TDR Targets

Basic information

Technical information

TDR Targets ID: 177380
Name: 2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]o ctan-3-yl)-3H-1-benzofuran-6-carboxamide
MW: 314.422 | Formula: C19H26N2O2
H donors: 1 H acceptors: 1 LogP: 3.03 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1C2CCC1CC(C2)NC(=O)c1ccc2c(c1)OC(C2)(C)C
InChi: 1S/C19H26N2O2/c1-19(2)11-13-5-4-12(8-17(13)23-19)18(22)20-14-9-15-6-7-16(10-14)21(15)3/h4-5,8,14-16H,6-7,9-11H2,1-3H3,(H,20,22)
InChiKey: DUBLWRYEIGALGI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3H-benzofuran-6-carboxamide
2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)coumaran-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0208	0.0478	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0208	0.0478	0.0478
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0473
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.3223	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.3223	1	1
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0208	0.0478	0.0401
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0471	0.131	0.1258
Loa Loa (eye worm)	hypothetical protein	0.0679	0.1967	0.1967
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3223	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.061	0.1747	0.164
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0473
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0208	0.0478	0.0422
Giardia lamblia	Hypothetical protein	0.0208	0.0478	0.0473
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0208	0.0478	0.0422
Trypanosoma cruzi	target of rapamycin kinase 3	0.2567	0.7926	0.7899
Brugia malayi	FAT domain containing protein	0.0471	0.131	0.1258
Mycobacterium ulcerans	hypothetical protein	0.0058	0.0005	0.5
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.061	0.1747	0.164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2162	0.6649	0.6634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0208	0.0478	0.0422
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0208	0.0478	0.0422
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0355
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0208	0.0478	0.0355
Schistosoma mansoni	fkbp-rapamycin associated protein	0.061	0.1747	0.1679
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1081	0.3235	0.3205
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0208	0.0478	0.0437
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0208	0.0478	0.0355
Loa Loa (eye worm)	phosphatidylinositol 3	0.3223	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1738	0.5309	0.5289
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1926	0.5904	0.5886
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0437
Trichomonas vaginalis	conserved hypothetical protein	0.0679	0.1967	0.1932
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3223	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.2567	0.7926	0.7899
Loa Loa (eye worm)	hypothetical protein	0.0402	0.109	0.109
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.061	0.1747	0.1711
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0208	0.0478	0.0422
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0208	0.0478	0.0401
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0099	0.0133	0.0005
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0208	0.0478	0.0422
Leishmania major	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0355
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0208	0.0478	0.0478
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0355
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.3223	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1339	0.4049	0.3972
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0437
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0473
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1081	0.3235	0.3195
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.061	0.1747	0.164
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.5
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0471	0.131	0.1258
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0208	0.0478	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0402	0.109	0.1051
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0208	0.0478	0.0355
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0355
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1081	0.3235	0.3148
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.3223	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Echinococcus granulosus	serine protein kinase ATM	0.061	0.1747	0.1698
Plasmodium vivax	hypothetical protein	0.0208	0.0478	0.5
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0058	0.0005	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0437
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.061	0.1747	0.1698
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0208	0.0478	0.0401
Loa Loa (eye worm)	phosphatidylinositol 3	0.0208	0.0478	0.0478
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.0099	0.0133	0.0074
Echinococcus multilocularis		0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0208	0.0478	0.0437
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0208	0.0478	0.0355
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.3223	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1738	0.5309	0.5289
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2564	0.7917	0.7908
Entamoeba histolytica	hypothetical protein	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.5318	0.5297
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0437
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0208	0.0478	0.0473
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0208	0.0478	0.0473
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1081	0.3235	0.3195
Echinococcus multilocularis	serine protein kinase ATM	0.061	0.1747	0.1698
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1081	0.3235	0.3148
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.061	0.1747	0.1698
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0208	0.0478	0.0401
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2564	0.7917	0.7908
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0355
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1524	0.4635	0.4566
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0208	0.0478	0.0437
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0208	0.0478	0.0437
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1081	0.3235	0.3148
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3223	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Entamoeba histolytica	hypothetical protein	0.0208	0.0478	0.0473
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0208	0.0478	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0208	0.0478	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2752	0.8512	0.8505
Toxoplasma gondii	FATC domain-containing protein	0.061	0.1747	0.1835
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0208	0.0478	0.0401
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1081	0.3235	0.3195
