Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0444 | 0.0385 | 0.0305 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0384 | 0.0277 | 0.0286 |
Schistosoma mansoni | roundabout | 0.0384 | 0.0277 | 0.0194 |
Brugia malayi | Prion-like- | 0.0384 | 0.0277 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0091 | 0.0091 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.5664 | 0.9699 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.028 | 0.0091 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0384 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | TK protein kinase | 0.5832 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.028 | 0.0091 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0384 | 0.0277 | 0.0194 |
Echinococcus granulosus | lachesin | 0.0384 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Echinococcus granulosus | peroxidasin | 0.0384 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.028 | 0.0091 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Schistosoma mansoni | septate junction protein | 0.0384 | 0.0277 | 0.0194 |
Toxoplasma gondii | hypothetical protein | 0.028 | 0.0091 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0384 | 0.0277 | 0.0286 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.176 | 0.2733 | 0.2818 |
Echinococcus granulosus | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0384 | 0.0277 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0384 | 0.0277 | 0.0286 |
Echinococcus multilocularis | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus granulosus | contactin | 0.0384 | 0.0277 | 0.0286 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.028 | 0.0091 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Brugia malayi | nicalin | 0.028 | 0.0091 | 0.0008 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0384 | 0.0277 | 0.0286 |
Leishmania major | hypothetical protein, conserved | 0.028 | 0.0091 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.028 | 0.0091 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.028 | 0.0091 | 0.0091 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.176 | 0.2733 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0091 | 0.0091 |
Brugia malayi | FXNA | 0.028 | 0.0091 | 0.0008 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0384 | 0.0277 | 0.0286 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Echinococcus multilocularis | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.028 | 0.0091 | 0.0094 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0384 | 0.0277 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0384 | 0.0277 | 0.0277 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.028 | 0.0091 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.028 | 0.0091 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.028 | 0.0091 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.176 | 0.2733 | 0.2672 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0384 | 0.0277 | 0.0277 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0384 | 0.0277 | 0.0194 |
Echinococcus granulosus | hemicentin 1 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0384 | 0.0277 | 0.0286 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.5664 | 0.9699 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.176 | 0.2733 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.5664 | 0.9699 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Schistosoma mansoni | septate junction protein | 0.0384 | 0.0277 | 0.0194 |
Schistosoma mansoni | neuroglian | 0.0384 | 0.0277 | 0.0194 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Onchocerca volvulus | 0.028 | 0.0091 | 0.0334 | |
Echinococcus multilocularis | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Brugia malayi | leucyl aminopeptidase | 0.028 | 0.0091 | 0.0008 |
Echinococcus multilocularis | hemicentin 1 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus granulosus | neuroglian | 0.0384 | 0.0277 | 0.0286 |
Schistosoma mansoni | tyrosine kinase | 0.5664 | 0.9699 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.028 | 0.0091 | 0.0094 |
Echinococcus multilocularis | neuroglian | 0.0384 | 0.0277 | 0.0286 |
Onchocerca volvulus | Fxna peptidase homolog | 0.028 | 0.0091 | 0.0334 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0384 | 0.0277 | 0.0286 |
Trichomonas vaginalis | conserved hypothetical protein | 0.028 | 0.0091 | 0.5 |
Echinococcus multilocularis | hemicentin 1 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.5664 | 0.9699 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.028 | 0.0091 | 0.0334 |
Schistosoma mansoni | cell adhesion molecule | 0.0384 | 0.0277 | 0.0194 |
Echinococcus multilocularis | lachesin | 0.0384 | 0.0277 | 0.0286 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.028 | 0.0091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.176 | 0.2733 | 0.2749 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0384 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0091 | 0.0091 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.028 | 0.0091 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.028 | 0.0091 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.028 | 0.0091 | 0.0094 |
Echinococcus granulosus | roundabout 2 | 0.0384 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Onchocerca volvulus | Fxna peptidase homolog | 0.028 | 0.0091 | 0.0334 |
Schistosoma mansoni | cell adhesion molecule | 0.0384 | 0.0277 | 0.0194 |
Leishmania major | glutaminyl cyclase, putative | 0.028 | 0.0091 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0384 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0276 | 0.0083 | 0.0083 |
Brugia malayi | Peroxidasin | 0.0384 | 0.0277 | 0.0196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Schistosoma mansoni | nephrin | 0.0384 | 0.0277 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0091 | 0.0091 |
Schistosoma mansoni | titin | 0.0384 | 0.0277 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.176 | 0.2733 | 0.2733 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0384 | 0.0277 | 0.0277 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.028 | 0.0091 | 0.0094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.028 | 0.0091 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0384 | 0.0277 | 0.0196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 3.99 | SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.