Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | AXL receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | TYRO3 protein tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | MER proto-oncogene, tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008957,Fibronectin, type III-like fold,domain-containing | Get druggable targets OG5_132328 | All targets in OG5_132328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.194 | 0.2407 |
Schistosoma mansoni | myosin-binding protein-related | 0.0017 | 0.194 | 0.2407 |
Schistosoma mansoni | nephrin | 0.0028 | 0.8018 | 0.9949 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0025 | 0.6078 | 1 |
Schistosoma mansoni | hemicentin | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0019 | 0.2866 | 0.4715 |
Schistosoma mansoni | nephrin | 0.0021 | 0.3922 | 0.4866 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0662 | 0.0662 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0017 | 0.194 | 0.3192 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.3922 | 0.6452 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | contactin | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Schistosoma mansoni | neuroglian | 0.0021 | 0.3922 | 0.4866 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | protein unc-22 | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | cell adhesion molecule | 0.0028 | 0.806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Echinococcus multilocularis | titin | 0.0017 | 0.194 | 0.194 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0019 | 0.2866 | 0.4715 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | titin | 0.0017 | 0.194 | 0.194 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0025 | 0.6078 | 1 |
Loa Loa (eye worm) | projectin | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | hypothetical protein | 0.0025 | 0.6078 | 1 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3922 | 0.6452 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | titin | 0.0017 | 0.194 | 0.2407 |
Echinococcus granulosus | nephrin | 0.0017 | 0.194 | 0.194 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0021 | 0.3922 | 0.4866 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.194 | 0.2407 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.3922 | 0.4866 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.194 | 0.2407 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0017 | 0.194 | 0.194 |
Echinococcus granulosus | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0017 | 0.194 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2643 | 0.4349 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0703 | 0.1156 |
Schistosoma mansoni | ephrin receptor | 0.0018 | 0.2163 | 0.2684 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0018 | 0.2163 | 0.2163 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.194 | 0.3192 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.3922 | 0.6452 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0703 | 0.0703 |
Onchocerca volvulus | 0.0017 | 0.194 | 1 | |
Echinococcus granulosus | neuroglian | 0.0015 | 0.0662 | 0.0662 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0021 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.6078 | 1 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0017 | 0.1982 | 0.1982 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0021 | 0.3922 | 0.6452 |
Echinococcus multilocularis | neuroglian | 0.0021 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.1982 | 0.326 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.1982 | 0.326 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.81 nM | Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 21 nM | Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
IC50 (binding) | = 70 nM | Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay | ChEMBL. | 24195762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.