Detailed information for compound 1876950

Basic information

Technical information
  • TDR Targets ID: 1876950
  • Name: 1-[(4-methoxyphenyl)methylideneamino]-4,6-dim ethyl-2-oxopyridine-3-carboxamide
  • MW: 299.324 | Formula: C16H17N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=N/n1c(C)cc(c(c1=O)C(=O)N)C
  • InChi: 1S/C16H17N3O3/c1-10-8-11(2)19(16(21)14(10)15(17)20)18-9-12-4-6-13(22-3)7-5-12/h4-9H,1-3H3,(H2,17,20)/b18-9+
  • InChiKey: YUVPOTNZHAAMHV-GIJQJNRQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-methoxyphenyl)methyleneamino]-4,6-dimethyl-2-oxo-pyridine-3-carboxamide
  • 1-[(4-methoxyphenyl)methyleneamino]-4,6-dimethyl-2-oxo-3-pyridinecarboxamide
  • 2-keto-1-[(4-methoxybenzylidene)amino]-4,6-dimethyl-nicotinamide
  • 1-[(4-methoxyphenyl)methylideneamino]-4,6-dimethyl-2-oxo-pyridine-3-carboxamide
  • Oprea1_239399
  • 1-[(4-methoxybenzylidene)amino]-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarboxamide
  • MLS000532308
  • CBDivE_012959
  • SMR000137247

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi serine-palmitoyl-CoA transferase, putative 0.0127 0.0141 1
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Brugia malayi RNase H family protein 0.0033 0.0002 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0017 0.0026
Echinococcus multilocularis 5 aminolevulinate synthase 0.0127 0.0141 0.0235
Echinococcus multilocularis ribonuclease H1 0.0033 0.0002 0.0002
Trichomonas vaginalis aspartate aminotransferase, putative 0.0361 0.0488 0.0814
Schistosoma mansoni phosphoglucomutase 0.0033 0.0002 0.0003
Mycobacterium ulcerans N-succinyldiaminopimelate aminotransferase 0.0127 0.0141 0.0488
Trichomonas vaginalis aspartate aminotransferase, putative 0.0361 0.0488 0.0814
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0141 0.0236
Leishmania major hypothetical protein, conserved 0.0043 0.0017 0.0314
Brugia malayi tyrosine aminotransferase 0.0127 0.0141 0.0236
Mycobacterium ulcerans aspartate aminotransferase 0.0361 0.0488 0.1854
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Trichomonas vaginalis serine palmitoyltransferase, putative 0.0127 0.0141 0.0233
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.029 0.0383 0.064
Brugia malayi Angiotensin-converting enzyme family protein 0.029 0.0383 0.064
Mycobacterium tuberculosis Probable aminotransferase 0.0127 0.0141 0.0488
Trichomonas vaginalis aspartate aminotransferase, putative 0.0127 0.0141 0.0233
Plasmodium vivax aspartate aminotransferase, mitochondrial precursor, putative 0.0127 0.0141 1
Trichomonas vaginalis tyrosine aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium ulcerans putative aminotransferase 0.0127 0.0141 0.0488
Echinococcus multilocularis nmda type glutamate receptor 0.0238 0.0306 0.051
Trichomonas vaginalis 2-amino-3-ketobutyrate coenzyme A ligase, putative 0.0127 0.0141 0.0233
Toxoplasma gondii ABC1 family protein 0.0043 0.0017 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0017 0.0029
Giardia lamblia Alanine aminotransferase, putative 0.0127 0.0141 0.0233
Loa Loa (eye worm) hypothetical protein 0.0127 0.0141 0.0236
Trypanosoma brucei serine palmitoyltransferase, putative 0.0127 0.0141 0.2861
Trypanosoma cruzi glutamic--pyruvic transaminase, putative 0.0127 0.0141 1
Trichomonas vaginalis alanine aminotransferase, putative 0.0127 0.0141 0.0233
Toxoplasma gondii aminotransferase, class I/II superfamily protein 0.0127 0.0141 0.0139
Trypanosoma brucei RNA helicase, putative 0.0124 0.0137 0.2782
Mycobacterium leprae Probable aminotransferase 0.0127 0.0141 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0055 0.0034 0.0066
