Detailed information for compound 1763365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.345 | Formula: C15H20N4O2
  • H donors: 2 H acceptors: 4 LogP: 1.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CCCCc1nnn(c1)Cc1ccc(cc1)C
  • InChi: 1S/C15H20N4O2/c1-12-6-8-13(9-7-12)10-19-11-14(16-18-19)4-2-3-5-15(20)17-21/h6-9,11,21H,2-5,10H2,1H3,(H,17,20)
  • InChiKey: YQPSZFIHNFUWOE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0067 0.1073
Echinococcus granulosus inhibitor of apoptosis protein 0.0053 0.0408 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0026 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1017 1
Brugia malayi N-terminal motif family protein 0.0196 0.1664 0.1664
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0097 0.0097
Echinococcus granulosus histone deacetylase 3 0.0077 0.0618 0.0618
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0024 0.0024
Toxoplasma gondii hypothetical protein 0.001 0.0024 0.0227
Echinococcus granulosus dnaJ subfamily B 0.0822 0.7189 0.7189
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.0249
Leishmania major histone deacetylase, putative 0.0022 0.0133 0.1296
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1017 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.0448 0.0448
Schistosoma mansoni inhibitor of apoptosis protein 0.0053 0.0408 0.0408
Brugia malayi nuclear hormone receptor 0.001 0.0026 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0338 0.0338
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0024 0.0024
Onchocerca volvulus 0.001 0.0026 0.0066
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0026 0.0026
Onchocerca volvulus 0.0058 0.0448 0.113
Schistosoma mansoni hypothetical protein 0.0822 0.7189 0.7189
Brugia malayi Histone deacetylase 1 0.0077 0.0618 0.0618
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0007 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0506 0.4399 0.4399
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.2525
Loa Loa (eye worm) hypothetical protein 0.0022 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0067 0.1092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0037 0.0267 0.0267
Trypanosoma brucei histone deacetylase, putative 0.0022 0.0133 0.119
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1019 0.1019
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0067 0.1092
Loa Loa (eye worm) hypothetical protein 0.0254 0.2178 0.2178
Schistosoma mansoni histone deacetylase hda2 0.0022 0.0133 0.0133
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0133 0.2152
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0005 0.0005
Schistosoma mansoni histone deacetylase 4 5 0.0022 0.0133 0.0133
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0026 0.0026
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0053 0.0408 0.0408
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0067 0.0067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0904 0.8886
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0037 0.0267 0.4321
Brugia malayi hypothetical protein 0.0126 0.1054 0.1054
Echinococcus multilocularis GPCR, family 2 0.008 0.0648 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0001 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0067 0.0067
Brugia malayi MH2 domain containing protein 0.0092 0.0752 0.0752
Loa Loa (eye worm) histone deacetylase 11 0.0022 0.0133 0.0133
Leishmania major histone deacetylase, putative 0.0077 0.0618 0.6068
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0026 0.0026
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0408 0.0408
Echinococcus multilocularis muscleblind protein 0.0154 0.1299 0.1299
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0005 0.0005
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Echinococcus multilocularis dnaJ subfamily B 0.0822 0.7189 0.7189
Brugia malayi histone deacetylase 1 (HD1) 0.0077 0.0618 0.0618
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.0005 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0648 0.0648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0026 0.0026
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0026 0.0026
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1017 0.1017
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.2509
Loa Loa (eye worm) hypothetical protein 0.0126 0.1054 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1664 0.4192
Schistosoma mansoni hypothetical protein 0.008 0.0648 0.0648
Echinococcus granulosus histone deacetylase 0.0022 0.0133 0.0133
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0026 0.0066
Brugia malayi hypothetical protein 0.0037 0.0267 0.0267
Echinococcus granulosus histone deacetylase 1 0.0077 0.0618 0.0618
Echinococcus granulosus geminin 0.0506 0.4399 0.4399
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0067 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0097 0.0097
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0773 0.0773
Plasmodium vivax histone deacetylase, putative 0.0022 0.0133 0.119
Loa Loa (eye worm) hypothetical protein 0.0032 0.0222 0.0222
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0026 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0026 0.0026
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0024 0.0024
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0745 0.0745
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0133 0.2152
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0026 0.0026
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0005 0.0005
Brugia malayi ecdysteroid receptor 0.001 0.0026 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0448 0.0448
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0026 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0338 0.0338
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0066 0.0066
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0618 1
