Detailed information for compound 1756838

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.343 | Formula: C19H18O5
  • H donors: 4 H acceptors: 5 LogP: 3.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccc(c(c1)O)O)/C=C/CCc1ccc(c(c1)O)O
  • InChi: 1S/C19H18O5/c20-15(8-5-14-7-10-17(22)19(24)12-14)4-2-1-3-13-6-9-16(21)18(23)11-13/h2,4-12,21-24H,1,3H2/b4-2+,8-5+
  • InChiKey: BQXWNGCLBOSNPN-MSGXFJBMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis inositol monophosphatase, putative 0.0029 0.0123 0.0123
Plasmodium vivax SET domain protein, putative 0.0053 0.0372 0.0605
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0147 0.0239
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0483 0.4797 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0825 0.1342
Echinococcus multilocularis lysosomal alpha glucosidase 0.0119 0.1054 0.1448
Trichomonas vaginalis chromobox protein, putative 0.0104 0.09 0.09
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0614 0.6146 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0053 0.0372 0.0511
Trichomonas vaginalis Heterochromatin protein, putative 0.0028 0.0118 0.0118
Echinococcus granulosus eukaryotic initiation factor 4A 0.0614 0.6146 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0199 0.1872 0.3046
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0725 0.7281 1
Brugia malayi Pre-SET motif family protein 0.0053 0.0372 0.0605
Leishmania major pyruvate kinase 0.0029 0.0124 0.0201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0082 0.0133
Brugia malayi Inositol-1 0.0029 0.0123 0.02
Brugia malayi jmjC domain containing protein 0.0119 0.1051 0.171
Echinococcus granulosus Chromobox protein 3 0.0028 0.0118 0.0193
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0119 0.1054 0.1715
Plasmodium vivax pyruvate kinase, putative 0.0029 0.0124 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0201 0.1892 0.3079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0372 0.0605
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Schistosoma mansoni protein phosphatase 2C 0.0031 0.015 0.0244
Echinococcus granulosus intermediate filament protein 0.0021 0.0043 0.007
Mycobacterium ulcerans lipase LipD 0.0031 0.0147 0.0307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0147 0.0239
Schistosoma mansoni hypothetical protein 0.0097 0.0827 0.1346
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0186 0.0303
Leishmania major pyruvate kinase 0.0029 0.0124 0.0201
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0029 0.0123 0.02
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0147 0.0239
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0123 0.0123
Schistosoma mansoni alpha-glucosidase 0.0103 0.0883 0.1437
Echinococcus granulosus geminin 0.044 0.4349 0.7076
Schistosoma mansoni alpha-glucosidase 0.0103 0.0883 0.1437
Mycobacterium ulcerans hypothetical protein 0.0031 0.0147 0.0307
Brugia malayi hypothetical protein 0.0028 0.0118 0.0193
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0099 0.0099
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0028 0.0118 0.0193
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0082 0.0133
Brugia malayi latrophilin 2 splice variant baaae 0.0053 0.0377 0.0613
Mycobacterium ulcerans pyruvate kinase 0.0029 0.0124 0.0258
Echinococcus granulosus chromobox protein 2 0.0028 0.0118 0.0193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0147 0.0202
Schistosoma mansoni phd/f-box containing protein 0.0031 0.015 0.0244
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0124 0.0132
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.015 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0147 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0082 0.0133
Plasmodium vivax heterochromatin protein 1, putative 0.0028 0.0118 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0029 0.0047
Onchocerca volvulus 0.0031 0.0147 0.017
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0032 0.0154 0.0251
Trichomonas vaginalis chromobox protein, putative 0.0104 0.09 0.09
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0043 0.007
Echinococcus multilocularis phd:f box containing protein 0.0031 0.015 0.0206
Echinococcus multilocularis PHD finger protein rhinoceros 0.0097 0.0827 0.1136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0143 0.0143
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0029 0.0123 1
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0118 0.0118
Echinococcus multilocularis lamin dm0 0.0021 0.0043 0.0059
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.015 0.0244
Brugia malayi PHD-finger family protein 0.0033 0.0167 0.0272
Loa Loa (eye worm) hypothetical protein 0.0053 0.0377 0.0613
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0058 0.0095
Plasmodium falciparum heterochromatin protein 1 0.0028 0.0118 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0533 0.0533
Echinococcus multilocularis Chromo domain 0.0028 0.0118 0.0163
Brugia malayi Pyruvate kinase, muscle isozyme 0.0029 0.0124 0.0201
Loa Loa (eye worm) CHromoDomain protein family member 0.003 0.0132 0.0214
Brugia malayi Pyruvate kinase, M2 isozyme 0.0029 0.0124 0.0201
Loa Loa (eye worm) hypothetical protein 0.0053 0.0372 0.0605
Schistosoma mansoni hypothetical protein 0.0025 0.0082 0.0133
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0147 0.0147
