TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 433.424 | Formula: C22H22F3N3O3
H donors: 1 H acceptors: 3 LogP: 3.96 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1cc(cc2c1nc(n2Cc1cccc(c1C)C(F)(F)F)C)N1CCOCC1
InChi: 1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
InChiKey: XTKLTGBKIDQGQL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	582 aa	491 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0031	0.0079	0.1563
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0107	0.0424	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0025	0.0053	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0378	0.1655	0.3868
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0107	0.0424	0.9197
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0025	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0031	0.0079	0.0185
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0317	0.138	0.3485
Trypanosoma cruzi	oligopeptidase b	0.0025	0.0053	0.0413
Brugia malayi	calpain family protein 1	0.002	0.0029	0.0069
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0031	0.0079	0.0274
Onchocerca volvulus		0.0886	0.396	1
Onchocerca volvulus		0.0017	0.0015	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0309	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0053	0.0125
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0038	0.009
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0886	0.396	0.9254
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0114	0.0457	0.2764
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0704	0.1646
Brugia malayi	prolyl oligopeptidase family protein	0.0317	0.138	0.3225
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0025	0.0053	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0038	0.0232
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Onchocerca volvulus		0.0508	0.2244	0.5667
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0036
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0031	0.0079	0.1112
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0021	0.0034	0.0118
Loa Loa (eye worm)	hypothetical protein	0.002	0.0029	0.0069
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0107	0.0424	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0031	0.0079	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0131	0.0305
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0017	0.0015	0.0036
Echinococcus multilocularis	prolyl endopeptidase	0.0025	0.0053	0.0189
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0114	0.0457	0.2764
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0031	0.0079	1
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0164	0.0682	0.1595
Entamoeba histolytica	hypothetical protein, conserved	0.0025	0.0053	0.0413
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0042	0.0131	0.0462
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.0047	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0508	0.2244	0.5244
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0025	0.0053	0.0413
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0042	0.0131	0.0305
Loa Loa (eye worm)	prolyl oligopeptidase	0.0317	0.138	0.3225
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0031	0.0079	0.1023
Onchocerca volvulus		0.0886	0.396	1
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0025	0.0053	1
Trypanosoma cruzi	oligopeptidase b	0.0025	0.0053	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0378	0.1655	0.3868
Brugia malayi	Hypothetical 112.3 kDa protein K02A2.3 in chromosome II	0.0094	0.0366	0.0856
Toxoplasma gondii	peptidylprolyl isomerase	0.0021	0.0036	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0013
Schistosoma mansoni	cathepsin D (A01 family)	0.0017	0.0015	0.0015
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0107	0.0424	0.0424
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0031	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0025	0.0053	0.0413
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.0457	0.1069
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0031	0.0079	0.1023
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0036
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0025	0.0053	0.0413
Echinococcus granulosus	sodium and chloride dependent glycine	0.0042	0.0131	0.0453
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0031	0.0079	0.0274
Toxoplasma gondii	hypothetical protein	0.0025	0.0053	0.0934
Trichomonas vaginalis	rotamase, putative	0.0022	0.0038	0.0232
Schistosoma mansoni	rotamase	0.0022	0.0038	0.0038
Trypanosoma brucei	prolyl endopeptidase	0.0025	0.0053	0.0449
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0025	0.0053	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0031	0.0079	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0682	0.1595
Brugia malayi	aspartic protease BmAsp-1, identical	0.0017	0.0015	0.0036
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0107	0.0424	0.1466
Loa Loa (eye worm)	amino acid permease	0.0094	0.0366	0.0856
Onchocerca volvulus		0.0886	0.396	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0508	0.2244	0.5244
Brugia malayi	hypothetical protein	0.0082	0.0309	0.0723
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0031	0.0079	0.0478
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0042	0.0131	0.0462
