TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.62 | Formula: C30H27N3S
H donors: 1 H acceptors: 0 LogP: 4.98 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C1C2=C(N=c3n1c(cs3)c1ccccc1)/C(=C/c1ccc(cc1)C)/CNC2
InChi: 1S/C30H27N3S/c1-20-8-12-22(13-9-20)16-25-17-31-18-26-28(25)32-30-33(29(26)24-14-10-21(2)11-15-24)27(19-34-30)23-6-4-3-5-7-23/h3-16,19,29,31H,17-18H2,1-2H3/b25-16+
InChiKey: KGZWOOTZJBDGCI-PCLIKHOPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Electrophorus electricus	Acetylcholinesterase	Starlite/ChEMBL	References
Equus caballus	Cholinesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	633 aa	517 aa	25.1 %
Echinococcus granulosus	neuroligin	Cholinesterase	574 aa	492 aa	24.4 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	633 aa	549 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	633 aa	597 aa	25.1 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	633 aa	576 aa	23.4 %
Onchocerca volvulus		Cholinesterase	574 aa	551 aa	29.9 %
Onchocerca volvulus	Galectin homolog	Cholinesterase	574 aa	531 aa	39.7 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	633 aa	622 aa	24.9 %
Schistosoma mansoni	gliotactin	Cholinesterase	574 aa	587 aa	27.9 %
Onchocerca volvulus	Putative nuclear protein	Cholinesterase	574 aa	572 aa	40.9 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	633 aa	576 aa	28.8 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	633 aa	690 aa	32.3 %
Schistosoma japonicum	ko:K01050 cholinesterase [EC3.1.1.8], putative	Cholinesterase	574 aa	577 aa	36.9 %
Brugia malayi	Carboxylesterase family protein	Cholinesterase	574 aa	538 aa	31.4 %
Onchocerca volvulus		Acetylcholinesterase	633 aa	648 aa	25.3 %
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Cholinesterase	574 aa	554 aa	36.1 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	633 aa	690 aa	31.7 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	633 aa	620 aa	28.4 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	633 aa	507 aa	23.9 %
Onchocerca volvulus		Cholinesterase	574 aa	578 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0537	0.5	0.5
Trichomonas vaginalis	TK family protein kinase	0.0537	0.5	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Giardia lamblia	Protein 21.1	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0537	0.5	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0537	0.5	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0537	0.5	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0537	0.5	0.5
Giardia lamblia	Kinase, NEK	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	insulin receptor	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Brugia malayi	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Brugia malayi	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0537	0.5	0.5
Echinococcus multilocularis	heat shock protein 70	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0537	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0537	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0537	0.5	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Giardia lamblia	Kinase	0.0537	0.5	0.5
Toxoplasma gondii	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Leishmania major	protein kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0537	0.5	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0537	0.5	0.5
Giardia lamblia	Kinase, NEK	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	ephrin receptor	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0537	0.5	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0537	0.5	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0537	0.5	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	SRC-1	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	insulin receptor	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0537	0.5	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0537	0.5	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0537	0.5	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Echinococcus granulosus	tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0537	0.5	0.5
Echinococcus granulosus	activin receptor type	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0537	0.5	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0537	0.5	0.5
Brugia malayi	protein-tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Trypanosoma cruzi	protein kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trypanosoma cruzi	protein kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Plasmodium falciparum	protein kinase, putative	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0537	0.5	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0537	0.5	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Plasmodium falciparum	protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0537	0.5	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Schistosoma mansoni	ephrin receptor	0.0537	0.5	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0537	0.5	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0537	0.5	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0537	0.5	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0537	0.5	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0537	0.5	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0537	0.5	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0537	0.5	0.5
Trypanosoma brucei	protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Leishmania major	protein kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0537	0.5	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0537	0.5	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Brugia malayi	Raf kinase	0.0537	0.5	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	serine/threonine RGC	0.0537	0.5	0.5
Brugia malayi	SH2 domain containing protein	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0537	0.5	0.5
Plasmodium falciparum	protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus granulosus	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	SRC-1	0.0537	0.5	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0537	0.5	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	STE family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0537	0.5	0.5
Brugia malayi	integrin-linked kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0537	0.5	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0537	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0537	0.5	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Loa Loa (eye worm)	TK protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0537	0.5	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Toxoplasma gondii	STE kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0537	0.5	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0537	0.5	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Plasmodium vivax	protein kinase, putative	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0537	0.5	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	protein kinase	0.0537	0.5	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0537	0.5	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0537	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0537	0.5	0.5
Onchocerca volvulus		0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Echinococcus multilocularis	activin receptor type	0.0537	0.5	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0537	0.5	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0537	0.5	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0537	0.5	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0537	0.5	0.5
Brugia malayi	hypothetical protein	0.0537	0.5	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0537	0.5	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0537	0.5	0.5
Brugia malayi	SH2 domain containing protein	0.0537	0.5	0.5
Echinococcus multilocularis	protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0537	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0537	0.5	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0537	0.5	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0537	0.5	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0537	0.5	0.5
Schistosoma mansoni	tyrosine kinase	0.0537	0.5	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0537	0.5	0.5
Brugia malayi	Protein kinase domain containing protein	0.0537	0.5	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.53 uM	Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method	ChEMBL.	24369842
IC50 (binding)	= 1.71 uM	Inhibition of equine serum butyrylcholinesterase using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method	ChEMBL.	24369842
Ratio IC50 (binding)	= 4	Ratio of galanthamine IC50 to compound IC50 for Electrophorus electricus acetylcholinesterase	ChEMBL.	24369842
Ratio IC50 (binding)	= 10	Ratio of galanthamine IC50 to compound IC50 for equine serum butyrylcholinesterase	ChEMBL.	24369842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3104317

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1818613