TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.881 | Formula: C19H17ClN4O3S
H donors: 0 H acceptors: 4 LogP: 2.76 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1CN1C(=O)N(Cc2ccccc2)S(=O)(=O)c2c1cnn2C
InChi: 1S/C19H17ClN4O3S/c1-22-18-17(11-21-22)23(13-15-9-5-6-10-16(15)20)19(25)24(28(18,26)27)12-14-7-3-2-4-8-14/h2-11H,12-13H2,1H3
InChiKey: FZENYZPNIOAKRW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	protein kinase domain-containing protein	0.0072	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Trypanosoma brucei	pyruvate kinase 1	0.007	0.0052	0.8158
Echinococcus granulosus	pyruvate kinase	0.007	0.0052	0.0027
Entamoeba histolytica	p21-activated kinase	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0939	0.3087	0.307
Loa Loa (eye worm)	hypothetical protein	0.007	0.0052	0.0027
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1333	0.4464	0.445
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0072	0.0058	1
Echinococcus multilocularis	dynamin 1	0.0062	0.0025	0.0025
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0394	0.1184	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0337	0.0314
Brugia malayi	Muscleblind-like protein	0.0152	0.0337	0.0705
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0072	0.0058	1
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0062	0.0025	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0058	0.0075
Trypanosoma brucei	pyruvate kinase 1, putative	0.007	0.0052	0.8158
Loa Loa (eye worm)	PXA domain-containing protein	0.0394	0.1184	0.1162
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2919	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0072	0.0058	0.0058
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0072	0.0058	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0394	0.1184	0.2612
Echinococcus multilocularis	regulator of G protein signaling 3	0.0394	0.1184	0.1184
Echinococcus granulosus	regulator of G protein signaling 3	0.0394	0.1184	0.1162
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0939	0.3087	0.6898
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0072	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Echinococcus granulosus	muscleblind protein	0.0152	0.0337	0.0314
Echinococcus multilocularis	muscleblind protein	0.0152	0.0337	0.0337
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.007	0.0052	0.5
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0072	0.0058	0.0286
Onchocerca volvulus	Pyruvate kinase homolog	0.007	0.0052	1
Echinococcus multilocularis	axis inhibition protein axin	0.0394	0.1184	0.1184
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0062	0.0025	0.0025
Leishmania major	pyruvate kinase	0.007	0.0052	0.8158
Loa Loa (eye worm)	pyruvate kinase	0.007	0.0052	0.0027
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0072	0.0058	1
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0072	0.0058	1
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0072	0.0058	1
Leishmania major	protein kinase, putative	0.0072	0.0058	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Schistosoma mansoni	z-protein (S1r protein)	0.0394	0.1184	0.1162
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0394	0.1184	0.1162
Schistosoma mansoni	pyruvate kinase	0.007	0.0052	0.0027
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0072	0.0058	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0072	0.0058	1
Schistosoma mansoni	axis inhibition protein axin	0.0394	0.1184	0.1162
Loa Loa (eye worm)	pyruvate kinase	0.007	0.0052	0.0027
Echinococcus multilocularis	Oxysterol binding protein 11	0.0062	0.0025	0.0025
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0394	0.1184	0.1184
Echinococcus multilocularis	regulator of G protein signaling 3	0.0394	0.1184	0.1184
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2919	1	1
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0062	0.0025	0.0025
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0394	0.1184	0.1184
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0939	0.3087	0.307
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Echinococcus granulosus	regulator of G protein signaling 7	0.0394	0.1184	0.1162
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0062	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2524	0.8623	0.8619
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0072	0.0058	1
Echinococcus multilocularis	oxysterol binding protein 9	0.0062	0.0025	0.0025
Trypanosoma cruzi	pyruvate kinase 2, putative	0.007	0.0052	0.8158
Echinococcus multilocularis	actin binding protein anillin	0.0062	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Onchocerca volvulus	Pyruvate kinase homolog	0.007	0.0052	1
Echinococcus multilocularis	pyruvate kinase	0.007	0.0052	0.0052
Entamoeba histolytica	hypothetical protein	0.0394	0.1184	1
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Schistosoma mansoni	serine/threonine-protein kinase	0.0072	0.0058	0.0033
Plasmodium falciparum	pyruvate kinase	0.007	0.0052	0.8158
Echinococcus multilocularis	pyruvate kinase	0.007	0.0052	0.0052
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0072	0.0058	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0062	0.0025	0.0025
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0072	0.0058	0.0033
Echinococcus multilocularis	oxysterol binding protein 1	0.0062	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	oxysterol binding protein 3	0.0062	0.0025	0.0025
Brugia malayi	regulator of G-protein signaling rgs-7	0.0394	0.1184	0.2612
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Brugia malayi	A-kinase anchor protein 10, precursor	0.0394	0.1184	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0939	0.3087	0.3087
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus multilocularis	regulator of G protein signaling 7	0.0394	0.1184	0.1184
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Entamoeba histolytica	hypothetical protein	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0072	0.0058	0.0286
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0072	0.0058	1
Leishmania major	pyruvate kinase	0.007	0.0052	0.8158
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0072	0.0058	1
Trypanosoma brucei	protein kinase, putative	0.0072	0.0058	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0062	0.0025	0.0025
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus multilocularis	regulator of G protein signaling	0.0394	0.1184	0.1184
