 22 uM Inhibitory activity against coagulation factor X. ChEMBL. 9301673
Ki (binding) = 22 uM Inhibitory activity against coagulation factor X. ChEMBL. 9301673
Ki (binding) = 27 uM Inhibitory activity against Kallikrein (PK) ChEMBL. 9301673
Ki (binding) = 27 uM Inhibitory activity against Kallikrein (PK) ChEMBL. 9301673
Ki (binding) = 39 uM Inhibitory activity against Activated protein C ChEMBL. 9301673
Ki (binding) = 39 uM Inhibitory activity against Activated protein C ChEMBL. 9301673
Ki (binding) = 140 uM Inhibitory activity against UK. ChEMBL. 9301673
Ki (binding) = 140 uM Inhibitory activity against UK. ChEMBL. 9301673
Ki (binding) = 180 uM Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator) ChEMBL. 9301673
Ki (binding) = 180 uM Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator) ChEMBL. 9301673
Ki (binding) = 400 uM Inhibitory activity against Coagulation factor XII ChEMBL. 9301673
Ki (binding) = 400 uM Inhibitory activity against Coagulation factor XII ChEMBL. 9301673
Ki (binding) > 1000 uM Inhibitory activity against glandularkallikrein (GK) ChEMBL. 9301673
Ki (binding) > 1000 uM Inhibitory activity against glandularkallikrein (GK) ChEMBL. 9301673

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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