Detailed information for compound 1779564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.334 | Formula: C19H16FNO3
  • H donors: 1 H acceptors: 3 LogP: 4.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)c1nc2ccc(cc2c(c1)C(=O)O)F
  • InChi: 1S/C19H16FNO3/c1-2-9-24-14-6-3-12(4-7-14)18-11-16(19(22)23)15-10-13(20)5-8-17(15)21-18/h3-8,10-11H,2,9H2,1H3,(H,22,23)
  • InChiKey: BHTAJFZTHLHDNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1133 0.1133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.001 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0035 0.0129
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.001 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.001 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0202 0.0734
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0202 0.0734
Loa Loa (eye worm) glutathione reductase 0.0093 0.0626 0.2273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0273 0.0273
Schistosoma mansoni alpha-glucosidase 0.0138 0.0967 0.0967
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0273 0.0273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.1685 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0273 0.0273
Plasmodium vivax glutathione reductase, putative 0.0093 0.0626 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1133 0.4114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.001 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0359 0.5734
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.001 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0129
Mycobacterium tuberculosis Probable reductase 0.0211 0.151 0.8958
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.001 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0176 0.2803
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0176 0.2803
Schistosoma mansoni survival motor neuron protein 0.0047 0.0286 0.0286
Trypanosoma brucei glucosidase, putative 0.0036 0.0202 0.3228
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1133 0.1133
Echinococcus granulosus glycogen phosphorylase 0.0379 0.2754 0.2754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0211 0.151 0.8958
Plasmodium falciparum thioredoxin reductase 0.0032 0.0176 0.2803
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0202 0.0734
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0035 0.0129
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.1685 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0202 0.3228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.001 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0129
Schistosoma mansoni cpg binding protein 0.003 0.016 0.016
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Echinococcus multilocularis microtubule associated protein 2 0.1352 1 1
Plasmodium falciparum thioredoxin reductase 0.0093 0.0626 1
Schistosoma mansoni microtubule-associated protein tau 0.1352 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0626 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.001 0.0035
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0176 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.001 0.0035
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0176 0.2803
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Trichomonas vaginalis glycogen phosphorylase, putative 0.0379 0.2754 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0035 0.0567
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0176 0.2803
Schistosoma mansoni cpg binding protein 0.0032 0.0172 0.0172
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0211 0.151 0.8958
Onchocerca volvulus 0.0093 0.0629 0.2282
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.001 0.0035
Loa Loa (eye worm) glutaminase 2 0.0285 0.2059 0.7476
Brugia malayi steroid hormone receptor 0.001 0.001 0.0035
Brugia malayi follicle stimulating hormone receptor 0.0225 0.1613 0.5856
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0112 0.0407
Entamoeba histolytica glycogen phosphorylase, putative 0.0379 0.2754 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.001 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0626 0.0626
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.041 0.041
Echinococcus multilocularis glycogen phosphorylase 0.0379 0.2754 0.2754
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.2803
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0141 0.0511
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0202 0.3228
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.097 0.5757
Echinococcus granulosus FTZ F1 alpha 0.001 0.001 0.001
Brugia malayi Steroid receptor seven-up type 2 0.001 0.001 0.0035
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.001 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0626 0.0626
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0176 0.0852
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0202 0.0202
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0202 0.0734
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.001 0.001
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0164 0.1155 0.5609
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0176 0.0637
Echinococcus granulosus glycogen phosphorylase 0.0379 0.2754 0.2754
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Entamoeba histolytica glycogen phosphorylase, putative 0.0379 0.2754 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.2052 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0273 0.0273
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0047 0.0286 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Entamoeba histolytica glycogenphosphorylase, putative 0.0164 0.1155 0.4193
Brugia malayi CXXC zinc finger family protein 0.003 0.016 0.0579
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1648 0.1648
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0626 0.3716
Loa Loa (eye worm) glycogen phosphorylase 0.0379 0.2754 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0176 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.001 0.0035
Schistosoma mansoni glycogen phosphorylase 0.0164 0.1155 0.1155
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0202 0.0734
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.0027 0.0141 0.0511
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.001 0.001
Chlamydia trachomatis glycogen phosphorylase 0.0379 0.2754 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0176 0.2803
Entamoeba histolytica glycogen phosphorylase, putative 0.0164 0.1155 0.4193
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0176 0.0852
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0852
Echinococcus multilocularis Glycosyl transferase, family 35 0.0379 0.2754 0.2754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0273 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0035 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Giardia lamblia Glycogen phosphorylase 0.0379 0.2754 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0035 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.001 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.001
