TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.868 | Formula: C22H22ClNO3
H donors: 1 H acceptors: 1 LogP: 5.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N(Cc1ccc(c(c1)O)OC)Cc1ccc(cc1)Cl
InChi: 1S/C22H22ClNO3/c1-26-20-10-8-19(9-11-20)24(14-16-3-6-18(23)7-4-16)15-17-5-12-22(27-2)21(25)13-17/h3-13,25H,14-15H2,1-2H3
InChiKey: KKOLVLLYVAVJRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0962	0.1325	0.1316
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.5192	0.794	0.7938
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4367	0.6649	0.6649
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Trichomonas vaginalis	immunophilin, putative	0.0122	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0431	0.0493	0.0484
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.0493	0.0484
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.9346
Onchocerca volvulus		0.0431	0.0493	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0497	0.0596	0.0587
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0564	0.0701	0.0692
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.6509	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.6509	1	1
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0122	0.001	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1393	0.1999	0.2176
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.6509	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.0484
Trichomonas vaginalis	conserved hypothetical protein	0.0962	0.1325	0.1325
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0431	0.0493	0.9346
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.064	0.082	0.081
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1263	0.1795	0.1795
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.6509	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.5192	0.794	0.7938
Loa Loa (eye worm)	hypothetical protein	0.1393	0.1999	0.1991
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.9346
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0829	0.1116	0.1107
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.064	0.082	0.082
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0431	0.0493	0.0484
Entamoeba histolytica	hypothetical protein	0.1251	0.1776	0.1768
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.064	0.082	0.081
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0189	0.0115	0.0106
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0453	0.0527	0.0518
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0453	0.0527	0.0049
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0431	0.0493	0.0484
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0453	0.0527	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6509	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0431	0.0493	0.0493
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0431	0.0493	0.0493
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0453	0.0527	0.0518
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2269	0.3368	0.3361
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4853	0.741	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3891	0.5905	0.5905
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3531	0.5341	0.5341
Entamoeba histolytica	hypothetical protein	0.0431	0.0493	0.0484
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Mycobacterium leprae	conserved hypothetical protein	0.0431	0.0493	0.5
Loa Loa (eye worm)	hypothetical protein	0.082	0.1102	0.1093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2214	0.3281	0.3281
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.6509	1	1
Loa Loa (eye worm)	hypothetical protein	0.0431	0.0493	0.0484
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0453	0.0527	0.0518
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.0493	0.0484
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0497	0.0596	0.0587
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.6509	1	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0453	0.0527	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0431	0.0493	0.0484
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2716	0.4067	0.4061
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0572	0.0714	0.0714
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2214	0.3281	0.3281
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1263	0.1795	0.1786
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0962	0.1325	0.1316
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0453	0.0527	0.0527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6509	1	1
Leishmania major	phosphatidylinositol kinase, putative	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3531	0.5341	0.5341
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.0493	0.0484
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.082	0.1102	0.1093
Leishmania major	hypothetical protein, unknown function	0.0431	0.0493	0.0484
Trichomonas vaginalis	fk506-binding protein, putative	0.0122	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3536	0.535	0.535
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5187	0.7932	0.7932
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0431	0.0493	0.0484
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0431	0.0493	0.0484
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2214	0.3281	0.3275
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1251	0.1776	0.1768
Entamoeba histolytica	hypothetical protein	0.0431	0.0493	0.0484
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0431	0.0493	0.0484
Loa Loa (eye worm)	hypothetical protein	0.1251	0.1776	0.1768
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2225	0.33	0.3293
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0453	0.0527	0.0518
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0122	0.001	0.5
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0712	0.0933	0.0924
Echinococcus multilocularis	Zinc finger, PHD finger	0.0453	0.0527	0.0518
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1251	0.1776	0.1768
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0564	0.0701	0.0692
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0122	0.001	0.001
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0528	0.0646	0.0636
Entamoeba histolytica	hypothetical protein	0.0431	0.0493	0.0484
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0124	0.0013	0.0003
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.064	0.082	0.082
Loa Loa (eye worm)	phosphatidylinositol 3	0.2225	0.33	0.3293
Echinococcus multilocularis	serine protein kinase ATM	0.1251	0.1776	0.1768
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0431	0.0493	0.0484
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0962	0.1325	0.1316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3536	0.535	0.535
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0497	0.0596	0.0587
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0453	0.0527	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5187	0.7932	0.7932
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0431	0.0493	0.9346
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0431	0.0493	0.9346
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.0493	0.0484
Echinococcus granulosus	serine protein kinase ATM	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1251	0.1776	0.1776
