Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Cavia porcellus | Kappa opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0065 | 0.0405 | 0.0598 |
Brugia malayi | Sugar transporter family protein | 0.0226 | 0.3107 | 0.4581 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0065 | 0.0405 | 0.0598 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.3107 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Onchocerca volvulus | 0.0065 | 0.0405 | 1 | |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.6781 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.6781 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Plasmodium vivax | hexose transporter | 0.0226 | 0.3107 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.6781 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0226 | 0.3107 | 1 |
Echinococcus granulosus | General substrate transporter | 0.0194 | 0.2574 | 0.2574 |
Schistosoma mansoni | glucose transport protein | 0.0226 | 0.3107 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.6781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0226 | 0.3107 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0226 | 0.3107 | 0.4581 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0636 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0226 | 0.3107 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Schistosoma mansoni | glucose transport protein | 0.0226 | 0.3107 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Echinococcus multilocularis | General substrate transporter | 0.0194 | 0.2574 | 0.2574 |
Plasmodium falciparum | hexose transporter | 0.0226 | 0.3107 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3133 | 0.462 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0226 | 0.3107 | 0.3107 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.6781 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guinea pig brain membrane at 1 uM | ChEMBL. | 24856182 | |
IC50 (binding) | > 1 uM | Displacement of [3H]-deltorphin 2 from human delta-opioid receptor transfected in CHO-K1 cell by scintillation counting | ChEMBL. | 24856182 |
IC50 (binding) | > 1 uM | Displacement of [3H]-naloxone from human mu-opioid receptor transfected in CHO-K1 cell by scintillation counting | ChEMBL. | 24856182 |
Ki (binding) | = 2.1 nM | Displacement of [3H]U-69593 from kappa-opioid receptor in guinea pig brain membrane | ChEMBL. | 24856182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.