TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.46 | Formula: C20H32N3O4P
H donors: 3 H acceptors: 4 LogP: 5.16 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCc1ccc(cc1)CC[C@@](/C=C/P(=O)(O)O)(N=[N+]=[N-])CO
InChi: 1S/C20H32N3O4P/c1-2-3-4-5-6-7-8-18-9-11-19(12-10-18)13-14-20(17-24,22-23-21)15-16-28(25,26)27/h9-12,15-16,24H,2-8,13-14,17H2,1H3,(H2,25,26,27)/b16-15+/t20-/m0/s1
InChiKey: IUICHFFRDGVCQT-APHAIJBRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sphingosine kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Conserved protein	Get druggable targets OG5_128162	All targets in OG5_128162
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128162	All targets in OG5_128162
Candida albicans	similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase	Get druggable targets OG5_128162	All targets in OG5_128162
Echinococcus multilocularis	sphingosine kinase 1	Get druggable targets OG5_128162	All targets in OG5_128162
Schistosoma japonicum	ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative	Get druggable targets OG5_128162	All targets in OG5_128162
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128162	All targets in OG5_128162
Schistosoma mansoni	sphingosine kinase A B	Get druggable targets OG5_128162	All targets in OG5_128162
Schistosoma mansoni	sphingoid long chain base kinase	Get druggable targets OG5_128162	All targets in OG5_128162
Candida albicans	similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase	Get druggable targets OG5_128162	All targets in OG5_128162
Echinococcus granulosus	sphingosine kinase 1	Get druggable targets OG5_128162	All targets in OG5_128162
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_128162	All targets in OG5_128162

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CYP4Cod1	0.0061	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5033	0.5033
Onchocerca volvulus		0.0055	0.0935	0.029
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0101	0.2549	0.2549
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0101	0.2549	0.4705
Echinococcus multilocularis	histone deacetylase 7	0.0047	0.0676	0.0676
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0101	0.2549	0.2549
Echinococcus granulosus	glycine receptor subunit beta	0.0101	0.2549	0.2549
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0101	0.2549	0.2549
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0061	0.1145	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0028	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.0061	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Schistosoma mansoni	neurotransmitter gated ion channel	0.0047	0.0664	0.1225
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0047	0.0664	0.0664
Giardia lamblia	Beta tubulin	0.0028	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0055	0.0935	0.0935
Onchocerca volvulus		0.0101	0.2549	0.2019
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Giardia lamblia	Beta tubulin	0.0028	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.0061	0.1145	0.1145
Mycobacterium tuberculosis	Conserved protein	0.0185	0.5418	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0101	0.2549	0.2549
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0101	0.2549	0.4705
Echinococcus granulosus	cytochrome P450 2K1	0.0061	0.1145	0.1145
Schistosoma mansoni	acetylcholine receptor-related	0.0047	0.0664	0.1225
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0061	0.1145	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.1145	0.1145
Brugia malayi	Cation transporter family protein	0.0173	0.5033	0.5033
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0047	0.0664	0.0664
Leishmania major	histone deacetylase, putative	0.0047	0.0676	0.5907
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0047	0.0664	0.0664
Trypanosoma cruzi	histone deacetylase, putative	0.0047	0.0676	0.5907
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549
Echinococcus granulosus	nAChR subunit	0.0055	0.0935	0.0935
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549
Trypanosoma cruzi	cytochrome P450, putative	0.0061	0.1145	1
Loa Loa (eye worm)	histone deacetylase 7A	0.0047	0.0676	0.0676
Schistosoma mansoni	histone deacetylase hda2	0.0047	0.0676	0.1249
Echinococcus granulosus	glycine receptor subunit beta	0.0101	0.2549	0.2549
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0317	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0101	0.2549	0.4705
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0101	0.2549	0.2549
Onchocerca volvulus		0.0173	0.5033	0.468
Leishmania major	cytochrome p450-like protein	0.0061	0.1145	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Schistosoma mansoni	cytochrome P450	0.0061	0.1145	0.2114
