TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.357 | Formula: C19H18N2O5
H donors: 3 H acceptors: 4 LogP: 3.03 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)NNC(=O)/C(=C/C(=O)c1ccc(cc1)C)/O
InChi: 1S/C19H18N2O5/c1-12-3-5-13(6-4-12)16(22)11-17(23)19(25)21-20-18(24)14-7-9-15(26-2)10-8-14/h3-11,23H,1-2H3,(H,20,24)(H,21,25)/b17-11-
InChiKey: QTNQNLKIJVSZAV-BOPFTXTBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	synuclein, alpha (non A4 component of amyloid precursor)	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4651	0.7307
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0101	0.6365	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0101	0.6365	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.7647	0.7647
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0066	0.3933	0.6179
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0164	0.0258
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.0815	0.128
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0164	0.0258
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0164	0.0215
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0101	0.6365	1
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0035	0.1745	0.2281
Brugia malayi	MH2 domain containing protein	0.0119	0.7647	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0164	0.0258
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.0815	0.128
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0164	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0164	0.0164
Toxoplasma gondii	LsmAD domain-containing protein	0.0022	0.0815	0.128
Plasmodium vivax	ataxin-2 like protein, putative	0.0022	0.0815	0.128
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0101	0.6365	1
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0066	0.3933	0.3933
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0164	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0164	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0164	0.0215
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0031	0.1497	0.2353
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0164	0.0215
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0164	0.0258
Trypanosoma brucei	PAB1-binding protein , putative	0.0022	0.0815	0.128
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0164	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0066	0.3929	0.6173
Brugia malayi	hypothetical protein	0.0014	0.0282	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3933	0.3933
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0101	0.6365	1
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0101	0.6365	0.6365
Brugia malayi	RNA binding protein	0.0076	0.4651	0.6082
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0164	0.0258
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4651	0.7307
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0031	0.1497	0.2353
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0101	0.6365	1
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0035	0.1748	0.5
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0815	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0164	0.0258
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.4651	0.7307
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0031	0.1497	0.1958
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0164	0.0258
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0101	0.6365	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4651	0.7307
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0101	0.6365	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0066	0.3929	0.6173
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2506	0.3937
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.2506	0.2506
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2506	0.3937
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0101	0.6365	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.2506	0.3277
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0164	0.0164
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0164	0.0164
Echinococcus granulosus	tar DNA binding protein	0.0076	0.4651	0.7307
Loa Loa (eye worm)	hypothetical protein	0.0153	1	1
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0035	0.1748	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0164	0.0258
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0101	0.6365	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0164	0.0258
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0164	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Schistosoma mansoni	coup transcription factor	0.0012	0.0164	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0164	0.0164
Brugia malayi	steroid hormone receptor	0.0012	0.0164	0.0215
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0035	0.1745	0.2741
Brugia malayi	ecdysteroid receptor	0.0012	0.0164	0.0215
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0066	0.3933	0.6179
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0164	0.0164
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0164	0.0258
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0164	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0164	0.0215
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0164	1
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0101	0.6365	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.4651	0.6082
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.007	0.418	0.418
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0101	0.6365	0.6365
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0164	0.0258
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0164	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.4651	0.4651
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0101	0.6365	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2506	0.3937
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2506	0.3937
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0066	0.3929	0.6173
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0101	0.6365	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0164	0.0258
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0101	0.6365	1
Brugia malayi	nuclear hormone receptor	0.0012	0.0164	0.0215
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0066	0.3933	0.6179
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0164	0.0258
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0066	0.3933	0.6179
Brugia malayi	hypothetical protein	0.0022	0.0815	0.1065
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0164	0.0215
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2506	0.3937
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0164	0.0215
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0101	0.6365	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0101	0.6365	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0164	0.0258
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0066	0.3929	0.6173
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0164	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0164	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0101	0.6365	0.8323
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0164	0.0215
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0164	0.0258
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0031	0.1497	0.2353
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0164	0.0215
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.0815	0.128
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.4651	0.4651
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0101	0.6365	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0031	0.1497	0.2353
Loa Loa (eye worm)	RNA binding protein	0.0076	0.4651	0.4651
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4651	0.7307
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.0815	0.128
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0101	0.6365	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0164	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0164	0.0215
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2506	0.3937
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0164	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0164	0.0215
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0101	0.6365	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0101	0.6365	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0164	0.0258
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0164	0.0215
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0164	0.0258
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.007	0.418	0.418
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0164	0.0258
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0164	0.0215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2506	0.3937
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0164	0.0258
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0164	0.0258
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0164	0.0258
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0164	0.0258
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4651	0.7307
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0164	0.0215
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0153	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.7647	0.7647
Brugia malayi	TAR-binding protein	0.0076	0.4651	0.6082
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0101	0.6365	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0164	0.0164
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0031	0.1497	0.2353
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0164	0.0258
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0101	0.6365	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0101	0.6365	1
Onchocerca volvulus		0.0012	0.0164	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0101	0.6365	1
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0066	0.3933	0.3933
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0164	0.0258
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0164	0.0258
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0164	0.0164
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0101	0.6365	0.6365
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0066	0.3929	0.5612
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0101	0.6365	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0164	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3192639

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1857037