Onchocerca volvulus		0.0208	0.0478	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.5318	0.5297
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2564	0.7917	0.7908
Loa Loa (eye worm)	hypothetical protein	0.0471	0.131	0.131
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0099	0.0133	0.0005
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0355
Loa Loa (eye worm)	hypothetical protein	0.061	0.1747	0.1747
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.061	0.1747	0.1698
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0473
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0208	0.0478	0.0422
Giardia lamblia	GTOR	0.3223	1	1
Leishmania major	hypothetical protein, conserved	0.0208	0.0478	0.0355
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0208	0.0478	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2397	0.7392	0.738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.5318	0.5297
Onchocerca volvulus		0.0208	0.0478	1
Trichomonas vaginalis	conserved hypothetical protein	0.0402	0.109	0.1051
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0208	0.0478	0.0355
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0208	0.0478	0.5
Schistosoma mansoni	6-phosphofructokinase	0.0099	0.0133	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2093	0.6429	0.6414
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0208	0.0478	0.5
Loa Loa (eye worm)	hypothetical protein	0.0657	0.1896	0.1896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0208	0.0478	0.0437
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0099	0.0133	0.0005
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1081	0.3235	0.3148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1907	0.5843	0.5825
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0208	0.0478	0.0401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0865	0.2553	0.252
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.5
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0208	0.0478	0.5
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.3223	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0208	0.0478	0.0422
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1081	0.3235	0.3148
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.3223	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.061	0.1747	0.1698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1926	0.5904	0.5886
Loa Loa (eye worm)	phosphatidylinositol 3	0.1081	0.3235	0.3235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1081	0.3235	0.3205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0127	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1081	0.3235	0.3205
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.3223	1	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0208	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0208	0.0478	0.0478
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.061	0.1747	0.1679
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0075	0.0059	0.0059
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0208	0.0478	0.0437
Leishmania major	hypothetical protein, unknown function	0.0208	0.0478	0.0355
Loa Loa (eye worm)	phosphatidylinositol 3	0.0208	0.0478	0.0478
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0679	0.1967	0.2153
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0099	0.0133	0.0005
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.3223	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.0473
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0208	0.0478	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1081	0.3235	0.3205
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1081	0.3235	0.318
Schistosoma mansoni	hypothetical protein	0.0471	0.131	0.1239
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0208	0.0478	0.0355
Trichomonas vaginalis	PIKK family atypical protein kinase	0.061	0.1747	0.1711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2564	0.7917	0.7908
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.3223	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1081	0.3235	0.3148
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.061	0.1747	0.1742
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1081	0.3235	0.3205
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0208	0.0478	0.0401
Mycobacterium leprae	conserved hypothetical protein	0.0208	0.0478	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1741	0.5318	0.5297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.061	0.1747	0.1711
Loa Loa (eye worm)	phosphatidylinositol 3	0.0208	0.0478	0.0478
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2397	0.7392	1
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.0099	0.0133	0.0074
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.3223	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0208	0.0478	0.0422
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0473
Entamoeba histolytica	protein kinase rad3, putative	0.061	0.1747	0.1742
Entamoeba histolytica	hypothetical protein	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2564	0.7917	0.7908
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0208	0.0478	0.0437
Schistosoma mansoni	hypothetical protein	0.0208	0.0478	0.0401
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0208	0.0478	0.0422
Entamoeba histolytica	hypothetical protein	0.061	0.1747	0.1742
Echinococcus multilocularis	Zinc finger, PHD finger	0.0208	0.0478	0.0422
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0402	0.109	0.0975
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0208	0.0478	0.0355
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0208	0.0478	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0471	0.131	0.1272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1926	0.5904	0.5886
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0208	0.0478	0.0437
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.2567	0.7926	0.7899
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0028	0.0028
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0208	0.0478	0.0422
Entamoeba histolytica	hypothetical protein	0.0208	0.0478	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1907	0.5843	0.5825
Loa Loa (eye worm)	phosphatidylinositol 3	0.0208	0.0478	0.0478
Loa Loa (eye worm)	phosphatidylinositol 3	0.0208	0.0478	0.0478
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0208	0.0478	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1738	0.5309	0.5289
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0133	0.0133

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	5-hydroxytryptamine 3 receptor antagonistic activity measured by inhibition of 5-HT-induced bradycardia (iv administration 10 ug/kg dose in urethane-anesthetized rats)	ChEMBL.	1732548
Inhibition (functional)	= 0 %	5-hydroxytryptamine 3 receptor antagonistic activity measured by inhibition of 5-HT-induced bradycardia (iv administration 10 ug/kg dose in urethane-anesthetized rats)	ChEMBL.	1732548

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 14838270

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 177380