Detailed information for compound 1830811

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 750.29 | Formula: C39H53ClFNO10
  • H donors: 1 H acceptors: 1 LogP: 8.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1ccc(c(c1)Cl)F)O[C@H]([C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3)C[C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
  • InChi: 1S/C39H53ClFNO10/c1-19-7-10-26-21(3)30(44-33-38(26)24(19)13-15-36(5,47-33)49-51-38)18-31(45-35(43)42-23-9-12-29(41)28(40)17-23)32-22(4)27-11-8-20(2)25-14-16-37(6)48-34(46-32)39(25,27)52-50-37/h9,12,17,19-22,24-27,30-34H,7-8,10-11,13-16,18H2,1-6H3,(H,42,43)/t19-,20-,21-,22-,24+,25+,26+,27+,30-,31+,32+,33-,34-,36-,37-,38-,39-/m1/s1
  • InChiKey: DOZOJXNVOKZNIH-RKAIAWGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major fucose kinase, putative 0.0077 0.1017 0.1017
Echinococcus granulosus N acetylgalactosamine kinase 0.0277 0.4483 0.4483
Brugia malayi Pre-SET motif family protein 0.021 0.3326 0.7418
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0244 0.0244
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0077 0.1017 0.1557
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Loa Loa (eye worm) galactokinase 0.0277 0.4483 0.8837
Loa Loa (eye worm) glutaminase 0.0273 0.442 0.8713
Trypanosoma brucei homoserine kinase 0.0182 0.2837 0.4343
Schistosoma mansoni hypothetical protein 0.0036 0.0294 0.0535
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0396
Trypanosoma brucei mevalonate kinase, putative 0.0182 0.2837 0.4343
Treponema pallidum hypothetical protein 0.0182 0.2837 0.3276
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0077 0.1017 0.298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0365
Trypanosoma cruzi galactokinase, putative 0.0594 1 1
Onchocerca volvulus 0.0153 0.2326 0.5857
Trypanosoma cruzi mevalonate kinase, putative 0.0182 0.2837 0.2837
Trichomonas vaginalis ran, putative 0.0021 0.0049 0.011
Brugia malayi Pre-SET motif family protein 0.003 0.0201 0.0448
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0915 0.2041
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0077 0.1017 0.1557
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0661 0.0661
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0201 0.0201
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0182 0.2837 0.2837
Mycobacterium ulcerans galactokinase 0.0594 1 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0183 0.0183
Leishmania major importin beta-1 subunit, putative 0.0024 0.0087 0.0087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0462 0.091
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0049 0.011
Treponema pallidum galactokinase 0.0517 0.866 1
Trichomonas vaginalis galactokinase, putative 0.0277 0.4483 1
Plasmodium vivax SET domain protein, putative 0.003 0.0201 0.2194
Onchocerca volvulus 0.0071 0.0915 0.1968
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0311 0.0476
Schistosoma mansoni hypothetical protein 0.0335 0.5502 1
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.7634 0.7634
Mycobacterium ulcerans hypothetical protein 0.0071 0.0915 0.0915
Trypanosoma cruzi homoserine kinase 0.0182 0.2837 0.2837
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0294 0.0294
Giardia lamblia Mevalonate kinase 0.0182 0.2837 1
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0077 0.1017 0.1017
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0277 0.4483 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0915 0.0915
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0915 0.2041
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0661 0.1202
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0661 0.0661
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0595 0.1173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0311 0.0693
Leishmania major GTP-binding protein, putative 0.0021 0.0049 0.0049
Trichomonas vaginalis mevalonate kinase, putative 0.0077 0.1017 0.2269
Loa Loa (eye worm) beta-lactamase 0.0071 0.0915 0.1804
Echinococcus multilocularis galactokinase 0.0594 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0915 0.0915
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0311 0.1096
Schistosoma mansoni galactokinase 0.0277 0.4483 0.8149
Brugia malayi beta-lactamase family protein 0.0071 0.0915 0.2041
Plasmodium vivax importin-beta 2, putative 0.0029 0.0183 0.1999
Plasmodium falciparum importin beta, putative 0.0029 0.0183 1
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.7634 0.7634
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0201 0.0201
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0077 0.1017 0.1017
Schistosoma mansoni mevalonate kinase 0.0182 0.2837 0.5157
Trichomonas vaginalis galactokinase, putative 0.0277 0.4483 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0174
Echinococcus granulosus snurportin 1 0.0311 0.5073 0.5073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0462 0.0839
Brugia malayi Importin beta-1 subunit 0.0029 0.0183 0.0408
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0311 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1017 0.2269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0462 0.0462
