TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.196 | Formula: C15H15BrN2O
H donors: 2 H acceptors: 1 LogP: 3.51 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1Br)N[C@H](c1ccccc1)C
InChi: 1S/C15H15BrN2O/c1-11(12-7-3-2-4-8-12)17-15(19)18-14-10-6-5-9-13(14)16/h2-11H,1H3,(H2,17,18,19)/t11-/m0/s1
InChiKey: XTZJACNMLRGLOX-NSHDSACASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Echinococcus multilocularis	ecdysone induced protein 78C	0.0044	0.0147	0.0418
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0003	0.0009
Echinococcus granulosus	survival motor neuron protein 1	0.0211	0.0978	0.3174
Echinococcus granulosus	microtubule associated protein 2	0.0616	0.2987	0.9697
Loa Loa (eye worm)	heat shock protein 75	0.0024	0.0048	0.0048
Schistosoma mansoni	microtubule-associated protein tau	0.0616	0.2987	1
Echinococcus multilocularis	lamin	0.0024	0.005	0.0141
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.0033	0.0033
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0096	0.0408	0.8837
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0044	0.0147	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Toxoplasma gondii	heat shock protein 90, putative	0.0058	0.0218	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0017	0.0013	0.0684
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0044	0.0147	0.0493
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0033	0.0106
Echinococcus multilocularis	geminin	0.0151	0.0681	0.1933
Echinococcus granulosus	heat shock protein 90	0.0046	0.0159	0.0518
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0023	0.0045	0.0045
Toxoplasma gondii	heat shock protein HSP90	0.0058	0.0218	1
Plasmodium falciparum	endoplasmin, putative	0.0036	0.0107	0.4831
Echinococcus granulosus	pangolin	0.0137	0.061	0.1981
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0044	0.0147	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Toxoplasma gondii	thioredoxin reductase	0.0042	0.014	0.6355
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0159	0.7277
Echinococcus multilocularis	protein pangolin J	0.0137	0.061	0.1732
Treponema pallidum	heat shock protein 90	0.0046	0.0159	1
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0033	0.0109
Brugia malayi	nuclear receptor NHR-67	0.0021	0.0033	0.0033
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0044	0.0147	0.0493
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0044	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0045
Brugia malayi	ecdysone receptor	0.0021	0.0033	0.0033
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0096	0.0408	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Echinococcus multilocularis	beta catenin	0.0205	0.0947	0.269
Trichomonas vaginalis	endoplasmin, putative	0.0036	0.0107	0.4831
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0045
Schistosoma mansoni	pangolin	0.0137	0.061	0.2043
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.0033	0.0033
Brugia malayi	tailless protein	0.0021	0.0033	0.0033
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Loa Loa (eye worm)	HMG box family protein	0.0137	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Trypanosoma brucei	heat shock protein 84, putative	0.0024	0.0048	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0044	0.0147	0.0478
Schistosoma mansoni	endoplasmin	0.0058	0.0218	0.073
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0147	0.0418
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0033	0.0033
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Plasmodium vivax	heat shock protein 86, putative	0.0058	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0045
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.0461	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0147	0.0478
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0044	0.0147	0.0478
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0045
Plasmodium falciparum	heat shock protein 90, putative	0.0024	0.0048	0.2108
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0017	0.0013	0.0498
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Brugia malayi	intermediate filament protein	0.0024	0.005	0.005
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.014	0.6355
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.0033	0.0033
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0044	0.0147	0.0147
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.01	0.4522
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0044	0.0147	0.0418
Trypanosoma brucei	Heat shock protein 83, putative	0.0058	0.0218	1
Loa Loa (eye worm)	DR-78	0.0021	0.0033	0.0033
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0033	0.0033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0044	0.0147	0.0147
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Mycobacterium tuberculosis	Probable reductase	0.0096	0.0408	0.8837
Brugia malayi	Armadillo/beta-catenin-like repeat family protein	0.0205	0.0947	0.0947
Trypanosoma cruzi	heat shock protein 85, putative	0.0058	0.0218	1
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Echinococcus granulosus	endoplasmin	0.0046	0.0159	0.0518