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0028 0.0118 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0118 0.0193
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0104 0.09 0.1404
Leishmania major hypothetical protein, conserved 0.002 0.0029 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.015 0.0244
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0163 0.0265
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0163 0.0224
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.015 0.0244
Trypanosoma cruzi DNA polymerase eta, putative 0.0025 0.0079 0.0129
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0614 0.6146 1
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0029 0.0047
Schistosoma mansoni lamin 0.0021 0.0043 0.007
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0099 0.0099
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0123 0.02
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0614 0.6146 0.6146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0234 0.038
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0147 0.0239
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.015 0.0244
Brugia malayi intermediate filament protein 0.0021 0.0043 0.007
Entamoeba histolytica hypothetical protein 0.0028 0.0118 0.0118
Echinococcus multilocularis peregrin 0.0097 0.0827 0.1136
Echinococcus granulosus chromobox protein 1 0.0173 0.1607 0.2614
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0186 0.0303
Brugia malayi Heterochromatin protein 1 0.0173 0.1607 0.2614
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0043 0.007
Echinococcus granulosus Chromo domain 0.0028 0.0118 0.0193
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0099 0.0099
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.0099 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0029 0.0047
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0154 0.0251
Brugia malayi eukaryotic initiation factor 4A 0.0614 0.6146 1
Leishmania major DNA polymerase eta, putative 0.0025 0.0079 0.0129
Schistosoma mansoni chromobox protein 0.0028 0.0118 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0029 0.0047
Echinococcus multilocularis inositol monophosphatase 1 0.0029 0.0123 0.0169
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0099 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0032 0.0154 0.0251
Brugia malayi AF-10 protein 0.0032 0.0154 0.0251
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0118 0.0118
Echinococcus granulosus lamin dm0 0.0021 0.0043 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0372 0.0605
Echinococcus multilocularis cpg binding protein 0.0024 0.0071 0.0098
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Brugia malayi Bromodomain containing protein 0.0097 0.0827 0.1346
Brugia malayi jmjC domain containing protein 0.0031 0.015 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Echinococcus granulosus inositol monophosphatase 1 0.0029 0.0123 0.02
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0099 0.0099
Brugia malayi Protein cec-1. 0.0028 0.0118 0.0193
Giardia lamblia Fructose-bisphosphate aldolase 0.0989 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0118 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Schistosoma mansoni hypothetical protein 0.0053 0.0377 0.0613
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0082 0.0112
Schistosoma mansoni inositol monophosphatase 0.0029 0.0123 0.02
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0171 0.0171
Echinococcus granulosus lamin 0.0021 0.0043 0.007
Onchocerca volvulus 0.0069 0.0537 0.0809
Schistosoma mansoni chromobox protein 0.0028 0.0118 0.0193
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0118 0.0193
Trichomonas vaginalis chromobox protein, putative 0.0173 0.1607 0.1607
Onchocerca volvulus 0.0022 0.0058 0.0025
Echinococcus multilocularis musashi 0.0021 0.0043 0.0059
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0614 0.6146 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.015 0.0244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0234 0.038
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0614 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0244
Leishmania major eukaryotic initiation factor 4a, putative 0.0614 0.6146 1
Toxoplasma gondii pyruvate kinase PyK1 0.0029 0.0124 0.0201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0078 0.0631 0.1027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0078 0.0631 0.1027
Brugia malayi jmjC domain containing protein 0.0031 0.015 0.0244
Echinococcus granulosus jumonji domain containing protein 0.0135 0.1219 0.1984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0614 0.6146 0.6146
Echinococcus granulosus PHD finger protein rhinoceros 0.0097 0.0827 0.1346
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0029 0.0123 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0118 0.0118
Echinococcus multilocularis chromobox protein 1 0.0173 0.1607 0.2207
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.015 0.0206
Echinococcus multilocularis neutral alpha glucosidase AB 0.0026 0.0099 0.0137
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0124 0.0132
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0123 0.02
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0028 0.0118 0.0193
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0483 0.4797 1
