Detailed information for compound 1802897

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.213 | Formula: C17H16Cl2O4
  • H donors: 0 H acceptors: 1 LogP: 4.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(c1cccc(c1)COc1ccc(cc1Cl)Cl)C(=O)OC
  • InChi: 1S/C17H16Cl2O4/c1-21-16(17(20)22-2)12-5-3-4-11(8-12)10-23-15-7-6-13(18)9-14(15)19/h3-9,16H,10H2,1-2H3
  • InChiKey: FPEMBXBUFQZMPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0364 0.3344
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0027 0.0058
Brugia malayi beta-lactamase 0.0075 0.0364 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0157 0.006
Echinococcus multilocularis neuropeptide s receptor 0.048 0.2852 0.2852
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0211 0.0255
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Loa Loa (eye worm) hypothetical protein 0.0166 0.0924 0.1991
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Echinococcus multilocularis cpg binding protein 0.0063 0.029 0.029
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0364 0.9716
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0669 0.1298
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0364 0.0499
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0157 0.0157
Leishmania major GTP-binding protein, putative 0.0046 0.0183 0.2729
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0375 0.0808
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0375 0.0728
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Echinococcus multilocularis Excitatory amino acid transporter 0.0771 0.4643 0.4643
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.007 0.0328 0.0707
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0089 0.0173
Echinococcus granulosus neutral amino acid transporter A 0.0771 0.4643 0.9011
Loa Loa (eye worm) hypothetical protein 0.0245 0.1409 0.3035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0457 0.0705
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0375 0.0375
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0498 0.2204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0089 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0089 0.0173
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Brugia malayi hypothetical protein 0.0026 0.0061 0.0131
Schistosoma mansoni hypothetical protein 0.005 0.0208 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0284 0.0284
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0089 0.0173
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Onchocerca volvulus 0.0064 0.0292 0.0444
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0089 0.0173
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0457 0.2082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0098 0.0212
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0364 0.0499
Brugia malayi Pre-SET motif family protein 0.0436 0.2581 0.5558
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0006 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0364 0.0364
Plasmodium vivax glutathione reductase, putative 0.004 0.0144 0.3961
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0089 0.0173
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0375 0.0837
Brugia malayi Importin beta-1 subunit 0.0062 0.0284 0.0612
Schistosoma mansoni cpg binding protein 0.006 0.0269 0.0522
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Echinococcus granulosus neuropeptide s receptor 0.048 0.2852 0.5534
Echinococcus granulosus muscleblind protein 0.0166 0.0924 0.1794
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0098 0.0191
Echinococcus multilocularis Excitatory amino acid transporter 0.0771 0.4643 0.4643
Echinococcus multilocularis snurportin 1 0.0666 0.3999 0.3999
Schistosoma mansoni ran 0.0046 0.0183 0.0355
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.6429
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0089
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0144 0.3961
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0375 0.0837
Loa Loa (eye worm) hypothetical protein 0.0042 0.0157 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0192
Brugia malayi ecdysteroid receptor 0.0031 0.0089 0.0192
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.014 0.2087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0131
Treponema pallidum glutamate/aspartate transporter 0.0342 0.2002 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0375 0.0728
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0669 0.1298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0774 0.0774
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0028 0.0055
Echinococcus multilocularis expressed conserved protein 0.0091 0.0462 0.0462
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0089 0.0089
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0755 0.1465
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.014 0.3722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0364 0.0707
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0628
Echinococcus multilocularis protein dispatched 1 0.0048 0.0193 0.0193
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Brugia malayi CHE-14 protein 0.0042 0.0157 0.0338
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.3722
Onchocerca volvulus 0.005 0.0208 0.0261
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.4915
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0211 0.0255
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0669 0.1298
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0061 0.1669
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0375 0.0728
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0375 0.0728
Echinococcus granulosus snurportin 1 0.0666 0.3999 0.7761
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0089
Brugia malayi beta-lactamase family protein 0.0075 0.0364 0.0785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Onchocerca volvulus 0.006 0.0269 0.0395
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.1766 0.8729
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.014 0.0301
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0292 0.0566
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0669 0.0669
Leishmania major hypothetical protein, conserved 0.0075 0.0364 0.5447
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Treponema pallidum glutamate transporter 0.0342 0.2002 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0457 0.0705
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.2581 0.5558
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0669 1
Trichomonas vaginalis ran, putative 0.0046 0.0183 0.0153
Schistosoma mansoni hypothetical protein 0.0666 0.3999 0.7761
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0394
Onchocerca volvulus 0.0075 0.0364 0.0604
Brugia malayi nuclear receptor NHR-88 0.0031 0.0089 0.0192
Schistosoma mansoni cpg binding protein 0.0063 0.029 0.0563
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0292 0.0566
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0089 0.0192
Loa Loa (eye worm) glutathione reductase 0.004 0.0144 0.0311
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.014 0.0271
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0375 0.1447
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0364 0.0799
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.3831
Loa Loa (eye worm) beta-lactamase 0.0075 0.0364 0.0785
Mycobacterium ulcerans lipase LipD 0.0075 0.0364 0.3344
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0028 0.0061
Toxoplasma gondii ABC1 family protein 0.0075 0.0364 0.5447
Onchocerca volvulus 0.0075 0.0364 0.0604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0173
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0669 0.1175
