TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 233.227 | Formula: C10H11N5O2
H donors: 3 H acceptors: 1 LogP: 1.51 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(/N=N/C(=N)N)c([nH]c2cc1)O
InChi: 1S/C10H11N5O2/c1-17-5-2-3-7-6(4-5)8(9(16)13-7)14-15-10(11)12/h2-4,13,16H,1H3,(H3,11,12)/b15-14+
InChiKey: AQGNCVVRLICTLW-CCEZHUSRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0189	0.0229
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0039	0.0048
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0944	0.7908	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.8216	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0058	0.0163	0.0198
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0097	0.0503	0.0612
Schistosoma mansoni	alpha tubulin	0.0057	0.0152	0.0218
Entamoeba histolytica	tubulin family protein	0.0071	0.0272	0.0689
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.0272	0.0391
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.0152	0.0184
Echinococcus granulosus	Polycystic kidney disease protein	0.0097	0.0503	0.0724
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0097	0.0503	0.0612
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0189	0.1687
Echinococcus granulosus	Niemann Pick C1 protein	0.0058	0.0163	0.0234
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.0152	0.0184
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.0152	0.0184
Trypanosoma brucei	beta tubulin	0.0071	0.0272	0.304
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0067	0.0234	0.0234
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0058	0.0163	0.0234
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.0152	0.1354
Trypanosoma brucei	alpha tubulin	0.0057	0.0152	0.1693
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.0152	0.1351
Echinococcus multilocularis	protein patched	0.0058	0.0163	0.0198
Schistosoma mansoni	hypothetical protein	0.0097	0.0503	0.0724
Echinococcus granulosus	tubulin alpha chain	0.0057	0.0152	0.0218
Loa Loa (eye worm)	tubulin beta-1 chain	0.0071	0.0272	0.2429
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0039	0.0056
Echinococcus granulosus	lipoxygenase domain containing protein	0.0097	0.0503	0.0724
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0039	0.0056
Echinococcus granulosus	sterol regulatory element binding protein	0.0058	0.0163	0.0234
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.0152	0.1354
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.0152	0.1354
Entamoeba histolytica	carbonic anhydrase, putative	0.049	0.3939	1
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Loa Loa (eye worm)	hypothetical protein	0.006	0.0178	0.1588
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Brugia malayi	Tubulin beta-1 chain	0.0071	0.0272	0.2427
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0189	0.0272
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Echinococcus granulosus	tubulin beta 4A class IVa	0.0071	0.0272	0.0391
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0039	0.0352
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0011	0.0096
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Trichomonas vaginalis	conserved hypothetical protein	0.1183	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0071	0.0272	0.0391
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Brugia malayi	hypothetical protein	0.0097	0.0503	0.4489
Echinococcus multilocularis	tubulin subunit TubB	0.0057	0.0152	0.0184
Echinococcus multilocularis	Polycystic kidney disease protein	0.0097	0.0503	0.0612
Trypanosoma brucei	alpha tubulin	0.0057	0.0152	0.1693
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.0272	0.0391
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0189	0.0272
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0071	0.0272	0.0331
Schistosoma mansoni	rab6-interacting	0.0097	0.0503	0.0724
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0178	0.1588
Echinococcus granulosus	Protein patched homolog 1	0.0058	0.0163	0.0234
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0085	0.0393	0.0566
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.0152	0.0218
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0189	0.0272
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus multilocularis	jun protein	0.0085	0.0393	0.0478
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0142	0.0894	0.1087
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.0152	0.0184
Schistosoma mansoni	lipoxygenase	0.0222	0.1591	0.2293
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.0272	0.0391
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.0152	0.0218
Schistosoma mansoni	tubulin subunit beta	0.0071	0.0272	0.0391
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0189	0.1687
Trypanosoma brucei	alpha tubulin	0.0057	0.0152	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0152	0.1354
Trypanosoma brucei	beta tubulin	0.0071	0.0272	0.304
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.0152	0.0184
Echinococcus granulosus	lipoxygenase domain containing protein	0.0097	0.0503	0.0724
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0039	0.0056
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0057	0.0152	0.0152
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.0152	0.0184
Toxoplasma gondii	beta-1 tubulin, putative	0.0071	0.0272	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0189	0.0272
