Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Prostaglandin E synthase | 0.1383 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1383 | 1 | 0.5 |
Onchocerca volvulus | 0.1383 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1383 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1383 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.1383 | 1 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1383 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human MAO-A | ChEMBL. | 24139167 | |
IC50 (binding) | > 10 uM | Inhibition of human MAO-B | ChEMBL. | 24139167 |
Inhibition (binding) | = 8 % | Displacement of [3H]PSB-603 from human adenosine A2B receptor relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 20 % | Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells relative to control | ChEMBL. | 24139167 |
Inhibition (binding) | = 36 % | Inhibition of human MAO-B at 10 uM relative to control | ChEMBL. | 24139167 |
Ki (binding) | Displacement of [3H]MSX-2 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 24139167 | |
Ki (binding) | = 0.469 uM | Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex | ChEMBL. | 24139167 |
Ki (binding) | > 1 uM | Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 24139167 |
Ki (binding) | > 1 uM | Displacement of [3H]PSB-603 from human adenosine A2B receptor | ChEMBL. | 24139167 |
Ki (binding) | = 3.03 uM | Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatum | ChEMBL. | 24139167 |
Ki (binding) | = 9.49 uM | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 24139167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.