TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.467 | Formula: C24H26FNO2
H donors: 0 H acceptors: 2 LogP: 5.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OC1C[C@H]2[C@@H]([C@H]1/C=C/c1ccc(cn1)c1cccc(c1)F)CCCC2
InChi: 1S/C24H26FNO2/c1-16(27)28-24-14-18-5-2-3-8-22(18)23(24)12-11-21-10-9-19(15-26-21)17-6-4-7-20(25)13-17/h4,6-7,9-13,15,18,22-24H,2-3,5,8,14H2,1H3/b12-11+/t18-,22-,23+,24?/m0/s1
InChiKey: MOWYCFGPSCEBJA-HMWKPFPJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor II (thrombin) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0215	0.0306
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0126	0.0126
Brugia malayi	regulator of G-protein signaling egl-10	0.002	0.0176	0.0416
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0215	0.0388
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.251	0.6733
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.002	0.0176	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0015	0.0106	0.0106
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0176	0.0176
Brugia malayi	regulator of G-protein signaling rgs-7	0.002	0.0176	0.0416
Onchocerca volvulus		0.0021	0.0184	0.0344
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0096	0.1219	0.3171
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0126	0.028
Echinococcus granulosus	heat shock protein 90	0.0015	0.0106	0.0106
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0015	0.0106	0.0084
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0215	0.0388
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0215	1
Loa Loa (eye worm)	thioredoxin reductase	0.0067	0.0819	0.2174
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0215	0.0306
Schistosoma mansoni	hypothetical protein	0.0179	0.2377	0.2377
Brugia malayi	hypothetical protein	0.002	0.0176	0.0416
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0015	0.0106	0.2176
Onchocerca volvulus	Glucosylceramidase homolog	0.0179	0.2377	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0176	0.0176
Plasmodium falciparum	glutathione reductase	0.0067	0.0819	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0176	0.0176
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0015	0.0106	0.2176
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0126
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0184	0.1097
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0273	0.368	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0176	0.0176
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Schistosoma mansoni	endoplasmin	0.0015	0.0106	0.0106
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0176	0.0176
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0127	0.0282
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.002	0.0176	0.0417
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Echinococcus multilocularis	dnaJ subfamily B	0.0433	0.5885	0.5885
Echinococcus multilocularis	Regulator of G protein signaling 20	0.002	0.0176	0.0176
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0184	0.0184
Echinococcus multilocularis	cpg binding protein	0.0032	0.034	0.034
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.002	0.0176	0.0176
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Entamoeba histolytica	hypothetical protein	0.002	0.0176	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0184	0.0439
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0015	0.0106	0.2176
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0184	0.0439
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0176	0.0176
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0015	0.0106	0.2176
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0273	0.368	0.368
Schistosoma mansoni	cpg binding protein	0.0032	0.034	0.034
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0273	0.3677	0.9991
Schistosoma mansoni	pyruvate dehydrogenase	0.0273	0.368	0.368
Brugia malayi	PXA domain containing protein	0.002	0.0176	0.0416
Leishmania major	hypothetical protein, conserved	0.0015	0.0106	0.0084
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0127	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0176	0.0176
Loa Loa (eye worm)	RGS-3 protein	0.002	0.0176	0.0417
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0215	0.1535
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0273	0.3677	0.9991
Entamoeba histolytica	hypothetical protein	0.002	0.0176	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0126
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.002	0.0176	0.0196
Echinococcus granulosus	cpg binding protein	0.0032	0.034	0.034
Brugia malayi	Endoplasmin precursor	0.0015	0.0106	0.0225
Plasmodium falciparum	thioredoxin reductase	0.0067	0.0819	1
Echinococcus granulosus	neuropeptide receptor A26	0.0492	0.6706	0.6706
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0015	0.0106	0.0225
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0176	0.0176
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0273	0.368	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0127	0.0127
Echinococcus granulosus	geminin	0.0179	0.2377	0.2377
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0625	0.1646
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Leishmania major	DNA topoisomerase ii	0.0015	0.0106	0.0084
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0126	0.0126
Echinococcus granulosus	beta-adrenergic receptor kinase	0.002	0.0176	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0015	0.0106	0.2176
Schistosoma mansoni	rab6-interacting	0.0021	0.0184	0.0184
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0395	0.1014
Trypanosoma brucei	heat shock protein 90, putative	0.0015	0.0106	0.0084
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Echinococcus multilocularis	beta adrenergic receptor kinase	0.002	0.0176	0.0176
Schistosoma mansoni	cpg binding protein	0.0032	0.034	0.034
Echinococcus multilocularis	heat shock protein	0.0015	0.0106	0.0106
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0215	0.0215
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0215	0.0388
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0176	0.0176
Echinococcus multilocularis	microtubule associated protein 2	0.073	1	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0215	0.0388
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0127	0.0292
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0131	0.0291
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0215	0.1535
Echinococcus multilocularis	RUN	0.0021	0.0184	0.0184
Schistosoma mansoni	hypothetical protein	0.0021	0.0184	0.0184
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0215	0.1535
