Detailed information for compound 1802897

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.213 | Formula: C17H16Cl2O4
  • H donors: 0 H acceptors: 1 LogP: 4.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(c1cccc(c1)COc1ccc(cc1Cl)Cl)C(=O)OC
  • InChi: 1S/C17H16Cl2O4/c1-21-16(17(20)22-2)12-5-3-4-11(8-12)10-23-15-7-6-13(18)9-14(15)19/h3-9,16H,10H2,1-2H3
  • InChiKey: FPEMBXBUFQZMPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0173 0.0965 0.1872
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0297 0.0576
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0669 0.1298
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0364 0.0799
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0364 0.0707
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0774 0.1666
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0342 0.2002 0.2002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0183 0.2729
Schistosoma mansoni ran 0.0046 0.0183 0.0355
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0507 0.0985
Entamoeba histolytica Ran family GTPase 0.0046 0.0183 0.0264
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1766 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0811 0.1491
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0375 0.0837
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0526 0.1134
Brugia malayi jmjC domain containing protein 0.0064 0.0297 0.0639
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0364 0.0499
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0498 0.2204
Loa Loa (eye worm) excitatory amino acid transporter 0.0771 0.4643 1
Chlamydia trachomatis glutamate symporter 0.0771 0.4643 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0089 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.1622
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Trichomonas vaginalis esterase, putative 0.0075 0.0364 0.0799
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0089 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0192
Brugia malayi Muscleblind-like protein 0.0166 0.0924 0.1991
Trichomonas vaginalis set domain proteins, putative 0.0496 0.295 1
Echinococcus granulosus importin subunit beta 1 0.0062 0.0284 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0192
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0089 0.0173
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0811 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Schistosoma mansoni survival motor neuron protein 0.005 0.0208 0.0404
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1409 0.1409
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0173
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0089 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0192
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0089 0.0173
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0157 0.0304
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0061 0.1622
Echinococcus granulosus Excitatory amino acid transporter 0.0771 0.4643 0.9011
Schistosoma mansoni hypothetical protein 0.0173 0.0965 0.1872
Onchocerca volvulus 0.0075 0.0364 0.0604
Echinococcus granulosus excitatory amino acid transporter 2 0.0771 0.4643 0.9011
Schistosoma mansoni hypothetical protein 0.007 0.0328 0.0637
Trypanosoma brucei trypanothione reductase 0.004 0.0144 0.3848
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Leishmania major importin beta-1 subunit, putative 0.0051 0.0211 0.3159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0157 0.0338
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0375 0.0728
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1409 0.2735
Brugia malayi steroid hormone receptor 0.0031 0.0089 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0192
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0364 0.9716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0192
Echinococcus multilocularis protein patched 0.0042 0.0157 0.0157
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0089
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0669 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0098 0.0212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0173
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0375 0.1447
Echinococcus granulosus microtubule associated protein 2 0.0704 0.4235 0.8219
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Echinococcus multilocularis geminin 0.0173 0.0965 0.0965
Schistosoma mansoni patched 1 0.0042 0.0157 0.0304
Brugia malayi nuclear receptor NHR-88 0.0031 0.0089 0.0192
Echinococcus granulosus excitatory amino acid transporter 3 0.0771 0.4643 0.9011
Brugia malayi hypothetical protein 0.0245 0.1409 0.3035
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0364 0.9716
Echinococcus granulosus neutral amino acid transporter A 0.0771 0.4643 0.9011
Treponema pallidum glutamate/aspartate transporter 0.0342 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0131
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0157 0.0338
Brugia malayi ecdysteroid receptor 0.0031 0.0089 0.0192
Brugia malayi beta-lactamase family protein 0.0075 0.0364 0.0785
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0364 0.0499
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.1766 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0342 0.2002 0.2002
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0284 0.7574
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0173
Plasmodium vivax glutathione reductase, putative 0.004 0.0144 0.3961
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0089 0.0173
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.3722
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.014 0.0271
Brugia malayi RNA, U transporter 1 0.0177 0.0992 0.2136
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0811 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0771 0.4643 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0089
Echinococcus multilocularis muscleblind protein 0.0166 0.0924 0.0924
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0211 0.0255
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0394
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0628
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0211 0.0255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0098 0.0212
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0526 0.1134
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Treponema pallidum glutamate transporter 0.0342 0.2002 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0457 0.0705
Onchocerca volvulus 0.0075 0.0364 0.0604
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0375 0.0728
Echinococcus multilocularis expressed conserved protein 0.0091 0.0462 0.0462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0173
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0006 0.0011
Loa Loa (eye worm) beta-lactamase 0.0075 0.0364 0.0785
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0166 0.0924 0.1991
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0297 0.0576
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0364 0.0499
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0364 0.0785
Leishmania major GTP-binding protein, putative 0.0046 0.0183 0.2729
Trichomonas vaginalis ran, putative 0.0046 0.0183 0.0153
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0173
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0457 0.0705
