TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.415 | Formula: C20H14N4O3S
H donors: 0 H acceptors: 5 LogP: 4.14 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccccc1c1ccc(cc1)CSc1nnc(o1)c1ccncc1
InChi: 1S/C20H14N4O3S/c25-24(26)18-4-2-1-3-17(18)15-7-5-14(6-8-15)13-28-20-23-22-19(27-20)16-9-11-21-12-10-16/h1-12H,13H2
InChiKey: PSLRGVBAUBPLDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 alpha	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0196	0.2121	0.4774
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0196	0.2121	0.4774
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0119	0.096	0.1391
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0119	0.096	0.077
Leishmania major	hypothetical protein, conserved	0.0119	0.096	0.4526
Echinococcus multilocularis	SWI:SNF matrix associated	0.0335	0.4217	0.4096
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0335	0.4217	0.4096
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0119	0.096	0.4526
Onchocerca volvulus		0.0119	0.096	0.0611
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0117	0.092	0.1781
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.092	0.1781
Brugia malayi	SWIB/MDM2 domain containing protein	0.0335	0.4217	0.6111
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0119	0.096	0.1391
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0335	0.4217	0.6111
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0117	0.092	0.4337
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.092	1
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.092	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0119	0.096	0.077
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0119	0.096	0.1391
Leishmania major	hypothetical protein, conserved	0.0119	0.096	0.4526
Trypanosoma cruzi	WLM domain containing protein, putative	0.0119	0.096	0.4526
Onchocerca volvulus		0.0119	0.096	0.0611
Schistosoma mansoni	hypothetical protein	0.0335	0.4217	0.5992
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0117	0.092	0.1067
Brugia malayi	serine/threonine-protein kinase 6	0.0069	0.0206	0.0298
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0196	0.2121	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0119	0.096	0.4526
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0119	0.096	0.4526
Onchocerca volvulus		0.0119	0.096	0.0611
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0206	0.0298
Brugia malayi	serine/threonine kinase 12	0.0069	0.0206	0.0298
Toxoplasma gondii	ran binding protein	0.0119	0.096	0.1881
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0119	0.096	0.4526
Echinococcus granulosus	protein kinase shaggy	0.0117	0.092	0.0729
Schistosoma mansoni	fusion	0.0119	0.096	0.1127
Echinococcus multilocularis	tumor protein p63	0.0719	1	1
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0206	0.0298
Brugia malayi	brahma associated protein 60 kDa	0.0335	0.4217	0.6111
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0119	0.096	0.4526
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0196	0.2121	0.4774
Brugia malayi	intracellular kinase	0.0117	0.092	0.1333
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0206	0.0298
Trypanosoma brucei	protein kinase, putative	0.0117	0.092	0.4337
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0119	0.096	0.4526
Brugia malayi	brahma associated protein 60 kDa	0.0335	0.4217	0.6111
Trypanosoma brucei	aurora B kinase	0.0069	0.0206	0.0969
Echinococcus multilocularis	SWI:SNF matrix associated	0.0335	0.4217	0.4096
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0117	0.092	0.4337
Echinococcus granulosus	ring and YY1 binding protein	0.0119	0.096	0.077
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0117	0.092	0.1333
Loa Loa (eye worm)	dihydrofolate reductase	0.0513	0.6901	1
Loa Loa (eye worm)	brahma associated protein	0.0335	0.4217	0.6111
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0119	0.096	0.4526
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0117	0.092	0.0729
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0335	0.4217	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0119	0.096	0.1391
Schistosoma mansoni	zinc finger protein	0.0119	0.096	0.1127
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.092	0.1781
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0335	0.4217	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0335	0.4217	0.4096
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0119	0.096	0.077
Giardia lamblia	Kinase, CMGC GSK	0.0117	0.092	1
Trypanosoma brucei	hypothetical protein, conserved	0.0119	0.096	0.4526
Loa Loa (eye worm)	hypothetical protein	0.0119	0.096	0.1391
