Detailed information for compound 178179

Basic information

Technical information
  • TDR Targets ID: 178179
  • Name: 4-(1-butyl-3,6-dihydro-2H-pyridin-5-yl)-N-met hyl-1,3-thiazol-2-amine
  • MW: 251.391 | Formula: C13H21N3S
  • H donors: 1 H acceptors: 1 LogP: 2.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1CCC=C(C1)c1csc(n1)NC
  • InChi: 1S/C13H21N3S/c1-3-4-7-16-8-5-6-11(9-16)12-10-17-13(14-2)15-12/h6,10H,3-5,7-9H2,1-2H3,(H,14,15)
  • InChiKey: KKGUCVMOJNBBFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(1-butyl-3,6-dihydro-2H-pyridin-5-yl)-N-methyl-thiazol-2-amine
  • 4-(1-butyl-3,6-dihydro-2H-pyridin-5-yl)-N-methyl-2-thiazolamine
  • [4-(1-butyl-3,6-dihydro-2H-pyridin-5-yl)thiazol-2-yl]-methyl-amine
  • 4-(1-butyl-5,6-dihydro-2H-pyridin-3-yl)-N-methyl-1,3-thiazol-2-amine
  • 4-(1-butyl-5,6-dihydro-2H-pyridin-3-yl)-N-methyl-thiazol-2-amine
  • 4-(1-butyl-5,6-dihydro-2H-pyridin-3-yl)-N-methyl-2-thiazolamine
  • [4-(1-butyl-5,6-dihydro-2H-pyridin-3-yl)thiazol-2-yl]-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol kinase 0.0336 0.0453 0.0442
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0465 0.0715 0.0704
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0538 0.0864 0.0864
Loa Loa (eye worm) phosphatidylinositol 3 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.4017 0.7926 0.7926
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0496 0.0485
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2375 0.4594 0.4587
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0336 0.0453 0.0442
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0357 0.0496 0.0485
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0357 0.0496 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4291 0.8484 0.8484
Trichomonas vaginalis PIKK family atypical protein kinase 0.1731 0.3285 0.3285
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0357 0.0496 0.0496
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5038 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0357 0.0496 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.2741 0.5336 0.5336
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0496 0.0485
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0399 0.0582 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4017 0.7926 0.7926
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0747 0.1288 0.1278
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0336 0.0453 0.9121
Echinococcus multilocularis serine protein kinase ATM 0.0972 0.1746 0.1736
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0336 0.0453 0.0442
Loa Loa (eye worm) phosphatidylinositol 3 0.1731 0.3285 0.3278
Leishmania major phosphatidylinositol 3-kinase, putative 0.0357 0.0496 0.0485
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0399 0.0582 0.0582
Loa Loa (eye worm) phosphatidylinositol 3 0.5038 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0637 0.1064 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.2741 0.5336 0.5336
Loa Loa (eye worm) phosphatidylinositol 3 0.0336 0.0453 0.0442
Echinococcus granulosus serine protein kinase ATM 0.0972 0.1746 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.1746 0.1746
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0336 0.0453 0.9121
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0473 0.0731 0.0731
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0039 0.0027
Leishmania major phosphatidylinositol 3-kinase, putative 0.1719 0.3262 0.3254
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0721 0.1236 0.1226
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0336 0.0453 0.0453
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0016 0.0005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0357 0.0496 0.0061
Loa Loa (eye worm) hypothetical protein 0.1018 0.1838 0.1828
Trichomonas vaginalis PIKK family atypical protein kinase 0.327 0.6409 0.6409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0637 0.1064 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.2999 0.586 0.586
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0336 0.0453 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.2519 0.2519
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0357 0.0496 0.0485
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0378 0.054 0.0529
Giardia lamblia GTOR 0.5038 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5038 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0972 0.1746 0.1736
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1731 0.3285 0.3278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.0582 0.0571
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5038 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0399 0.0582 0.0582
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0399 0.0582 0.0582
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0972 0.1746 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.3012 0.5886 0.5886
Trichomonas vaginalis PIKK family atypical protein kinase 0.1719 0.3262 0.3262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1773 0.3371 0.3363
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0016 0.0005
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1773 0.3371 0.3363
Trichomonas vaginalis conserved hypothetical protein 0.1083 0.197 0.197
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5038 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0202 0.0182 0.0171
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0628 0.0618
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0016 0.0005
Echinococcus multilocularis 0.0336 0.0453 0.0442
Loa Loa (eye worm) hypothetical protein 0.0465 0.0715 0.0704
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1773 0.3371 0.3363
Brugia malayi FAT domain containing protein 0.0747 0.1288 0.1278
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0357 0.0496 0.0485
Leishmania major hypothetical protein, conserved 0.0432 0.0649 0.0639
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1773 0.3371 0.3363
Plasmodium vivax hypothetical protein 0.0336 0.0453 0.9121
Toxoplasma gondii FATC domain-containing protein 0.0972 0.1746 0.186
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1773 0.3371 0.3363
Leishmania major phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.0442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0336 0.0453 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0972 0.1746 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.4017 0.7926 0.7926
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5038 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1719 0.3262 0.3262
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0336 0.0453 0.0442
Entamoeba histolytica hypothetical protein 0.0495 0.0777 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0357 0.0496 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.2741 0.5336 0.5336
Giardia lamblia Hypothetical protein 0.0336 0.0453 0.0442
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0608 0.1006 0.0996
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0972 0.1746 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.4017 0.7926 0.7926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0336 0.0453 0.0442
Onchocerca volvulus 0.0336 0.0453 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0399 0.0582 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.1746 0.1746
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0538 0.0864 0.0853
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0336 0.0453 0.0442
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0972 0.1746 0.1736