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0164 0.1155 0.6854
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0129
Trichomonas vaginalis glycogen phosphorylase, putative 0.0379 0.2754 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.001 0.001
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1133 0.1133
Schistosoma mansoni cpg binding protein 0.0032 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.001 0.001
Echinococcus granulosus cpg binding protein 0.0032 0.0172 0.0172
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.1613 0.5856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0035
Schistosoma mansoni alpha-glucosidase 0.0138 0.0967 0.0967
Trypanosoma brucei trypanothione reductase 0.0093 0.0626 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0273 0.0273
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.001 0.0035
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0176 0.2803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Toxoplasma gondii thioredoxin reductase 0.0093 0.0626 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0273 0.0273
Brugia malayi carbohydrate phosphorylase 0.0379 0.2754 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0211 0.151 0.8958
Loa Loa (eye worm) glutaminase 0.0285 0.2059 0.7476
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0202 0.0734
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Schistosoma mansoni coup transcription factor 0.001 0.001 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.001 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0273 0.0989
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0176 0.1042
Treponema pallidum NADH oxidase 0.0032 0.0176 0.0855
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.001 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0035 0.0129
Onchocerca volvulus Glycogen phosphorylase homolog 0.0379 0.2754 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0211 0.151 0.8958
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0202 0.0734
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.001 0.001
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0035 0.0567
Onchocerca volvulus 0.001 0.001 0.0035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.097 0.4711
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.2052 0.7451
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0626 0.2273
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.001 0.0035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0211 0.151 0.8958
Onchocerca volvulus 0.003 0.016 0.0579
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0202 0.0734
Echinococcus granulosus Glycosyl transferase family 35 0.0379 0.2754 0.2754
Echinococcus multilocularis FTZ F1 alpha 0.001 0.001 0.001
Brugia malayi glutaminase DH11.1 0.0285 0.2059 0.7476
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.2803
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.001 0.001
Echinococcus granulosus dnaJ subfamily B 0.0427 0.3112 0.3112
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0176 0.0637
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Schistosoma mansoni hypothetical protein 0.0427 0.3112 0.3112
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0202 0.0734
Schistosoma mansoni glycogen phosphorylase 0.0379 0.2754 0.2754
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0035 0.0567
Schistosoma mansoni alpha glucosidase 0.0036 0.0202 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Mycobacterium ulcerans glutaminase 0.0285 0.2059 1
Loa Loa (eye worm) hypothetical protein 0.023 0.1648 0.5984
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0286 0.1037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0035 0.0129
Entamoeba histolytica glycogen phosphorylase, putative 0.0164 0.1155 0.4193
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0129
Brugia malayi hypothetical protein 0.023 0.1648 0.5984
Onchocerca volvulus 0.0047 0.0286 0.1037
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0202 0.3228
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.2803
Brugia malayi Thioredoxin reductase 0.0093 0.0626 0.2273
Plasmodium falciparum glutathione reductase 0.0093 0.0626 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0202 0.3228
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.2803
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0176 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0202 0.0734
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.016 0.0579
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0176 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0035
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0035 0.0567
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0112 0.0407
Plasmodium falciparum glutathione reductase 0.0032 0.0176 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.001 0.0035
Leishmania major trypanothione reductase 0.0093 0.0626 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0202 0.0734
Echinococcus multilocularis glycogen phosphorylase 0.0379 0.2754 0.2754
Echinococcus multilocularis cpg binding protein 0.0032 0.0172 0.0172
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0202 0.0734
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0211 0.151 0.8958
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.1685 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.001 0.0035
Trichomonas vaginalis glutaminase, putative 0.0285 0.2059 0.7476
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0176 0.0637
Schistosoma mansoni glycogen phosphorylase 0.0379 0.2754 0.2754
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0626 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0176 0.0637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0035
Schistosoma mansoni glutaminase 0.0285 0.2059 0.2059
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.2803
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0176 0.2803
Brugia malayi ecdysteroid receptor 0.001 0.001 0.0035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1133 0.4114
Brugia malayi glutathione reductase 0.0093 0.0626 0.2273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2052 0.7451
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0035
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.3112 0.3112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0273 0.0989
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.1685 1
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0176 0.0637
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0202 0.0202
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.097 0.5757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0202 0.0734
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0035
Loa Loa (eye worm) steroid hormone receptor 0.001 0.001 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1648 0.1648
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.001 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.001 0.001 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.