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0029 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0118 0.0118
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0099 0.0099
Echinococcus multilocularis Chromobox protein 3 0.0028 0.0118 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.003 0.0132 0.0181
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0028 0.0118 0.0193
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0147 0.0117
Plasmodium vivax RNA helicase-1, putative 0.0614 0.6146 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0033 0.0168 0.0274
Loa Loa (eye worm) beta-lactamase 0.0031 0.0147 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0147 0.0239
Echinococcus multilocularis lysine specific demethylase 5A 0.0118 0.1038 0.1425
Brugia malayi hypothetical protein 0.002 0.0029 0.0047
Echinococcus granulosus GPCR family 2 0.0025 0.0082 0.0133
Echinococcus multilocularis dna polymerase eta 0.0035 0.0186 0.0255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.038
Loa Loa (eye worm) hypothetical protein 0.0167 0.1542 0.2509
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0123 0.02
Schistosoma mansoni pyruvate kinase 0.0029 0.0124 0.0201
Loa Loa (eye worm) hypothetical protein 0.0614 0.6146 1
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0124 0.0124
Mycobacterium tuberculosis Conserved protein 0.0031 0.0147 0.0239
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0614 0.6146 0.8441
Echinococcus granulosus lysosomal alpha glucosidase 0.0119 0.1054 0.1715
Schistosoma mansoni intermediate filament proteins 0.0021 0.0043 0.007
Schistosoma mansoni hypothetical protein 0.0025 0.0082 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0181 0.1683 0.2739
Trypanosoma brucei pyruvate kinase 1 0.0029 0.0124 0.0201
Leishmania major DNA polymerase eta, putative 0.0035 0.0186 0.0303
Schistosoma mansoni jumonji domain containing protein 0.0253 0.243 0.3953
Plasmodium falciparum eukaryotic initiation factor 4A 0.0614 0.6146 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0231 0.0376
Schistosoma mansoni chromodomain helicase DNA binding protein 0.003 0.0132 0.0214
Trichomonas vaginalis set domain proteins, putative 0.0417 0.4115 0.4115
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0118 0.0193
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Trypanosoma brucei glucosidase, putative 0.0026 0.0099 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Toxoplasma gondii PHD-finger domain-containing protein 0.0097 0.0827 0.1346
Echinococcus granulosus dna polymerase eta 0.0035 0.0186 0.0303
Echinococcus multilocularis pyruvate kinase 0.0023 0.0061 0.0084
Onchocerca volvulus 0.0031 0.0147 0.017
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0124 0.0201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0186 0.0303
Loa Loa (eye worm) inositol-1 0.0029 0.0123 0.02
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0147 0.0147
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.015 0.0244
Brugia malayi Associated with TFs and helicases family protein 0.0028 0.0118 0.0193
Echinococcus multilocularis jumonji domain containing protein 0.0135 0.1219 0.1674
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0028 0.0118 0.0193
Brugia malayi jmjC domain containing protein 0.0031 0.015 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0064
Leishmania major hypothetical protein, conserved 0.0031 0.0147 0.0239
Echinococcus multilocularis lysosomal alpha glucosidase 0.0119 0.1054 0.1448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0028 0.0118 0.0193
Brugia malayi jmjC domain containing protein 0.0319 0.3103 0.5049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0123 0.02
Mycobacterium tuberculosis Conserved protein 0.0031 0.0147 0.0239
Echinococcus granulosus lysine specific demethylase 5A 0.0119 0.1051 0.171
Schistosoma mansoni pyruvate kinase 0.0029 0.0124 0.0201
Echinococcus multilocularis pyruvate kinase 0.0029 0.0124 0.017
Schistosoma mansoni cpg binding protein 0.0022 0.0058 0.0095
Leishmania major eukaryotic initiation factor 4a, putative 0.0614 0.6146 1
Schistosoma mansoni jumonji domain containing protein 0.0031 0.015 0.0244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0147 0.0307
Mycobacterium leprae Probable pyruvate kinase PykA 0.0029 0.0124 0.0067
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0028 0.0118 0.0193
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0118 0.0118
Schistosoma mansoni cpg binding protein 0.0024 0.0071 0.0116
Schistosoma mansoni cpg binding protein 0.0024 0.0071 0.0116
Giardia lamblia PHD finger protein 15 0.0097 0.0827 0.0827
Echinococcus granulosus phd:f box containing protein 0.0031 0.015 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0234 0.038
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0614 0.6146 0.6146
Onchocerca volvulus 0.0028 0.0118 0.0123
Brugia malayi PHD-finger family protein 0.0097 0.0827 0.1346
Brugia malayi Pre-SET motif family protein 0.0366 0.3595 0.585
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.003 0.0132 0.0214
Loa Loa (eye worm) hypothetical protein 0.0078 0.0631 0.1027
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0614 0.6146 0.6146
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0533 0.0533
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.015 0.0244
Brugia malayi follicle stimulating hormone receptor 0.0181 0.1683 0.2739
