TDR Targets

Basic information

Technical information

TDR Targets ID: 1806546
Name: (2E)-2-[2-(3-hydroxyphenoxy)phenyl]-2-methoxy imino-N-methylacetamide
MW: 300.309 | Formula: C16H16N2O4
H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CO/N=C(\c1ccccc1Oc1cccc(c1)O)/C(=O)NC
InChi: 1S/C16H16N2O4/c1-17-16(20)15(18-21-2)13-8-3-4-9-14(13)22-12-7-5-6-11(19)10-12/h3-10,19H,1-2H3,(H,17,20)/b18-15+
InChiKey: XKEYKHSHCXQXQU-OBGWFSINSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E)-2-[2-(3-hydroxyphenoxy)phenyl]-2-methoxyimino-N-methyl-acetamide
(2E)-2-[2-(3-hydroxyphenoxy)phenyl]-2-methoxyimino-N-methyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0022	0.0639	0.0639
Onchocerca volvulus	Fatty acid synthase homolog	0.0041	0.1583	0.132
Brugia malayi	Thioredoxin reductase	0.0041	0.1553	0.1876
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0173	0.8046	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0013	0.0186	0.0186
Mycobacterium ulcerans	thioesterase	0.0019	0.0485	0.0315
Mycobacterium ulcerans	hypothetical protein	0.0033	0.1179	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0688	0.0784
Mycobacterium tuberculosis	Probable reductase	0.0093	0.4129	0.4129
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0034	0.1234	0.1234
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0024	0.0744	0.1043
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0024	0.0744	0.0744
Schistosoma mansoni	transient receptor potential channel	0.0055	0.2272	0.3312
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.1179	0.4884
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0173	0.8046	1
Schistosoma mansoni	transient receptor potential channel	0.0084	0.367	0.54
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0173	0.8046	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0019	0.0453	0.0274
Brugia malayi	hypothetical protein	0.0015	0.0282	0.0285
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0068	0.2868	0.4201
Echinococcus granulosus	transient receptor potential gamma protein	0.0084	0.367	0.54
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0093	0.4129	0.8823
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0173	0.8046	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0055	0.2272	0.3312
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.1179	0.1408
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0068	0.2868	0.5924
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0239	0.0231
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0053	0.2164	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.1179	0.1204
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.2164	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0023	0.0674	0.0557
Onchocerca volvulus		0.0033	0.1179	0.0778
Schistosoma mansoni	hypothetical protein	0.0031	0.1072	0.1518
Plasmodium falciparum	glutathione reductase	0.0041	0.1553	0.4999
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0033	0.1179	0.1179
Onchocerca volvulus		0.004	0.1512	0.1225
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0053	0.2164	0.2465
Loa Loa (eye worm)	hypothetical protein	0.0028	0.094	0.1099
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0688	0.1708
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0023	0.0674	0.0557
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.4129	0.4129
Mycobacterium ulcerans	thioesterase TesA	0.0019	0.0485	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0034	0.1234	0.1234
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.06	0.0683
Mycobacterium ulcerans	lipase LipD	0.0033	0.1179	0.1204
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0024	0.0744	0.1043
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	0.3367
Brugia malayi	glutathione reductase	0.0041	0.1553	0.1876
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0173	0.8046	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0033	0.1179	0.1204
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0104	0.4641	1
Schistosoma mansoni	transient receptor potential channel 4	0.0084	0.367	0.54
Echinococcus granulosus	peptidase Clp S14 family	0.0044	0.1722	0.2489
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0044	0.1687	0.2044
Trypanosoma brucei	hypothetical protein, conserved	0.0033	0.1179	0.4884
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0019	0.0468	0.0468
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0688	0.1708
Mycobacterium tuberculosis	Probable esterase LipL	0.0033	0.1179	0.1179
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0044	0.1722	0.1722
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.1553	0.1553
Plasmodium vivax	glutathione reductase, putative	0.0041	0.1553	0.4999
Loa Loa (eye worm)	hypothetical protein	0.0084	0.367	0.4518
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0173	0.8046	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0033	0.1179	0.1204
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0023	0.0674	0.0881
Plasmodium falciparum	thioredoxin reductase	0.0041	0.1553	0.4999
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0031	0.1072	0.1518
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0688	0.2334
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0023	0.0674	0.0674
Schistosoma mansoni	hypothetical protein	0.0146	0.6748	1
Mycobacterium ulcerans	beta-lactamase	0.0033	0.1179	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2868	0.3514
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1444	0.173
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.06	0.06
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.1553	0.4999
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0173	0.8046	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0068	0.2868	1
Loa Loa (eye worm)	glutathione reductase	0.0041	0.1553	0.1867
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.1179	0.1204
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0068	0.2868	1
Schistosoma mansoni	hypothetical protein	0.0146	0.6748	1
Brugia malayi	beta-lactamase	0.0033	0.1179	0.1408
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0023	0.0674	0.0674
Echinococcus multilocularis	short transient receptor potential channel 6	0.0055	0.2272	0.3312
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0068	0.2868	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0688	0.2334
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0024	0.0744	0.0744
Mycobacterium tuberculosis	Probable hydrolase	0.0033	0.1179	0.1179
Mycobacterium tuberculosis	Conserved protein	0.0033	0.1179	0.1179
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0023	0.0688	0.1708
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.012	0.5425	0.5425
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0024	0.0744	0.0647
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0019	0.0485	0.0485
Leishmania major	hypothetical protein, conserved	0.0023	0.0688	0.2334
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.0744	0.0744
Trypanosoma brucei	trypanothione reductase	0.0041	0.1553	0.6827
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0688	0.1709
Echinococcus granulosus	short transient receptor potential channel 6	0.0055	0.2272	0.3312
Mycobacterium tuberculosis	Probable lipase LipD	0.0033	0.1179	0.1179
Onchocerca volvulus		0.0033	0.1179	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.1179	0.1678
Mycobacterium tuberculosis	Conserved protein	0.0033	0.1179	0.1179