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0096	0.0408	0.8233
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0024	0.0048	0.0156
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0147	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0044	0.0147	0.0147
Brugia malayi	HMG box family protein	0.0137	0.061	0.061
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Loa Loa (eye worm)	heat shock protein 90	0.0058	0.0218	0.0218
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0033	0.0109
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Schistosoma mansoni	zinc finger protein	0.0021	0.0033	0.0109
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.0033	0.0109
Onchocerca volvulus		0.0024	0.005	0.0188
Onchocerca volvulus	Bile acid receptor homolog	0.0044	0.0147	0.1263
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0017	0.0013	0.0234
Brugia malayi	glutathione reductase	0.0042	0.014	0.014
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0023	0.0045	0.0127
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0017	0.0013	0.0498
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0044	0.0147	0.0493
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Brugia malayi	conserved hypotetical protein	0.0021	0.0033	0.0033
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0044	0.0147	0.0478
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0024	0.0048	0.1695
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0044	0.0147	0.0147
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.0147	0.0493
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0147	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0044	0.0147	0.0147
Brugia malayi	nuclear hormone receptor	0.0021	0.0033	0.0033
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.0033	0.0106
Schistosoma mansoni	heat shock protein	0.0024	0.0048	0.0161
Schistosoma mansoni	lamin	0.0024	0.005	0.0166
Onchocerca volvulus	Protein ultraspiracle homolog	0.0044	0.0147	0.1263
Brugia malayi	nuclear receptor RXR	0.0023	0.0045	0.0045
Toxoplasma gondii	exonuclease III APE	0.0017	0.0013	0.0498
Brugia malayi	nuclear receptor RXR	0.0021	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.0147	0.0147
Echinococcus granulosus	intermediate filament protein	0.0024	0.005	0.0161
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.014	0.2985
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0017	0.0013	0.0013
Echinococcus granulosus	lamin dm0	0.0024	0.005	0.0161
Schistosoma mansoni	nuclear hormone receptor	0.0044	0.0147	0.0493
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0023	0.0045	0.015
Giardia lamblia	Grp94/Hsp90	0.0046	0.0159	0.7277
Schistosoma mansoni	hypothetical protein	0.0043	0.0144	0.0481
Schistosoma mansoni	intermediate filament proteins	0.0024	0.005	0.0166
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0044	0.0151	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0044	0.0147	0.0147
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.0461	1
Echinococcus multilocularis	microtubule associated protein 2	0.0616	0.2987	0.848
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0017	0.0013	0.0013
Brugia malayi	nuclear hormone receptor	0.0044	0.0147	0.0147
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0015	0.0003	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0044	0.0147	0.0493
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.0033	0.0092
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0045	0.015
Brugia malayi	Thioredoxin reductase	0.0042	0.014	0.014
Echinococcus multilocularis	musashi	0.0024	0.005	0.0141
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0017	0.0013	0.0498
Trichomonas vaginalis	heat shock protein, putative	0.0036	0.0107	0.4831
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0147	0.0418
Schistosoma mansoni	beta-catenin	0.0205	0.0947	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0017	0.0013	0.0498
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0044	0.0151	0.0151
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0046	0.0159	0.7277
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Echinococcus granulosus	FTZ F1 alpha	0.0044	0.0147	0.0478
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0044	0.0147	0.0478
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0044	0.0147	0.0418
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0017	0.0013	0.0684
Plasmodium falciparum	thioredoxin reductase	0.0042	0.014	0.6355
Echinococcus multilocularis	endoplasmin	0.0046	0.0159	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.0461	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0147	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0044	0.0147	0.0147
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0033	0.0106
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0044	0.0151	0.0151
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Loa Loa (eye worm)	steroid hormone receptor	0.0044	0.0147	0.0147
Echinococcus granulosus	thioredoxin glutathione reductase	0.0042	0.014	0.0453
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0044	0.0147	0.0493
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0044	0.0147	0.0418