Toxoplasma gondii 5-aminolevulinic acid synthase domain-containing protein 0.0127 0.0141 0.0139
Loa Loa (eye worm) beta-lactamase 0.0043 0.0017 0.0029
Onchocerca volvulus 0.0127 0.0141 0.0236
Entamoeba histolytica glycogenphosphorylase, putative 0.1756 0.2557 0.414
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0076 0.0066 0.0109
Trichomonas vaginalis histidinol-phosphate aminotransferase, putative 0.0127 0.0141 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0017 0.0026
Wolbachia endosymbiont of Brugia malayi 5-aminolevulinate synthase 0.0127 0.0141 0.2861
Trypanosoma cruzi serine palmitoyltransferase, putative 0.0127 0.0141 1
Trypanosoma brucei glycine acetyltransferase, putative 0.0127 0.0141 0.2861
Onchocerca volvulus 0.0043 0.0017 0.0029
Toxoplasma gondii 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0139
Trypanosoma brucei unspecified product 0.0036 0.0006 0.0086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0365 0.1368
Trypanosoma cruzi glutamic--pyruvic transaminase, putative 0.0127 0.0141 1
Echinococcus granulosus aspartate aminotransferase 0.0127 0.0141 0.0235
Trichomonas vaginalis histidinol-phosphate aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium ulcerans 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0488
Wolbachia endosymbiont of Brugia malayi aspartate aminotransferase 0.0361 0.0488 1
Mycobacterium ulcerans aminotransferase 0.0127 0.0141 0.0488
Echinococcus granulosus serine palmitoyltransferase long chain base 0.0127 0.0141 0.0235
Echinococcus multilocularis alanine aminotransferase 2 0.0127 0.0141 0.0235
Giardia lamblia Glycogen phosphorylase 0.4062 0.5975 1
Treponema pallidum hypothetical protein 0.0361 0.0488 1
Leishmania major cysteine conjugate beta-lyase, aminotransferase- like protein 0.0361 0.0488 1
Entamoeba histolytica glycogen phosphorylase, putative 0.4062 0.5975 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0036 0.0006 0.0086
Loa Loa (eye worm) aspartate aminotransferase 0.0127 0.0141 0.0236
Schistosoma mansoni hypothetical protein 0.0124 0.0137 0.023
Echinococcus granulosus Glycosyl transferase family 35 0.4062 0.5975 1
Leishmania major alanine aminotransferase 0.0127 0.0141 0.2861
Mycobacterium ulcerans aminotransferase AlaT 0.0127 0.0141 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0017 0.1098
Toxoplasma gondii glycine C-acetyltransferase, putative 0.0127 0.0141 0.0139
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Brugia malayi aspartate aminotransferase, identical 0.0127 0.0141 0.0236
Brugia malayi RNase H family protein 0.0033 0.0002 0.0003
Echinococcus granulosus glycogen phosphorylase 0.4062 0.5975 1
Trichomonas vaginalis serine palmitoyltransferase I, putative 0.0127 0.0141 0.0233
Entamoeba histolytica glycogen phosphorylase, putative 0.1756 0.2557 0.414
Echinococcus granulosus 5 aminolevulinate synthase 0.0127 0.0141 0.0235
Leishmania major tyrosine aminotransferase 0.0127 0.0141 0.2861
Trypanosoma cruzi serine-palmitoyl-CoA transferase, putative 0.0127 0.0141 1
Echinococcus multilocularis nmda type glutamate receptor 0.0303 0.0402 0.0672
Trichomonas vaginalis aspartate aminotransferase, putative 0.0127 0.0141 0.0233
Trypanosoma brucei glutamine aminotransferase (GlnAT) 0.0361 0.0488 1
Leishmania major aspartate aminotransferase, putative 0.0127 0.0141 0.2861
Mycobacterium tuberculosis Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic trans 0.0234 0.03 0.1113
Trypanosoma cruzi serine palmitoyltransferase, putative 0.0127 0.0141 1
Trypanosoma cruzi alanine aminotransferase, putative 0.0127 0.0141 1
