Detailed information for compound 1799991

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.407 | Formula: C19H25NO2
  • H donors: 0 H acceptors: 0 LogP: 4.71 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCOc1ccc(cc1)Oc1ccccc1)C
  • InChi: 1S/C19H25NO2/c1-3-4-14-20(2)15-16-21-17-10-12-19(13-11-17)22-18-8-6-5-7-9-18/h5-13H,3-4,14-16H2,1-2H3
  • InChiKey: RSKVCDAZZIAFIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0086 0.0092 0.5
Entamoeba histolytica diacylglycerol kinase, putative 0.0142 0.033 0.486
Schistosoma mansoni serine/threonine kinase 0.0201 0.0582 0.0582
Echinococcus granulosus heat shock protein 90 0.0086 0.0092 0.0098
Leishmania major DNA topoisomerase ii 0.0086 0.0092 0.0147
Brugia malayi heat shock protein 90 0.0086 0.0092 0.0108
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Echinococcus multilocularis protein kinase c eta type 0.0142 0.033 0.0352
Echinococcus multilocularis N chimaerin 0.0142 0.033 0.0352
Plasmodium falciparum heat shock protein 90 0.0086 0.0092 0.5
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Trypanosoma brucei rac serine-threonine kinase, putative 0.0201 0.0582 0.0928
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0086 0.0092 0.5
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0086 0.0092 0.5
Brugia malayi Protein kinase domain containing protein 0.0201 0.0582 0.068
Entamoeba histolytica protein kinase, putative 0.0201 0.0582 1
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Brugia malayi protein kinase C3,putative 0.2077 0.8564 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0624 0.2381 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0086 0.0092 0.0147
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.0092 0.0147
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0086 0.0092 0.5
Echinococcus multilocularis serine:threonine protein kinase 38 0.0201 0.0582 0.062
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0201 0.0582 0.0635
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0086 0.0092 0.0147
Chlamydia trachomatis DNA gyrase subunit B 0.0086 0.0092 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0342 0.1184 0.1292
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.0092 0.0147
Schistosoma mansoni protein kinase C mu 0.0142 0.033 0.033
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0201 0.0582 0.062
Brugia malayi kinase, mitochondrial precursor 0.1539 0.6274 0.7326
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0538 0.2017 0.3214
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0086 0.0092 0.1587
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Brugia malayi RhoGAP domain containing protein 0.0142 0.033 0.0386
Echinococcus multilocularis Diacylglycerol kinase theta 0.0142 0.033 0.0352
Brugia malayi diacylglycerol kinase 0.0142 0.033 0.0386
Trypanosoma cruzi DNA topoisomerase II, putative 0.0086 0.0092 0.0147
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Onchocerca volvulus 0.0147 0.0352 1
Loa Loa (eye worm) TOPoisomerase family member 0.0086 0.0092 0.0101
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0086 0.0092 0.5
Schistosoma mansoni DNA topoisomerase II 0.0086 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0201 0.0582 0.0635
Schistosoma mansoni diacylglycerol kinase theta 0.0142 0.033 0.033
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0086 0.0092 0.0147
Brugia malayi protein kinase C II. 0.0342 0.1184 0.1383
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Echinococcus granulosus Rac GTPase activating protein 1 0.0142 0.033 0.0352
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1539 0.6274 0.6676
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Loa Loa (eye worm) heat shock protein 90 0.0086 0.0092 0.0101
Trypanosoma brucei DNA topoisomerase ii 0.0086 0.0092 0.0147
Mycobacterium tuberculosis Conserved protein 0.0086 0.0092 0.5
Echinococcus granulosus unc 13 munc13 0.0142 0.033 0.0352
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0146 0.0351 0.0374
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0086 0.0092 0.5
Brugia malayi C1-like domain containing protein 0.0146 0.0351 0.041
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0146 0.0351 0.041
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Plasmodium vivax endoplasmin, putative 0.0086 0.0092 0.5
Brugia malayi diacylglycerol kinase 0.0142 0.033 0.0386
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0538 0.2017 0.8471
Trichomonas vaginalis heat shock protein, putative 0.0086 0.0092 0.1587
Schistosoma mansoni heat shock protein 0.0086 0.0092 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.0092 0.0147
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0086 0.0092 0.5
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0201 0.0582 0.062
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0142 0.033 0.0352
