Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0095 | 0.4555 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1264 | 0.1264 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1264 | 0.1264 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0095 | 0.4555 | 0.4555 |
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1264 | 0.1264 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.796 | 0.796 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.796 | 0.796 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1264 | 0.1264 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1264 | 0.1264 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0095 | 0.4555 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0095 | 0.4555 | 0.4555 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.796 | 0.796 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1264 | 0.1264 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.796 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.796 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0145 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0145 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0145 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0145 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1264 | 0.1264 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0095 | 0.4555 | 0.4555 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.4555 | 0.4555 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1264 | 0.1264 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0145 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1264 | 0.1264 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0145 | 1 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 0.4555 | 0.4555 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1264 | 0.1264 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0095 | 0.4555 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1264 | 0.1264 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0145 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.668 uM | Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane | ChEMBL. | 7932565 |
Ki (binding) | = 0.668 uM | Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane | ChEMBL. | 7932565 |
Ki (binding) | = 1.2 uM | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | ChEMBL. | 7932565 |
Ki (binding) | = 1.2 uM | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | ChEMBL. | 7932565 |
Ki (binding) | = 74.2 uM | Displacement of [125I]-AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNA | ChEMBL. | 7932565 |
Ki (binding) | = 74.2 uM | Displacement of [125I]-AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNA | ChEMBL. | 7932565 |
Ratio (binding) | = 62 | Ratio of selectivity for A3 and A2a receptors at rat brain | ChEMBL. | 7932565 |
Ratio (binding) | = 110 | Ratio of selectivity for A3 and A1 receptors at rat brain | ChEMBL. | 7932565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.