TDR Targets

Basic information

Technical information

TDR Targets ID: 183478
Name: 2-(benzylamino)-6-(2,6-dichlorophenyl)-8-meth ylpyrido[2,3-d]pyrimidin-7-one
MW: 411.284 | Formula: C21H16Cl2N4O
H donors: 1 H acceptors: 3 LogP: 4.83 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1c1cc2cnc(nc2n(c1=O)C)NCc1ccccc1)Cl
InChi: 1S/C21H16Cl2N4O/c1-27-19-14(10-15(20(27)28)18-16(22)8-5-9-17(18)23)12-25-21(26-19)24-11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,24,25,26)
InChiKey: GCVONYYXPDJZOE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(benzylamino)-6-(2,6-dichlorophenyl)-8-methyl-pyrido[2,3-d]pyrimidin-7-one
2-(benzylamino)-6-(2,6-dichlorophenyl)-8-methyl-7-pyrido[2,3-d]pyrimidinone
6-(2,6-dichlorophenyl)-8-methyl-2-(phenylmethylamino)pyrido[2,3-d]pyrimidin-7-one
6-(2,6-dichlorophenyl)-8-methyl-2-(phenylmethylamino)pyrido[6,5-d]pyrimidin-7-one
6-(2,6-dichlorophenyl)-8-methyl-2-(phenylmethylamino)-7-pyrido[6,5-d]pyrimidinone
2-(benzylamino)-6-(2,6-dichlorophenyl)-8-methyl-pyrido[6,5-d]pyrimidin-7-one
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 27