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.2029	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0147	0.0147
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0048	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0024	0.005	0.005
Schistosoma mansoni	endoplasmin	0.0058	0.0218	0.073
Echinococcus multilocularis	heat shock protein 90	0.0046	0.0159	0.0453
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0023	0.0045	0.0146
Echinococcus multilocularis	T cell transcription factor 4 long C terminal	0.0137	0.061	0.1732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0044	0.0147	0.0147
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0045	0.0045
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.0033	0.0109
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0044	0.0147	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0042	0.014	0.0396
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0044	0.0147	0.0418
Onchocerca volvulus		0.0024	0.005	0.0188
Toxoplasma gondii	heat shock protein 75, putative	0.0024	0.0048	0.2108
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0024	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0046	0.0159	0.7277
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.0033	0.0033
Leishmania major	trypanothione reductase	0.0042	0.014	0.6355
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0033	0.0092
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0017	0.0013	0.0498
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.014	0.6355
Brugia malayi	Intermediate filament tail domain containing protein	0.0024	0.005	0.005
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.0033	0.0092
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0033	0.0092
Trichomonas vaginalis	heat shock protein, putative	0.0058	0.0218	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0211	0.0978	0.2776
Trypanosoma cruzi	Heat shock protein 83, putative	0.0058	0.0218	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0003	0.0009
Loa Loa (eye worm)	intermediate filament protein	0.0024	0.005	0.005
Echinococcus granulosus	T cell transcription factor 4 long C terminal	0.0137	0.061	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0147	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0044	0.0147	0.0147
Echinococcus granulosus	lamin	0.0024	0.005	0.0161
Schistosoma mansoni	lamin	0.0024	0.005	0.0166
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0044	0.0147	0.0493
Brugia malayi	nuclear receptor NHR-88	0.0044	0.0147	0.0147
Trypanosoma cruzi	heat shock protein 85, putative	0.0058	0.0218	1
Trypanosoma cruzi	heat shock protein, putative	0.0024	0.0048	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0151	0.0151
Echinococcus multilocularis	heat shock protein	0.0058	0.0218	0.0619
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Schistosoma mansoni	hypothetical protein	0.0151	0.0681	0.2279
Schistosoma mansoni	heat shock protein	0.0058	0.0218	0.073
Brugia malayi	Steroid receptor seven-up type 2	0.0044	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.003	0.0081	0.0271
Schistosoma mansoni	survival motor neuron protein	0.0043	0.0144	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0045
Leishmania major	heat shock protein, putative	0.0024	0.0048	0.2108
Plasmodium falciparum	heat shock protein 90, putative	0.0024	0.0048	0.2108
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0017	0.0013	0.0498
Brugia malayi	latrophilin 2 splice variant baaae	0.003	0.0081	0.0081
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0147	0.0478
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.0033	0.0033
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0159	0.7277
Brugia malayi	heat shock protein 90	0.0058	0.0218	0.0218
Trypanosoma cruzi	heat shock protein 90, putative	0.0058	0.0218	1
Brugia malayi	hypothetical protein	0.0211	0.0978	0.0978
Onchocerca volvulus	Cirhin homolog	0.0204	0.0941	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0044	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0046	0.0159	0.0533
Plasmodium vivax	glutathione reductase, putative	0.0042	0.014	0.6355
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0044	0.0147	0.0147
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0081	0.0081
Schistosoma mansoni	nuclear receptor	0.0021	0.0033	0.0109
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0024	0.0048	0.0171
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0058	0.0218	1
Trichomonas vaginalis	ap endonuclease, putative	0.0017	0.0013	0.0498
Brugia malayi	steroid hormone receptor	0.0044	0.0147	0.0147
Brugia malayi	hypothetical protein	0.0021	0.0033	0.0033
Onchocerca volvulus		0.0044	0.0147	0.1263
Schistosoma mansoni	RAR-like nuclear receptor	0.0044	0.0147	0.0493
Brugia malayi	ecdysteroid receptor	0.0044	0.0147	0.0147
Schistosoma mansoni	ap endonuclease	0.0017	0.0013	0.0045
Mycobacterium tuberculosis	Probable dehydrogenase	0.0096	0.0408	0.8837
Echinococcus granulosus	geminin	0.0151	0.0681	0.221
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0159	0.7277
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0044	0.0147	0.0147