Plasmodium falciparum aspartate transaminase 0.0127 0.0141 0.5
Loa Loa (eye worm) glycogen phosphorylase 0.4062 0.5975 1
Mycobacterium tuberculosis Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synth 0.0127 0.0141 0.0488
Schistosoma mansoni glycogen phosphorylase 0.4062 0.5975 1
Trypanosoma cruzi alanine aminotransferase, putative 0.0127 0.0141 1
Entamoeba histolytica glycogen phosphorylase, putative 0.1756 0.2557 0.414
Leishmania major serine palmitoyltransferase, putative 0.0127 0.0141 0.2861
Chlamydia trachomatis 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.018
Leishmania major aspartate aminotransferase, putative 0.0127 0.0141 0.2861
Schistosoma mansoni aspartate aminotransferase 0.0127 0.0141 0.0236
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0055 0.0034 0.0659
Toxoplasma gondii aspartate aminotransferase 0.0127 0.0141 0.0139
Giardia lamblia Alanine aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium leprae PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHE 0.0127 0.0141 1
Trypanosoma cruzi tyrosine aminotransferase, putative 0.0127 0.0141 1
Echinococcus multilocularis 2 amino 3 ketobutyrate coenzyme A ligase 0.0127 0.0141 0.0235
Echinococcus multilocularis glutamate receptor NMDA 0.0227 0.0289 0.0483
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0017 0.0026
Echinococcus granulosus nmda type glutamate receptor 0.0303 0.0402 0.0672
Schistosoma mansoni serine palmitoyltransferase 2 0.0127 0.0141 0.0236
Brugia malayi kynurenine-oxoglutarate transaminase 0.0361 0.0488 0.0817
Mycobacterium leprae PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT) 0.0127 0.0141 1
Echinococcus multilocularis aspartate aminotransferase, mitochondrial 0.0127 0.0141 0.0235
Chlamydia trachomatis aromatic amino acid aminotransferase 0.0127 0.0141 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Mycobacterium ulcerans 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0488
Giardia lamblia Serine palmitoyltransferase 1 0.0127 0.0141 0.0233
Trypanosoma cruzi 2-amino-3-ketobutyrate coenzyme A ligase, putative 0.0127 0.0141 1
Schistosoma mansoni glycogen phosphorylase 0.1756 0.2557 0.4279
Mycobacterium ulcerans histidinol-phosphate aminotransferase 0.0127 0.0141 0.0488
Brugia malayi beta-lactamase family protein 0.0043 0.0017 0.0029
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0055 0.0034 0.0659
Toxoplasma gondii aminotransferase, putative 0.0127 0.0141 0.0139
Echinococcus granulosus 5 aminolevulinate synthase 0.0127 0.0141 0.0235
Trichomonas vaginalis histidinol-phosphate aminotransferase, putative 0.0127 0.0141 0.0233
Trichomonas vaginalis glycogen phosphorylase, putative 0.4062 0.5975 1
Mycobacterium tuberculosis Probable aminotransferase 0.0127 0.0141 0.0488
Schistosoma mansoni branched-chain amino acid aminotransferase 0.0127 0.0141 0.0236
Trypanosoma cruzi aspartate aminotransferase, putative 0.0127 0.0141 1
Echinococcus granulosus serine palmitoyltransferase long chain base 0.0127 0.0141 0.0235
Plasmodium vivax delta-aminolevulinic acid synthetase, putative 0.0127 0.0141 1
Brugia malayi hypothetical protein 0.0127 0.0141 0.0236
Trichomonas vaginalis alanine aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium ulcerans 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0488
Trypanosoma cruzi aspartate aminotransferase, putative 0.0127 0.0141 1
Trypanosoma cruzi 2-amino-3-ketobutyrate coenzyme A ligase, putative 0.0127 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0029
Loa Loa (eye worm) tyrosine aminotransferase 0.0127 0.0141 0.0236
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0017 0.0029