Schistosoma mansoni hypothetical protein 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0538 0.0864 0.0853
Trypanosoma cruzi target of rapamycin kinase 3 0.4021 0.7934 0.7932
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0357 0.0496 0.0485
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0721 0.1236 0.1226
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0357 0.0496 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.3012 0.5886 0.5886
Loa Loa (eye worm) hypothetical protein 0.0747 0.1288 0.1278
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0495 0.0777 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0637 0.1064 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5328 0.5328
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0039 0.0027
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0336 0.0453 0.9121
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2999 0.586 0.586
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0399 0.0582 0.0571
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5038 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5038 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0399 0.0582 0.0571
Onchocerca volvulus 0.0336 0.0453 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0465 0.0715 0.0704
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.9121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0984 0.1769 0.1769
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0538 0.0864 0.0853
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0336 0.0453 0.9121
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0747 0.1288 0.1288
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1083 0.197 0.2182
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0118 0.0012 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5038 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0972 0.1746 0.1736
Trichomonas vaginalis immunophilin, putative 0.0118 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.338 0.6633 0.6633
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.0442
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4021 0.7934 0.7932
Schistosoma mansoni hypothetical protein 0.0747 0.1288 0.1278
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0336 0.0453 0.0453
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0972 0.1746 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1773 0.3371 0.3363
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0357 0.0496 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0496 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0336 0.0453 0.0453
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0357 0.0496 0.0485
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0357 0.0496 0.0061
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0336 0.0453 0.0442
Entamoeba histolytica hypothetical protein 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5328 0.5328
Trichomonas vaginalis PIKK family atypical protein kinase 0.3012 0.5886 0.5886
Toxoplasma gondii target of rapamycin (TOR), putative 0.3759 0.7402 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0336 0.0453 0.0442
Loa Loa (eye worm) hypothetical protein 0.1083 0.197 0.1961
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5038 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4021 0.7934 0.7932
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0184 0.0144 0.0133
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0538 0.0864 0.0853
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0336 0.0453 0.9121
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0721 0.1236 0.1226
Entamoeba histolytica hypothetical protein 0.0972 0.1746 0.1736
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0538 0.0864 0.0864
Giardia lamblia Phosphatidylinositol 4-kinase 0.0336 0.0453 0.0442
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0357 0.0496 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5038 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0399 0.0582 0.0571
Loa Loa (eye worm) phosphatidylinositol 3 0.0336 0.0453 0.0442
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0984 0.1769 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.1719 0.3262 0.3262
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0357 0.0496 0.0496
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0747 0.1288 0.1278
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0473 0.0731 0.0731
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0336 0.0453 0.0442
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2104 0.4044 0.4037
Mycobacterium leprae conserved hypothetical protein 0.0336 0.0453 0.5
Loa Loa (eye worm) hypothetical protein 0.0336 0.0453 0.0442
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0357 0.0496 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.1719 0.3262 0.3262
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5038 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0679 0.115 0.114
Echinococcus multilocularis Zinc finger, PHD finger 0.0357 0.0496 0.0485
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0608 0.1006 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.3759 0.7402 0.7402
Schistosoma mansoni fkbp-rapamycin associated protein 0.0972 0.1746 0.1736
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0357 0.0496 0.0485
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0118 0.0012 0.5
Entamoeba histolytica hypothetical protein 0.0336 0.0453 0.0442
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.043 0.0645 0.0634
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0016 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0538 0.0864 0.0864
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0465 0.0715 0.0704
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0118 0.0012 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0972 0.1746 0.1736
Trichomonas vaginalis fk506-binding protein, putative 0.0118 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.2741 0.5336 0.5336
Trichomonas vaginalis PIKK family atypical protein kinase 0.4017 0.7926 0.7926
Leishmania major phosphatidylinositol kinase related protein, putative 0.0336 0.0453 0.0442
Loa Loa (eye worm) hypothetical protein 0.0637 0.1064 0.1054
Leishmania major hypothetical protein, unknown function 0.0336 0.0453 0.0442
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0336 0.0453 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2737 0.5328 0.5328
Leishmania major phosphatidylinositol kinase, putative 0.0336 0.0453 0.0442
Loa Loa (eye worm) hypothetical protein 0.0972 0.1746 0.1736
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1731 0.3285 0.3278
Entamoeba histolytica hypothetical protein 0.0336 0.0453 0.0442
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0972 0.1746 0.1736
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0336 0.0453 0.0442
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0336 0.0453 0.0442
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1719 0.3262 0.3254

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 4.4 mg kg-1 Inhibition of locomotor activity was determined after interperitoneal administration in mouse ChEMBL. 1967314
ED50 (functional) = 16.7 mg kg-1 Inhibition of locomotor activity was determined after oral administration in rat ChEMBL. 1967314
IC50 (binding) > 1000 nM Inhibition of [3H]-haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (25% inhibition at 10 e-6 M) ChEMBL. 1967314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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