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Gallus gallus	Tyrosine-protein kinase SRC	Starlite/ChEMBL	References
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.9 %
Schistosoma mansoni	tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	501 aa	35.3 %
Onchocerca volvulus	Cyclin-H homolog	Tyrosine-protein kinase SRC	533 aa	453 aa	44.8 %
Onchocerca volvulus		Tyrosine-protein kinase SRC	533 aa	435 aa	27.4 %
Echinococcus granulosus	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.5 %
Echinococcus granulosus	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.7 %
Brugia malayi	Tyrosine-protein kinase abl-1	Tyrosine-protein kinase SRC	533 aa	455 aa	44.4 %
Echinococcus granulosus	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Echinococcus multilocularis	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.1 %
Schistosoma mansoni	serine/threonine protein kinase	Tyrosine-protein kinase SRC	533 aa	473 aa	24.5 %
Echinococcus multilocularis	tyrosine protein kinase Abl	Tyrosine-protein kinase SRC	533 aa	506 aa	36.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	conserved hypothetical protein	0.0924	0.0454	0.3377
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Leishmania major	monoglyceride lipase, putative	0.016	0.0073	0.0123
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.5154	0.2563	0.2563
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0014	0.0014
Brugia malayi	SRC-1	0.0047	0.0016	0.0016
Echinococcus granulosus	BC026374 protein S09 family	0.0529	0.0257	0.0257
Mycobacterium ulcerans	putative regulatory protein	0.0924	0.0454	0.1703
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.1113
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Giardia lamblia	hypothetical protein	0.0356	0.0171	1
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0356	0.0171	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Echinococcus granulosus	neuroglian	0.0018	0.0002	0.0002
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Brugia malayi	Lipase family protein	0.0098	0.0042	0.0042
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.2421	0.12	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0356	0.0171	0.0511
Loa Loa (eye worm)	hypothetical protein	2.0071	1	1
Loa Loa (eye worm)	TK protein kinase	0.0125	0.0055	0.0055
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.1113
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0047	0.0016	0.0016
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.016	0.0073	1
Trypanosoma brucei	monoglyceride lipase, putative	0.016	0.0073	0.0123
Trichomonas vaginalis	lipase containing protein, putative	0.5154	0.2563	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0356	0.0171	0.0511
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	1.1369	0.5661	0.5661
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0073	0.0123
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0356	0.0171	0.0171
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0047	0.0016	0.0016
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0356	0.0171	0.0511
Echinococcus multilocularis	neuroligin	0.0529	0.0257	0.0257
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.2421	0.12	0.4594
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Echinococcus multilocularis	carboxylesterase 5A	0.0529	0.0257	0.0257
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Plasmodium falciparum	lysophospholipase, putative	0.016	0.0073	0.0267
Toxoplasma gondii	hypothetical protein	0.0924	0.0454	1
Mycobacterium ulcerans	amidase	0.2421	0.12	0.5042
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.128	0.0631	0.0631
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.2421	0.12	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Loa Loa (eye worm)	acetylcholinesterase 1	0.0529	0.0257	0.0257
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0047	0.0016	0.0016
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0098	0.0042	0.0042
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0356	0.0171	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0924	0.0454	0.1633
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0529	0.0257	0.0257
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0122	0.0054	0.0054
Plasmodium vivax	PST-A protein	0.016	0.0073	0.0267
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.0014	0.0014
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus granulosus	fatty acid amide hydrolase 1	2.0071	1	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Brugia malayi	Lipase family protein	0.0098	0.0042	0.0042
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Mycobacterium ulcerans	peptide amidase, GatA	0.2421	0.12	0.5042
Trypanosoma cruzi	hypothetical protein, conserved	0.5154	0.2563	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus granulosus	acetylcholinesterase	0.0529	0.0257	0.0257
Onchocerca volvulus		0.0529	0.0257	0.0853
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.128	0.0631	0.0631
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Entamoeba histolytica	lipase, putative	0.0098	0.0042	0.4922
Schistosoma mansoni	fatty-acid amide hydrolase	0.2421	0.12	0.12
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus granulosus	acetylcholinesterase	0.0529	0.0257	0.0257
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0047	0.0016	0.0016
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Leishmania major	hypothetical protein, conserved	0.0356	0.0171	0.0511
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.016	0.0073	0.0123
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.2421	0.12	0.12
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Brugia malayi	Amidase family protein	0.2421	0.12	0.12
Loa Loa (eye worm)	PDE1B protein	0.0356	0.0171	0.0171
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.0014	0.0014
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0098	0.0042	0.0042
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Brugia malayi	putative amidase	0.2421	0.12	0.12
Trichomonas vaginalis	lipase containing protein, putative	0.5154	0.2563	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0356	0.0171	0.0171
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0012	0.0012
Trypanosoma brucei	hypothetical protein, conserved	0.0356	0.0171	0.0511
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0924	0.0454	0.1703
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0529	0.0257	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0171	0.0171
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0529	0.0257	0.0257
Schistosoma mansoni	nephrin	0.0018	0.0002	0.0002
Schistosoma mansoni	tyrosine kinase	0.0122	0.0054	0.0054
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0122	0.0054	0.0054
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.2421	0.12	0.5042
Echinococcus granulosus	twitchin	0.0018	0.0002	0.0002
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Trichomonas vaginalis	conserved hypothetical protein	0.128	0.0631	0.2338
Onchocerca volvulus		0.0529	0.0257	0.0853
Mycobacterium ulcerans	amidase	0.2421	0.12	0.5042
Toxoplasma gondii	hypothetical protein	0.0924	0.0454	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0529	0.0257	0.0853
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.2421	0.12	0.5
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.2421	0.12	0.12
Schistosoma mansoni	tyrosine kinase	0.0047	0.0016	0.0016
Giardia lamblia	Hypothetical protein	0.0356	0.0171	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0356	0.0171	0.0171
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0047	0.0016	0.0016
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0122	0.0054	0.0054
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0356	0.0171	0.0511
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0017	0.0001	0.0001
Echinococcus multilocularis	neuroglian	0.0018	0.0002	0.0002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0529	0.0257	0.0257
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.2421	0.12	0.5042
Brugia malayi	Lipase family protein	0.0098	0.0042	0.0042
Echinococcus granulosus	neuroligin	0.0529	0.0257	0.0257
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.016	0.0073	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0171	0.0171
Leishmania major	hypothetical protein, conserved	0.0356	0.0171	0.0511
Schistosoma mansoni	amidase	2.0071	1	1
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0356	0.0171	0.0511
Trichomonas vaginalis	conserved hypothetical protein	0.0924	0.0454	0.1633
Brugia malayi	Amidase family protein	0.2421	0.12	0.12
Trypanosoma cruzi	hypothetical protein, conserved	0.5154	0.2563	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	2.0071	1	1
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0171	0.0171
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0013	0.0013
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0356	0.0171	0.1113
Plasmodium vivax	hypothetical protein, conserved	0.0924	0.0454	0.3554
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.0012	0.0012
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.2421	0.12	1
Echinococcus granulosus	carboxylesterase 5A	0.0529	0.0257	0.0257
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.2421	0.12	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0356	0.0171	0.1113
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.016	0.0073	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.0171	0.0511
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.2421	0.12	0.5042
Mycobacterium ulcerans	amidase	0.2421	0.12	0.5042
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.1113
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0529	0.0257	0.0257
Schistosoma mansoni	BC026374 protein (S09 family)	0.0529	0.0257	0.0257