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0072	0.0058	1
Entamoeba histolytica	hypothetical protein	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0072	0.0058	1
Schistosoma mansoni	regulator of G protein signaling	0.0394	0.1184	0.1162
Echinococcus granulosus	axis inhibition protein axin	0.0394	0.1184	0.1162
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0072	0.0058	1
Schistosoma mansoni	serine/threonine protein kinase	0.2919	1	1
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0062	0.0025	0.0025
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0394	0.1184	0.1162
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2524	0.8623	0.8623
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.0337	0.0337
Leishmania major	protein kinase, putative	0.0072	0.0058	1
Trichomonas vaginalis	pyruvate kinase, putative	0.007	0.0052	0.0233
Echinococcus multilocularis	beta 1 syntrophin	0.0062	0.0025	0.0025
Trypanosoma cruzi	Protein kinase B	0.0072	0.0058	1
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0939	0.3087	0.307
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0072	0.0058	1
Leishmania major	folate/biopterin transporter, putative	0.0072	0.0058	1
Echinococcus multilocularis	expressed protein	0.0394	0.1184	0.1184
Mycobacterium ulcerans	pyruvate kinase	0.007	0.0052	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.2919	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus granulosus	regulator of G protein signaling 3	0.0394	0.1184	0.1162
Echinococcus granulosus	Regulator of G protein signaling 20	0.0394	0.1184	0.1162
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1333	0.4464	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0072	0.0058	0.0033
Entamoeba histolytica	hypothetical protein	0.0394	0.1184	1
Echinococcus granulosus	pyruvate kinase	0.007	0.0052	0.0027
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	cytohesin 1	0.0062	0.0025	0.0025
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0062	0.0025	0.0025
Chlamydia trachomatis	pyruvate kinase	0.007	0.0052	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Schistosoma mansoni	regulator of G protein signaling	0.0394	0.1184	0.1162
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Brugia malayi	PXA domain containing protein	0.0394	0.1184	0.2612
Trypanosoma cruzi	NIMA-related kinase, putative	0.0072	0.0058	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	pdz domain containing protein	0.0062	0.0025	0.0025
Schistosoma mansoni	regulator of G protein signaling	0.0394	0.1184	0.1162
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0062	0.0025	0.0025
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0394	0.1184	0.1162
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0062	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	regulator of G protein signaling 7	0.0394	0.1184	0.1184
Leishmania major	serine/threonine-protein kinase a, putative	0.0072	0.0058	1
Trichomonas vaginalis	pyruvate kinase, putative	0.007	0.0052	0.0233
Brugia malayi	PXA domain containing protein	0.0394	0.1184	0.2612
Echinococcus granulosus	serine/threonine protein kinase	0.0072	0.0058	0.0033
Schistosoma mansoni	axis inhibition protein axin	0.0394	0.1184	0.1162
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Schistosoma mansoni	pyruvate kinase	0.007	0.0052	0.0027
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0062	0.0025	0.0025
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0025	0.0025
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0394	0.1184	0.2612
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0394	0.1184	1
Brugia malayi	hypothetical protein	0.0394	0.1184	0.2612
Brugia malayi	hypothetical protein	0.0394	0.1184	0.2612
Echinococcus granulosus	axis inhibition protein axin	0.0394	0.1184	0.1162
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0394	0.1184	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.0394	0.1184	1
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Schistosoma mansoni	regulator of G protein signaling	0.0394	0.1184	0.1162
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0062	0.0025	0.0025
Trypanosoma cruzi	NIMA-related kinase, putative	0.0072	0.0058	1
Toxoplasma gondii	pyruvate kinase PyK1	0.007	0.0052	0.8158
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Loa Loa (eye worm)	pyruvate kinase	0.007	0.0052	0.0027
Mycobacterium leprae	Probable pyruvate kinase PykA	0.007	0.0052	0.5
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0062	0.0025	0.0025
Onchocerca volvulus	Pyruvate kinase homolog	0.007	0.0052	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0394	0.1184	0.1162
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus granulosus	expressed protein	0.0394	0.1184	0.1162
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0072	0.0058	1
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	myotubularin protein 13	0.0062	0.0025	0.0025
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Echinococcus granulosus	regulator of G protein signaling 7	0.0394	0.1184	0.1162
Brugia malayi	Pyruvate kinase, muscle isozyme	0.007	0.0052	0.0061
Brugia malayi	Pyruvate kinase, M2 isozyme	0.007	0.0052	0.0061
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0025	0.0025
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0072	0.0058	1
Plasmodium vivax	pyruvate kinase, putative	0.007	0.0052	0.8158
Giardia lamblia	Pyruvate kinase	0.007	0.0052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0337	0.0314
Entamoeba histolytica	protein kinase, putative	0.0072	0.0058	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Loa Loa (eye worm)	RGS-3 protein	0.0394	0.1184	0.1162
Schistosoma mansoni	regulator of G protein signaling	0.0394	0.1184	0.1162
Schistosoma mansoni	serine/threonine protein kinase	0.1333	0.4464	0.445
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Echinococcus multilocularis	axis inhibition protein axin	0.0394	0.1184	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1184	0.1162
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0062	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0058	0.0286
Trypanosoma cruzi	pyruvate kinase 2, putative	0.007	0.0052	0.8158
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0072	0.0058	0.0286
Entamoeba histolytica	hypothetical protein	0.0394	0.1184	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2440472

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1792825