Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0481 | 0.1528 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0481 | 0.1528 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0481 | 0.1528 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0481 | 0.1528 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0481 | 0.1528 | 0.1528 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.302 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0481 | 0.1528 | 0.1528 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.302 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0481 | 0.1528 | 0.1528 |
Brugia malayi | nicalin | 0.0481 | 0.1528 | 0.1528 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0481 | 0.1528 | 0.1528 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0481 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0481 | 0.1528 | 0.1528 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0481 | 0.1528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.302 | 1 | 1 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0481 | 0.1528 | 0.1528 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0481 | 0.1528 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0481 | 0.1528 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0481 | 0.1528 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.1528 | 0.1528 | |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1528 | 0.1528 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0481 | 0.1528 | 0.1528 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.302 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1528 | 0.1528 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.302 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1528 | 0.1528 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0481 | 0.1528 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0481 | 0.1528 | 0.1528 |
Toxoplasma gondii | hypothetical protein | 0.0481 | 0.1528 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0481 | 0.1528 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0481 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1528 | 0.1528 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0481 | 0.1528 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0481 | 0.1528 | 0.1528 |
Brugia malayi | leucyl aminopeptidase | 0.0481 | 0.1528 | 0.1528 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0481 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0481 | 0.1528 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0481 | 0.1528 | 0.5 |
Brugia malayi | FXNA | 0.0481 | 0.1528 | 0.1528 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0481 | 0.1528 | 0.1528 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0481 | 0.1528 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2500 nM | Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | = 2500 nM | Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | > 100000 nM | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | > 100000 nM | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | ChEMBL. | 9301675 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.