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0015	0.0106	0.0084
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0215	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0111	0.1429	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0176	0.0176
Schistosoma mansoni	hypothetical protein	0.0036	0.0395	0.0395
Schistosoma mansoni	DNA topoisomerase II	0.0015	0.0106	0.0106
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0015	0.0106	0.0084
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0015	0.0106	0.0106
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0176	0.0176
Leishmania major	mitochondrial DNA topoisomerase II	0.0015	0.0106	0.0084
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0106	0.0225
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0273	0.368	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0096	0.1219	0.3171
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Trypanosoma cruzi	heat shock protein 90, putative	0.0015	0.0106	0.0084
Loa Loa (eye worm)	endoplasmin	0.0015	0.0106	0.0225
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0176	0.0176
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0015	0.0106	0.2176
Loa Loa (eye worm)	glutathione reductase	0.0067	0.0819	0.2174
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0176	0.0176
Schistosoma mansoni	microtubule-associated protein tau	0.073	1	1
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Schistosoma mansoni	hypothetical protein	0.0433	0.5885	0.5885
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0184	0.0184
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0215	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0067	0.0819	1
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0127	0.0127
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Echinococcus multilocularis	geminin	0.0179	0.2377	0.2377
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0023	0.0215	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0127	0.0127
Echinococcus multilocularis	regulator of G protein signaling	0.002	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0106	0.0225
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0176	0.0176
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0067	0.0819	0.0819
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0076	0.0142
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.0176	0.0417
Echinococcus multilocularis	expressed protein	0.0395	0.5361	0.5361
Mycobacterium ulcerans	putative regultory protein	0.0015	0.0106	0.2176
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0126	0.0126
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Onchocerca volvulus		0.003	0.0316	0.0925
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0176	0.0176
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0127	0.0157
Plasmodium falciparum	glutathione reductase	0.0023	0.0215	0.1535
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0184	0.0184
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0704	0.0704
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0215	0.0827
Toxoplasma gondii	thioredoxin reductase	0.0067	0.0819	0.5386
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0026
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0015	0.0106	0.0084
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0096	0.1219	0.3171
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Schistosoma mansoni	endoplasmin	0.0015	0.0106	0.0106
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0184	0.0184
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.251	0.6733
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0176	0.0176
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0215	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0692	0.443
Brugia malayi	Probable DNA topoisomerase II	0.0015	0.0106	0.0225
Echinococcus granulosus	heat shock protein	0.0015	0.0106	0.0106
Schistosoma mansoni	polycystin 1-related	0.0021	0.0184	0.0184
Trypanosoma cruzi	trypanothione reductase, putative	0.0067	0.0819	0.2061
Schistosoma mansoni	cpg binding protein	0.003	0.0316	0.0316
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0126	0.0126
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0126	0.0281
Schistosoma mansoni	heat shock protein	0.0015	0.0106	0.0106
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0184	0.0439
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0015	0.0106	0.0084
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0176	0.0176
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0215	0.0524
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0273	0.368	0.368
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0076	0.0142
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0076	0.0141
Brugia malayi	kinase, mitochondrial precursor	0.0273	0.368	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0625	0.1645
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0026
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0015	0.0106	0.0084
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0215	0.1535
Echinococcus granulosus	GPCR family 2	0.0017	0.0126	0.0126
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0127	0.0142
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Trypanosoma cruzi	heat shock protein 90, putative	0.0015	0.0106	0.0084
Trypanosoma cruzi	Heat shock protein 83, putative	0.0015	0.0106	0.0084
Brugia malayi	heat shock protein 90	0.0015	0.0106	0.0225
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.0176	0.0416
Schistosoma mansoni	lipoxygenase	0.0021	0.0184	0.0184
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0106	0.0084
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0126	0.0126
Entamoeba histolytica	hypothetical protein	0.002	0.0176	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Echinococcus granulosus	expressed protein	0.0395	0.5361	0.5361
Mycobacterium ulcerans	DNA gyrase subunit B	0.0015	0.0106	0.2176
Brugia malayi	Thioredoxin reductase	0.0067	0.0819	0.2174
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0625	0.1645
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0184	0.1097
Schistosoma mansoni	rab6-interacting	0.0021	0.0184	0.0184
Echinococcus granulosus	dnaJ subfamily B	0.0433	0.5885	0.5885
Onchocerca volvulus		0.0021	0.0184	0.0344
Loa Loa (eye worm)	TOPoisomerase family member	0.0015	0.0106	0.0225
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0127	0.0292
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0015	0.0106	0.0084
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0127	0.0127
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0395	0.1013
Mycobacterium ulcerans	two component sensor kinase MprB	0.0015	0.0106	0.2176