Brugia malayi glutaminase DH11.1 0.0273 0.442 0.986
Mycobacterium ulcerans glutaminase 0.0273 0.442 0.442
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.3708 0.7308
Giardia lamblia Diphosphomevalonate decarboxylase 0.0077 0.1017 0.3585
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0915 0.0915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0462 0.0462
Schistosoma mansoni ran 0.0021 0.0049 0.009
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0182 0.2837 0.2837
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0915 0.0915
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0077 0.1017 0.1017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0915 0.1804
Entamoeba histolytica hypothetical protein 0.0036 0.0294 0.0294
Echinococcus granulosus neuropeptide s receptor 0.0458 0.7634 0.7634
Leishmania major hypothetical protein, conserved 0.0071 0.0915 0.0915
Trypanosoma cruzi galactokinase, putative 0.0594 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0462 0.0839
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0915 0.2041
Entamoeba histolytica Ran family GTPase 0.0021 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0182 0.2837 0.5593
Onchocerca volvulus 0.0071 0.0915 0.1968
Trypanosoma cruzi galactokinase, putative 0.0517 0.866 0.866
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0182 0.2837 0.4343
Leishmania major galactokinase-like protein 0.0594 1 1
Brugia malayi hypothetical protein 0.0153 0.2326 0.5189
Schistosoma mansoni inositol monophosphatase 0.0036 0.0311 0.0565
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0915 0.0915
Trypanosoma cruzi fucose kinase, putative 0.0105 0.1498 0.1498
Schistosoma mansoni glutaminase 0.0273 0.442 0.8034
Brugia malayi follicle stimulating hormone receptor 0.0232 0.3708 0.827
Entamoeba histolytica galactokinase, putative 0.0594 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0087 0.0087
Mycobacterium ulcerans phosphomevalonate kinase 0.0182 0.2837 0.2837
Onchocerca volvulus 0.0077 0.1017 0.225
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0077 0.1017 0.1017
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0311 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0915 0.2041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0311 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0915 0.2041
Mycobacterium tuberculosis Conserved protein 0.0071 0.0915 0.0915
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0661 0.1475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0462 0.0839
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0311 0.0311
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0201 0.0448
Brugia malayi hypothetical protein 0.0036 0.0294 0.0657
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0183 0.0408
Echinococcus granulosus geminin 0.0335 0.5502 0.5502
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0365
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0915 0.0915
Trichomonas vaginalis galactokinase, putative 0.0077 0.1017 0.2269
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.5073 1
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0077 0.1017 0.1017
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0077 0.1017 0.2269
Loa Loa (eye worm) hypothetical protein 0.0153 0.2326 0.4585
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0915 0.0915
Echinococcus multilocularis N acetylgalactosamine kinase 0.0277 0.4483 0.4483
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0077 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0077 0.1017 0.2005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0915 0.0915
Echinococcus multilocularis geminin 0.0335 0.5502 0.5502
Brugia malayi beta-lactamase 0.0071 0.0915 0.2041
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0182 0.2837 1
Brugia malayi mevalonate kinase family protein 0.0182 0.2837 0.6329
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0915 0.1663
Toxoplasma gondii ABC1 family protein 0.0071 0.0915 0.2041
Echinococcus granulosus importin subunit beta 1 0.0029 0.0183 0.0183
Trypanosoma brucei galactokinase-like protein, putative 0.0395 0.6534 1
Trichomonas vaginalis galactokinase, putative 0.0277 0.4483 1
Mycobacterium ulcerans homoserine kinase 0.0182 0.2837 0.2837
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0087 0.0195
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0098
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0183 0.028
Brugia malayi RNA, U transporter 1 0.0083 0.1115 0.2487
Trichomonas vaginalis set domain proteins, putative 0.0239 0.383 0.8542
Trichomonas vaginalis esterase, putative 0.0071 0.0915 0.2041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0087 0.0195
Mycobacterium ulcerans beta-lactamase 0.0071 0.0915 0.0915
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0201 0.0201
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0311 0.0311
Leishmania major fucose kinase, putative 0.0077 0.1017 0.1017
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0915 0.14
Echinococcus granulosus Mevalonate galactokinase 0.0182 0.2837 0.2837
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0049 0.0541
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0182 0.0182