Chlamydia trachomatis	dihydrofolate reductase	0.0513	0.6901	1
Brugia malayi	Dihydrofolate reductase	0.0513	0.6901	1
Echinococcus granulosus	SWI:SNF matrix associated	0.0335	0.4217	0.4096
Schistosoma mansoni	RNA binding protein	0.0119	0.096	0.1127
Leishmania major	hypothetical protein, conserved	0.0119	0.096	0.4526
Loa Loa (eye worm)	hypothetical protein	0.0119	0.096	0.1391
Trypanosoma cruzi	WLM domain containing protein, putative	0.0119	0.096	0.4526
Onchocerca volvulus		0.0335	0.4217	1
Entamoeba histolytica	protein kinase, putative	0.0117	0.092	1
Trypanosoma brucei	hypothetical protein, conserved	0.0119	0.096	0.4526
Leishmania major	hypothetical protein, conserved	0.0119	0.096	0.4526
Schistosoma mansoni	hypothetical protein	0.0335	0.4217	0.5992
Trypanosoma cruzi	hypothetical protein, conserved	0.0119	0.096	0.4526
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0335	0.4217	1
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0513	0.6901	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0119	0.096	0.4526
Loa Loa (eye worm)	hypothetical protein	0.0119	0.096	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0748	0.1084
Schistosoma mansoni	hypothetical protein	0.0119	0.096	0.1127
Brugia malayi	serine/threonine protein kinase 6	0.0069	0.0206	0.0298
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0335	0.4217	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0513	0.6901	0.5
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0119	0.096	0.0611
Plasmodium falciparum	glycogen synthase kinase 3	0.0117	0.092	0.1781
Trypanosoma cruzi	hypothetical protein, conserved	0.0119	0.096	0.4526
Brugia malayi	dihydrofolate reductase family protein	0.0513	0.6901	1
Trichomonas vaginalis	conserved hypothetical protein	0.0335	0.4217	1
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0119	0.096	0.1881
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0117	0.092	0.0729
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0335	0.4217	0.4096
Trypanosoma cruzi	aurora B kinase, putative	0.0069	0.0206	0.0969
Echinococcus multilocularis	dihydrofolate reductase	0.0513	0.6901	0.6836
Echinococcus granulosus	dihydrofolate reductase	0.0513	0.6901	0.6836
Onchocerca volvulus		0.0119	0.096	0.0611
Plasmodium vivax	hypothetical protein, conserved	0.0335	0.4217	1
Brugia malayi	YY1-associated factor 2	0.0119	0.096	0.1391
Schistosoma mansoni	cellular tumor antigen P53	0.0105	0.0748	0.081
Schistosoma mansoni	dihydrofolate reductase	0.0513	0.6901	1
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0119	0.096	0.077
Leishmania major	hypothetical protein, conserved	0.0119	0.096	0.4526
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0119	0.096	0.1881
Loa Loa (eye worm)	hypothetical protein	0.0119	0.096	0.1391
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0117	0.092	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0119	0.096	0.1391
Schistosoma mansoni	TRABID protein (C64 family)	0.0119	0.096	0.1127
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0513	0.6901	1
Echinococcus multilocularis	protein kinase shaggy	0.0117	0.092	0.0729
Echinococcus granulosus	zinc finger protein Ran binding	0.0119	0.096	0.077
Schistosoma mansoni	hypothetical protein	0.0335	0.4217	0.5992
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0117	0.092	0.1781
Leishmania major	protein kinase, putative	0.0069	0.0206	0.0969
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0335	0.4217	1
Echinococcus multilocularis	zinc finger protein Ran binding	0.0119	0.096	0.077
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0196	0.2121	1
Onchocerca volvulus		0.0117	0.092	0.0495
Schistosoma mansoni	brg-1 associated factor	0.0335	0.4217	0.5992
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0196	0.2121	1
Giardia lamblia	Kinase, CMGC GSK	0.0117	0.092	1
Echinococcus multilocularis	ring and YY1 binding protein	0.0119	0.096	0.077

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.027 uM	Inhibition of human recombinant GSK3alpha by FRET assay	ChEMBL.	22749643
IC50 (binding)	= 0.164 uM	Inhibition of human recombinant GSK3beta by FRET assay	ChEMBL.	22749643
IC50 (binding)	= 5 uM	Inhibition of human recombinant AURKA by FRET assay	ChEMBL.	22749643
IC50 (binding)	> 100 uM	Inhibition of human recombinant PKCalpha by FRET assay	ChEMBL.	22749643
IC50 (binding)	> 100 uM	Inhibition of human recombinant CK1epsilon by FRET assay	ChEMBL.	22749643
IC50 (binding)	> 100 uM	Inhibition of human recombinant Cdk5/p35 by FRET assay	ChEMBL.	22749643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391133

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1781718