Trichomonas vaginalis	conserved hypothetical protein	0.082	0.1102	0.1102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3536	0.535	0.535
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0453	0.0527	0.0518
Loa Loa (eye worm)	phosphatidylinositol 3	0.6509	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.0493	0.0484
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0497	0.0596	0.0596
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0453	0.0527	0.0518
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.3071	0.4622	0.4616
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5187	0.7932	0.7932
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.064	0.082	0.082
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0431	0.0493	0.0484
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0564	0.0701	0.0692
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0453	0.0527	0.0518
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.6509	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2225	0.33	0.33
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0453	0.0527	0.0527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5547	0.8495	0.8495
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0431	0.0493	0.0484
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0453	0.0527	0.0518
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0453	0.0527	1
Giardia lamblia	GTOR	0.6509	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0475	0.0562	0.0553
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0497	0.0596	0.0587
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2225	0.33	0.3293
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.6509	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.1251	0.1776	0.1768
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0453	0.0527	0.0049
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0431	0.0493	0.0493
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0124	0.0013	0.0003
Loa Loa (eye worm)	phosphatidylinositol 3	0.0785	0.1047	0.1038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4224	0.6427	0.6427
Loa Loa (eye worm)	hypothetical protein	0.1317	0.1879	0.1871
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0829	0.1116	0.1107
Schistosoma mansoni	voltage-gated potassium channel	0.0135	0.003	0.0021
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2214	0.3281	0.3275
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0572	0.0714	0.0714
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1748	0.2553	0.2553
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0453	0.0527	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.387	0.5872	0.5872
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0431	0.0493	0.0493
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0453	0.0527	0.0518
Plasmodium vivax	hypothetical protein	0.0431	0.0493	0.9346
Leishmania major	hypothetical protein, conserved	0.0531	0.0649	0.064
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2269	0.3368	0.3361
Brugia malayi	FAT domain containing protein	0.0962	0.1325	0.1316
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2269	0.3368	0.3361
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.6509	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2214	0.3281	0.3281
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0431	0.0493	0.5
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5187	0.7932	0.7932
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0431	0.0493	0.0484
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2269	0.3368	0.3361
Toxoplasma gondii	FATC domain-containing protein	0.1251	0.1776	0.1855
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0124	0.0013	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2269	0.3368	0.3361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3891	0.5905	0.5905
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2214	0.3281	0.3281
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2269	0.3368	0.3361
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0497	0.0596	0.0596
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1251	0.1776	0.1768
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.6509	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0497	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0564	0.0701	0.0692
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0124	0.0013	0.0003
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.052	0.0633	0.0623
Echinococcus multilocularis		0.0431	0.0493	0.0484
Trichomonas vaginalis	conserved hypothetical protein	0.1393	0.1999	0.1999
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.6509	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0209	0.0146	0.0136
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0453	0.0527	0.0527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3891	0.5905	0.5905
Loa Loa (eye worm)	hypothetical protein	0.0962	0.1325	0.1316
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0453	0.0527	0.0518
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0829	0.1116	0.1107
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.064	0.082	0.081
Trypanosoma cruzi	target of rapamycin kinase 3	0.5192	0.794	0.7938
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0497	0.0596	0.0587
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0122	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.387	0.5872	0.5872
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0431	0.0493	0.0484
Plasmodium vivax	hypothetical protein, conserved	0.0431	0.0493	0.9346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3531	0.5341	0.5341
Schistosoma mansoni	voltage-gated potassium channel	0.0135	0.003	0.0021
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0596	0.0751	0.0742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.082	0.1102	0.1102
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1251	0.1776	0.1768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3536	0.535	0.535
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0712	0.0933	0.0924
Giardia lamblia	Hypothetical protein	0.0431	0.0493	0.0484
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0453	0.0527	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4853	0.741	0.741
Entamoeba histolytica	hypothetical protein	0.0596	0.0751	0.0742
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6509	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1251	0.1776	0.1768
Schistosoma mansoni	hypothetical protein	0.0431	0.0493	0.0484
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0431	0.0493	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1251	0.1776	0.1776
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0497	0.0596	0.0587
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.064	0.082	0.081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5187	0.7932	0.7932
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0431	0.0493	0.0484
Onchocerca volvulus		0.0431	0.0493	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 59.76 uM	Antileishmanial activity against Leishmania donovani promastigotes after 72 hr by alamar blue assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2262199

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1841060