Schistosoma mansoni histone deacetylase 4 5 0.0022 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0457 0.397 0.397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0338 0.0338
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1017 0.1017
Schistosoma mansoni cpg binding protein 0.0061 0.0478 0.0478
Echinococcus multilocularis geminin 0.0506 0.4399 0.4399
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Onchocerca volvulus 0.0147 0.1235 0.3111
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0026 0.0026
Brugia malayi RNA binding protein 0.013 0.1087 0.1087
Plasmodium vivax histone deacetylase, putative 0.0022 0.0133 0.119
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0648 0.0648
Brugia malayi hypothetical protein 0.0016 0.0079 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1017 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0267 0.0267
Schistosoma mansoni thyroid hormone receptor 0.001 0.0026 0.0026
Plasmodium falciparum histone deacetylase 1 0.0077 0.0618 1
Trichomonas vaginalis hypothetical protein 0.0007 0.0001 0.0022
Echinococcus multilocularis tar DNA binding protein 0.013 0.1087 0.1087
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0249 0.0249
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0007 0.0005 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.2525
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0067 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0026 0.0026
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1141 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0026 0.0026
Echinococcus granulosus histone deacetylase 8 0.0022 0.0133 0.0133
Brugia malayi Latrophilin receptor protein 2 0.008 0.0648 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.1141 1 1
Echinococcus granulosus GPCR family 2 0.008 0.0648 0.0648
Loa Loa (eye worm) runx1 0.0057 0.0445 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Schistosoma mansoni coup transcription factor 0.001 0.0026 0.0026
Toxoplasma gondii exonuclease III APE 0.0015 0.0067 0.0651
Brugia malayi nuclear receptor NHR-88 0.001 0.0026 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0005 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0267 0.0267
Schistosoma mansoni hypothetical protein 0.0053 0.0408 0.0408
Echinococcus granulosus cpg binding protein 0.0061 0.0478 0.0478
Onchocerca volvulus 0.0053 0.0408 0.1026
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0005 0.0073
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0491 0.0491
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0005 0.0073
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.2178 0.2178
Echinococcus multilocularis inhibitor of apoptosis protein 0.0053 0.0408 0.0408
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0053 0.0408 0.0408
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0133 0.2152
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0005 0.0005
Plasmodium falciparum histone deacetylase 2 0.0022 0.0133 0.2136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0648 0.0648
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1017 0.1017
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0133 0.0133
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0026 0.0026
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.0154 0.1299 0.1299
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0024 0.0024
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0026 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0067 0.0067
Schistosoma mansoni transient receptor potential channel 0.0094 0.0773 0.0773
Schistosoma mansoni dep domain containing protein 0.001 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0133 0.2152
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0156 0.1608
Echinococcus granulosus muscleblind protein 0.0154 0.1299 0.1299
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0026 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0001 0.0001
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0618 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0491 0.0491
Schistosoma mansoni histone deacetylase 1 2 3 0.0022 0.0133 0.0133
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0026 0.0026
Schistosoma mansoni ap endonuclease 0.0015 0.0067 0.0067
Echinococcus multilocularis histone deacetylase 1 0.0077 0.0618 0.0618
Brugia malayi steroid hormone receptor 0.001 0.0026 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0648 0.0648
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0097 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0092 0.0752 0.0752
Leishmania major histone deacetylase, putative 0.0077 0.0618 0.6068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.1087 0.1087
Echinococcus multilocularis histone deacetylase 0.0022 0.0133 0.0133
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0037 0.0037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1017 0.1017
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0745 0.0745
Brugia malayi Histone deacetylase family protein 0.0022 0.0133 0.0133
Echinococcus multilocularis histone deacetylase 3 0.0077 0.0618 0.0618
Loa Loa (eye worm) RNA binding protein 0.013 0.1087 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Loa Loa (eye worm) TAR-binding protein 0.013 0.1087 0.1087
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0126 0.1054 0.1054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Echinococcus granulosus histone deacetylase 6 0.0022 0.0133 0.0133
Brugia malayi Histone deacetylase family protein 0.0022 0.0133 0.0133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0026 0.0026
Schistosoma mansoni histone deacetylase 0.0077 0.0618 0.0618
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0267 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0338 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0026 0.0026
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0773 0.0773