Onchocerca volvulus 0.0064 0.0292 0.0444
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0276 0.0535
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0375 0.0728
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0089 0.0192
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0144 0.0311
Schistosoma mansoni hypothetical protein 0.005 0.0208 0.0404
Echinococcus multilocularis dnaJ subfamily B 0.0853 0.5152 0.5152
Leishmania major trypanothione reductase 0.004 0.0144 0.2157
Echinococcus granulosus neuropeptide receptor A26 0.048 0.2852 0.5534
Toxoplasma gondii ABC1 family protein 0.0075 0.0364 0.5447
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0669 0.1298
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0364 0.0499
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0375 0.0808
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0183 0.5011
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0457 0.2082
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0089 0.0173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0089 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0192
Echinococcus multilocularis Excitatory amino acid transporter 0.0771 0.4643 0.4643
Brugia malayi nuclear hormone receptor 0.0031 0.0089 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0028 0.0028
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0148 0.0287
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0364 0.0499
Echinococcus multilocularis neuropeptide s receptor 0.048 0.2852 0.2852
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.052 0.0844
Toxoplasma gondii exonuclease III APE 0.0039 0.014 0.2087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Echinococcus multilocularis Excitatory amino acid transporter 0.0771 0.4643 0.4643
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0089 0.0173
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0211 0.5636
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0375 0.1447
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0102 0.0526 0.1134
Echinococcus granulosus neuropeptide s receptor 0.048 0.2852 0.5534
Brugia malayi Thioredoxin reductase 0.004 0.0144 0.0311
Echinococcus multilocularis protein dispatched 1 0.0048 0.0193 0.0193
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0669 0.1298
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0498 0.1073
Mycobacterium ulcerans beta-lactamase 0.0075 0.0364 0.3344
Brugia malayi beta-lactamase 0.0075 0.0364 0.0785
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.4235 0.8219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0364 0.0707
Plasmodium falciparum importin beta, putative 0.0062 0.0284 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0364 0.0707
Brugia malayi jmjC domain containing protein 0.0061 0.0276 0.0593
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0292 0.4357
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0364 0.0499
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.1766 0.8729
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0021 0.0041
Schistosoma mansoni hypothetical protein 0.0853 0.5152 1
Brugia malayi CHE-14 protein 0.0042 0.0157 0.0338
Brugia malayi hypothetical protein 0.0017 0.0004 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0375 0.5606
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0192
Echinococcus multilocularis muscleblind protein 1 0.0166 0.0924 0.0924
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0061 0.0909
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0774 0.1502
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0375 0.0837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Mycobacterium ulcerans lipase LipD 0.0075 0.0364 0.3344
Echinococcus granulosus geminin 0.0173 0.0965 0.1872
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0375 0.0728
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0183 0.0355
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0284 0.7574
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0771 0.4643 0.4643
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0166 0.0924 0.1991
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.052 0.0844
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0774 0.1502
Plasmodium vivax importin-beta 2, putative 0.0062 0.0284 0.7795
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Mycobacterium ulcerans hypothetical protein 0.0075 0.0364 0.3344
Echinococcus granulosus excitatory amino acid transporter 2 0.0771 0.4643 0.9011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0457 0.0705
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.6429
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.2141
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0284 0.4246
Echinococcus multilocularis excitatory amino acid transporter 2 0.0771 0.4643 0.4643
Onchocerca volvulus 0.005 0.0208 0.0261
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0375 0.0375
Brugia malayi Pre-SET motif family protein 0.0064 0.0292 0.0628
Schistosoma mansoni cpg binding protein 0.0063 0.029 0.0563
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.007 0.0328 0.0707
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0208 0.0448
Plasmodium vivax SET domain protein, putative 0.0064 0.0292 0.8
Entamoeba histolytica hypothetical protein 0.0051 0.0211 0.0441
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0498 0.0498
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0098 0.0098
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0157 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0774 0.1666
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0292 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0192
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0375 0.0728
Echinococcus granulosus sodium:dicarboxylate symporter 0.0771 0.4643 0.9011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0192
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.4915
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0097 0.0498 0.1073
Mycobacterium tuberculosis Probable reductase 0.0091 0.0457 0.0705
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0098 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0192
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0157 0.0157
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0292 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0669 0.0669
Echinococcus granulosus snurportin 1 0.0666 0.3999 0.7761
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Brugia malayi glutathione reductase 0.004 0.0144 0.0311
Schistosoma mansoni importin beta-1 0.0062 0.0284 0.0551
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0089 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0328 0.0707
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0457 0.0705
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0375 0.0375
Echinococcus granulosus GPCR family 2 0.0032 0.0098 0.0191
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1766 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0098 0.0191
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.014 0.0301
Echinococcus granulosus expressed conserved protein 0.0091 0.0462 0.0896
Leishmania major hypothetical protein, conserved 0.0026 0.0061 0.0909
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0364 0.9716
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0276 0.0276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0211 0.0255
