Detailed information for compound 1764049

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 551.654 | Formula: C29H33N3O6S
  • H donors: 1 H acceptors: 6 LogP: 4.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(C(=O)c1nc2c(o1)cccc2)NC(=O)[C@@H]1C[C@H](CN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1
  • InChi: 1S/C29H33N3O6S/c1-2-22(26(33)28-31-23-15-9-10-16-25(23)38-28)30-27(34)24-17-21(39(36,37)20-13-7-4-8-14-20)18-32(24)29(35)19-11-5-3-6-12-19/h4,7-10,13-16,19,21-22,24H,2-3,5-6,11-12,17-18H2,1H3,(H,30,34)/t21-,22?,24+/m1/s1
  • InChiKey: COPOVXUTXSVAAO-FTPWCCPUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax vivapain-2 0.0059 0.1901 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1901 0.26
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Onchocerca volvulus 0.0059 0.1901 0.1792
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0133 0.0015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.1901 0.2474
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Echinococcus granulosus cysteine protease 0.0033 0.0691 0.079
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0691 0.3154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0489 0.0509
Onchocerca volvulus 0.0059 0.1901 0.1792
Brugia malayi ABC transporter family protein 0.0021 0.0133 0.0153
Brugia malayi Cathepsin L-like precursor 0.0041 0.1076 0.1239
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Toxoplasma gondii cathepsin B 0.0065 0.2169 1
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.1076 0.1471
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Echinococcus multilocularis cathepsin L 0.0033 0.0691 0.079
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0691 0.079
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0133 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0691 0.0945
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.7313 1
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0691 0.0945
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.8686 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.2169 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0691 0.3154
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1901 0.26
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.1076 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1901 0.1792
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0691 0.0945
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0539 0.0737
Brugia malayi cathepsin L-like precursor 0.0041 0.1076 0.1239
Loa Loa (eye worm) hypothetical protein 0.0029 0.0539 0.062
Plasmodium vivax SET domain protein, putative 0.0029 0.0539 0.2834
Giardia lamblia Cathepsin B precursor 0.0065 0.2169 0.5
Giardia lamblia Cathepsin B precursor 0.0065 0.2169 0.5
Brugia malayi Pre-SET motif family protein 0.0205 0.8686 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0133 0.0015
Schistosoma mansoni multidrug resistance protein 0.0021 0.0133 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0691 0.0565
Trichomonas vaginalis set domain proteins, putative 0.0234 1 1
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1901 0.2189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1901 0.2474
Echinococcus multilocularis cathepsin b 0.0176 0.7313 1
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0539 0.0737
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.1076 0.1239
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.1076 0.5333
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0133 0.0153
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0539 0.0579
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Onchocerca volvulus 0.0059 0.1901 0.1792
Loa Loa (eye worm) hypothetical protein 0.0041 0.1076 0.1239
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.2169 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0133 0.0015
Echinococcus multilocularis cysteine protease 0.0059 0.1901 0.2474
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0133 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0133 0.0015
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Plasmodium vivax unspecified product 0.0033 0.0691 0.3634
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Toxoplasma gondii cathepsin CPL 0.0059 0.1901 0.8685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0133 0.0015
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0133 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.1901 1
Onchocerca volvulus 0.0041 0.1076 0.0956
Loa Loa (eye worm) hypothetical protein 0.0021 0.0133 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1901 0.26
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1901 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0133 0.0701
Entamoeba histolytica cysteine protease, putative 0.0059 0.1901 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1901 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Loa Loa (eye worm) hypothetical protein 0.0041 0.1076 0.1239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0539 0.0737
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0133 0.0015
Brugia malayi Cathepsin L-like precursor 0.0041 0.1076 0.1239
Echinococcus granulosus cathepsin l1 0.0041 0.1076 0.1326
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1901 0.26
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.1901 0.2474
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.1901 0.2189
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0133 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.7313 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Loa Loa (eye worm) cysteine protease 0.0059 0.1901 0.2189