Trichomonas vaginalis chromobox protein, putative 0.0173 0.1607 0.1607
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0124 0.0201
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0118 0.0118
Schistosoma mansoni chromobox protein 0.0173 0.1607 0.2614
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0272
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0118 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0372 0.0511
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0245 0.0398
Onchocerca volvulus Alhambra homolog 0.0097 0.0827 0.1285
Echinococcus multilocularis lamin 0.0021 0.0043 0.0059
Brugia malayi beta-lactamase family protein 0.0031 0.0147 0.0239
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Brugia malayi Valyl-tRNA synthetase 0.0028 0.0118 0.0193
Brugia malayi jmjC domain containing protein 0.0031 0.015 0.0244
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0029 0.0123 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0827 0.1346
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0082 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0147 0.0239
Loa Loa (eye worm) PHD-finger family protein 0.0097 0.0827 0.1346
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0043 0.007
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0614 0.6146 0.8441
Trichomonas vaginalis hypothetical protein 0.0028 0.0118 0.0118
Brugia malayi beta-lactamase 0.0031 0.0147 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Plasmodium falciparum pyruvate kinase 0.0029 0.0124 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0099 0.0099
Schistosoma mansoni inositol monophosphatase 0.0029 0.0123 0.02
Echinococcus granulosus pyruvate kinase 0.0029 0.0124 0.0201
Echinococcus multilocularis chromobox protein 1 0.0173 0.1607 0.2207
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0319 0.3103 0.4262
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0614 0.6146 0.6146
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.0099 0.0162
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0124 0.0201
Chlamydia trachomatis pyruvate kinase 0.0029 0.0124 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0099 0.0162
Echinococcus granulosus pyruvate kinase 0.0029 0.0124 0.0201
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0147 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0147 0.0239
Schistosoma mansoni chromobox protein 0.0173 0.1607 0.2614
Entamoeba histolytica hypothetical protein 0.0028 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Onchocerca volvulus 0.0417 0.4115 0.6672
Schistosoma mansoni lamin 0.0021 0.0043 0.007
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0614 0.6146 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Brugia malayi CXXC zinc finger family protein 0.0022 0.0058 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0078 0.0631 0.1027
Toxoplasma gondii PHD-finger domain-containing protein 0.0097 0.0827 0.1346
Schistosoma mansoni DNA polymerase eta 0.0035 0.0186 0.0303
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0097 0.0827 0.1346
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0053 0.0372 0.0605
Entamoeba histolytica hypothetical protein 0.0028 0.0118 0.0118
Trichomonas vaginalis sucrase-isomaltase, putative 0.0026 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0025 0.0082 0.0133
Echinococcus granulosus chromobox protein 1 0.0173 0.1607 0.2614
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0099 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0099 0.0162
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0244
Echinococcus granulosus neutral alpha glucosidase AB 0.0026 0.0099 0.0162
Brugia malayi chromobox protein homolog 3 0.0097 0.0825 0.1342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0147 0.0239
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0082 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0366 0.3595 0.585
Loa Loa (eye worm) helicase 0.0028 0.0118 0.0193
Toxoplasma gondii ABC1 family protein 0.0031 0.0147 0.0239
Brugia malayi SET domain containing protein 0.0031 0.0143 0.0233
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0372 0.0605
Echinococcus multilocularis GPCR, family 2 0.0025 0.0082 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0337 0.0549
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.1051 0.171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0171 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.015 0.0244
Treponema pallidum fructose-bisphosphate aldolase 0.0989 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0319 0.3103 0.5049
Schistosoma mansoni hypothetical protein 0.0025 0.0082 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0028 0.0118 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0321
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0026 0.0099 0.0162
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.015 0.0244
Onchocerca volvulus 0.0031 0.0147 0.017
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.015 0.0244
Schistosoma mansoni alpha glucosidase 0.0026 0.0099 0.0162
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0186 0.0303
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0614 0.6146 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0285 0.0464
Brugia malayi CHD4 protein 0.003 0.0132 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0201