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.1622
Schistosoma mansoni importin beta-1 0.0062 0.0284 0.0551
Echinococcus granulosus geminin 0.0173 0.0965 0.1872
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0364 0.0499
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0375 0.1447
Onchocerca volvulus 0.0496 0.295 0.6282
Echinococcus granulosus neuropeptide receptor A26 0.048 0.2852 0.5534
Brugia malayi steroid hormone receptor 0.0031 0.0089 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0173
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0394
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0173
Brugia malayi Excitatory amino acid transporter 0.0771 0.4643 1
Echinococcus granulosus dnaJ subfamily B 0.0853 0.5152 1
Schistosoma mansoni coup transcription factor 0.0031 0.0089 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0364 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0276 0.0535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0526 0.1134
Brugia malayi RNA, U transporter 1 0.0177 0.0992 0.2136
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0364 0.0799
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0284 0.7574
Brugia malayi Thioredoxin reductase 0.004 0.0144 0.0311
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0021 0.0041
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0342 0.2002 0.2002
Schistosoma mansoni cpg binding protein 0.0063 0.029 0.0563
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0211 0.5636
Mycobacterium ulcerans beta-lactamase 0.0075 0.0364 0.3344
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0 0.0001
Echinococcus multilocularis protein patched 0.0042 0.0157 0.0157
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0811 0.1491
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0853 0.5152 1
Schistosoma mansoni hypothetical protein 0.0173 0.0965 0.1872
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0183 0.5011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0666 0.3999 0.8612
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Toxoplasma gondii thioredoxin reductase 0.004 0.0144 0.2157
Schistosoma mansoni ran 0.0046 0.0183 0.0355
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.014 0.014
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0089 0.0192
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0811 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0212
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0364 0.0499
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0457 0.0705
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Echinococcus granulosus expressed conserved protein 0.0091 0.0462 0.0896
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0364 0.0499
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Echinococcus granulosus excitatory amino acid transporter 3 0.0771 0.4643 0.9011
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0144 0.001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0507 0.0985
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0271
Leishmania major importin beta-1 subunit, putative 0.0051 0.0211 0.3159
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.1622
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0284 0.7574
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0364 0.0785
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0148 0.0287
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0208 0.0448
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0457 0.0705
Loa Loa (eye worm) hypothetical protein 0.0097 0.0498 0.1073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0364 0.9716
Mycobacterium tuberculosis Probable reductase 0.0091 0.0457 0.0705
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Trypanosoma brucei trypanothione reductase 0.004 0.0144 0.3848
Brugia malayi hypothetical protein 0.0245 0.1409 0.3035
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.2852 0.2852
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0061 0.1622
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0089 0.0173
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Echinococcus multilocularis muscleblind protein 0.0166 0.0924 0.0924
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0375 0.0728
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0774 0.1666
Plasmodium falciparum glutathione reductase 0.004 0.0144 0.5081
Entamoeba histolytica hypothetical protein 0.0051 0.0211 0.0441
Plasmodium vivax importin-beta 2, putative 0.0062 0.0284 0.7795
Echinococcus granulosus Excitatory amino acid transporter 0.0771 0.4643 0.9011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0192
Plasmodium falciparum thioredoxin reductase 0.004 0.0144 0.5081
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0771 0.4643 0.4643
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0364 0.0499
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0364 0.0499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Trichomonas vaginalis set domain proteins, putative 0.0496 0.295 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Brugia malayi jmjC domain containing protein 0.0061 0.0276 0.0593
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0276 0.0276
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0089 0.0173
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1409 0.1409
Echinococcus granulosus GPCR family 2 0.0032 0.0098 0.0191
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0192
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0364 0.0785
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0292 0.4357
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Echinococcus multilocularis excitatory amino acid transporter 2 0.0771 0.4643 0.4643
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0774 0.1666
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0276 0.0535
Plasmodium falciparum importin beta, putative 0.0062 0.0284 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0098 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0192
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0269 0.0579
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0089 0.0173
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0292 0.0292
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0192
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0173
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0375 0.0808
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0211 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0089 0.0192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0292 0.0292
Echinococcus granulosus excitatory amino acid transporter 2 0.0771 0.4643 0.9011
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0098 0.0212
Entamoeba histolytica Ran family GTPase 0.0046 0.0183 0.0264
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0375 0.5606
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0089 0.0192
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0771 0.4643 1
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0271
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0157 0.0304
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0771 0.4643 0.4643
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.2141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Schistosoma mansoni hypothetical protein 0.0173 0.0965 0.1872
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0526 0.1134
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Brugia malayi Pre-SET motif family protein 0.0064 0.0292 0.0628
Toxoplasma gondii exonuclease III APE 0.0039 0.014 0.2087
Echinococcus granulosus sodium:dicarboxylate symporter 0.0771 0.4643 0.9011
Plasmodium vivax SET domain protein, putative 0.0064 0.0292 0.8
