Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0576 | 0.7859 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0576 | 0.7859 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0576 | 0.7859 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0576 | 0.7859 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0576 | 0.7859 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0576 | 0.7859 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0576 | 0.7859 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0576 | 0.7859 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0576 | 0.7859 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0576 | 0.7859 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0576 | 0.7859 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0576 | 0.7859 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0576 | 0.7859 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0576 | 0.7859 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9236 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0576 | 0.7859 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0576 | 0.7859 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0576 | 0.7859 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0576 | 0.7859 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0576 | 0.7859 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0576 | 0.7859 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0576 | 0.7859 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Inhibition of human MAO-B | ChEMBL. | 24139167 |
IC50 (binding) | > 10 uM | Inhibition of human MAO-A | ChEMBL. | 24139167 |
Inhibition (binding) | = -15 % | Displacement of [3H]PSB-603 from human adenosine A2B receptor relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 1 % | Inhibition of human MAO-A at 10 uM relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 3 % | Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 32 % | Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 40 % | Inhibition of human MAO-B at 10 uM relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 41 % | Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatum relative to control | ChEMBL. | 24139167 |
Ki (binding) | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 24139167 | |
Ki (binding) | Displacement of [3H]MSX-2 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 24139167 | |
Ki (binding) | > 1 uM | Displacement of [3H]PSB-603 from human adenosine A2B receptor | ChEMBL. | 24139167 |
Ki (binding) | > 1.5 uM | Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex | ChEMBL. | 24139167 |
Ki (binding) | > 10 uM | Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 24139167 |
Ki (binding) | > 10 uM | Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatum | ChEMBL. | 24139167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.