Echinococcus multilocularis	hypothetical protein	0.0057	0.0152	0.0184
Brugia malayi	alpha-tubulin	0.0057	0.0152	0.1351
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0067	0.0234	0.0234
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Loa Loa (eye worm)	doublecortin family protein	0.0097	0.0503	0.4491
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0142	0.0894	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0189	0.0272
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Echinococcus granulosus	peroxisome assembly protein 26	0.0057	0.0152	0.0218
Echinococcus granulosus	jun protein	0.0085	0.0393	0.0566
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Giardia lamblia	Beta tubulin	0.0071	0.0272	1
Schistosoma mansoni	hypothetical protein	0.007	0.026	0.0374
Brugia malayi	TAR-binding protein	0.0061	0.0189	0.1684
Toxoplasma gondii	alpha tubulin TUBA1	0.0057	0.0152	0.5569
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.0272	0.0391
Schistosoma mansoni	patched 1	0.0058	0.0163	0.0234
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.0152	0.1351
Brugia malayi	hypothetical protein	0.0064	0.0211	0.1881
Trypanosoma brucei	beta tubulin	0.0071	0.0272	0.304
Trichomonas vaginalis	tubulin gamma chain, putative	0.0071	0.0272	0.0272
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.0272	0.0331
Trichomonas vaginalis	tubulin, putative	0.0071	0.0272	0.0272
Echinococcus multilocularis	tubulin beta 1 chain	0.0071	0.0272	0.0331
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0039	0.0349
Plasmodium falciparum	LCCL domain-containing protein	0.0097	0.0503	1
Schistosoma mansoni	rab6-interacting	0.0097	0.0503	0.0724
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Entamoeba histolytica	tubulin alpha chain, putative	0.0057	0.0152	0.0384
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Echinococcus granulosus	RUN	0.0097	0.0503	0.0724
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0397	0.3124	0.4502
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0039	0.0056
Brugia malayi	hypothetical protein	0.0097	0.0503	0.4489
Echinococcus granulosus	alpha tubulin	0.0057	0.0152	0.0218
Trichomonas vaginalis	tubulin alpha chain, putative	0.0071	0.0272	0.0272
Trypanosoma cruzi	beta tubulin, putative	0.0071	0.0272	0.304
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Schistosoma mansoni	lipoxygenase	0.0397	0.3124	0.4502
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.0152	0.0184
Loa Loa (eye worm)	tubulin beta-4 chain	0.0071	0.0272	0.2429
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0163	0.0163
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.0152	0.0218
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.0152	0.0218
Mycobacterium ulcerans	carbonic anhydrase	0.049	0.3939	0.3571
Echinococcus multilocularis	tubulin subunit beta	0.0071	0.0272	0.0331
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0067	0.0234	0.8606
Trichomonas vaginalis	conserved hypothetical protein	0.1183	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0071	0.0272	0.2429
Loa Loa (eye worm)	tubulin beta chain	0.0071	0.0272	0.2429
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0039	0.0048
Plasmodium falciparum	tubulin beta chain	0.0071	0.0272	0.5405
Brugia malayi	RNA binding protein	0.0061	0.0189	0.1684
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0058	0.0163	0.1453
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.0152	0.0218
Trypanosoma brucei	alpha tubulin	0.0057	0.0152	0.1693
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.694	0.8447
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0142	0.0894	1
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0189	0.1684
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.0152	0.0218
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0163	0.0198
Loa Loa (eye worm)	beta-tubulin	0.0071	0.0272	0.2429
Onchocerca volvulus		0.0097	0.0503	0.2487
Echinococcus granulosus	beta tubulin	0.0071	0.0272	0.0391
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0468	0.3745	0.3344
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0894	0.7982
Entamoeba histolytica	tubulin alpha-1 chain	0.0057	0.0152	0.0384
Onchocerca volvulus		0.0168	0.112	0.7741
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.0152	0.0152
Plasmodium vivax	multidomain scavenger receptor, putative	0.0097	0.0503	1
Echinococcus granulosus	tubulin alpha chain	0.0057	0.0152	0.0218
Schistosoma mansoni	carbonic anhydrase	0.049	0.3939	0.5676
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0142	0.0894	0.7981
Onchocerca volvulus	Putative sulfate transporter	0.0198	0.1385	1
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.0152	0.301
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.0272	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0163	0.1453
Brugia malayi	bZIP transcription factor family protein	0.0085	0.0393	0.3511
Onchocerca volvulus		0.0097	0.0503	0.2487
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0178	0.1585
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.0272	0.0331
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.0152	0.0184
Giardia lamblia	Beta tubulin	0.0071	0.0272	1
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0142	0.0894	0.1287
Loa Loa (eye worm)	tubulin gamma chain	0.004	0	0.0003
Schistosoma mansoni	loxhd1	0.0097	0.0503	0.0724
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0142	0.0894	0.034