Echinococcus multilocularis serine palmitoyltransferase, long chain base 0.0127 0.0141 0.0235
Plasmodium falciparum delta-aminolevulinic acid synthetase 0.0127 0.0141 0.5
Mycobacterium tuberculosis Probable aminotransferase 0.0127 0.0141 0.0488
Trichomonas vaginalis glycogen phosphorylase, putative 0.4062 0.5975 1
Mycobacterium tuberculosis Possible aminotransferase CobC 0.0127 0.0141 0.0488
Brugia malayi RNase H family protein 0.0033 0.0002 0.0003
Loa Loa (eye worm) 2-amino-3-ketobutyrate coenzyme A ligase 0.0127 0.0141 0.0236
Schistosoma mansoni phosphoglucomutase 0.0033 0.0002 0.0003
Trichomonas vaginalis esterase, putative 0.0043 0.0017 0.0026
Brugia malayi 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor 0.0127 0.0141 0.0236
Trypanosoma cruzi tyrosine aminotransferase, putative 0.0127 0.0141 1
Plasmodium falciparum serine C-palmitoyltransferase, putative 0.0127 0.0141 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0017 0.1098
Brugia malayi beta-lactamase family protein 0.0043 0.0017 0.0029
Echinococcus multilocularis glycogen phosphorylase 0.4062 0.5975 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.1756 0.2557 1
Schistosoma mansoni alanine aminotransferase 0.0127 0.0141 0.0236
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Giardia lamblia Serine palmitoyltransferase 2 0.0127 0.0141 0.0233
Schistosoma mansoni glutamate receptor NMDA 0.0259 0.0337 0.0564
Trypanosoma cruzi tyrosine aminotransferase, putative 0.0127 0.0141 1
Trichomonas vaginalis histidinol-phosphate aminotransferase, putative 0.0127 0.0141 0.0233
Schistosoma mansoni 5-aminolevulinic acid synthase 0.0127 0.0141 0.0236
Trichomonas vaginalis acc synthase, putative 0.0127 0.0141 0.0233
Brugia malayi carbohydrate phosphorylase 0.4062 0.5975 1
Mycobacterium ulcerans aminotransferase 0.0361 0.0488 0.1854
Trypanosoma cruzi 2-amino-3-ketobutyrate coenzyme A ligase, putative 0.0127 0.0141 1
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0017 0.0029
Trichomonas vaginalis tyrosine aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium ulcerans GntR family transcriptional regulator 0.0127 0.0141 0.0488
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0017 0.0314
Mycobacterium ulcerans 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0488
Loa Loa (eye worm) hypothetical protein 0.0127 0.0141 0.0236
Echinococcus multilocularis 5 aminolevulinate synthase 0.0127 0.0141 0.0235
Onchocerca volvulus Ribonuclease H1 homolog 0.0033 0.0002 0.0003
Echinococcus multilocularis aspartate aminotransferase 0.0127 0.0141 0.0235
Giardia lamblia Aspartate aminotransferase, cytoplasmic 0.0127 0.0141 0.0233
Trichomonas vaginalis histidinol-phosphate aminotransferase, putative 0.0127 0.0141 0.0233
Echinococcus multilocularis glycogen phosphorylase 0.4062 0.5975 1
Trypanosoma brucei hypothetical protein, conserved 0.0127 0.0141 0.2861
Trypanosoma brucei aspartate aminotransferase 0.0127 0.0141 0.2861
Loa Loa (eye worm) kynurenine-oxoglutarate transaminase 0.0361 0.0488 0.0817
Entamoeba histolytica aspartate aminotransferase, putative 0.0361 0.0488 0.0595
Mycobacterium tuberculosis Probable aspartate aminotransferase AspC (transaminase A) (ASPAT) 0.0127 0.0141 0.0488
Onchocerca volvulus Glycogen phosphorylase homolog 0.4062 0.5975 1
Trypanosoma brucei ingi protein (ORF1) 0.0036 0.0006 0.0086
Echinococcus granulosus alanine aminotransferase 2 0.0127 0.0141 0.0235
Trypanosoma brucei aspartate aminotransferase, mitochondrial 0.0127 0.0141 0.2861
Trypanosoma brucei serine palmitoyltransferase, putative 0.0127 0.0141 0.2861
