Detailed information for compound 1757255

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.506 | Formula: C21H24N4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](n1cnc2c(c1=O)cc(cc2)C)CC1CCCCC1)Nc1nccs1
  • InChi: 1S/C21H24N4O2S/c1-14-7-8-17-16(11-14)20(27)25(13-23-17)18(12-15-5-3-2-4-6-15)19(26)24-21-22-9-10-28-21/h7-11,13,15,18H,2-6,12H2,1H3,(H,22,24,26)/t18-/m0/s1
  • InChiKey: BNNFFESNNWERGJ-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hexokinase 0.0096 0.027 0.027
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0067 0.0136 0.0136
Giardia lamblia Casein kinase II beta chain 0.0454 0.1948 0.1838
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Echinococcus multilocularis dual specificity 0.0263 0.105 0.105
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.105 0.105
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Echinococcus granulosus protein kinase shaggy 0.0073 0.0159 0.0159
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0109 0.0328 0.0195
Toxoplasma gondii CMGC kinase, CK2 family 0.2173 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0067 0.0136 0.0136
Plasmodium vivax casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Brugia malayi Protein kinase domain containing protein 0.0188 0.07 0.07
Trypanosoma brucei hexokinase 0.0096 0.027 0.0137
Echinococcus multilocularis dual specificity 0.0263 0.105 0.105
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Echinococcus granulosus cyclin dependent kinase 5 0.0067 0.0136 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0188 0.07 0.07
Entamoeba histolytica casein kinase, putative 0.2173 1 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0067 0.0136 0.0136
Plasmodium vivax casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0231 0.09 0.09
Loa Loa (eye worm) hexokinase 0.006 0.0102 0.0102
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0067 0.0136 0.0136
Leishmania major hexokinase, putative 0.0096 0.027 0.027
Echinococcus granulosus death associated protein kinase 1 0.0697 0.3086 0.3086
Leishmania major casein kinase II, putative 0.2173 1 1
Plasmodium falciparum glycogen synthase kinase 3 0.0073 0.0159 0.0159
Loa Loa (eye worm) hexokinase type II 0.0096 0.027 0.027
Toxoplasma gondii ck2 beta subunit 0.0454 0.1948 0.1948
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0116 0.0364 0.0364
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Echinococcus multilocularis death associated protein kinase 1 0.0971 0.4367 0.4367
Plasmodium vivax hexokinase, putative 0.0096 0.027 0.0137
Plasmodium falciparum casein kinase II beta chain 0.0454 0.1948 0.1948
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Loa Loa (eye worm) hypothetical protein 0.0208 0.0792 0.0792
Entamoeba histolytica protein kinase, putative 0.0073 0.0159 0.0024
Onchocerca volvulus 0.0096 0.027 0.0909
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0073 0.0159 0.0159
Brugia malayi Csnk2b protein 0.0454 0.1948 0.1948
Brugia malayi Hexokinase family protein 0.0096 0.027 0.027
Echinococcus multilocularis hexokinase 0.0096 0.027 0.027
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0116 0.0364 0.0364
Entamoeba histolytica protein kinase domain containing protein 0.2173 1 1
Echinococcus multilocularis dual specificity 0.0231 0.09 0.09
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Echinococcus granulosus cyclin dependent kinase 1 0.0067 0.0136 0.0136
Onchocerca volvulus 0.0096 0.027 0.0909
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0454 0.1948 0.1948
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Echinococcus multilocularis casein kinase ii subunit alpha 0.2173 1 1
Brugia malayi hexokinase 0.0096 0.027 0.027
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.079 0.3519 0.3519
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Echinococcus multilocularis hexokinase 0.0096 0.027 0.027
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0454 0.1948 0.1838
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Entamoeba histolytica protein kinase domain containing protein 0.079 0.3519 0.343
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Trypanosoma cruzi casein kinase II, putative 0.2173 1 1
Entamoeba histolytica protein kinase, putative 0.0231 0.09 0.0775
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0188 0.07 0.07
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0263 0.105 0.0927
Echinococcus multilocularis cyclin dependent kinase 1 0.0067 0.0136 0.0136
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0067 0.0136 0.0136
Onchocerca volvulus 0.0073 0.0159 0.0309
Brugia malayi Protein kinase domain containing protein 0.0231 0.09 0.09
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0454 0.1948 0.1838
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Trypanosoma brucei hexokinase, putative 0.0096 0.027 0.0137
Plasmodium falciparum hexokinase 0.0096 0.027 0.027
Giardia lamblia Kinase, CMGC CK2 0.2173 1 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0454 0.1948 0.1948
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0067 0.0136 0.0136
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0073 0.0159 0.0159
Schistosoma mansoni protein kinase 0.2173 1 1
Brugia malayi Hexokinase family protein 0.006 0.0102 0.0102
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0263 0.105 0.105
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0231 0.09 0.09
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0159 0.0024
Echinococcus granulosus hexokinase type 2 0.0096 0.027 0.027
Echinococcus granulosus hexokinase 0.0096 0.027 0.027
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0133 0.0441 0.031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0073 0.0159 0.0159
Onchocerca volvulus 0.0096 0.027 0.0909
Trypanosoma brucei protein kinase, putative 0.0073 0.0159 0.0024
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0414 0.0414
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Loa Loa (eye worm) hypothetical protein 0.0066 0.0127 0.0127
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0263 0.105 0.105
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0116 0.0364 0.0364
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0188 0.07 0.07
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0109 0.0328 0.0195
Echinococcus multilocularis protein kinase shaggy 0.0073 0.0159 0.0159
Plasmodium vivax glycogen synthase kinase 3, putative 0.0073 0.0159 0.0024
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0188 0.07 0.07
Giardia lamblia Kinase, CMGC DYRK 0.0263 0.105 0.0927