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.0033	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0045
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.0033	0.0033
Trypanosoma cruzi	heat shock protein 85, putative	0.0058	0.0218	1
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0043	0.0144	0.0144
Loa Loa (eye worm)	glutathione reductase	0.0042	0.014	0.014
Entamoeba histolytica	heat shock protein 90, putative	0.0058	0.0218	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0724	0.3522	1
Schistosoma mansoni	hypothetical protein	0.0499	0.2406	0.8057
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0017	0.0013	0.0038
Plasmodium vivax	heat shock protein, putative	0.0024	0.0048	0.2108
Trypanosoma brucei	heat shock protein 90, putative	0.0058	0.0218	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0033	0.0106
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0147	0.0493
Brugia malayi	Hsp90 protein	0.0024	0.0048	0.0048
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0147	0.0147
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0033	0.0033
Plasmodium vivax	heat shock protein 90, putative	0.0024	0.0048	0.2108
Echinococcus granulosus	beta catenin	0.0205	0.0947	0.3076
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0044	0.0147	0.1263
Schistosoma mansoni	hypothetical protein	0.0151	0.0681	0.2279
Trypanosoma cruzi	heat shock protein 90, putative	0.0046	0.0159	0.7277
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Trypanosoma brucei	heat shock protein 90, putative	0.0058	0.0218	1
Plasmodium vivax	endoplasmin, putative	0.0058	0.0218	1
Onchocerca volvulus		0.0043	0.0144	0.1225
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.0033	0.0033
Loa Loa (eye worm)	HMP-2 protein	0.0205	0.0947	0.0947
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0044	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0045
Plasmodium falciparum	heat shock protein 90	0.0058	0.0218	1
Mycobacterium ulcerans	heat shock protein 90	0.0046	0.0159	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0044	0.0147	0.0147
Schistosoma mansoni	coup transcription factor	0.0044	0.0147	0.0493
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0046	0.0159	0.0518
Schistosoma mansoni	nuclear receptor	0.0021	0.0033	0.0109
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0147	0.0147
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0017	0.0013	0.0044
Trypanosoma brucei	heat shock protein, putative	0.0058	0.0218	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0003	0.0003
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0046	0.0159	1
Echinococcus multilocularis	lamin dm0	0.0024	0.005	0.0141
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0017	0.0013	0.0498
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0047	0.0047
Echinococcus multilocularis	heat shock protein 90	0.0058	0.0218	0.0619
Brugia malayi	hypothetical protein	0.0021	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0096	0.0408	0.8837
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.0033	0.0106
Entamoeba histolytica	heat shock protein 90, putative	0.0058	0.0218	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0024	0.0048	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0033	0.0092
Echinococcus granulosus	hypothetical protein	0.0635	0.308	1
Trypanosoma brucei	trypanothione reductase	0.0042	0.014	0.6355
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0003	0.0008
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0096	0.0408	0.8837
Echinococcus granulosus	heat shock protein 90	0.0058	0.0218	0.0708
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.0033	0.0092
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.0033	0.0106
Brugia malayi	Endoplasmin precursor	0.0058	0.0218	0.0218
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0044	0.0147	0.0478
Leishmania major	heat shock protein 83-1	0.0058	0.0218	1
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0159	0.7277
Echinococcus multilocularis	FTZ F1 alpha	0.0044	0.0147	0.0418
Echinococcus granulosus	heat shock protein	0.0058	0.0218	0.0708
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0024	0.0048	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0978	0.0978
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.0461	1
Schistosoma mansoni	ap endonuclease	0.0017	0.0013	0.0045
Loa Loa (eye worm)	endoplasmin	0.0058	0.0218	0.0218
Trichomonas vaginalis	ap endonuclease, putative	0.0017	0.0013	0.0498
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0046	0.0159	0.3418
Plasmodium falciparum	glutathione reductase	0.0042	0.014	0.6355
Schistosoma mansoni	heat shock protein	0.0058	0.0218	0.073
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0017	0.0013	0.0684

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)	= 0 %	Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions	ChEMBL.	27393589
Activity (functional)	= 87 %	Relieving activity against bensulfuron-methyl induced injury to Oryza sativa (rice) assessed as growth rate at 1 uM (Rbv = 46 to 53%)	ChEMBL.	27393060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2271531

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1841927