Detailed information for compound 1810158

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 289.369 | Formula: C17H23NO3
  • H donors: 1 H acceptors: 2 LogP: 1.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCCCC1)COc1cccc2c1C(=O)CC2
  • InChi: 1S/C17H23NO3/c19-14(11-18-9-2-1-3-10-18)12-21-16-6-4-5-13-7-8-15(20)17(13)16/h4-6,14,19H,1-3,7-12H2/t14-/m1/s1
  • InChiKey: YMVZHRHXNWZPAA-CQSZACIVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum multidrug resistance protein 2 0.0004 0.0051 0.1497
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0051 0.0051
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Onchocerca volvulus 0.0013 0.0343 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0343 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0.0051 1
Leishmania major pentamidine resistance protein 1 0.0004 0.0051 0.1497
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0.0051 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0343 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Leishmania major ABC-thiol transporter 0.0004 0.0051 0.1497
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0343 1
Entamoeba histolytica protein kinase, putative 0.0003 0.0004 0.0004
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0343 0.0343
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0004 0.0051 0.1497
Plasmodium falciparum ABC transporter B family member 3, putative 0.0004 0.0051 0.1497
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0343 1
Giardia lamblia MRP-like ABC transporter 0.0004 0.0051 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Plasmodium vivax ABC transporter B family member 6, putative 0.0004 0.0051 0.1497
Entamoeba histolytica protein kinase domain containing protein 0.0003 0.0004 0.0004
Plasmodium vivax multidrug resistance protein 2, putative 0.0004 0.0051 0.1497
Echinococcus granulosus ATP binding cassette sub family B 0.0004 0.0047 0.0047
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0.0047 0.1362
Loa Loa (eye worm) ABC transporter 0.0004 0.0051 0.1497
Echinococcus granulosus multidrug resistance associated protein 7 0.0004 0.0051 0.0051
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0003 0.0004 0.0778
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0343 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0302 0.9996 0.9996
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0343 1
Entamoeba histolytica protein kinase, putative 0.0302 1 1
Entamoeba histolytica protein kinase, putative 0.0003 0.0004 0.0004
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0004 0.0051 0.1497
Entamoeba histolytica protein kinase, putative 0.0003 0.0004 0.0004
Plasmodium falciparum multidrug resistance-associated protein 2 0.0004 0.0051 0.1497
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0047 0.1362
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0.0051 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0.0051 0.1497
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0343 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0.0051 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0004 0.0051 0.1497
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0003 0.0004 0.0778
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Entamoeba histolytica protein kinase, putative 0.0302 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0343 0.0343
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0.0047 0.9098
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0051 0.0051
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0051 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0343 0.0343
Trypanosoma brucei multidrug resistance protein E 0.0004 0.0051 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0339 0.0339
Schistosoma mansoni multidrug resistance protein 0.0013 0.0343 0.0343
Plasmodium falciparum ABC transporter B family member 5, putative 0.0004 0.0051 0.1497
Entamoeba histolytica ABC transporter, putative 0.0004 0.0051 0.0051
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0302 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0343 0.0343
Brugia malayi multidrug resistance protein 3 0.0013 0.0343 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0004 0.0047 0.0047
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0.0047 0.1362
Schistosoma mansoni multidrug resistance protein 0.0004 0.0051 0.0051
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0.0047 0.1362
Trichomonas vaginalis taga, putative 0.0013 0.0343 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0215 0.0215
Schistosoma mansoni smdr2 0.0013 0.0343 0.0343
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0.0051 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0343 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0051 0.0051
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0343 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0004 0.0051 0.1497
Plasmodium falciparum ABC transporter B family member 6, putative 0.0004 0.0051 0.1497
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0004 0.0051 0.1497
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0.0051 0.5
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0004 0.0051 1
Loa Loa (eye worm) ABC transporter 0.0004 0.0051 0.1497
Schistosoma mansoni multidrug resistance protein 0.0013 0.0343 0.0343
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0004 0.0051 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0.0051 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0302 0.9996 0.9996
Plasmodium falciparum ABC transporter B family member 4, putative 0.0004 0.0051 0.1497
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0004 0.0047 0.0047
Brugia malayi ABC transporter transmembrane region family protein 0.0004 0.0047 0.1362
Loa Loa (eye worm) hypothetical protein 0.0004 0.0047 0.1362
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0343 0.0343
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0343 0.0343
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0343 0.0343
Entamoeba histolytica serine/threonine- protein kinase DCAMKL3, putative 0.0003 0.0004 0.0004
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0343 0.0343
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0013 0.0343 1
Brugia malayi ABC transporter family protein 0.0013 0.0343 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0343 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0339 0.0339
Trypanosoma brucei p-glycoprotein 0.0004 0.0051 1
Leishmania major protein kinase, putative 0.0003 0.0004 0.0117
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0343 1
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0.0051 0.1497
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0343 0.0343
Plasmodium falciparum multidrug resistance-associated protein 1 0.0004 0.0051 0.1497
Schistosoma mansoni serine/threonine protein kinase 0.0302 1 1
Leishmania major serine-threonine protein kinase-like protein 0.0003 0.0004 0.0117
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0343 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0339 0.9865
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0003 0.0004 0.0778
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Brugia malayi ABC transporter family protein 0.0004 0.0051 0.1497