Schistosoma mansoni	fatty-acid amide hydrolase	2.0071	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0047	0.0016	0.0016
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus granulosus	fatty acid amide hydrolase 1	0.2421	0.12	0.12
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0356	0.0171	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0924	0.0454	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.2421	0.12	0.5042
Trichomonas vaginalis	conserved hypothetical protein	0.0924	0.0454	0.1633
Loa Loa (eye worm)	SRC-1	0.0047	0.0016	0.0016
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0356	0.0171	0.0171
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Brugia malayi	Lipase family protein	0.5154	0.2563	0.2563
Plasmodium falciparum	lysophospholipase, putative	0.016	0.0073	0.0267
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0356	0.0171	0.0171
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0356	0.0171	0.0511
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.5154	0.2563	0.2563
Entamoeba histolytica	lipase, putative	0.0098	0.0042	0.4922
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0002	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Echinococcus granulosus	fatty acid amide hydrolase 1	2.0071	1	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.016	0.0073	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0122	0.0054	0.0054
Trypanosoma brucei	monoglyceride lipase, putative	0.016	0.0073	0.0123
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.016	0.0073	0.0123
Echinococcus multilocularis	roundabout 2	0.0018	0.0002	0.0002
Loa Loa (eye worm)	carboxylesterase	0.0529	0.0257	0.0257
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	1.1369	0.5661	0.5661
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.128	0.0631	0.0631
Plasmodium falciparum	esterase, putative	0.016	0.0073	0.0267
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0014	0.0014
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.128	0.0631	0.0631
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.2421	0.12	0.5
Plasmodium falciparum	lysophospholipase, putative	0.016	0.0073	0.0267
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.2421	0.12	0.12
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.128	0.0631	0.2338
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Toxoplasma gondii	GAF domain-containing protein	0.0924	0.0454	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus multilocularis	acetylcholinesterase	0.0529	0.0257	0.0257
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Plasmodium vivax	phosphodiesterase gamma, putative	0.0356	0.0171	0.1113
Schistosoma mansoni	tyrosine kinase	0.0047	0.0016	0.0016
Loa Loa (eye worm)	lipase	0.5154	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.128	0.0631	0.2338
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.0014	0.0014
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0356	0.0171	0.0171
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0356	0.0171	0.0171
Leishmania major	hypothetical protein, conserved	0.5154	0.2563	1
Leishmania major	hypothetical protein, conserved	0.2421	0.12	0.4594
Echinococcus multilocularis	acetylcholinesterase	0.0529	0.0257	0.0257
Onchocerca volvulus		0.0529	0.0257	0.0853
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.016	0.0073	0.0123
Mycobacterium ulcerans	amidase	0.2421	0.12	0.5042
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0125	0.0055	0.0055
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.0012	0.0012
Echinococcus granulosus	roundabout 2	0.0018	0.0002	0.0002
Trypanosoma brucei	lipase domain protein, putative	0.5154	0.2563	1
Schistosoma mansoni	acetylcholinesterase	0.0529	0.0257	0.0257
Trichomonas vaginalis	spcc417.12 protein, putative	0.0529	0.0257	0.0853
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trypanosoma brucei	lipase domain protein, putative	0.5154	0.2563	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0529	0.0257	0.0257
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0356	0.0171	0.0171
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0001	0.0001
Brugia malayi	Lipase family protein	0.0098	0.0042	0.0042
Onchocerca volvulus		0.0529	0.0257	0.0853
Loa Loa (eye worm)	hypothetical protein	1.0089	0.5023	0.5023
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.128	0.0631	0.2338
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Onchocerca volvulus		0.5154	0.2563	1
Loa Loa (eye worm)	lipase	0.0098	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.128	0.0631	0.0631
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0016	0.0016
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.1113
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0356	0.0171	0.0171
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.2421	0.12	0.5042
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0047	0.0016	0.0016
Brugia malayi	Carboxylesterase family protein	0.0529	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	1.1013	0.5484	0.5484
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Mycobacterium ulcerans	putative regulatory protein	0.0924	0.0454	0.1703
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus multilocularis	fatty acid amide hydrolase 1	2.0071	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.0171	0.0511
Mycobacterium tuberculosis	Carboxylesterase LipT	0.4644	0.2309	1
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0356	0.0171	0.0511
Plasmodium falciparum	phosphodiesterase delta, putative	0.0356	0.0171	0.1113
Trichomonas vaginalis	conserved hypothetical protein	0.0924	0.0454	0.1633
Loa Loa (eye worm)	carboxylesterase	0.0529	0.0257	0.0257
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0529	0.0257	0.0257
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.0014	0.0014
Trypanosoma cruzi	amidase, putative	0.2421	0.12	0.4594
Schistosoma mansoni	gliotactin	0.0529	0.0257	0.0257
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.128	0.0631	0.2338
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.016	0.0073	0.0123
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0047	0.0016	0.0016
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0013	0.0013
Entamoeba histolytica	lipase, putative	0.0098	0.0042	0.4922
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0047	0.0016	0.0016
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.128	0.0631	0.2338
Loa Loa (eye worm)	hypothetical protein	0.0529	0.0257	0.0257
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0356	0.0171	0.0511
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Schistosoma mansoni	lipase	0.0098	0.0042	0.0042
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0356	0.0171	0.0171
Plasmodium falciparum	GAF domain-related protein, putative	0.0924	0.0454	0.3554
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0356	0.0171	0.0171
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0356	0.0171	0.0171
Trypanosoma cruzi	monoglyceride lipase, putative	0.016	0.0073	0.0123
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus granulosus	tyrosine kinase	0.0042	0.0014	0.0014
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0356	0.0171	0.0171
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0529	0.0257	0.0257
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Loa Loa (eye worm)	amidase	0.2421	0.12	0.12
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.2421	0.12	0.5
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.2421	0.12	0.12
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.0016	0.0016
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0356	0.0171	0.0511
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.128	0.0631	0.2338
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Loa Loa (eye worm)	carboxylesterase	0.0529	0.0257	0.0257
Echinococcus granulosus	para nitrobenzyl esterase	0.0529	0.0257	0.0257
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0356	0.0171	0.0511
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	1.1369	0.5661	0.5661
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.0016	0.0016
Loa Loa (eye worm)	lipase	0.0098	0.0042	0.0042
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0356	0.0171	0.0171
Toxoplasma gondii	hypothetical protein	0.0924	0.0454	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0356	0.0171	0.313
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0356	0.0171	0.0171
Loa Loa (eye worm)	amidase	0.2421	0.12	0.12
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0356	0.0171	0.0511
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0356	0.0171	0.0171
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Entamoeba histolytica	hypothetical protein	0.0098	0.0042	0.4922
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.128	0.0631	0.2338
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0529	0.0257	0.0257
Mycobacterium ulcerans	carboxylesterase, LipT	0.4644	0.2309	1
Brugia malayi	hypothetical protein	0.0529	0.0257	0.0257
Trypanosoma cruzi	amidase, putative	0.2421	0.12	0.4594
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0002	0.0002
Entamoeba histolytica	lipase, putative	0.0098	0.0042	0.4922
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.128	0.0631	0.0631
Echinococcus multilocularis	para nitrobenzyl esterase	0.0529	0.0257	0.0257
Onchocerca volvulus		0.0529	0.0257	0.0853
Brugia malayi	protein-tyrosine kinase	0.0042	0.0014	0.0014
Mycobacterium ulcerans	amidase	0.2421	0.12	0.5042
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0073	0.0123
Trypanosoma cruzi	hypothetical protein, conserved	0.0356	0.0171	0.0511
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.2421	0.12	0.5042
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0924	0.0454	0.1703
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0529	0.0257	0.0823