Plasmodium falciparum casein kinase 2, alpha subunit 0.2173 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Echinococcus granulosus hexokinase 0.0096 0.027 0.027
Plasmodium falciparum protein kinase 5 0.0067 0.0136 0.0136
Schistosoma mansoni hexokinase 0.0096 0.027 0.027
Entamoeba histolytica hexokinase 1 0.0096 0.027 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Loa Loa (eye worm) casein kinase II 0.0133 0.0441 0.0441
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0159 0.0024
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0454 0.1948 0.1948
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0073 0.0159 0.0159
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0231 0.09 0.0775
Toxoplasma gondii hexokinase 0.0096 0.027 0.027
Echinococcus multilocularis cyclin dependent kinase 5 0.0067 0.0136 0.0136
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trypanosoma cruzi hexokinase, putative 0.0096 0.027 0.0137
Echinococcus granulosus homeodomain interacting protein kinase 3 0.079 0.3519 0.3519
Treponema pallidum hexokinase (hxk) 0.0096 0.027 0.5
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0263 0.105 0.105
Plasmodium falciparum casein kinase II beta chain 0.0454 0.1948 0.1948
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.07 0.07
Trichomonas vaginalis CMGC family protein kinase 0.0263 0.105 0.0927
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0136 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.079 0.3519 0.3519
Echinococcus granulosus dual specificity 0.0263 0.105 0.105
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.2173 1 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0073 0.0159 0.0159
Loa Loa (eye worm) hexokinase 0.0096 0.027 0.027
Echinococcus granulosus dual specificity 0.0263 0.105 0.105
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0159 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0027 0.0027
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0073 0.0159 0.0159
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Leishmania major hexokinase, putative 0.0096 0.027 0.027
Loa Loa (eye worm) hexokinase 0.0096 0.027 0.027
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0188 0.07 0.07
Trypanosoma brucei Casein kinase II 0.2173 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Brugia malayi intracellular kinase 0.0073 0.0159 0.0159
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Loa Loa (eye worm) Csnk2b protein 0.0454 0.1948 0.1948
Brugia malayi Homeodomain interacting protein kinase protein 1 0.079 0.3519 0.3519
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0231 0.09 0.0775
Trypanosoma brucei hexokinase 0.0096 0.027 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.2173 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0292 0.0292
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0116 0.0364 0.0364
Echinococcus granulosus casein kinase ii subunit alpha 0.2173 1 1
Trypanosoma cruzi hexokinase, putative 0.0096 0.027 0.0137
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0073 0.0159 0.0024
Entamoeba histolytica hexokinase 2 0.0096 0.027 0.0137
Echinococcus multilocularis cyclin dependent kinase 1 0.0067 0.0136 0.0136
Entamoeba histolytica protein kinase domain containing protein 0.0231 0.09 0.0775
Echinococcus multilocularis hexokinase 0.0096 0.027 0.027
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.2173 1 1
Echinococcus multilocularis cyclin dependent kinase 0.0067 0.0136 0.0136
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Giardia lamblia Casein kinase II beta chain 0.0133 0.0441 0.031
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0414 0.0414
Giardia lamblia Kinase, CMGC GSK 0.0073 0.0159 0.0024
Trichomonas vaginalis casein kinase II beta chain, putative 0.0133 0.0441 0.031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0454 0.1948 0.1838
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0073 0.0159 0.0159
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0067 0.0136 0.0136
Entamoeba histolytica protein kinase, putative 0.0263 0.105 0.0927
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0188 0.07 0.3239
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0454 0.1948 0.1838
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.105 0.0927
Plasmodium vivax unspecified product 0.2173 1 1
Entamoeba histolytica hypothetical protein 0.0231 0.09 0.0775
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0454 0.1948 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0133 0.0441 0.031
Brugia malayi casein kinase II, putaitve 0.0133 0.0441 0.0441
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0263 0.105 0.0927
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.09 0.09
Echinococcus granulosus casein kinase ii subunit beta 0.0454 0.1948 0.1948
Schistosoma mansoni serine/threonine protein kinase 0.079 0.3519 0.3519
Echinococcus granulosus dual specificity 0.0263 0.105 0.105
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0133 0.0441 0.031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Giardia lamblia Kinase, CMGC GSK 0.0073 0.0159 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0136 0.0136
Echinococcus granulosus cyclin dependent kinase 0.0067 0.0136 0.0136
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0231 0.09 0.0775
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0454 0.1948 1
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0159 0.0024
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0454 0.1948 0.1838
Schistosoma mansoni casein kinase II beta subunit 0.0454 0.1948 0.1948
Echinococcus granulosus dual specificity 0.0231 0.09 0.09
Echinococcus multilocularis dual specificity 0.0263 0.105 0.105
Entamoeba histolytica protein kinase, putative 0.0231 0.09 0.0775
Trichomonas vaginalis casein kinase II beta chain, putative 0.0454 0.1948 0.1838
Echinococcus multilocularis hexokinase type 2 0.0096 0.027 0.027
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0263 0.105 0.105
Loa Loa (eye worm) hypothetical protein 0.0208 0.0792 0.0792
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0133 0.0441 0.031
Brugia malayi cell division control protein 2 homolog 0.0067 0.0136 0.0136
Brugia malayi Protein kinase domain containing protein 0.0067 0.0136 0.0136
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0454 0.1948 0.1838

Activities

Activity type Activity value Assay description Source Reference
%max (binding) = 86 % Activation of glucokinase (unknown origin) relative to control ChEMBL. 23434031
EC50 (binding) = 2.5 uM Activation of glucokinase (unknown origin) ChEMBL. 23434031

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.