TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 235.282 | Formula: C12H17N3O2
H donors: 1 H acceptors: 1 LogP: 2.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(/C=N/C(=O)NOCc1ccc(cc1)C)C
InChi: 1S/C12H17N3O2/c1-10-4-6-11(7-5-10)8-17-14-12(16)13-9-15(2)3/h4-7,9H,8H2,1-3H3,(H,14,16)/b13-9+
InChiKey: YUTAHEQKSQBAIN-UKTHLTGXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	EYA transcriptional coactivator and phosphatase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	eyes absent homolog	Get druggable targets OG5_129664	All targets in OG5_129664
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Brugia malayi	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative	Get druggable targets OG5_129664	All targets in OG5_129664
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	plasmepsin VII	0.0073	0.0279	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0275	0.1412	0.1412
Echinococcus multilocularis	para nitrobenzyl esterase	0.0275	0.1412	0.1572
Echinococcus multilocularis	carboxylesterase 5A	0.1625	0.8982	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0182	0.0203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Onchocerca volvulus		0.0275	0.1412	1
Plasmodium vivax	plasmepsin V, putative	0.0073	0.0279	1
Brugia malayi	hypothetical protein	0.0275	0.1412	0.1572
Mycobacterium ulcerans	carboxylesterase, LipT	0.0275	0.1412	1
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0026	0.0029
Plasmodium falciparum	plasmepsin VIII, putative	0.0073	0.0279	1
Plasmodium falciparum	plasmepsin X	0.0073	0.0279	1
Onchocerca volvulus		0.0275	0.1412	1
Onchocerca volvulus		0.0275	0.1412	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0182	0.0203
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0182	0.0182
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0	0.5
Plasmodium falciparum	plasmepsin VI	0.0073	0.0279	1
Loa Loa (eye worm)	carboxylesterase	0.1625	0.8982	1
Brugia malayi	Carboxylesterase family protein	0.1625	0.8982	1
Toxoplasma gondii	aspartyl protease ASP3	0.0073	0.0279	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0275	0.1412	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0275	0.1412	0.1412
Loa Loa (eye worm)	hypothetical protein	0.1625	0.8982	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0279	0.0311
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0275	0.1412	1
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0073	0.0279	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0279	0.0311
Schistosoma mansoni	cathepsin D (A01 family)	0.0073	0.0279	0.0279
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0275	0.1412	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0073	0.0279	0.0311
Toxoplasma gondii	aspartyl protease ASP1	0.0073	0.0279	1
Echinococcus multilocularis	acetylcholinesterase	0.1625	0.8982	1
Plasmodium vivax	plasmepsin IV, putative	0.0073	0.0279	1
Echinococcus granulosus	BC026374 protein S09 family	0.0275	0.1412	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Brugia malayi	aspartic protease BmAsp-2, identical	0.0073	0.0279	0.0311
Echinococcus granulosus	acetylcholinesterase	0.1625	0.8982	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0	0.5
Plasmodium falciparum	plasmepsin IX	0.0073	0.0279	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0182	0.0203
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0275	0.1412	0.1572
Schistosoma mansoni	eyes absent homolog	0.0106	0.0469	0.0469
Plasmodium vivax	aspartyl protease, putative	0.0073	0.0279	1
Plasmodium falciparum	plasmepsin V	0.0073	0.0279	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0	0.5
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0275	0.1412	0.1412
Loa Loa (eye worm)	aspartyl protease 6	0.0073	0.0279	0.0311
Plasmodium vivax	aspartyl protease, putative	0.0073	0.0279	1
Loa Loa (eye worm)	hypothetical protein	0.1625	0.8982	1
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0073	0.0279	0.0311
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0275	0.1412	0.1572
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0	0.5
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Echinococcus granulosus	para nitrobenzyl esterase	0.0275	0.1412	0.1572
Plasmodium falciparum	plasmepsin III	0.0073	0.0279	1
Echinococcus granulosus	neuroligin	0.0275	0.1412	0.1572
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0073	0.0279	0.0311
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Plasmodium falciparum	plasmepsin II	0.0073	0.0279	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Schistosoma mansoni	cathepsin D (A01 family)	0.0073	0.0279	0.0279
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0073	0.0279	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0182	0.0182
Trichomonas vaginalis	spcc417.12 protein, putative	0.0275	0.1412	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0275	0.1412	0.1572
Plasmodium vivax	aspartyl proteinase, putative	0.0073	0.0279	1
Brugia malayi	Carboxylesterase family protein	0.1625	0.8982	1
Onchocerca volvulus		0.0275	0.1412	1
Loa Loa (eye worm)	carboxylesterase	0.0275	0.1412	0.1572
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0026	0.0029
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0	0.5
Toxoplasma gondii	aspartyl protease	0.0073	0.0279	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Onchocerca volvulus		0.0275	0.1412	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.1625	0.8982	1
Loa Loa (eye worm)	carboxylesterase	0.0275	0.1412	0.1572
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0275	0.1412	0.1412
Echinococcus multilocularis	acetylcholinesterase	0.1625	0.8982	1
Schistosoma mansoni	acetylcholinesterase	0.0275	0.1412	0.1412
Brugia malayi	Carboxylesterase family protein	0.0275	0.1412	0.1572
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0073	0.0279	0.0311
Brugia malayi	Carboxylesterase family protein	0.0275	0.1412	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0279	0.0311
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0182	0.0203
Brugia malayi	Carboxylesterase family protein	0.0275	0.1412	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0182	0.0203
Schistosoma mansoni	gliotactin	0.0275	0.1412	0.1412
Echinococcus granulosus	carboxylesterase 5A	0.1625	0.8982	1
Echinococcus multilocularis	neuroligin	0.0275	0.1412	0.1572
Brugia malayi	Pepsin A precursor	0.0073	0.0279	0.0311
Brugia malayi	hypothetical protein	0.0073	0.0279	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1412	0.1572
Brugia malayi	Carboxylesterase family protein	0.0275	0.1412	0.1572
Brugia malayi	aspartic protease BmAsp-1, identical	0.0073	0.0279	0.0311
Plasmodium vivax	aspartyl protease, putative	0.0073	0.0279	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0182	0.0203
Brugia malayi	hypothetical protein	0.0106	0.0469	0.0522
Plasmodium vivax	aspartyl proteinase, putative	0.0073	0.0279	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0073	0.0279	0.1979
Plasmodium falciparum	plasmepsin IV	0.0073	0.0279	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0	0.5
Brugia malayi	hypothetical protein	0.0073	0.0279	0.0311
Echinococcus granulosus	acetylcholinesterase	0.1625	0.8982	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0469	0.0522
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1625	0.8982	0.8982
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0275	0.1412	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0469	0.0522
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0275	0.1412	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0073	0.0279	0.0279
Plasmodium falciparum	plasmepsin I	0.0073	0.0279	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0073	0.0279	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 4.466835922 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 28.18382931 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3193750

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1857129