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Echinococcus multilocularis heat shock protein 90 0.0086 0.0092 0.0098
Trichomonas vaginalis receptor histidine kinase, putative 0.0086 0.0092 0.1587
Plasmodium vivax DNA topoisomerase II, putative 0.0086 0.0092 0.5
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Loa Loa (eye worm) raf kinase 0.0142 0.033 0.036
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Trichomonas vaginalis receptor histidine kinase, putative 0.0086 0.0092 0.1587
Plasmodium falciparum endoplasmin, putative 0.0086 0.0092 0.5
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Schistosoma mansoni unc-13 (munc13) 0.0142 0.033 0.033
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1539 0.6274 0.6676
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Entamoeba histolytica protein kinase, putative 0.0201 0.0582 1
Entamoeba histolytica protein kinase, putative 0.0201 0.0582 1
Onchocerca volvulus Protein TFG homolog 0.0142 0.0331 0.9204
Leishmania major hypothetical protein, conserved 0.0142 0.0331 0.0528
Leishmania major developmentally regulated phosphoprotein-like protein 0.1539 0.6274 1
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0092 0.5
Toxoplasma gondii heat shock protein HSP90 0.0086 0.0092 0.0388
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0086 0.0092 0.5
Echinococcus multilocularis protein TFG 0.0142 0.0331 0.0352
Trypanosoma brucei heat shock protein 90, putative 0.0086 0.0092 0.0147
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0086 0.0092 0.5
Mycobacterium tuberculosis Probable two component sensor kinase 0.0086 0.0092 0.5
Schistosoma mansoni endoplasmin 0.0086 0.0092 0.0092
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0086 0.0092 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.0582 0.0582
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0086 0.0092 0.5
Entamoeba histolytica protein kinase, putative 0.0201 0.0582 1
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Echinococcus granulosus N chimaerin 0.0142 0.033 0.0352
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Brugia malayi Protein kinase c protein 2 0.0146 0.0351 0.041
Echinococcus multilocularis serine:threonine protein kinase N2 0.0201 0.0582 0.062
Brugia malayi RhoGAP domain containing protein 0.0142 0.033 0.0386
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0086 0.0092 0.5
Onchocerca volvulus 0.0142 0.033 0.9172
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0086 0.0092 0.0098
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0086 0.0092 0.1587
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0142 0.033 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.1184 0.1184
Loa Loa (eye worm) hypothetical protein 0.0142 0.0331 0.0361
Trichomonas vaginalis sensor histidine kinase, putative 0.0086 0.0092 0.1587
Schistosoma mansoni vav2 0.0142 0.033 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0351 0.0351
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0086 0.0092 0.5
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Plasmodium vivax DNA gyrase subunit B, putative 0.0086 0.0092 0.5
Loa Loa (eye worm) PAR-6 protein 0.0142 0.0331 0.0361
Schistosoma mansoni protein kinase C mu 0.0146 0.0351 0.0351
Loa Loa (eye worm) AGC/PKN protein kinase 0.0201 0.0582 0.0635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0201 0.0582 0.0635
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Echinococcus granulosus protein kinase C gamma type 0.0201 0.0582 0.062
Trypanosoma brucei PB1 domain containing protein, putative 0.0142 0.0331 0.0528
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0142 0.033 0.0352
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0351 0.0351
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0086 0.0092 0.5
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Brugia malayi Protein kinase domain containing protein 0.0146 0.0351 0.041
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0086 0.0092 0.5
Echinococcus granulosus myotubularin protein 13 0.0142 0.033 0.0352
Plasmodium falciparum DNA topoisomerase 2 0.0086 0.0092 0.5
Onchocerca volvulus 0.0142 0.033 0.9172
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.1184 0.1184
Trichomonas vaginalis heat shock protein, putative 0.0086 0.0092 0.1587
Echinococcus multilocularis serine threonine protein kinase 0.0201 0.0582 0.062
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Trypanosoma cruzi PB1 domain containing protein, putative 0.0142 0.0331 0.0528
Echinococcus multilocularis protein kinase c epsilon type 0.0342 0.1184 0.126
Brugia malayi Ras association domain family 1 isoform A 0.0142 0.033 0.0386
Schistosoma mansoni endoplasmin 0.0086 0.0092 0.0092
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0142 0.033 0.0352
Echinococcus granulosus Protein kinase C brain isozyme 0.0342 0.1184 0.126
Trypanosoma cruzi heat shock protein 90, putative 0.0086 0.0092 0.0147