Onchocerca volvulus 0.0059 0.1901 0.1792
Schistosoma mansoni smdr2 0.0021 0.0133 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.2169 0.2063
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0133 0.0015
Schistosoma mansoni multidrug resistance protein 0.0021 0.0133 0.0182
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0691 0.0945
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1901 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0691 0.0945
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Loa Loa (eye worm) hypothetical protein 0.0021 0.0133 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0691 0.3154
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0133 0.0015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1901 0.2474
Brugia malayi Cathepsin L-like precursor 0.0059 0.1901 0.2189
Loa Loa (eye worm) ctsf protein 0.0059 0.1901 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Loa Loa (eye worm) hypothetical protein 0.0176 0.7313 0.842
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0691 0.0796
Echinococcus granulosus cathepsin b 0.0176 0.7313 1
Plasmodium vivax vivapain-2 0.0059 0.1901 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0539 0.1992
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.7313 0.842
Leishmania major cysteine peptidase A (CPA) 0.0059 0.1901 0.8685
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0133 0.0015
Echinococcus granulosus cathepsin L 0.0033 0.0691 0.079
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1901 0.1792
Plasmodium vivax vivapain-3 0.0033 0.0691 0.3634
Loa Loa (eye worm) hypothetical protein 0.0059 0.1901 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.2169 0.2966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Brugia malayi Pre-SET motif family protein 0.0029 0.0539 0.062
Echinococcus multilocularis cathepsin b 0.0176 0.7313 1
Onchocerca volvulus 0.0059 0.1901 0.1792
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0691 0.3154
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0691 0.3154
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7313 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0691 0.0565
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1901 0.26
Onchocerca volvulus 0.0059 0.1901 0.1792
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0133 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0133 0.0015
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.1901 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0691 0.3154
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1901 0.1792
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.1901 0.2189
Onchocerca volvulus 0.0059 0.1901 0.1792
Echinococcus granulosus cathepsin l1 0.0059 0.1901 0.2474
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Echinococcus multilocularis cysteine protease 0.0059 0.1901 0.2474
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0691 0.0945
Leishmania major cathepsin L-like protease 0.0059 0.1901 0.8685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7313 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.1076 0.0956
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0691 0.3154
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0133 0.0015
Giardia lamblia Cathepsin B precursor 0.0065 0.2169 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.2169 0.2966
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0691 0.0945
Loa Loa (eye worm) fibroinase 0.0059 0.1901 0.2189
Loa Loa (eye worm) hypothetical protein 0.0041 0.1076 0.1239
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0539 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1901 0.1792
Onchocerca volvulus 0.0029 0.0539 0.0411
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.1901 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Onchocerca volvulus Cathepsin F homolog 0.0059 0.1901 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1901 0.1792
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.1076 0.1471
Brugia malayi multidrug resistance protein 3 0.0021 0.0133 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1901 0.8189
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0691 0.0945
Plasmodium vivax vivapain-1 0.0033 0.0691 0.3634
Echinococcus granulosus cathepsin b 0.0176 0.7313 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Schistosoma mansoni hypothetical protein 0.0051 0.1538 0.2103
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0539 0.0579
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Entamoeba histolytica cysteine protease, putative 0.0033 0.0691 0.3154
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1901 0.2474
Loa Loa (eye worm) cathepsin B 0.0065 0.2169 0.2497
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1901 0.26
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0141
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0133 0.0153
Schistosoma mansoni multidrug resistance protein 0.0021 0.0133 0.0182
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0691 0.0796
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1901 0.26
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7313 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0539 0.0737

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.3 nM Inhibition of human cathepsin-S ChEMBL. 23639544
IC50 (binding) > 10000 nM Inhibition of human cathepsin-K ChEMBL. 23639544
IC50 (binding) > 10000 nM Inhibition of human cathepsin-B ChEMBL. 23639544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.