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0991
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0147 0.0239
Leishmania major hypothetical protein, conserved 0.0031 0.015 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0081 0.0663 0.1079
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0029 0.0124 0.0201
Plasmodium vivax JmjC domain containing protein 0.0031 0.015 0.0244
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.015 0.0206
Onchocerca volvulus 0.0028 0.0118 0.0123
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0124 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0147 0.0239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0051 0.0347 0.0565
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0193
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0124 0.0124
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0614 0.6146 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.038
Trypanosoma brucei pyruvate kinase 1, putative 0.0029 0.0124 0.0201
Entamoeba histolytica pyruvate kinase, putative 0.002 0.0034 0.0034
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0124 0.0201
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0146 0.0146
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0825 0.0825
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0989 1 1
Schistosoma mansoni hypothetical protein 0.044 0.4349 0.7076
Trichomonas vaginalis esterase, putative 0.0031 0.0147 0.0147
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0079 0.0129
Mycobacterium leprae Probable lipase LipE 0.0031 0.0147 0.0117
Onchocerca volvulus 0.0076 0.0609 0.0927
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0147 0.0307
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0028 0.0118 0.0193
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0147 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0168 0.0274
Loa Loa (eye worm) pyruvate kinase-PB 0.002 0.0034 0.0055
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.015 0.0244
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.015 0.0244
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.015 0.0244
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0614 0.6146 1
Schistosoma mansoni hypothetical protein 0.0028 0.0118 0.0193
Loa Loa (eye worm) heterochromatin protein 1 0.0173 0.1607 0.2614
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0032 0.0154 0.0251
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0124 0.0201
Loa Loa (eye worm) hypothetical protein 0.0097 0.0827 0.1346
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0171 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0147 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0147 0.0239
Brugia malayi M-phase phosphoprotein, mpp8 0.0028 0.0118 0.0193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0239
Mycobacterium tuberculosis Conserved protein 0.0031 0.0147 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.1051 0.171
Brugia malayi Glycosyl hydrolases family 31 protein 0.0119 0.1054 0.1715
Echinococcus multilocularis geminin 0.044 0.4349 0.5973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0234 0.0321
Schistosoma mansoni hypothetical protein 0.0032 0.0154 0.0251
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0082 0.0133
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0099 0.0099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.1051 0.171
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0614 0.6146 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0989 1 1
Echinococcus granulosus peregrin 0.0097 0.0827 0.1346
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0097 0.0825 0.128
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0029 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0146 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0147 0.0147
Plasmodium falciparum phd finger protein, putative 0.0097 0.0827 0.1346
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0118 0.0118
Echinococcus granulosus cpg binding protein 0.0024 0.0071 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0234 0.038
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0092 0.015
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0118 0.0118
Onchocerca volvulus 0.0081 0.0663 0.1016
Treponema pallidum ATP-dependent RNA helicase 0.0614 0.6146 0.6146
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0483 0.4797 0.7804
Echinococcus multilocularis pyruvate kinase 0.0029 0.0124 0.017
Mycobacterium ulcerans beta-lactamase 0.0031 0.0147 0.0307
Echinococcus multilocularis chromobox protein 2 0.0028 0.0118 0.0163
Brugia malayi beta-lactamase family protein 0.0031 0.0147 0.0239
Schistosoma mansoni hypothetical protein 0.044 0.4349 0.7076
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0147 0.0239
Giardia lamblia Pyruvate kinase 0.0029 0.0124 0.0124
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.015 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0147 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0372 0.0605

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 36.5 % Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 100 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control ChEMBL. 23465614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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