Onchocerca volvulus		0.0033	0.1179	0.0778
Mycobacterium ulcerans	polyketide synthase Pks9	0.0015	0.0291	0.0066
Loa Loa (eye worm)	fatty acid synthase	0.0023	0.0659	0.0747
Echinococcus multilocularis	geminin	0.0146	0.6748	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.0744	0.0647
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0.0688	0.2084
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.1553	0.2237
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0688	0.1709
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0239	0.0273
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0053	0.2164	0.2465
Mycobacterium ulcerans	polyketide synthase Pks13	0.0034	0.1234	0.1274
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0031	0.1077	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0053	0.2135	0.2595
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0023	0.0674	0.0881
Brugia malayi	MH2 domain containing protein	0.0104	0.4681	0.5789
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0031	0.1072	0.1518
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.1179	0.1678
Mycobacterium ulcerans	polyketide synthase	0.0023	0.0674	0.0557
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0015	0.0291	0.0066
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0044	0.1722	0.329
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0044	0.1722	0.1722
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0068	0.2868	0.4201
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.1179	0.1204
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.4129	0.4129
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.4129	0.4129
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0044	0.1722	0.2489
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.1553	0.1867
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0688	0.1709
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0019	0.0453	0.0373
Schistosoma mansoni	peptidase Clp (S14 family)	0.0068	0.2868	0.4201
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0023	0.0674	0.0776
Leishmania major	hypothetical protein, conserved	0.0033	0.1179	0.4884
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.1179	0.1204
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.4129	0.4129
Mycobacterium leprae	Polyketide synthase Pks13	0.0034	0.1234	0.2168
Brugia malayi	hypothetical protein	0.0031	0.1072	0.1274
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	0.3367
Echinococcus granulosus	geminin	0.0146	0.6748	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0173	0.8046	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	1
Leishmania major	trypanothione reductase	0.0041	0.1553	0.6827
Brugia malayi	Transient-receptor-potential like protein	0.0031	0.1077	0.128
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.1179	0.4884
Loa Loa (eye worm)	transcription factor SMAD2	0.0104	0.4681	0.5785
Echinococcus granulosus	transient receptor potential ion channel A	0.0081	0.3532	0.5194
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.1179	0.1678
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.1553	0.6827
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0015	0.0277	0.0589
Mycobacterium ulcerans	polyketide synthase	0.0024	0.0744	0.0647
Toxoplasma gondii	NADPH-glutathione reductase	0.0014	0.0239	0.0453
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0019	0.0485	0.0448
Toxoplasma gondii	hypothetical protein	0.0023	0.0688	0.2084
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0033	0.1179	0.1179
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.2164	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0688	0.2334
Schistosoma mansoni	transcription factor LCR-F1	0.0031	0.1072	0.1518
Brugia malayi	Probable ClpP-like protease	0.0068	0.2868	0.3521
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0014	0.0239	0.0453
Brugia malayi	hypothetical protein	0.0023	0.0688	0.0793
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0173	0.8046	1
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0173	0.8046	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0239	0.0273
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0024	0.0744	0.2288
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0239	0.0273
Onchocerca volvulus		0.0173	0.8046	1
Brugia malayi	beta-lactamase family protein	0.0033	0.1179	0.1408
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.1553	0.2237
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.1179	0.1398
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0173	0.8046	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0023	0.0674	0.0557
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0023	0.0674	0.0674
Mycobacterium leprae	Probable lipase LipE	0.0033	0.1179	0.2042
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.1179	0.3576
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1077	0.1271
Schistosoma mansoni	transient receptor potential channel	0.0055	0.2272	0.3312
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.1179	0.2042
Mycobacterium tuberculosis	Conserved protein	0.0033	0.1179	0.1179
Echinococcus granulosus	TRP transient receptor potential channel	0.0031	0.1077	0.1526
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0019	0.0453	0.0274
Echinococcus multilocularis	transient receptor potential gamma protein	0.0084	0.367	0.54
Mycobacterium tuberculosis	Probable lipase LipE	0.0033	0.1179	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0104	0.4641	0.4641
Toxoplasma gondii	ABC1 family protein	0.0033	0.1179	0.3867
Leishmania major	hypothetical protein, conserved	0.0053	0.2164	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.06	0.0673
Trichomonas vaginalis	esterase, putative	0.0033	0.1179	0.1204
Mycobacterium tuberculosis	Probable oxidoreductase	0.0104	0.4641	0.4641
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.1179	0.1678
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0017	0.0355	0.0355
Toxoplasma gondii	type I fatty acid synthase, putative	0.0016	0.0348	0.0849
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0022	0.0639	0.0639
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.1179	0.1204
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0023	0.0688	0.0913
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0104	0.4641	0.4641
Loa Loa (eye worm)	beta-lactamase	0.0033	0.1179	0.1398
Echinococcus granulosus	short transient receptor potential channel 6	0.0055	0.2272	0.3312
Brugia malayi	beta-lactamase family protein	0.0033	0.1179	0.1408
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0014	0.0239	0.0239
Loa Loa (eye worm)	MH2 domain-containing protein	0.0104	0.4681	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1179	0.1398
Echinococcus multilocularis	transient receptor potential ion channel A	0.0081	0.3532	0.5194
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.4129	0.4129
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0033	0.1179	0.1179
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0068	0.2868	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0024	0.0744	0.1043
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0173	0.8046	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0023	0.0674	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0176	0.0142
Toxoplasma gondii	thioredoxin reductase	0.0041	0.1553	0.5225

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2288557

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806546