Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0012 | 0.0043 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0674 | 0.4407 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.1474 | 0.1437 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.0674 | 0.0633 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.002 | 0.0125 | 0.0082 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0674 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0043 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1474 | 0.1437 |
Plasmodium vivax | amine transporter, putative | 0.0012 | 0.0043 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0674 | 0.4407 |
Leishmania major | protein kinase, putative | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0.0043 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0012 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0674 | 0.4407 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0969 | 0.9996 | 0.9996 |
Plasmodium falciparum | amino acid transporter, putative | 0.0012 | 0.0043 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1474 | 0.1437 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.0674 | 0.0633 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0674 | 0.4407 |
Leishmania major | protein kinase, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.097 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0.0043 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0043 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0674 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.097 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0008 | 0 | 0.5 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0674 | 0.0633 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0012 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0674 | 0.4407 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1474 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.097 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0969 | 0.9996 | 0.9996 |
Onchocerca volvulus | 0.0073 | 0.0674 | 1 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.1474 | 0.1437 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0674 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0674 | 0.4407 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43 nM | Displacement of [3H]paroxetine from SERT in rat cortical membranes after 6 mins by liquid scintillation counting | ChEMBL. | 24262884 |
IC50 (binding) | = 4500 nM | Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells | ChEMBL. | 24262884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.