Trypanosoma brucei serine-palmitoyl-CoA transferase, putative 0.0127 0.0141 0.2861
Trichomonas vaginalis tyrosine aminotransferase, putative 0.0127 0.0141 0.0233
Schistosoma mansoni arylformamidase 0.0361 0.0488 0.0817
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.1756 0.2557 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0006 0.0086
Trypanosoma cruzi tyrosine aminotransferase 0.0127 0.0141 1
Brugia malayi hypothetical protein 0.0127 0.0141 0.0236
Chlamydia trachomatis glycogen phosphorylase 0.4062 0.5975 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0017 0.0026
Echinococcus multilocularis serine palmitoyltransferase, long chain base 0.0127 0.0141 0.0235
Schistosoma mansoni serine palmitoyltransferase 1 0.0127 0.0141 0.0236
Mycobacterium leprae PROBABLE AMINOTRANSFERASE 0.0127 0.0141 1
Schistosoma mansoni alanine aminotransferase 0.0127 0.0141 0.0236
Schistosoma mansoni phosphoglucomutase 0.0033 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0127 0.0141 0.0236
Plasmodium vivax serine C-palmitoyltransferase, putative 0.0127 0.0141 1
Schistosoma mansoni glycogen phosphorylase 0.4062 0.5975 1
Mycobacterium tuberculosis Probable histidinol-phosphate aminotransferase HisC1 0.0127 0.0141 0.0488
Echinococcus granulosus glycogen phosphorylase 0.4062 0.5975 1
Chlamydia trachomatis LL-diaminopimelate aminotransferase 0.0127 0.0141 0.018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0017 0.0028
Echinococcus granulosus aspartate aminotransferase mitochondrial 0.0127 0.0141 0.0235
Trichomonas vaginalis aspartate aminotransferase, putative 0.0127 0.0141 0.0233
Mycobacterium ulcerans hypothetical protein 0.0127 0.0141 0.0488
Echinococcus granulosus glutamate receptor NMDA 0.0227 0.0289 0.0483
Echinococcus multilocularis alanine aminotransferase 2 0.0127 0.0141 0.0235
Echinococcus multilocularis Glycosyl transferase, family 35 0.4062 0.5975 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0017 0.0029
Trypanosoma brucei ingi protein (ORF1) 0.0036 0.0006 0.0086
Echinococcus granulosus nmda type glutamate receptor 0.0238 0.0306 0.051
Mycobacterium leprae Probable histidinol-phosphate aminotransferase 1 HisC (Imidazole acetol-phosphate transaminase 1) 0.0127 0.0141 1
Mycobacterium tuberculosis Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synth 0.0127 0.0141 0.0488
Trypanosoma cruzi aspartate aminotransferase, mitochondrial, putative 0.0127 0.0141 1
Trypanosoma brucei alanine aminotransferase 0.0127 0.0141 0.2861
Mycobacterium ulcerans 8-amino-7-oxononanoate synthase 0.0127 0.0141 0.0488
Echinococcus granulosus ribonuclease H1 0.0033 0.0002 0.0002
Onchocerca volvulus 0.0043 0.0017 0.0029
Echinococcus granulosus 2 amino 3 ketobutyrate coenzyme A ligase 0.0127 0.0141 0.0235
Trichomonas vaginalis acc synthase, putative 0.0127 0.0141 0.0233
Entamoeba histolytica glycogen phosphorylase, putative 0.4062 0.5975 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0141 0.0236
Trichomonas vaginalis aspartate aminotransferase, putative 0.0127 0.0141 0.0233
Echinococcus granulosus alanine aminotransferase 2 0.0127 0.0141 0.0235
Onchocerca volvulus 0.0043 0.0017 0.0029
Brugia malayi beta-lactamase 0.0043 0.0017 0.0029
Trichomonas vaginalis acc synthase, putative 0.0127 0.0141 0.0233
Leishmania major serine palmitoyltransferase-like protein 0.0127 0.0141 0.2861
Mycobacterium tuberculosis Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at) 0.0361 0.0488 0.1854
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0055 0.0034 0.0066

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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