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.052 0.0844
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0375 0.0837
Leishmania major trypanothione reductase 0.004 0.0144 0.2157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0526 0.1134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0696 0.1352
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0457 0.0705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0498 0.0967
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.2141
Echinococcus granulosus Excitatory amino acid transporter 0.0771 0.4643 0.9011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0089 0.0173
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0297 0.0576
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Brugia malayi glutathione reductase 0.004 0.0144 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0364 0.0707
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0669 0.7876
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0284 0.4246
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.052 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.2866 0.6054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0089 0.0089
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.014 0.0301
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.3722
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0089 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Brugia malayi hypothetical protein 0.0017 0.0004 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0089 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0214 0.0462
Trichomonas vaginalis esterase, putative 0.0075 0.0364 0.0799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0774 0.1502
Echinococcus multilocularis excitatory amino acid transporter 2 0.0771 0.4643 0.4643
Echinococcus granulosus microtubule associated protein 2 0.0704 0.4235 0.8219
Brugia malayi Muscleblind-like protein 0.0166 0.0924 0.1991
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1766 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0098 0.0212
Brugia malayi CXXC zinc finger family protein 0.006 0.0269 0.0579
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0771 0.4643 1
Schistosoma mansoni hypothetical protein 0.004 0.0147 0.0286
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Echinococcus granulosus cpg binding protein 0.0063 0.029 0.0563
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0173
Loa Loa (eye worm) excitatory amino acid transporter 0.0771 0.4643 1
Brugia malayi nuclear hormone receptor 0.0031 0.0089 0.0192
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.4235 0.4235
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0364 0.0799
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0297 0.0639
Echinococcus multilocularis GPCR, family 2 0.0032 0.0098 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0173
Schistosoma mansoni patched 1 0.0042 0.0157 0.0304
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.052 0.0844
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0144 0.3848
Mycobacterium ulcerans hypothetical protein 0.0075 0.0364 0.3344
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0364 0.3344
Echinococcus multilocularis dnaJ subfamily B 0.0853 0.5152 0.5152
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0089 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0774 0.0774
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0192
Leishmania major hypothetical protein, conserved 0.0026 0.0061 0.0909
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.0166 0.0924 0.1991
Echinococcus multilocularis muscleblind protein 1 0.0166 0.0924 0.0924
Echinococcus multilocularis neutral amino acid transporter A 0.0771 0.4643 0.4643
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0183 0.2729
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1409 0.2735
Brugia malayi jmjC domain containing protein 0.0016 0 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0173
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0375 0.0375
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0098 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0774 0.1502
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.052 0.3473
Loa Loa (eye worm) hypothetical protein 0.0075 0.0364 0.0785
Chlamydia trachomatis glutamate symporter 0.0771 0.4643 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0375 1
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0102 0.0526 0.1134
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0364 0.0707
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0183 0.0355
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0771 0.4643 0.9011
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0183 0.0264
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0276 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0292 0.0566
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0375 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0328 0.0707
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0342 0.2002 0.3886
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0498 0.1073
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0297 0.0576
Echinococcus multilocularis geminin 0.0173 0.0965 0.0965
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Brugia malayi beta-lactamase family protein 0.0075 0.0364 0.0785
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0342 0.2002 0.3886
Brugia malayi jmjC domain containing protein 0.0064 0.0297 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0192
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0157 0.0338
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0183 0.4869
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0771 0.4643 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0192
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0498 0.0498
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0342 0.2002 0.2002
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.4235 0.8219
Schistosoma mansoni hypothetical protein 0.007 0.0328 0.0637
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0148 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0089 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0774 0.1502
Schistosoma mansoni survival motor neuron protein 0.005 0.0208 0.0404
Onchocerca volvulus 0.0075 0.0364 0.0604
Echinococcus granulosus importin subunit beta 1 0.0062 0.0284 0.0551
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0811 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.0364 0.0499
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0144 0.0311
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0669 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0771 0.4643 0.9011
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0157 0.0304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1766 0.5785
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.1766 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0192
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0061 0.0909
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0089 0.0173
Echinococcus granulosus neutral amino acid transporter A 0.0771 0.4643 0.9011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0297 0.0576
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0613 0.9165
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0364 0.9716
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0269 0.0523
Schistosoma mansoni hypothetical protein 0.0032 0.0098 0.0191
Echinococcus multilocularis excitatory amino acid transporter 3 0.0771 0.4643 0.4643
Echinococcus granulosus neutral amino acid transporter 0.0771 0.4643 0.9011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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