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0508	0.2244	0.5244
Echinococcus multilocularis	expressed protein	0.0022	0.0038	0.0136
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0114	0.0457	0.1584
Trypanosoma brucei	oligopeptidase b	0.0025	0.0053	0.0449
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0025	0.0053	0.0413
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0107	0.0424	1
Brugia malayi	hypothetical protein	0.0017	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Onchocerca volvulus		0.0886	0.396	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0131	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0025	0.0053	0.0449
Brugia malayi	LBP/BPI	0.0378	0.1655	0.3868
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0025	0.0053	0.0053
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0017	0.0015	0.0053
Onchocerca volvulus		0.0886	0.396	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0031	0.0079	0.0185
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0025	0.0053	0.0189
Onchocerca volvulus		0.0886	0.396	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0031	0.0079	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Brugia malayi	prolyl oligopeptidase family protein	0.0025	0.0053	0.0125
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0031	0.0079	0.1023
Schistosoma mansoni	sodium/chloride dependent transporter	0.0042	0.0131	0.0131
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0025	0.0053	0.0449
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0025	0.0053	0.0413
Echinococcus granulosus	calpain A	0.0021	0.0034	0.0116
Onchocerca volvulus	CoRest homolog	0.0169	0.0704	0.1778
Brugia malayi	Amino acid permease family protein	0.0094	0.0366	0.0856
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0107	0.0424	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0508	0.2244	0.5244
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	0.1023
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0025	0.0053	0.0934
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0079	0.0185
Brugia malayi	hypothetical protein	0.0378	0.1655	0.3868
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0042	0.0131	0.0305
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0031	0.0079	0.1563
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0317	0.138	0.138
Brugia malayi	prolyl oligopeptidase family protein	0.0107	0.0424	0.099
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	0.1112
Echinococcus multilocularis	solute carrier family 12	0.0094	0.0366	0.1294
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0053	0.5973
Loa Loa (eye worm)	hypothetical protein	0.0508	0.2244	0.5244
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0017	0.0015	0.0036
Echinococcus granulosus	hypothetical protein	0.065	0.2889	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0053	0.0413
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0031	0.0079	0.0478
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0024	0.0047	0.0269
Brugia malayi	Pepsin A precursor	0.0017	0.0015	0.0036
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0508	0.2244	0.5244
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0886	0.396	0.9254
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0036
Schistosoma mansoni	solute carrier family 12 electroneutral k-cl cotransporter	0.0094	0.0366	0.0366
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0025	0.0053	0.0323
Schistosoma mansoni	cathepsin D (A01 family)	0.0017	0.0015	0.0015
Trichomonas vaginalis	rotamase, putative	0.0021	0.0036	0.0218
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0317	0.138	0.4876
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0053	0.0125
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0025	0.0053	0.0449
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0053	0.0323
Brugia malayi	hypothetical protein	0.0508	0.2244	0.5244
Echinococcus multilocularis	Zinc finger, PHD finger	0.0031	0.0079	0.028
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0025	0.0053	0.0135
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0031	0.0079	0.0478
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0021	0.0034	0.0116
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0025	0.0053	0.0449
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0021	0.0034	0.0034
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0025	0.0053	0.0413
Echinococcus granulosus	expressed protein	0.0022	0.0038	0.0133
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	0.1023
Trypanosoma cruzi	prolyl endopeptidase	0.0025	0.0053	0.0413
Onchocerca volvulus		0.0886	0.396	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0017	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0956	0.4279	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0114	0.0457	0.2764
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0025	0.0053	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0956	0.4279	1
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0022	0.0038	0.009
Toxoplasma gondii	prolyl endopeptidase	0.0025	0.0053	0.0934
Loa Loa (eye worm)	calpain family protein 1	0.002	0.0029	0.0069
Onchocerca volvulus		0.0886	0.396	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0031	0.0079	0.1023
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0031	0.0079	0.028
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0886	0.396	0.9254