Entamoeba histolytica	hypothetical protein, conserved	0.0185	0.5418	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0028	0	0.5
Brugia malayi	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0101	0.2549	0.2549
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Brugia malayi	Cation transporter family protein	0.0101	0.2549	0.2549
Brugia malayi	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0317	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0061	0.1145	0.5
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0061	0.1145	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	histone deacetylase 6	0.0047	0.0676	0.0676
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0317	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0101	0.2549	0.2549
Trypanosoma brucei	cytochrome P450, putative	0.0061	0.1145	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0101	0.2549	0.2549
Brugia malayi	hypothetical protein	0.0047	0.0664	0.0664
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0061	0.1145	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	histone deacetylase 6	0.0047	0.0676	0.0676
Leishmania major	histone deacetylase, putative	0.0047	0.0676	0.5907
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0101	0.2549	0.2549
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Brugia malayi	hypothetical protein	0.0047	0.0664	0.0664
Brugia malayi	excitatory GABA receptor EXP-1A	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Plasmodium falciparum	histone deacetylase, putative	0.0047	0.0676	1
Loa Loa (eye worm)	ACC-1 protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Brugia malayi	Cytochrome P450 family protein	0.0061	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5033	0.5033
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0101	0.2549	0.2549
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549
Trypanosoma brucei	histone deacetylase, putative	0.0047	0.0676	0.5907
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0101	0.2549	0.2549
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0055	0.0935	0.0935
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0317	1	1
Brugia malayi	cytochrome P450	0.0061	0.1145	0.1145
Brugia malayi	Histone deacetylase family protein	0.0047	0.0676	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0676	0.0676
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0047	0.0664	0.0664
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Leishmania major	cytochrome p450-like protein	0.0061	0.1145	1
Trypanosoma cruzi	histone deacetylase, putative	0.0047	0.0676	0.5907
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0061	0.1145	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0101	0.2549	0.2549
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0055	0.0935	0.1725
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0173	0.5033	0.9289
Trypanosoma brucei	histone deacetylase 4	0.0047	0.0676	0.5907
Echinococcus multilocularis	sphingosine kinase 1	0.0185	0.5418	0.5418
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0676	0.0676
Trichomonas vaginalis	tubulin, putative	0.0028	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Entamoeba histolytica	hypothetical protein	0.0055	0.0935	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Onchocerca volvulus	Putative nachr subunit	0.0317	1	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Schistosoma mansoni	neurotransmitter gated ion channel	0.0047	0.0664	0.1225
Onchocerca volvulus		0.0173	0.5033	0.468
Schistosoma mansoni	nAChR subunit	0.0047	0.0664	0.1225
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0317	1	1
Echinococcus multilocularis	histone deacetylase	0.0047	0.0676	0.0676
Onchocerca volvulus		0.0101	0.2549	0.2019
Brugia malayi	hypothetical protein	0.0047	0.0664	0.0664
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0101	0.2549	0.2549
Echinococcus granulosus	histone deacetylase 6	0.0047	0.0676	0.0676
Schistosoma mansoni	nAChR subunit	0.0047	0.0664	0.1225
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0101	0.2549	0.2549
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0101	0.2549	0.4705
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.1145	0.1145
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0055	0.0935	0.0935
Schistosoma mansoni	neurotransmitter gated ion channel	0.0055	0.0935	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0101	0.2549	0.2549
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0061	0.1145	1
Plasmodium vivax	histone deacetylase, putative	0.0047	0.0676	1
Plasmodium vivax	histone deacetylase 2, putative	0.0047	0.0676	1
Brugia malayi	Cytochrome P450 family protein	0.0061	0.1145	0.1145
Echinococcus granulosus	histone deacetylase 6	0.0047	0.0676	0.0676