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1017 1
Onchocerca volvulus 0.0457 0.397 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1235 0.1235
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0133 0.2152
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0156 0.1522
Loa Loa (eye worm) AGC/PKG protein kinase 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0463 0.0463
Schistosoma mansoni transient receptor potential channel 0.0062 0.0491 0.0491
Onchocerca volvulus 0.001 0.0024 0.0061
Plasmodium falciparum histone deacetylase, putative 0.0022 0.0133 0.2136
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.013 0.1087 0.1087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0026 0.0026
Loa Loa (eye worm) histone deacetylase 1 0.0077 0.0618 0.0618
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0067 0.0651
Brugia malayi hypothetical protein 0.0147 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0007 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0026 0.0026
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0026 0.0026
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1141 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0026 0.0026
Schistosoma mansoni dishevelled 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0077 0.0618 0.0618
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.0005 0.0005
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0007 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0338 0.0338
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0024 0.0024
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0024 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.013 0.1087 0.1087
Echinococcus multilocularis Protein lozenge 0.0057 0.0445 0.0445
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0007 0.0005 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0092 0.0752 0.0752
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0005 0.0005
Loa Loa (eye worm) histone deacetylase 3 0.0077 0.0618 0.0618
Trypanosoma brucei histone deacetylase 4 0.0022 0.0133 0.119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0037 0.0037
Loa Loa (eye worm) histone deacetylase 7A 0.0022 0.0133 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0026 0.0026
Brugia malayi TAR-binding protein 0.013 0.1087 0.1087
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0037
Echinococcus multilocularis expressed conserved protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0024 0.0024
Echinococcus multilocularis histone deacetylase 7 0.0022 0.0133 0.0133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0055 0.0888
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0067 0.1092
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0026 0.0026
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0007 0.0005 0.0005
Onchocerca volvulus Histone deacetylase 10 homolog 0.0022 0.0133 0.0335
Entamoeba histolytica hypothetical protein 0.0037 0.0267 0.4321
Toxoplasma gondii histone deacetylase HDAC3 0.0077 0.0618 0.6068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0053 0.0408 0.0408
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0249 0.0249
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0026 0.0026
Echinococcus granulosus cGMP dependent protein kinase 1 0.0007 0.0001 0.0001
Plasmodium vivax histone deacetylase 2, putative 0.0022 0.0133 0.119
Schistosoma mansoni histone deacetylase hda2 0.0022 0.0133 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Brugia malayi DIX domain containing protein 0.001 0.0024 0.0024
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0007 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0025 0.0156 0.1522
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0024 0.0061
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0007 0.0001 0.0001
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.0005 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0005 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0648 0.0648
Giardia lamblia Histone deacetylase 0.0077 0.0618 1
Schistosoma mansoni cpg binding protein 0.0061 0.0478 0.0478
Leishmania major histone deacetylase, putative 0.0022 0.0133 0.1296
Schistosoma mansoni lozenge 0.0057 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0457 0.397 0.397
Schistosoma mansoni nuclear hormone receptor 0.001 0.0026 0.0026
Echinococcus granulosus tar DNA binding protein 0.013 0.1087 0.1087
Onchocerca volvulus Huntingtin homolog 0.0126 0.1054 0.2656
Brugia malayi histone deacetylase 3 (HD3) 0.0077 0.0618 0.0618
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0506 0.4399 0.4399
Schistosoma mansoni hypothetical protein 0.008 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0173 0.147 0.147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0067 0.1092
Trichomonas vaginalis helicase, putative 0.0013 0.0055 0.0888
Schistosoma mansoni transient receptor potential channel 0.0062 0.0491 0.0491
Onchocerca volvulus Deterin homolog 0.0053 0.0408 0.1026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0026 0.0026
Brugia malayi histone deacetylase 11 0.0022 0.0133 0.0133
Schistosoma mansoni dishevelled 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0196 0.1664 0.1664
Echinococcus granulosus FTZ F1 alpha 0.001 0.0026 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0007 0.0005 0.0005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0005 0.0005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0005
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0053 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0053 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0005
Echinococcus multilocularis voltage gated potassium channel 0.0007 0.0005 0.0005
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0133 0.0133
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0773 0.0773
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0648 0.0648