Leishmania major phosphomevalonate kinase protein, putative 0.0182 0.2837 0.2837
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0311 0.0693
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0077 0.1017 0.1017
Trichomonas vaginalis galactokinase, putative 0.0277 0.4483 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0661 0.0661
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0077 0.1017 0.2269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0915 0.1663
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0294 0.0535
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0294 0.0294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0915 0.0915
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0183 0.028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0201 0.0365
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0077 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.7634 0.7634
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0077 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0915 0.0915
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0915 0.0915
Mycobacterium tuberculosis Conserved protein 0.0071 0.0915 0.0915
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.7584 0.7584
Toxoplasma gondii GHMP kinase, putative 0.0182 0.2837 0.6329
Mycobacterium tuberculosis Conserved protein 0.0071 0.0915 0.0915
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0594 1 1
Entamoeba histolytica hypothetical protein 0.0024 0.0087 0.0087
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0915 0.2586
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0049
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0915 0.0915
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0311 0.0693
Trypanosoma cruzi galactokinase-like protein, putative 0.0517 0.866 0.866
Trichomonas vaginalis galactokinase, putative 0.0105 0.1498 0.3341
Schistosoma mansoni inositol monophosphatase 0.0036 0.0311 0.0565
Schistosoma mansoni importin beta-1 0.0029 0.0183 0.0332
Mycobacterium leprae Probable lipase LipE 0.0071 0.0915 0.2586
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0077 0.1017 0.1849
Loa Loa (eye worm) glutaminase 2 0.0273 0.442 0.8713
Trypanosoma cruzi homoserine kinase 0.0182 0.2837 0.2837
Trypanosoma cruzi fucose kinase, putative 0.0105 0.1498 0.1498
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Onchocerca volvulus 0.0239 0.383 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0076
Entamoeba histolytica hypothetical protein 0.0036 0.0294 0.0294
Echinococcus multilocularis snurportin 1 0.0311 0.5073 0.5073
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0661 0.0661
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0915 0.2041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0071 0.0915 0.1804
Brugia malayi beta-lactamase family protein 0.0071 0.0915 0.2041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0915 0.0915
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0462 0.103
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.3326 0.6555
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0311 0.0311
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.2705
Schistosoma mansoni ran 0.0021 0.0049 0.009
Schistosoma mansoni hypothetical protein 0.0311 0.5073 0.9221
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0077 0.1017 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0365
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0661 0.0661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0462 0.0462
Echinococcus multilocularis Mevalonate galactokinase 0.0182 0.2837 0.2837
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0087 0.0195
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0182 0.2837 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0049 0.0049
Onchocerca volvulus 0.0071 0.0915 0.1968
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.011
Brugia malayi Inositol-1 0.0036 0.0311 0.0693
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0182 0.2837 0.2837
Entamoeba histolytica hypothetical protein 0.0036 0.0294 0.0294
Trichomonas vaginalis glutaminase, putative 0.0273 0.442 0.986
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0915 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0915 0.0915
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0335 0.5502 1
Leishmania major mevalonate kinase, putative 0.0182 0.2837 0.2837
Brugia malayi galactokinase family protein 0.0277 0.4483 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0462 0.0462
Loa Loa (eye worm) inositol-1 0.0036 0.0311 0.0613
Entamoeba histolytica hypothetical protein 0.0036 0.0294 0.0294
Leishmania major homoserine kinase, putative 0.0182 0.2837 0.2837

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8 % Antimalarial activity against Plasmodium berghei ANKA infected in C57BL/6J mouse assessed as parasitemia level at 5 mg/kg, po administered after 24 hrs post infection measured after 30 days in presence of 15 mg/kg of mefloquine hydrochloride relative to control ChEMBL. 24508128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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