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0023	0.0215	0.1535
Trypanosoma brucei	heat shock protein 90, putative	0.0015	0.0106	0.0084
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0215	0.0827
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0076	0.0142
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0215	0.1535
Treponema pallidum	NADH oxidase	0.0023	0.0215	1
Leishmania major	trypanothione reductase	0.0067	0.0819	0.2061
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0176	0.0196
Echinococcus granulosus	RUN	0.0021	0.0184	0.0184
Brugia malayi	A-kinase anchor protein 10, precursor	0.002	0.0176	0.0416
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0076	0.0141
Trypanosoma brucei	DNA topoisomerase ii	0.0015	0.0106	0.0084
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0215	0.0388
Schistosoma mansoni	pyruvate dehydrogenase	0.0258	0.347	0.347
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0625	0.1646
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0176	0.0416
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0215	0.0388
Schistosoma mansoni	z-protein (S1r protein)	0.002	0.0176	0.0176
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0215	0.0215
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0215	0.0388
Loa Loa (eye worm)	heat shock protein 90	0.0015	0.0106	0.0225
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0215	0.0215
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0126
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0273	0.368	1
Brugia malayi	PXA domain containing protein	0.002	0.0176	0.0416
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0215	0.1535
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0106	0.0084
Schistosoma mansoni	hypothetical protein	0.0179	0.2377	0.2377
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.0176	0.0176
Schistosoma mansoni	lipoxygenase	0.0058	0.0704	0.0704
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0316	0.0799
Loa Loa (eye worm)	hypothetical protein	0.002	0.0176	0.0417
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0127	0.0127
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0176	0.0176
Brugia malayi	Doublecortin family protein	0.0021	0.0184	0.0438
Brugia malayi	hypothetical protein	0.0021	0.0184	0.0438
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0176	0.0176
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0127	0.0142
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0126
Loa Loa (eye worm)	PXA domain-containing protein	0.002	0.0176	0.0417
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0215	0.0388
Brugia malayi	hypothetical protein	0.0021	0.0184	0.0438
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0015	0.0106	0.0225
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2377	0.6359
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0176	0.0176
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0015	0.0106	0.2176
Echinococcus multilocularis	heat shock protein 90	0.0015	0.0106	0.0106
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0106	0.0084
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0215	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0215	1
Schistosoma mansoni	loxhd1	0.0021	0.0184	0.0184
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0184	0.0184
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0015	0.0106	0.0084
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Brugia malayi	hypothetical protein	0.002	0.0176	0.0416
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0127	0.0292
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0215	0.1535
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.002	0.0176	0.0417
Brugia malayi	CXXC zinc finger family protein	0.003	0.0316	0.0799
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0176	0.0176
Echinococcus multilocularis	neuropeptide s receptor	0.0492	0.6706	0.6706
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0176	0.0416
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0127	0.0281
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0096	0.1219	0.8409
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0704	0.0704
Trypanosoma brucei	trypanothione reductase	0.0067	0.0819	0.2061
Echinococcus multilocularis	neuropeptide receptor A26	0.0492	0.6706	0.6706
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0127	0.0142
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0184	0.0184
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0126	0.028
Echinococcus granulosus	Regulator of G protein signaling 20	0.002	0.0176	0.0176
Plasmodium vivax	glutathione reductase, putative	0.0067	0.0819	1
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0127	0.0157
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0015	0.0106	0.2176
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0127	0.0281
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0106	0.0084
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Trypanosoma brucei	Heat shock protein 83, putative	0.0015	0.0106	0.0084
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0215	0.0388
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0176	0.0176
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0788	0.0788
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0215	0.0388
Schistosoma mansoni	pyruvate dehydrogenase	0.0258	0.347	0.347
Leishmania major	heat shock protein 83-1	0.0015	0.0106	0.0084
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0015	0.0106	0.2176
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.3677	1
Echinococcus granulosus	neuropeptide s receptor	0.0492	0.6706	0.6706
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0127	0.0127
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0176	0.0176
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0273	0.368	0.368
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0127	0.0142
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0026	0.0005
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0023	0.0215	0.1535
Plasmodium vivax	thioredoxin reductase, putative	0.0067	0.0819	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0131	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0126	0.0281
Brugia malayi	glutathione reductase	0.0067	0.0819	0.2174
Echinococcus granulosus	thioredoxin glutathione reductase	0.0067	0.0819	0.0819
Schistosoma mansoni	heat shock protein	0.0015	0.0106	0.0106

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.067 uM	Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysis	ChEMBL.	24900604

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3091985

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1826151