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10.4 uM	Inhibition of avian c-Src tyrosine kinase	ChEMBL.	9703473
IC50 (binding)	= 10.4 uM	Inhibition of avian c-Src tyrosine kinase	ChEMBL.	9703473
IC50 (binding)	= 14 uM	Inhibitory concentration evaluated against fibroblast growth factor receptor 1.	ChEMBL.	9703473
IC50 (binding)	= 14 uM	Inhibitory concentration evaluated against fibroblast growth factor receptor 1.	ChEMBL.	9703473
IC50 (binding)	= 23.8 uM	Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase	ChEMBL.	9703473
IC50 (binding)	= 23.8 uM	Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase	ChEMBL.	9703473
IC50 (binding)	> 50 uM	Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase	ChEMBL.	9703473
IC50 (binding)	> 50 uM	Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase	ChEMBL.	9703473
Inhibition (binding)		Inhibition of human gamma-secretase assessed as inhibition of notch1 processing at 100 uM using N100Flag as substrate by western blot analysis	ChEMBL.	27038496
Inhibition (binding)	= 0 %	Inhibition of human gamma-secretase assessed as inhibition of amyloid beta 40 production using recombinant APP C100FLAG as substrate at 100 uM after 4 hrs by ELISA relative to control	ChEMBL.	27038496

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113356
PubChem: 5327874

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 183478