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0343 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0004 0.0051 0.1497
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0343 1
Brugia malayi multidrug resistance related protein 1 0.0004 0.0051 0.1497
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0051 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0215 0.0215
Giardia lamblia ABC transporter, putative 0.0004 0.0051 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0004 0.0051 0.1497
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0004 0.0051 0.1497
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0343 1
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0004 0.0051 0.1497
Loa Loa (eye worm) hypothetical protein 0.0004 0.0051 0.1497
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0051 1
Entamoeba histolytica protein kinase domain containing protein 0.0003 0.0004 0.0004
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0343 1
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0343 0.0343
Echinococcus granulosus ATP binding cassette sub family B 0.0004 0.0051 0.0051
Brugia malayi ABC transporter family protein 0.0004 0.0051 0.1497
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0343 0.0343
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0.0051 1
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.0215 0.0215
Leishmania major protein kinase, putative 0.0003 0.0004 0.0117
Entamoeba histolytica protein kinase domain containing protein 0.0003 0.0004 0.0004
Brugia malayi ABC transporter 0.0004 0.0047 0.1362
Echinococcus multilocularis ATP binding cassette sub family B 0.0004 0.0051 0.0051
Leishmania major p-glycoprotein 0.0013 0.0343 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0343 0.0343
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0343 0.0343
Plasmodium vivax ABC transporter B family member 4, putative 0.0004 0.0051 0.1497
Plasmodium vivax ABC transporter B family member 5, putative 0.0004 0.0051 0.1497
Brugia malayi P-glycoprotein-like protein 0.0004 0.0051 0.1497
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0343 0.0343
Schistosoma mansoni multidrug resistance protein 0.0004 0.0051 0.0051
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0343 1
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0004 0.0047 0.9098
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0343 0.0343
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0343 0.0343
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0004 0.0051 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Echinococcus multilocularis multidrug resistance associated protein 7 0.0004 0.0051 0.0051
Trichomonas vaginalis abcb9, putative 0.0013 0.0343 1
Entamoeba histolytica hypothetical protein 0.0004 0.0051 0.0051
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Entamoeba histolytica P-glycoprotein 6, putative 0.0004 0.0051 0.0051
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0004 0.0051 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0004 0.0051 0.0051
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0343 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0343 0.0343
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0004 0.0051 0.1497
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0.0051 0.5
Leishmania major protein kinase, putative 0.0003 0.0004 0.0117
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0004 0.0051 0.0051
Brugia malayi hypothetical protein 0.0004 0.0051 0.1497
Entamoeba histolytica P-glycoprotein 6, putative 0.0004 0.0051 0.0051
Echinococcus multilocularis multidrug resistance associated protein 1 0.0004 0.0051 0.0051
Brugia malayi ABC transporter transmembrane region family protein 0.0004 0.0051 0.1497
Trypanosoma brucei Forkhead Kinase, putative 0.0003 0.0004 0.0778
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0004 0.0051 0.1497
Echinococcus granulosus ATP binding cassette sub family B 0.0004 0.0051 0.0051
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0343 0.0343
Schistosoma mansoni multidrug resistance protein 0.0004 0.0051 0.0051
Plasmodium vivax ABC transporter B family member 3, putative 0.0004 0.0051 0.1497
Echinococcus granulosus multidrug resistance associated protein 1 0.0004 0.0051 0.0051
Leishmania major p-glycoprotein e 0.0004 0.0051 0.1497
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0004 0.0047 0.1362
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0343 1
Entamoeba histolytica protein kinase domain containing protein 0.0003 0.0004 0.0004
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0051 0.0051
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0051 0.1497
Echinococcus multilocularis 0.0004 0.0051 0.0051
Schistosoma mansoni smdr1 0.0004 0.0051 0.0051
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0215 0.6263
Toxoplasma gondii ABC transporter family protein 0.0004 0.0051 0.1497
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0004 0.0051 0.1497
Trichomonas vaginalis abcb9, putative 0.0013 0.0343 1
Entamoeba histolytica multidrug resistance protein, putative 0.0004 0.0051 0.0051
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0343 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0004 0.0051 0.1497
Giardia lamblia Hypothetical protein 0.0004 0.0047 0.9098
Schistosoma mansoni multidrug resistance protein 0.0004 0.0051 0.0051
Brugia malayi ABC transporter transmembrane region family protein 0.0004 0.0051 0.1497
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1
Schistosoma mansoni multidrug resistance protein 0.0004 0.0051 0.0051
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0004 0.0051 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0004 0.0047 0.0047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Plasmodium vivax ABC transporter B family member 7, putative 0.0004 0.0051 0.1497
Schistosoma mansoni multidrug resistance protein 0.0004 0.0047 0.0047
Toxoplasma gondii ABC transporter, putative 0.0004 0.0051 0.1497
Trypanosoma cruzi multidrug resistance protein E, putative 0.0004 0.0051 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0343 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0004 0.0051 0.0051
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0.0051 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.0004 0.0051 0.1497
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0004 0.0051 0.1497
Loa Loa (eye worm) ABC transporter 0.0004 0.0051 0.1497
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0343 1
Brugia malayi ABC transporter family protein 0.0004 0.0051 0.1497
Echinococcus multilocularis ATP binding cassette sub family B 0.0004 0.0051 0.0051
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0343 0.0343
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0.0051 1
Entamoeba histolytica protein kinase domain containing protein 0.0003 0.0004 0.0004
Brugia malayi ABC transporter 0.0004 0.0051 0.1497
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0004 0.0051 0.1497
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0343 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0343 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.01 SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.