Schistosoma mansoni	hypothetical protein	0.0061	0.1145	0.2114
Loa Loa (eye worm)	histone deacetylase	0.0047	0.0676	0.0676
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Brugia malayi	Histone deacetylase family protein	0.0047	0.0676	0.0676
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0028	0	0.5
Loa Loa (eye worm)	LGC-31 protein	0.0101	0.2549	0.2549
Echinococcus granulosus	sphingosine kinase 1	0.0185	0.5418	0.5418
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0047	0.0664	0.0664
Loa Loa (eye worm)	GABA receptor subunit	0.0055	0.0935	0.0935
Loa Loa (eye worm)	ACC-1 protein	0.0101	0.2549	0.2549
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0317	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0055	0.0935	0.1725
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0055	0.0935	0.0935
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Onchocerca volvulus		0.0055	0.0935	0.029
Trichomonas vaginalis	tubulin beta chain, putative	0.0028	0	0.5
Echinococcus granulosus	nAChR subunit	0.0101	0.2549	0.2549
Trypanosoma brucei	histone deacetylase 3	0.0047	0.0676	0.5907
Mycobacterium leprae	putative cytochrome p450	0.0061	0.1145	0.5
Mycobacterium ulcerans	hypothetical protein	0.0185	0.5418	1
Onchocerca volvulus		0.0173	0.5033	0.468
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Toxoplasma gondii	histone deacetylase HDAC1	0.0047	0.0676	0.5907
Trichomonas vaginalis	tubulin alpha chain, putative	0.0028	0	0.5
Echinococcus multilocularis		0.0061	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.1145	0.1145
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0047	0.0664	0.0664
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0101	0.2549	0.2549
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0047	0.0664	0.0664
Schistosoma mansoni	sphingosine kinase A B	0.0185	0.5418	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0127	0.3418	0.3418
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Echinococcus multilocularis	nAChR subunit	0.0055	0.0935	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0935	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Schistosoma mansoni	nAChR subunit	0.0101	0.2549	0.4705
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0664	0.0664
Onchocerca volvulus		0.0101	0.2549	0.2019
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0101	0.2549	0.2549
Echinococcus granulosus	histone deacetylase 6	0.0047	0.0676	0.0676
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549
Echinococcus multilocularis	glycine receptor subunit beta	0.0101	0.2549	0.2549
Schistosoma mansoni	histone deacetylase 4 5	0.0047	0.0676	0.1249
Echinococcus multilocularis	nAChR subunit	0.0101	0.2549	0.2549
Schistosoma mansoni	histone deacetylase 4 5	0.0047	0.0676	0.1249
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0101	0.2549	0.2549
Plasmodium falciparum	histone deacetylase 2	0.0047	0.0676	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2549	0.2549
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0173	0.5033	0.9289
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0047	0.0664	0.1225
Echinococcus granulosus	histone deacetylase	0.0047	0.0676	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	glycine receptor subunit beta	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5418	0.5418
Schistosoma mansoni	sphingoid long chain base kinase	0.0185	0.5418	1
Trypanosoma cruzi	histone deacetylase, putative	0.0047	0.0676	0.5907
Giardia lamblia	Beta tubulin	0.0028	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Leishmania major	cytochrome p450-like protein	0.0061	0.1145	1
Trypanosoma cruzi	cytochrome P450, putative	0.0061	0.1145	1
Loa Loa (eye worm)	cytochrome P450	0.0061	0.1145	0.1145
Echinococcus multilocularis	histone deacetylase 6	0.0047	0.0676	0.0676
Echinococcus granulosus	histone deacetylase 7	0.0047	0.0676	0.0676
Brugia malayi	Cation transporter family protein	0.0101	0.2549	0.2549
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0101	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0664	0.0664
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0317	1	1
Loa Loa (eye worm)	acetylcholine receptor protein	0.0047	0.0664	0.0664
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0101	0.2549	0.2549

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 30 %	Activation of recombinant GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate at 50 uM after 30 mins by Cerenkov counting analysis relative to control	ChEMBL.	23541833
EC50 (binding)	= 8.3 uM	Activation of recombinant GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins by Cerenkov counting analysis	ChEMBL.	23541833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376444

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1766666