Echinococcus multilocularis	peroxisome assembly protein 26	0.0057	0.0152	0.0184
Giardia lamblia	Beta tubulin	0.0071	0.0272	1
Echinococcus granulosus	tubulin alpha chain	0.0057	0.0152	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0011	0.01
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.0152	0.0218
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0142	0.0894	1
Loa Loa (eye worm)	BEN-1 protein	0.0071	0.0272	0.2429
Brugia malayi	Doublecortin family protein	0.0097	0.0503	0.4489
Loa Loa (eye worm)	BEN-1 protein	0.0071	0.0272	0.2429
Brugia malayi	tubulin alpha chain - mouse	0.0057	0.0152	0.1351
Echinococcus multilocularis	beta tubulin	0.0071	0.0272	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0344	0.3076
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0189	0.0272
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.0152	0.0218
Schistosoma mansoni	polycystin 1-related	0.0097	0.0503	0.0724
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.694	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0039	0.0056
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.0152	0.0152
Brugia malayi	Tubulin alpha chain	0.0057	0.0152	0.1351
Brugia malayi	beta-tubulin, identical	0.0071	0.0272	0.2427
Plasmodium falciparum	alpha tubulin 1	0.0057	0.0152	0.301
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.0152	0.0218
Giardia lamblia	Alpha-tubulin	0.0057	0.0152	0.5569
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.0152	0.301
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0142	0.0894	0.2268
Echinococcus granulosus	tubulin subunit beta	0.0071	0.0272	0.0391
Echinococcus granulosus	tubulin subunit TubB	0.0057	0.0152	0.0218
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.0152	0.1354
Echinococcus multilocularis	sterol regulatory element binding protein	0.0058	0.0163	0.0198
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0178	0.1585
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.0152	0.0184
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0085	0.0393	0.0478
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.0152	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0503	0.4491
Echinococcus granulosus	tubulin alpha chain	0.0057	0.0152	0.0218
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.694	1
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0397	0.3124	0.3802
Echinococcus multilocularis	RUN	0.0097	0.0503	0.0612
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.049	0.3939	1
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Schistosoma mansoni	jun-related protein	0.007	0.026	0.0374
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Giardia lamblia	Alpha-tubulin	0.0057	0.0152	0.5569
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.0272	0.0331
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0057	0.0152	0.1354
Brugia malayi	hypothetical protein	0.0168	0.112	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0503	0.4491
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Toxoplasma gondii	beta tubulin	0.0071	0.0272	1
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Leishmania major	alpha tubulin	0.0057	0.0152	0.0384
Toxoplasma gondii	beta-tubulin, putative	0.0071	0.0272	1
Brugia malayi	tubulin alpha-2 chain	0.0057	0.0152	0.1351
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.0152	0.0184
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.0272	0.0272
Toxoplasma gondii	alpha-tubulin I, putative	0.0057	0.0152	0.5569
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.0272	0.0331
Leishmania major	carbonic anhydrase family protein, putative	0.049	0.3939	1
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.0152	0.0184
Brugia malayi	CHE-14 protein	0.0058	0.0163	0.145
Trypanosoma cruzi	alpha tubulin, putative	0.0057	0.0152	0.1693
Plasmodium vivax	tubulin beta chain, putative	0.0071	0.0272	0.5405
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0189	0.1687
Entamoeba histolytica	tubulin family protein	0.0071	0.0272	0.0689
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.0272	0.0272
Echinococcus multilocularis	beta tubulin	0.0071	0.0272	0.0331
Trypanosoma brucei	beta tubulin	0.0071	0.0272	0.304
Schistosoma mansoni	alpha tubulin	0.0057	0.0152	0.0218
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0251	0.1848	0.031
Schistosoma mansoni	alpha tubulin	0.0057	0.0152	0.0218
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0142	0.0894	0.1287
Schistosoma mansoni	hypothetical protein	0.0041	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0168	0.112	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.0272	0.0272
Echinococcus granulosus	beta tubulin	0.0071	0.0272	0.0391
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0067	0.0234	0.0234
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.0152	0.0152
Plasmodium falciparum	alpha tubulin 2	0.0057	0.0152	0.301
Onchocerca volvulus		0.0198	0.1385	1
Echinococcus granulosus	tubulin alpha chain	0.0057	0.0152	0.0218
Leishmania major	beta tubulin	0.0071	0.0272	0.0689
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.0152	0.0218
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.0272	0.0331

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1995 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	0.3981 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2369284

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1747969