Echinococcus granulosus voltage gated potassium channel 0.0007 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0026 0.0026
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0024 0.0024
Loa Loa (eye worm) histone deacetylase 0.0022 0.0133 0.0133
Schistosoma mansoni thyroid hormone receptor 0.001 0.0026 0.0026
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0491 0.0491
Brugia malayi hypothetical protein 0.0457 0.397 0.397
Schistosoma mansoni hypothetical protein 0.0173 0.147 0.147
Echinococcus multilocularis histone deacetylase 8 0.0022 0.0133 0.0133
Echinococcus granulosus histone deacetylase 7 0.0022 0.0133 0.0133
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0408 0.0408
Echinococcus granulosus histone deacetylase 6 0.0022 0.0133 0.0133
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0026 0.0026
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.0005 0.0005
Brugia malayi Serine/threonine-protein kinase SULU 0.1141 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.0005 0.0005
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1141 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.0058 0.0448 0.0448
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0618 1
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.2178 0.2178
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.013 0.1087 0.1087
Trypanosoma brucei histone deacetylase 1 0.0077 0.0618 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.1087 0.1087
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.147 0.147
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0055 0.0888
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0024 0.0024
Entamoeba histolytica histone deacetylase, putative 0.0077 0.0618 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.2509
Brugia malayi hypothetical protein 0.0025 0.0156 0.0156
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1017 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0156 0.1608
Plasmodium vivax histone deacetylase 1, putative 0.0077 0.0618 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.013 0.1087 0.1087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0026 0.0026
Toxoplasma gondii histone deacetylase HDAC2 0.0077 0.0618 0.6068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0026 0.0026
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0648 0.0648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0338 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.008 0.0648 0.0648
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0066 0.0066
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0618 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0055 0.0888
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.013 0.1087 0.1087
Brugia malayi hypothetical protein 0.001 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0037 0.0267 0.4321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0338 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0022
Entamoeba histolytica hypothetical protein 0.0037 0.0267 0.4321
Brugia malayi Muscleblind-like protein 0.0154 0.1299 0.1299
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0491 0.0491
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0024
Trypanosoma brucei histone deacetylase 3 0.0022 0.0133 0.119
Schistosoma mansoni regulator of G protein signaling 0.001 0.0024 0.0024
Echinococcus granulosus cGMP dependent protein kinase 0.0007 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0015 0.0067 0.0067
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0154 0.1299 0.1299
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0067 0.5
Brugia malayi Egg laying defective protein 4 0.0007 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0338 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0026 0.0026
Schistosoma mansoni histone deacetylase 0.0077 0.0618 0.0618
Trypanosoma brucei histone deacetylase 2 0.0022 0.0133 0.119
Echinococcus multilocularis cpg binding protein 0.0061 0.0478 0.0478
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0026 0.0026
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0005 0.0005
Brugia malayi hypothetical protein 0.001 0.0024 0.0024
Echinococcus granulosus histone deacetylase 6 0.0022 0.0133 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0026 0.0026
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0618 1
Toxoplasma gondii histone deacetylase HDAC4 0.0022 0.0133 0.1296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.2178 0.2178
Onchocerca volvulus Huntingtin homolog 0.0126 0.1054 0.2656
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0024 0.0024
Toxoplasma gondii histone deacetylase HDAC5 0.0022 0.0133 0.1296
Toxoplasma gondii histone deacetylase HDAC1 0.0022 0.0133 0.1296
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0067 0.1092
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0026 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0338 0.0338
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.0094 0.0773 0.0773
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0026 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0055 0.0888
Schistosoma mansoni hypothetical protein 0.008 0.0648 0.0648
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0005 0.0005
Echinococcus granulosus cGMP dependent protein kinase 1 0.0007 0.0001 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0026 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0026 0.0026
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0249 0.0249
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0095 0.0095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1017 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.44 uM Inhibition of human recombinant HDAC1 incubated for 10 mins prior to substrate addition measured after 60 mins by spectrophotometric analysis ChEMBL. 23601706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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