Brugia malayi Excitatory amino acid transporter 0.0771 0.4643 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.014 0.0301
Brugia malayi Importin beta-1 subunit 0.0062 0.0284 0.0612
Echinococcus multilocularis snurportin 1 0.0666 0.3999 0.3999
Schistosoma mansoni coup transcription factor 0.0031 0.0089 0.0173
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0364 0.0785
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0144 0.001
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0214 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.2866 0.6054
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.1622
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0089 0.0192
Onchocerca volvulus 0.0075 0.0364 0.0604
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0089 0.0173
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.052 0.0844
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0771 0.4643 0.9011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.014 0.3722
Brugia malayi CXXC zinc finger family protein 0.006 0.0269 0.0579
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0375 0.0837
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0498 0.0967
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0089 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0192
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0006 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0755 0.1465
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0098 0.0098
Echinococcus multilocularis excitatory amino acid transporter 3 0.0771 0.4643 0.4643
Schistosoma mansoni ran 0.0046 0.0183 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.2141
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.2581 0.5558
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.014 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0696 0.1352
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.052 0.3473
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0276 0.0276
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0771 0.4643 0.4643
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0098 0.0212
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0669 0.1175
Echinococcus multilocularis cpg binding protein 0.0063 0.029 0.029
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0457 0.0705
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0144 0.3961
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0061 0.1669
Echinococcus granulosus muscleblind protein 0.0166 0.0924 0.1794
Brugia malayi beta-lactamase family protein 0.0075 0.0364 0.0785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.014 0.2087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0297 0.0639
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0089 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0192
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0774 0.0774
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0144 0.3848
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0364 0.0799
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0269 0.0579
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0364 0.0499
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0089 0.0173
Echinococcus granulosus neutral amino acid transporter A 0.0771 0.4643 0.9011
Echinococcus granulosus neutral amino acid transporter 0.0771 0.4643 0.9011
Brugia malayi Pre-SET motif family protein 0.0436 0.2581 0.5558
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0028 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0292 0.0566
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0755 0.0755
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0089
Onchocerca volvulus 0.0496 0.295 0.6282
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0342 0.2002 0.3886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Onchocerca volvulus 0.006 0.0269 0.0395
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0271
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0342 0.2002 0.3886
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0028 0.0055
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0089 0.0173
Echinococcus granulosus dnaJ subfamily B 0.0853 0.5152 1
Echinococcus granulosus Excitatory amino acid transporter 0.0771 0.4643 0.9011
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0276 0.0535
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0183 0.0183
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0771 0.4643 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0774 0.0774
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0394
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Toxoplasma gondii thioredoxin reductase 0.004 0.0144 0.2157
Echinococcus multilocularis GPCR, family 2 0.0032 0.0098 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Loa Loa (eye worm) glutathione reductase 0.004 0.0144 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0364 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.3722
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0011
Plasmodium falciparum glutathione reductase 0.004 0.0144 0.5081
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0364 0.3344
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.4235 0.4235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0364 0.3344
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0613 0.9165
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Loa Loa (eye worm) hypothetical protein 0.0077 0.0375 0.0808
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0157 0.0304
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.2852 0.2852
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0089 0.0173
Leishmania major hypothetical protein, conserved 0.0075 0.0364 0.5447
Plasmodium falciparum thioredoxin reductase 0.004 0.0144 0.5081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0526 0.1134
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0089 0.0192
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0269 0.0523
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0669 1
Echinococcus granulosus cpg binding protein 0.0063 0.029 0.0563
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0666 0.3999 0.8612
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0292 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0192
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0148 0.0148
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0771 0.4643 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0771 0.4643 0.4643
Brugia malayi hypothetical protein 0.0026 0.0061 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0212
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.3831
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0612
Schistosoma mansoni cpg binding protein 0.0063 0.029 0.0563
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0297 0.0576
Schistosoma mansoni hypothetical protein 0.0666 0.3999 0.7761
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0089 0.0192
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0364 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0027 0.0058
Loa Loa (eye worm) hypothetical protein 0.0245 0.1409 0.3035
Schistosoma mansoni cpg binding protein 0.006 0.0269 0.0522

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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