Giardia lamblia Pms1-like protein 0.0086 0.0092 1
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Trichomonas vaginalis DNA topoisomerase II, putative 0.0086 0.0092 0.1587
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.1184 0.1184
Loa Loa (eye worm) AGC/AKT protein kinase 0.0201 0.0582 0.0635
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Toxoplasma gondii DNA topoisomerase 2, putative 0.0086 0.0092 0.0388
Echinococcus multilocularis heat shock protein 0.0086 0.0092 0.0098
Giardia lamblia Heat shock protein HSP 90-alpha 0.0086 0.0092 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0142 0.033 0.1388
Echinococcus granulosus protein kinase c eta type 0.0142 0.033 0.0352
Echinococcus multilocularis serine:threonine protein kinase N2 0.0201 0.0582 0.062
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0086 0.0092 0.5
Schistosoma mansoni heat shock protein 0.0086 0.0092 0.0092
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0086 0.0092 0.0098
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.1539 0.6274 0.6676
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0086 0.0092 0.5
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0086 0.0092 0.5
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0142 0.033 0.033
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Brugia malayi Pleckstrin Homology Domain 0.0142 0.033 0.0386
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0146 0.0351 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.0582 0.0582
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0086 0.0092 0.0147
Leishmania major hypothetical protein, conserved 0.0086 0.0092 0.0147
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0086 0.0092 0.0147
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0201 0.0582 0.0635
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Mycobacterium leprae Probable two component sensor kinase MprB 0.0086 0.0092 0.5
Plasmodium falciparum DNA gyrase subunit B 0.0086 0.0092 0.5
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Loa Loa (eye worm) endoplasmin 0.0086 0.0092 0.0101
Echinococcus granulosus protein kinase c iota type 0.2273 0.9397 1
Plasmodium vivax heat shock protein 86, putative 0.0086 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.1539 0.6274 0.6844
Brugia malayi RhoGEF domain containing protein 0.0142 0.033 0.0386
Entamoeba histolytica hypothetical protein, conserved 0.0142 0.0331 0.4876
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0201 0.0582 0.062
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0086 0.0092 0.5
Brugia malayi Variant SH3 domain containing protein 0.0142 0.033 0.0386
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0086 0.0092 0.0147
Echinococcus granulosus serine:threonine protein kinase N2 0.0201 0.0582 0.062
Echinococcus multilocularis partitioning defective protein 6 0.0142 0.0331 0.0352
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0201 0.0582 0.0635
Brugia malayi p70 ribosomal S6 kinase beta 0.0201 0.0582 0.068
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Echinococcus granulosus NDR protein kinase 0.0201 0.0582 0.062
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0086 0.0092 0.5
Schistosoma mansoni pyruvate dehydrogenase 0.1453 0.591 0.591
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Schistosoma mansoni protein kinase C 0.0142 0.033 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.0582 0.0582
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0086 0.0092 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0142 0.033 0.0352
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0538 0.2017 0.3214
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0086 0.0092 0.5
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0146 0.0351 0.0383
Entamoeba histolytica diacylglycerol kinase, putative 0.0142 0.033 0.486
Echinococcus multilocularis protein kinase c iota type 0.2273 0.9397 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0086 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Trypanosoma brucei Heat shock protein 83, putative 0.0086 0.0092 0.0147
Schistosoma mansoni diacylglycerol kinase theta 0.0142 0.033 0.033
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0086 0.0092 0.5
Onchocerca volvulus 0.0142 0.033 0.9172
Echinococcus multilocularis raf serine:threonine protein kinase 0.0142 0.033 0.0352
Echinococcus multilocularis Rac GTPase activating protein 1 0.0142 0.033 0.0352
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0086 0.0092 0.0108
Echinococcus granulosus Diacylglycerol kinase theta 0.0142 0.033 0.0352
Mycobacterium ulcerans two component regulator - sensor kinase 0.0086 0.0092 0.5
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0201 0.0582 0.062
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.1539 0.6274 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0342 0.1184 0.126