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0053	0.0125
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0114	0.0457	1
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0886	0.396	0.9254
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0403	0.1768	0.1768
Echinococcus granulosus	tm gpcr rhodopsin	0.0355	0.1552	0.5374
Echinococcus granulosus	solute carrier family 12	0.0094	0.0366	0.1268
Brugia malayi	NNMT/PNMT/TEMT family protein	0.0956	0.4279	1
Schistosoma mansoni	memapsin-2 (A01 family)	0.0417	0.1833	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Onchocerca volvulus		0.0508	0.2244	0.5667
Onchocerca volvulus		0.0378	0.1655	0.4179
Echinococcus multilocularis	calpain family protein 1, d	0.0015	0.0006	0.002
Loa Loa (eye worm)	prolyl oligopeptidase	0.0025	0.0053	0.0125
Entamoeba histolytica	hypothetical protein	0.0114	0.0457	1
Loa Loa (eye worm)	hypothetical protein	0.0508	0.2244	0.5244
Leishmania major	oligopeptidase b	0.0025	0.0053	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0366	0.0856
Schistosoma mansoni	sodium/chloride dependent transporter	0.0042	0.0131	0.0131
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0053	0.0413
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0508	0.2244	0.5244
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0107	0.0424	0.9197
Echinococcus granulosus	sodium and chloride dependent glycine	0.0042	0.0131	0.0453
Onchocerca volvulus		0.0017	0.0015	0.0039
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0017	0.0015	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0318	0.0742
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0107	0.0426	0.9246
Echinococcus granulosus	acylamino acid releasing enzyme	0.0025	0.0053	0.0185
Echinococcus granulosus	prolyl endopeptidase	0.0025	0.0053	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0378	0.1655	0.3868
Loa Loa (eye worm)	aspartyl protease 6	0.0017	0.0015	0.0036
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0025	0.0053	0.0053
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0031	0.0079	0.1112
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0017	0.0015	0.0054
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0107	0.0424	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0114	0.0457	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.0045
Brugia malayi	hypothetical protein	0.0017	0.0015	0.0036
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0031	0.0079	0.0478
Brugia malayi	prolyl oligopeptidase family protein	0.0025	0.0053	0.0125
Brugia malayi	Serotonin receptor	0.0437	0.1925	0.4498
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0305	0.0714
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0031	0.0079	0.028
Brugia malayi	prolyl oligopeptidase family protein	0.0025	0.0053	0.0125
Brugia malayi	aspartic protease BmAsp-2, identical	0.0017	0.0015	0.0036
Plasmodium falciparum	peptidase, putative	0.0025	0.0053	0.5973
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0031	0.0079	0.0185
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0031	0.0079	0.0079
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0031	0.0079	0.0478
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0886	0.396	0.9254
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0114	0.0457	0.0457
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.0457	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0021	0.0034	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.0457	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0031	0.0079	0.0478
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0114	0.0457	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0508	0.2244	0.5244
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0317	0.138	0.4777
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0114	0.0457	0.2764
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0355	0.1552	0.5485
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0025	0.0053	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.002	0.0029	0.0029
Echinococcus multilocularis	conserved hypothetical protein	0.0637	0.283	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0031	0.0079	0.1112
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0017	0.0015	0.0015
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0114	0.0457	0.2764
Brugia malayi	calpain family protein 1	0.002	0.0029	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.1655	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0114	0.0457	1
Loa Loa (eye worm)	hypothetical protein	0.0378	0.1655	0.3868
Loa Loa (eye worm)	hypothetical protein	0.0508	0.2244	0.5244
Brugia malayi	hypothetical protein	0.0508	0.2244	0.5244
Echinococcus multilocularis	calpain A	0.0021	0.0034	0.0118
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0031	0.0079	0.0079
Loa Loa (eye worm)	phosphatidylinositol 3	0.0114	0.0457	0.1069
Loa Loa (eye worm)	calpain family protein 1	0.0015	0.0006	0.0013
Mycobacterium tuberculosis	Probable peptidase	0.0025	0.0053	1
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0956	0.4279	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.89 nM	Inhibition of PI3K p110beta (unknown origin)	ChEMBL.	25387153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3188551

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1872617