TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.511 | Formula: C27H25FN4O2
H donors: 1 H acceptors: 2 LogP: 4.89 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1c(noc1C1CC1)c1ccnc(c1)Nc1ccc(cc1)N1CCOCC1
InChi: 1S/C27H25FN4O2/c28-21-5-3-18(4-6-21)25-26(31-34-27(25)19-1-2-19)20-11-12-29-24(17-20)30-22-7-9-23(10-8-22)32-13-15-33-16-14-32/h3-12,17,19H,1-2,13-16H2,(H,29,30)
InChiKey: FRQAHATZTUYBKE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 10	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 14		References
Homo sapiens	mitogen-activated protein kinase 11		References
Homo sapiens	mitogen-activated protein kinase 12		References
Homo sapiens	mitogen-activated protein kinase 13	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	c-Jun N-terminal kinases	Get druggable targets OG5_129677	All targets in OG5_129677
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	Stress-activated protein kinase jnk-1	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	ko:K04440 c-Jun N-terminal kinase, putative	Get druggable targets OG5_129677	All targets in OG5_129677
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	c Jun NH2 terminal kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 12	357 aa	362 aa	30.1 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 11	364 aa	361 aa	33.0 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 13	365 aa	366 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Schistosoma mansoni	ap endonuclease	0.0021	0.0075	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0366	0.0612
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.194	0.3247
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0019	0.0019	0.0019
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0034	0.0366	0.0612
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0019	0.0019	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.024	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0019	0.0019	0.0031
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0075	1
Schistosoma mansoni	ap endonuclease	0.0021	0.0075	0.0125
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0075	1
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0019	0.0019	0.0031
Echinococcus granulosus	mitogen activated protein kinase 14	0.0457	1	1
Echinococcus multilocularis	hypothetical protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0034	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4998	0.4998
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4998	0.4998
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0075	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0034	0.0366	0.0366
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0019	0.0019	0.0031
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0457	1	1
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0019	0.0019	0.0031
Leishmania major	hypothetical protein, conserved	0.0029	0.024	0.0222
Onchocerca volvulus		0.0253	0.5345	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0019	0.0019	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0034	0.0366	0.0366
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0034	0.0366	0.0366
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.194	0.194
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0075	0.0075
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0075	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.5427	0.5427
Brugia malayi	Protein-tyrosine phosphatase 1	0.0019	0.0019	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.194	0.3247
Echinococcus granulosus	mitogen activated protein kinase 11	0.0457	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Onchocerca volvulus	4.1 G protein, putative homolog	0.0019	0.0019	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.024	1
Onchocerca volvulus		0.0019	0.0019	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4998	0.4998
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0019	0.0019	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0103	0.194	0.194
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.024	0.0222
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0019	0.0019	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0281	0.5976	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0457	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus multilocularis		0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Schistosoma mansoni	pcd6 interacting protein-related	0.0019	0.0019	0.0031
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0019	0.0019	0.0019
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0075	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0457	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0457	1	1
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0457	1	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0034	0.0366	0.0366
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0366	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.194	0.194
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0457	1	1
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.194	0.194
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0075	0.0075
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0457	1	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0366	0.0612
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0034	0.0366	0.0366
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.024	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0075	0.5
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0019	0.0019	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0075	0.5
Brugia malayi	Stress-activated protein kinase jnk-1	0.0281	0.5976	0.5976
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.194	0.194
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0281	0.5976	0.5976
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0034	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0034	0.0366	0.0366
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0019	0.0019	0.0019
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0281	0.5976	0.5976
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0019	0.0019	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.194	0.3247
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0029	0.024	0.024
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0034	0.0366	0.0366
Brugia malayi	Protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0019	0.0019	0.0031
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Schistosoma mansoni	protein tyrosine phosphatase	0.0019	0.0019	0.0031
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0457	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Onchocerca volvulus		0.0019	0.0019	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0034	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0075	0.0056
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0019	0.0019	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0366	0.0612
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0075	0.0056
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.024	1
Onchocerca volvulus		0.0019	0.0019	0.0035
Onchocerca volvulus		0.0019	0.0019	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0034	0.0366	0.0366
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0018	0.001	0.001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0029	0.024	0.024
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0457	1	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0019	0.0019	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase	0.0272	0.5774	0.5774
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0103	0.194	0.194
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0019	0.0019	0.0019
Echinococcus granulosus	c-Jun N-terminal kinases	0.0281	0.5976	0.5976
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0019	0.0019	0.0019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.024	0.0222
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0019	0.0019
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0075	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.024	0.0222
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0019	0.0019	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0019	0.0019
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0075	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035
Onchocerca volvulus		0.0019	0.0019	0.0035
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0075	0.0056
Schistosoma mansoni	protein tyrosine phosphatase	0.0034	0.0366	0.0612
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0019	0.0019	0.0035

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of JNK1 (unknown origin)	ChEMBL.	24332487
IC50 (binding)	= 0.07 uM	Inhibition of JNK3 (39 to 402 amino acids) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated ATF2 as substrate after 15 mins by HTRF assay	ChEMBL.	24332487
IC50 (binding)	= 0.563 uM	Inhibition of p38 (unknown origin)	ChEMBL.	24332487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3099967

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821128