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0196 0.0561 0.9645
Brugia malayi Protein kinase domain containing protein 0.0201 0.0582 0.068
Schistosoma mansoni cell polarity protein 0.0142 0.0331 0.0331
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0142 0.033 0.036
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0086 0.0092 0.0388
Onchocerca volvulus 0.0142 0.0331 0.9204
Schistosoma mansoni unc-13 (munc13) 0.0142 0.033 0.033
Echinococcus multilocularis myotubularin protein 13 0.0142 0.033 0.0352
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0086 0.0092 0.1587
Mycobacterium ulcerans putative regultory protein 0.0086 0.0092 0.5
Schistosoma mansoni pyruvate dehydrogenase 0.1539 0.6274 0.6274
Brugia malayi Partitioning defective-6 homolog alpha 0.0142 0.0331 0.0387
Chlamydia trachomatis DNA gyrase subunit B 0.0086 0.0092 0.5
Brugia malayi Protein kinase domain containing protein 0.0147 0.0352 0.0411
Brugia malayi Endoplasmin precursor 0.0086 0.0092 0.0108
Schistosoma mansoni hypothetical protein 0.0142 0.033 0.033
Brugia malayi Probable DNA topoisomerase II 0.0086 0.0092 0.0108
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0086 0.0092 0.5
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0086 0.0092 0.0147
Mycobacterium ulcerans DNA gyrase subunit B 0.0086 0.0092 0.5
Trypanosoma cruzi heat shock protein 90, putative 0.0086 0.0092 0.0147
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0142 0.033 0.036
Mycobacterium tuberculosis Possible two component sensor kinase 0.0086 0.0092 0.5
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0147 0.0352 0.0384
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0201 0.0582 0.062
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.2219 0.9167 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0086 0.0092 0.5
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0086 0.0092 0.1587
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0086 0.0092 0.1587
Loa Loa (eye worm) RasGEF domain-containing protein 0.0142 0.033 0.036
Trypanosoma brucei developmentally regulated phosphoprotein 0.1539 0.6274 1
Mycobacterium leprae Probable two-component sensor kinase 0.0086 0.0092 0.5
Trypanosoma brucei heat shock protein 90, putative 0.0086 0.0092 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.033 0.033
Trichomonas vaginalis endoplasmin, putative 0.0086 0.0092 0.1587
Echinococcus granulosus protein kinase c epsilon type 0.0342 0.1184 0.126
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0538 0.2017 0.3214
Mycobacterium ulcerans two component sensor kinase MprB 0.0086 0.0092 0.5
Brugia malayi Hr1 repeat family protein 0.0201 0.0582 0.068
Trypanosoma cruzi Heat shock protein 83, putative 0.0086 0.0092 0.0147
Trypanosoma brucei heat shock protein, putative 0.0086 0.0092 0.0147
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0086 0.0092 0.0388
Echinococcus multilocularis unc 13 (munc13) 0.0142 0.033 0.0352
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0086 0.0092 0.5
Trypanosoma cruzi PB1 domain containing protein, putative 0.0142 0.0331 0.0528
Brugia malayi Protein kinase domain containing protein 0.0201 0.0582 0.068
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0086 0.0092 0.5
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0201 0.0582 0.062
Loa Loa (eye worm) hypothetical protein 0.0086 0.0092 0.0101
Toxoplasma gondii heat shock protein 90, putative 0.0086 0.0092 0.0388
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Loa Loa (eye worm) hypothetical protein 0.0086 0.0092 0.0101
Echinococcus granulosus raf serine:threonine protein kinase 0.0142 0.033 0.0352
Entamoeba histolytica hypothetical protein 0.0142 0.033 0.486
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Brugia malayi MH2 domain containing protein 0.0139 0.032 0.0374
Echinococcus granulosus heat shock protein 0.0086 0.0092 0.0098
Leishmania major mitochondrial DNA topoisomerase II 0.0086 0.0092 0.0147
Loa Loa (eye worm) hypothetical protein 0.0142 0.033 0.036
Schistosoma mansoni pyruvate dehydrogenase 0.1453 0.591 0.591
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.032 0.035
Loa Loa (eye worm) AGC/NDR protein kinase 0.0201 0.0582 0.0635
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.032 0.035
Toxoplasma gondii AGC kinase 0.0201 0.0582 0.2445
Loa Loa (eye worm) zinc finger protein 0.0142 0.0331 0.0361
Leishmania major heat shock protein 83-1 0.0086 0.0092 0.0147
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0086 0.0092 0.5
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0142 0.033 0.036
Trichomonas vaginalis AGC family protein kinase 0.0201 0.0582 1
Echinococcus granulosus protein TFG 0.0142 0.0331 0.0352
Schistosoma mansoni rac gtpase activating protein 0.0142 0.033 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.0582 0.0582

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.